Latest topics page 24

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 24 of 52

Topic	Participants	Replies	Views	Activity
Rotating between abdomen, thigh and upper arm: absorption differences Practice › Administration injection site reaction needle gauge & length missed dose aseptic technique On the subject in the title: Rotating between abdomen, thigh and upper arm: absorption differences Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern…		2	3.5k	5mo
The most common factual error about semaglutide on the internet — what changed since Compounds › Semaglutide effect size randomised trial SELECT trial type 2 diabetes The most common factual error about semaglutide on the internet — what changed since — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 1 ( N…	+42	46	1.7k	5mo
Absence of evidence and evidence of absence Research Methods › Statistics effect size worked example number needed to treat Absence of evidence and evidence of absence Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med , 2024). Please read it before…	+16	20	3.9k	5mo
A genuinely late dose: what the labelling says and what people do Practice › Administration injection site rotation missed dose needle gauge & length injection site reaction On the subject in the title: A genuinely late dose: what the labelling says and what people do Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is…		2	18k	5mo
Reading a regulatory notice rather than an article about it Sourcing › Regulatory compounding personal import EMA Posting this under the heading it deserves: Reading a regulatory notice rather than an article about it Everything below is what sits behind that. Structured report rather than an opinion, following the…		2	2.9k	5mo
Waist circumference technique and its repeatability Outcomes › Progress reports data table long read effect size DXA Waist circumference technique and its repeatability — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes…	+55	60	11k	5mo
What I would record differently if I started again Outcomes › Progress reports DXA long read data table effect size Closed Asking directly, because I could not find a straight answer: What I would record differently if I started again Maintenance rather than loss, which is the part of this that almost nobody writes about. I have…		2	12k	5mo
Interpreting a result that disagrees with the supplier's certificate Sourcing › Independent verification Janoshik Analytical Medutest PeptideMeter third-party testing Interpreting a result that disagrees with the supplier's certificate Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+129	153	7.3k	5mo
The lowest dose that does anything: is that a real question? Practice › Dosing & titration dose reduction worked example missed dose titration Asking directly, because I could not find a straight answer: The lowest dose that does anything: is that a real question? I have read the maintained page on this and I still have a gap, so I am asking rather…	+100	111	9.1k	5mo
"Greater than or equal to 99%" as a specification rather than a result Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Solved "Greater than or equal to 99%" as a specification rather than a result Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would…	+132	146	47k	5mo
Journal club: PIONEER 6 as a safety trial Evidence › Journal club effect size journal club number needed to treat risk of bias Posting this under the heading it deserves: Journal club: PIONEER 6 as a safety trial Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it before posting; the…	+14	18	262	5mo
Revisiting: Language barriers in accessing a prescription abroad Access › International EMA telehealth personal import MHRA Posting this under the heading it deserves: Revisiting: Language barriers in accessing a prescription abroad Everything below is what sits behind that. Documenting an access outcome, dated, because everything…	+131	148	28k	5mo
[2026 update] Confounding by indication, explained with a concrete example Evidence › Study critique observational data disputed risk of bias Confounding by indication, explained with a concrete example Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…	+103	116	22k	5mo
Contributing data without breaching anyone's privacy Data & Tools › Datasets data table confounding observational data Solved Contributing data without breaching anyone's privacy Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+65	71	839	5mo
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Data & Tools › Calculators concentration maths site feedback syringe units On the subject in the title: Bug report: the reconstitution calculator and a rounding edge case Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked.…	+58	63	24k	5mo
[2026 update] Amylin and gastric emptying: overlapping mechanisms with incretins Compounds › Cagrilintide & amylin analogues amylin analogues randomised trial effect size cagrisema Amylin and gastric emptying: overlapping mechanisms with incretins — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before…	+21	25	44k	5mo
Storing lyophilised material long term: what governs the shelf life Practice › Storage & stability temperature excursion cold chain freeze-thaw On the subject in the title: Storing lyophilised material long term: what governs the shelf life Working notes rather than a conclusion. Practical question with the units stated, because I have seen how…	+83	90	1k	5mo
Why semaglutide's albumin binding is the whole reason weekly dosing works Compounds › Semaglutide STEP programme SELECT trial randomised trial effect size Solved Closed Asking directly, because I could not find a straight answer: Why semaglutide's albumin binding is the whole reason weekly dosing works Session topic: SELECT ( N Engl J Med , 2023). Please read it before…		2	63k	5mo
Revisiting: A page that has drifted out of date and needs a maintainer Documentation › Wiki requests maintainership promoted to docs wiki post review date Revisiting: A page that has drifted out of date and needs a maintainer Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the…	+112	119	8.8k	5mo
Peer-to-peer review: what actually happens on the call — one year on Access › Insurance & coverage appeals formulary insurance Peer-to-peer review: what actually happens on the call — one year on — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this…	+2	6	41k	5mo
Research-use-only labelling: what it means and what it does not Sourcing › Regulatory compounding research use only EMA FDA Posting this under the heading it deserves: Research-use-only labelling: what it means and what it does not Everything below is what sits behind that. I would like to talk about documentation quality as a…	+100	110	37k	5mo
[2026 update] Journal club: PIONEER 6 as a safety trial Evidence › Journal club journal club number needed to treat estimand Journal club: PIONEER 6 as a safety trial Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do not…	+14	18	55k	5mo
Follow-up: "Should I double up?" — answered once, at length, calmly Practice › Administration needle gauge & length aseptic technique injection site rotation subcutaneous injection On the subject in the title: "Should I double up?" — answered once, at length, calmly Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking…		2	9.7k	5mo
Dead volume across syringe and needle combinations Devices › Syringes & needles needle gauge & length subcutaneous injection dead volume syringe units On the subject in the title: Dead volume across syringe and needle combinations Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go wrong…	+72	80	28k	5mo
Specification in the result column: why that is a meaningful error Analytics › COA interpretation reference standards amino acid analysis certificate of analysis batch & lot numbers Under review Closed Posting this under the heading it deserves: Specification in the result column: why that is a meaningful error Everything below is what sits behind that. Working through the identity arithmetic and I would…	+107	129	41k	5mo
Coming back to: Reading a supplier's product description as a marketing document Compounds › Other compounds needs a source custom synthesis research use only mislabelling Reading a supplier's product description as a marketing document Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in…	+35	39	688	5mo
Measurement error in a self-reported exposure Evidence › Study critique confounding risk of bias effect size disputed Solved Closed Posting this under the heading it deserves: Measurement error in a self-reported exposure Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it before…	+117	129	45k	5mo
Reading SURMOUNT-1 without the press release — one year on Compounds › Tirzepatide effect size SURPASS programme randomised trial Solved Closed Reading SURMOUNT-1 without the press release — one year on — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim I do not…	+45	50	7.6k	5mo
Second pass at: Where impurities in solid-phase peptide synthesis come from Analytics › Impurities & related substances counter-ion content data table endotoxin testing HPLC Closed Posting this under the heading it deserves: Second pass at: Where impurities in solid-phase peptide synthesis come from Everything below is what sits behind that. A documentation question rather than an…	+47	51	3.3k	5mo
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Compounds › Oral incretins randomised trial SOUL trial oral semaglutide orforglipron Solved The SOUL trial and oral semaglutide cardiovascular outcomes — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim I do not…	+100	104	4.2k	5mo