Latest topics page 28

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 28 of 52

Topic	Participants	Replies	Views	Activity
Availability by country, dated, with primary sources — one year on Access › International personal import MHRA NHS Availability by country, dated, with primary sources — one year on — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this…	+7	11	850	7mo
Follow-up: The decimal-point error, and the habit that catches it Practice › Reconstitution concentration maths bacteriostatic water dead volume reconstitution Closed On the subject in the title: The decimal-point error, and the habit that catches it Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking…	+118	131	50k	7mo
Reading SURMOUNT-1 without the press release Compounds › Tirzepatide SURMOUNT programme effect size randomised trial SURPASS programme Posting this under the heading it deserves: Reading SURMOUNT-1 without the press release Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA , 2024) cited in support of a claim I do not…	+103	121	7k	7mo
Hair shedding at month three: mechanism and time course Practice › Side effects delayed gastric emptying fatigue constipation hair shedding On the subject in the title: Hair shedding at month three: mechanism and time course Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful to…		2	47k	7mo
Vomiting: when it is expected and when it is a reason to stop Practice › Side effects constipation nausea fatigue Solved Posting this under the heading it deserves: Vomiting: when it is expected and when it is a reason to stop Everything below is what sits behind that. Reporting something rather than asking about it, in case…	+116	124	43k	7mo
Batch date after test date, and other internal inconsistencies Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers documentation quality Batch date after test date, and other internal inconsistencies — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+27	31	4.9k	7mo
Second pass at: Cagrilintide's dosing interval and the pharmacokinetics behind it Compounds › Cagrilintide & amylin analogues cagrisema effect size randomised trial Wiki On the subject in the title: Second pass at: Cagrilintide's dosing interval and the pharmacokinetics behind it Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please…	+2	6	2.4k	7mo
Prescription requirements and telehealth models Sourcing › Regulatory FDA compounding research use only MHRA Prescription requirements and telehealth models Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than anywhere…	+91	97	5.4k	7mo
What a regulator's shortage notice actually authorises — what changed since Sourcing › Regulatory research use only EMA FDA compounding Solved The question in the title: What a regulator's shortage notice actually authorises — what changed since I will give what I have already checked below so nobody repeats it. A logistics question, since the…	+22	26	53k	7mo
Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide amylin analogues Closed Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 (…	+21	25	45k	7mo
Substitution between formats during a shortage Access › Shortages compounding FDA formulary shortage Solved Closed On the subject in the title: Substitution between formats during a shortage Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As of…	+114	123	47k	7mo
Meeting a protein target on a suppressed appetite Nutrition & Training › Protein & intake constipation micronutrients lean mass loss fatigue Meeting a protein target on a suppressed appetite Writing it up because I had to work it out twice and would rather nobody else did. Longitudinal report with the method stated, because a number without a…	+39	44	11k	7mo
Measurement error in home scales, with a worked standard deviation — a second dataset Research Methods › Statistics effect size confounding heterogeneity number needed to treat Solved Measurement error in home scales, with a worked standard deviation — a second dataset — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with SURPASS-2…		2	13k	7mo
An inter-laboratory comparison on one lot, tabulated — what changed since Analytics › Method validation stability-indicating method LOD & LOQ system suitability precision & repeatability An inter-laboratory comparison on one lot, tabulated — what changed since — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I…	+24	28	3.3k	7mo
Personal import allowances, compared Access › International EMA MHRA telehealth personal import Wiki On the subject in the title: Personal import allowances, compared Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As of July 2026, in…	+5	9	3.2k	7mo
Follow-up: Sodium, potassium and magnesium when intake drops Nutrition & Training › Hydration & electrolytes blood pressure fatigue heart rate On the subject in the title: Sodium, potassium and magnesium when intake drops Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is not a…	+8	12	335	7mo
Pricing far outside the range, in either direction Sourcing › Red flags disputed mislabelling underdosing moderation Solved Posting this under the heading it deserves: Pricing far outside the range, in either direction Everything below is what sits behind that. Structured report rather than an opinion, following the format the…	+3	7	27k	7mo
Airline travel with a temperature-sensitive injectable Devices › Cold chain freeze-thaw cold chain temperature excursion storage Posting this under the heading it deserves: Airline travel with a temperature-sensitive injectable Everything below is what sits behind that. A question about technique rather than about dose. I have been…	+19	23	4.9k	7mo
Coming back to: Over-dilution: when your dose falls below one readable graduation Practice › Reconstitution worked example dead volume syringe units bacteriostatic water Over-dilution: when your dose falls below one readable graduation Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…	+90	97	1.1k	7mo
Comparing my trajectory with the trial curves, carefully Outcomes › Progress reports DXA effect size long read data table Solved Posting this under the heading it deserves: Comparing my trajectory with the trial curves, carefully Everything below is what sits behind that. Maintenance rather than loss, which is the part of this that…	+86	92	54k	7mo
[2026 update] Whether protein timing matters at a large deficit Nutrition & Training › Protein & intake lean mass loss fatigue constipation micronutrients Whether protein timing matters at a large deficit — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number without a method is not a…	+4	8	46k	7mo
DXA precision and the least significant change for lean mass Outcomes › Body composition bioimpedance data table DXA Closed Posting this under the heading it deserves: DXA precision and the least significant change for lean mass Everything below is what sits behind that. Maintenance rather than loss, which is the part of this that…	+81	85	2.7k	7mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Clinical › Special populations older adults chronic kidney disease adolescents disordered eating Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a…	+64	69	15k	7mo
The decimal-point error, and the habit that catches it Practice › Reconstitution syringe units concentration maths worked example bacteriostatic water The decimal-point error, and the habit that catches it Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+110	121	10k	7mo
Publishing an inconvenient result: a case study — the long version Sourcing › Independent verification Janoshik Analytical PeptideMeter Medutest blind sampling Publishing an inconvenient result: a case study — the long version Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+68	74	12k	7mo
[2026 update] Conference abstracts as evidence: the weakest common citation Evidence › Preprints needs a source effect size preprint risk of bias Closed Conference abstracts as evidence: the weakest common citation — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURMOUNT-4 ( JAMA , 2024) and finding…		2	48k	7mo
Coming back to: Feature request: should a dose-equivalence tool exist at all? Data & Tools › Calculators syringe units concentration maths worked example site feedback Solved Feature request: should a dose-equivalence tool exist at all? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first…	+37	41	725	7mo
Persistent vomiting and the threshold for seeking help Safety › Adverse events vomiting hypoglycaemia gallbladder pancreatitis On the subject in the title: Persistent vomiting and the threshold for seeking help Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference…	+82	88	31k	7mo
Why tirzepatide titration schedules have more steps than semaglutide's Compounds › Tirzepatide SURMOUNT programme SURPASS programme randomised trial tirzepatide Solved Wiki Asking directly, because I could not find a straight answer: Why tirzepatide titration schedules have more steps than semaglutide's Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…		4	8.4k	7mo
Tracking a preprint to publication: a worked example Evidence › Preprints preprint risk of bias needs a source Tracking a preprint to publication: a worked example Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…	+133	147	15k	7mo