Latest topics page 22

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 22 of 52

Topic	Participants	Replies	Views	Activity
Coming back to: Training through a dose escalation week Nutrition & Training › Resistance training fatigue lean mass loss DXA On the subject in the title: Training through a dose escalation week Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is not a measurement.…	+68	74	46k	4mo
Follow-up: Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis CJC-1295 ipamorelin tesamorelin needs a source On the subject in the title: Evidence quality in the secretagogue literature: an honest assessment Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with LEADER ( N Engl J Med…	+20	24	18k	4mo
Grapefruit: why this class is not the class that cares Practice › Interactions needs a source hypoglycaemia metformin delayed gastric emptying Grapefruit: why this class is not the class that cares Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+126	139	4k	4mo
Reading U-100 graduations, with a conversion table — one year on Devices › Syringes & needles syringe units needle gauge & length worked example subcutaneous injection Reading U-100 graduations, with a conversion table — one year on Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have…	+3	7	662	4mo
Follow-up: State-level differences that actually matter Regional › North America FDA telehealth insurance State-level differences that actually matter — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the…	+90	96	4.1k	4mo
Preprint servers and what screening they do — the long version Evidence › Preprints risk of bias effect size needs a source On the subject in the title: Preprint servers and what screening they do — the long version Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+7	11	26k	4mo
Coming back to: Why most self-reports here are not experiments, and that is fine Research Methods › N-of-1 designs worked example data table effect size Solved Closed The question in the title: Why most self-reports here are not experiments, and that is fine I will give what I have already checked below so nobody repeats it. Comparing LEADER ( N Engl J Med , 2016) with…	+56	62	11k	4mo
Revisiting: Drawing up with one needle and injecting with another Practice › Administration subcutaneous injection injection site reaction needle gauge & length missed dose Revisiting: Drawing up with one needle and injecting with another Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have…	+76	83	1.1k	4mo
Half-life, steady state, and accumulation worked through — a second dataset Pharmacology › Pharmacokinetics semaglutide worked example liraglutide Half-life, steady state, and accumulation worked through — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…	+110	126	14k	4mo
Coming back to: Which fields on a certificate actually matter, ranked Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Solved Which fields on a certificate actually matter, ranked I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first three…		2	15k	4mo
What a documentation review can and cannot tell you — a second dataset Sourcing › Independent verification Janoshik Analytical VendorInvestigate blind sampling third-party testing The question in the title: What a documentation review can and cannot tell you — a second dataset I will give what I have already checked below so nobody repeats it. I would like to talk about documentation…		4	170	4mo
Injection volume, overload, and peak distortion — one year on Analytics › HPLC & UHPLC system suitability peak integration gradient method data table Under review Injection volume, overload, and peak distortion — one year on Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have…	+4	8	1.2k	4mo
[2026 update] Hello from a laboratory that does not do peptides Lounge › Introductions onboarding beginner friendly Hello from a laboratory that does not do peptides Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still applies if anyone makes a…		2	49k	4mo
Coming back to: Semaglutide in people without diabetes: what the evidence base looks like Compounds › Semaglutide effect size randomised trial SELECT trial On the subject in the title: Semaglutide in people without diabetes: what the evidence base looks like Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before…	+41	46	1.2k	4mo
Second pass at: How to ask a question when you cannot say why you are asking it Start Here › How to Ask onboarding worked example guidelines Solved Second pass at: How to ask a question when you cannot say why you are asking it — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to…	+73	81	16k	4mo
Pharmacy supply in the UK and the questions you will be asked Regional › UK & Ireland personal import cost per milligram MHRA NHS On the subject in the title: Pharmacy supply in the UK and the questions you will be asked Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+95	105	1.3k	4mo
Labelling requirements for research chemicals Sourcing › Regulatory research use only MHRA FDA Under review Labelling requirements for research chemicals — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the maintainers asked for.…	+5	9	45k	4mo
Which panel is worth repeating and which is worth ignoring — a second dataset Clinical › Bloodwork lipid panel liver enzymes eGFR & renal function lipase & amylase Asking directly, because I could not find a straight answer: Which panel is worth repeating and which is worth ignoring — a second dataset General question, not a request for advice about my own care — I know…	+108	117	46k	4mo
Liver enzymes drifting down and what that usually means Clinical › Bloodwork HbA1c liver enzymes eGFR & renal function Solved Closed Liver enzymes drifting down and what that usually means — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this…	+66	72	12k	4mo
[2026 update] Publication patterns in the BPC-157 literature, examined Compounds › Repair & healing peptides BPC-157 observational data TB-500 Solved Publication patterns in the BPC-157 literature, examined Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med , 2024). Please read it…	+15	19	11k	4mo
Second pass at: Submitting a sample: the process end to end Sourcing › Independent verification Janoshik Analytical PeptideMeter Medutest blind sampling Solved Second pass at: Submitting a sample: the process end to end Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better…	+12	16	41k	4mo
An ABAB design with a data table and honest limitations — a second dataset Research Methods › N-of-1 designs confounding effect size data table worked example Solved On the subject in the title: An ABAB design with a data table and honest limitations — a second dataset Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before…	+106	118	25k	4mo
Follow-up: Request: a per-category review queue Meta › Feature requests translation site feedback wiki post Closed On the subject in the title: Request: a per-category review queue Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic in question keeps being…		2	14k	4mo
Air bubbles in a subcutaneous injection: the honest risk assessment — does this still hold? Practice › Administration injection site rotation missed dose aseptic technique subcutaneous injection Wiki Asking directly, because I could not find a straight answer: Air bubbles in a subcutaneous injection: the honest risk assessment — does this still hold? Reporting something rather than asking about it, in…	+21	30	20k	4mo
Preprint servers and what screening they do Evidence › Preprints preprint effect size needs a source Preprint servers and what screening they do — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+95	106	5.6k	4mo
Second pass at: Counter-ion content and its effect on measured mass Analytics › Mass spectrometry mass error (ppm) counter-ion content MALDI-TOF charge states Solved Second pass at: Counter-ion content and its effect on measured mass Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like…		4	16k	4mo
Measurement error in home scales, with a worked standard deviation Research Methods › Statistics effect size heterogeneity number needed to treat confounding Solved Wiki Measurement error in home scales, with a worked standard deviation Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 1 ( N Engl…	+26	31	4.3k	4mo
Run-in periods and the population they select — the long version Evidence › Trials randomised trial estimand intention to treat surrogate endpoints Run-in periods and the population they select — the long version Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SUSTAIN 6 ( N Engl J Med , 2016). Please read…		2	8.9k	4mo
Second pass at: Identical chromatograms across two different lots Sourcing › Red flags disputed mislabelling moderation Posting this under the heading it deserves: Second pass at: Identical chromatograms across two different lots Everything below is what sits behind that. A logistics question, since the answers here are…	+81	93	13k	4mo
Second pass at: Choosing a concentration on purpose rather than by accident Practice › Reconstitution reconstitution syringe units concentration maths Second pass at: Choosing a concentration on purpose rather than by accident Writing it up because I had to work it out twice and would rather nobody else did. A question about technique rather than about…	+49	54	6k	4mo