Latest topics page 27

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 27 of 52

Topic	Participants	Replies	Views	Activity
Hepatic steatosis: what the MASH trial evidence supports — one year on Clinical › Comorbidities MASH / hepatic steatosis obstructive sleep apnoea chronic kidney disease blood pressure Solved On the subject in the title: Hepatic steatosis: what the MASH trial evidence supports — one year on Working notes rather than a conclusion. General question, not a request for advice about my own care — I…		2	4.1k	6mo
Coming back to: Private prescribing in the UK: what is actually involved Regional › UK & Ireland personal import MHRA NHS cost per milligram Private prescribing in the UK: what is actually involved Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that…	+62	67	2.1k	6mo
Distinguishing expected GI effects from something that needs urgent attention Practice › Side effects nausea hair shedding vomiting delayed gastric emptying Closed Distinguishing expected GI effects from something that needs urgent attention Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about…	+88	101	32k	6mo
Early satiety becoming a problem rather than a benefit Practice › Side effects vomiting fatigue hair shedding constipation Closed Early satiety becoming a problem rather than a benefit — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the same thing…	+20	24	2.5k	6mo
Aggregates and why a purity assay may miss them entirely Analytics › Impurities & related substances water content counter-ion content forced degradation HPLC Aggregates and why a purity assay may miss them entirely Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…	+61	69	2.9k	6mo
Coming back to: "Greater than or equal to 99%" as a specification rather than a result Analytics › COA interpretation documentation quality amino acid analysis certificate of analysis batch & lot numbers Posting this under the heading it deserves: "Greater than or equal to 99%" as a specification rather than a result Everything below is what sits behind that. Working through the identity arithmetic and I…		2	31k	6mo
Why "add 2 mL" is not an instruction Practice › Reconstitution reconstitution worked example syringe units dead volume The question in the title: Why "add 2 mL" is not an instruction I will give what I have already checked below so nobody repeats it. A question about technique rather than about dose. I have been doing the…	+23	27	3.5k	6mo
A partial dose because the pen emptied mid-injection Practice › Administration subcutaneous injection needle gauge & length injection site rotation missed dose Solved A partial dose because the pen emptied mid-injection Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+108	120	1.5k	7mo
Guidelines revision: what changed and why — does this still hold? Meta › Announcements trust levels site feedback guidelines moderation Guidelines revision: what changed and why — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Process question about how this site works. I have…		2	58k	7mo
Temperature logging at home: what is worth the effort Practice › Storage & stability storage beyond-use date cloudy or discoloured solution temperature excursion Temperature logging at home: what is worth the effort — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how quickly these go…		2	6.3k	7mo
Why oral semaglutide needs an absorption enhancer at all Compounds › Oral incretins randomised trial orforglipron oral semaglutide SOUL trial Solved Why oral semaglutide needs an absorption enhancer at all I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of…	+59	65	61k	7mo
Coming back to: Payment mechanics and the recovery options that do not exist Sourcing › Payments research use only payments documentation quality Under review On the subject in the title: Payment mechanics and the recovery options that do not exist Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers…	+7	11	2.6k	7mo
Second pass at: MALDI versus ESI for a quick identity check Analytics › Mass spectrometry MALDI-TOF mass error (ppm) high-resolution MS counter-ion content Solved Second pass at: MALDI versus ESI for a quick identity check Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it…		2	18k	7mo
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Compounds › Oral incretins oral semaglutide randomised trial PIONEER programme SOUL trial Solved Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SURPASS-4 ( Lancet , 2021)…	+130	135	11k	7mo
[2026 update] Reflux appearing for the first time at a dose step Practice › Side effects constipation delayed gastric emptying nausea vomiting Posting this under the heading it deserves: Reflux appearing for the first time at a dose step Everything below is what sits behind that. Reporting something rather than asking about it, in case the pattern…		2	980	7mo
The 2.5 mg starting dose is not a therapeutic dose — why that matters — a second dataset Compounds › Tirzepatide SURMOUNT programme tirzepatide randomised trial Posting this under the heading it deserves: The 2.5 mg starting dose is not a therapeutic dose — why that matters — a second dataset Everything below is what sits behind that. Session topic: STEP 8 ( JAMA ,…	+12	16	11k	7mo
Appeal templates and why they are deliberately unemotional Access › Insurance & coverage formulary insurance prior authorisation appeals Posting this under the heading it deserves: Appeal templates and why they are deliberately unemotional Everything below is what sits behind that. Documenting an access outcome, dated, because everything in…	+25	29	764	7mo
CJC-1295 with and without DAC: what the modification does — what changed since Compounds › Secretagogues & GH axis GHRP class observational data CJC-1295 tesamorelin CJC-1295 with and without DAC: what the modification does — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024)…		4	5.1k	7mo
How to read a forest plot, properly, from scratch Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Solved The question in the title: How to read a forest plot, properly, from scratch I will give what I have already checked below so nobody repeats it. Session topic: STEP 4 ( JAMA , 2021). Please read it before…	+73	81	17k	7mo
Why one laboratory's 98.4% and another's 96.1% may not contradict Analytics › Method validation stability-indicating method LOD & LOQ linearity Solved Wiki Why one laboratory's 98.4% and another's 96.1% may not contradict I have a specific reason for asking rather than idle curiosity, and the context is below. A documentation question rather than an analytical…	+28	37	457	7mo
Retatrutide's phase 2 heart-rate signal and how to think about it Compounds › Retatrutide randomised trial preprint TRIUMPH programme retatrutide On the subject in the title: Retatrutide's phase 2 heart-rate signal and how to think about it Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019) cited in support of a claim…	+19	23	20k	7mo
How to read a phase 2 result without treating it as a phase 3 result Compounds › Retatrutide randomised trial preprint effect size TRIUMPH programme The question in the title: How to read a phase 2 result without treating it as a phase 3 result I will give what I have already checked below so nobody repeats it. Session topic: FLOW ( N Engl J Med , 2024).…	+36	40	35k	7mo
Reverse causation in a cohort study of weight and outcome Evidence › Study critique disputed observational data effect size On the subject in the title: Reverse causation in a cohort study of weight and outcome Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with FLOW ( N Engl J Med , 2024) and…	+10	14	11k	7mo
What "verified" means on our vendor pages, stated narrowly Sourcing › Vendor reports batch & lot numbers disputed documentation quality third-party testing What "verified" means on our vendor pages, stated narrowly — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to talk about documentation quality as a…	+27	31	27k	7mo
Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club estimand number needed to treat journal club randomised trial Solved Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+7	11	33k	7mo
Tracking that stops updating and then resumes Sourcing › Logistics customs temperature excursion cold chain shipping Solved On the subject in the title: Tracking that stops updating and then resumes Working notes rather than a conclusion. A logistics question, since the answers here are usually better than anywhere else I have…	+58	62	1.9k	7mo
Documentation that appears only after payment Sourcing › Red flags documentation quality moderation mislabelling disputed Solved Documentation that appears only after payment Writing it up because I had to work it out twice and would rather nobody else did. I would like to talk about documentation quality as a signal, separately from…	+113	124	13k	7mo
What to include when your question involves arithmetic Start Here › How to Ask beginner friendly onboarding site feedback guidelines Solved Closed What to include when your question involves arithmetic — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried to…		2	3.1k	7mo
Follow-up: Glucagon receptor agonism in a weight-loss compound Pharmacology › Receptor biology amylin analogues long read tirzepatide retatrutide Glucagon receptor agonism in a weight-loss compound Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+5	9	21k	7mo
Selection into a registry and what it does to the estimate Evidence › Study critique risk of bias disputed observational data Selection into a registry and what it does to the estimate — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…		2	55k	7mo