Latest topics page 26
Topics ordered by most recent activity across all 71 subcategories.
1,535 topics · page 26 of 52
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Temperature loggers worth the money — the long version
On the subject in the title: Temperature loggers worth the money — the long version Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful to…
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+110 | 127 | 48k | 6mo |
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Revisiting: Sample handling between despatch and injection
Posting this under the heading it deserves: Revisiting: Sample handling between despatch and injection Everything below is what sits behind that. Posting the method first, because I know what the first three…
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+5 | 9 | 1.1k | 6mo |
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Lyophilisation and why the cake looks the way it does
Posting this under the heading it deserves: Lyophilisation and why the cake looks the way it does Everything below is what sits behind that. I would like to understand what this number means before I repeat…
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+33 | 37 | 60k | 6mo |
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Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold?
Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J Med ,…
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3 | 28k | 6mo | |
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Sample size calculations, read backwards from the published number
Sample size calculations, read backwards from the published number Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SUSTAIN 6 ( N Engl J Med , 2016). Please…
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2 | 8.1k | 6mo | |
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[2026 update] Evidence quality in the secretagogue literature: an honest assessment
Posting this under the heading it deserves: Evidence quality in the secretagogue literature: an honest assessment Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 1 ( N…
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+14 | 18 | 3.1k | 6mo |
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Alcohol: what is documented and what is folklore — the long version
Alcohol: what is documented and what is folklore — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern…
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+9 | 13 | 7.3k | 6mo |
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The nausea timeline across the first four weeks, with a tabulated log — what changed since
On the subject in the title: The nausea timeline across the first four weeks, with a tabulated log — what changed since Working notes rather than a conclusion. I have read the maintained page on this and I…
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+24 | 29 | 2.8k | 6mo |
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Second pass at: Why semaglutide's albumin binding is the whole reason weekly dosing works
Second pass at: Why semaglutide's albumin binding is the whole reason weekly dosing works Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet ,…
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2 | 39k | 6mo | |
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How to read a phase 2 result without treating it as a phase 3 result — what changed since
Asking directly, because I could not find a straight answer: How to read a phase 2 result without treating it as a phase 3 result — what changed since Session topic: STEP 2 ( Lancet , 2021). Please read it…
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+25 | 35 | 568 | 6mo |
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Promotion criteria, and the one that stops most nominations — the long version
On the subject in the title: Promotion criteria, and the one that stops most nominations — the long version Working notes rather than a conclusion. Nominating something for promotion into the documentation…
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+130 | 143 | 7.2k | 6mo |
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Designing a personal experiment that could change your mind
Posting this under the heading it deserves: Designing a personal experiment that could change your mind Everything below is what sits behind that. Session topic: STEP 8 ( JAMA , 2022). Please read it before…
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+2 | 6 | 695 | 6mo |
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Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a second dataset
On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a second dataset Working notes rather than a conclusion. Working through the identity…
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+53 | 58 | 7.5k | 6mo |
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The headache that turns out to be dehydration
The headache that turns out to be dehydration Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost nobody…
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+143 | 158 | 7.8k | 6mo |
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A pen that felt like it delivered nothing: diagnosing it afterwards
On the subject in the title: A pen that felt like it delivered nothing: diagnosing it afterwards Working notes rather than a conclusion. A question about technique rather than about dose. I have been doing…
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+35 | 39 | 584 | 6mo |
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A history of disordered eating: proceeding carefully
A history of disordered eating: proceeding carefully Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…
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+70 | 75 | 10k | 6mo |
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Second pass at: Pregnancy and pregnancy planning: contraindication and washout
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a…
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+111 | 127 | 1.6k | 6mo |
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Request: export my own posts
Posting this under the heading it deserves: Request: export my own posts Everything below is what sits behind that. Nominating something for promotion into the documentation commons. The topic in question…
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2 | 57k | 6mo | |
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Request: a diff view for wiki revisions — the long version
Posting this under the heading it deserves: Request: a diff view for wiki revisions — the long version Everything below is what sits behind that. Process question about how this site works. I have read the…
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+96 | 104 | 61k | 6mo |
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What a stability-indicating method is and how you demonstrate one
Asking directly, because I could not find a straight answer: What a stability-indicating method is and how you demonstrate one Working through the identity arithmetic and I would like it checked. retatrutide…
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4 | 57k | 6mo | |
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AOD-9604 and the fragment hypothesis, revisited
Posting this under the heading it deserves: AOD-9604 and the fragment hypothesis, revisited Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med , 2021) with SUSTAIN 6 ( N Engl J Med…
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+40 | 44 | 2.8k | 6mo |
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Tracking that stops updating and then resumes — the long version
Tracking that stops updating and then resumes — the long version — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…
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+61 | 69 | 27k | 6mo |
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Pen mechanics when the cartridge is nearly empty — does this still hold?
Asking directly, because I could not find a straight answer: Pen mechanics when the cartridge is nearly empty — does this still hold? Practical question with the units stated, because I have seen how quickly…
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+37 | 47 | 61k | 6mo |
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A genuinely late dose: what the labelling says and what people do — what changed since
A genuinely late dose: what the labelling says and what people do — what changed since — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still…
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+9 | 13 | 474 | 6mo |
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Muscle cramps: the ordinary causes before the exotic ones
Muscle cramps: the ordinary causes before the exotic ones Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…
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+80 | 90 | 27k | 6mo |
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Tirzepatide molecular mass and the charge states you would expect on ESI — does this still hold?
Asking directly, because I could not find a straight answer: Tirzepatide molecular mass and the charge states you would expect on ESI — does this still hold? Comparing STEP 2 ( Lancet , 2021) with…
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+7 | 11 | 281 | 6mo |
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What to include when your question involves a chromatogram
What to include when your question involves a chromatogram I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…
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+49 | 54 | 58k | 6mo |
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version
Posting this under the heading it deserves: Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Everything below is what sits behind that. I would like to understand…
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+57 | 63 | 1k | 6mo |
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What published stability data actually covers, and what it does not — what changed since
What published stability data actually covers, and what it does not — what changed since — that is the question, and I have not found it answered plainly anywhere I have looked. Practical question with the…
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3 | 43k | 6mo | |
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Dose numbers for oral formulations are not comparable to injectable ones
On the subject in the title: Dose numbers for oral formulations are not comparable to injectable ones Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it…
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+19 | 23 | 39k | 6mo |