Latest topics page 29

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1,535 topics · page 29 of 52

Topic	Participants	Replies	Views	Activity
Comparing two chromatograms from different laboratories, properly Analytics › HPLC & UHPLC peak integration system suitability UV & DAD detection gradient method Solved Closed Posting this under the heading it deserves: Comparing two chromatograms from different laboratories, properly Everything below is what sits behind that. I would like to understand what this number means…	+35	40	22k	7mo
Pooling trials with different estimands — what changed since Evidence › Meta-analyses publication bias risk of bias meta-analysis effect size Pooling trials with different estimands — what changed since — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURPASS-4 ( Lancet , 2021) and finding…	+57	64	12k	7mo
Severe gastroparesis and why this class is a poor fit — one year on Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Closed Severe gastroparesis and why this class is a poor fit — one year on — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+19	23	23k	7mo
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long version Compounds › Tirzepatide SURMOUNT programme randomised trial effect size tirzepatide Closed On the subject in the title: Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long version Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med ,…	+85	90	13k	7mo
Tirzepatide's shorter half-life and its one practical consequence Compounds › Tirzepatide SURPASS programme randomised trial effect size tirzepatide Wiki On the subject in the title: Tirzepatide's shorter half-life and its one practical consequence Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I…	+18	29	20k	8mo
Documentation that materially improves an appeal's chances Access › Insurance & coverage insurance appeals formulary prior authorisation Documentation that materially improves an appeal's chances — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what…	+93	98	3.6k	8mo
Robustness: the parameters worth deliberately varying Analytics › Method validation stability-indicating method linearity precision & repeatability Robustness: the parameters worth deliberately varying Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…	+53	57	664	8mo
Second pass at: Asking a follow-up: new topic or new reply? Start Here › How to Ask guidelines site feedback worked example beginner friendly Solved Wiki The question in the title: Second pass at: Asking a follow-up: new topic or new reply? I will give what I have already checked below so nobody repeats it. I want to check my reasoning rather than get a…		4	81	8mo
Water content on a certificate and why it changes the arithmetic — what changed since Analytics › COA interpretation documentation quality batch & lot numbers reference standards certificate of analysis On the subject in the title: Water content on a certificate and why it changes the arithmetic — what changed since Working notes rather than a conclusion. A documentation question rather than an analytical…		3	801	8mo
[2026 update] Why mass spectrometry cannot tell you about an epimer Analytics › Mass spectrometry high-resolution MS counter-ion content MALDI-TOF Why mass spectrometry cannot tell you about an epimer — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity arithmetic and I would like it…		2	1k	8mo
Where the integrator drew the baseline, and how much it moved the number Analytics › HPLC & UHPLC system suitability gradient method UV & DAD detection data table Solved Where the integrator drew the baseline, and how much it moved the number — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three…	+20	24	1.6k	8mo
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since Compounds › Semaglutide semaglutide SELECT trial type 2 diabetes STEP programme Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA ,…	+6	10	6.1k	8mo
How the vendor documentation pages are maintained, and by whom — what changed since Sourcing › Vendor reports third-party testing disputed batch & lot numbers Solved Asking directly, because I could not find a straight answer: How the vendor documentation pages are maintained, and by whom — what changed since A logistics question, since the answers here are usually better…	+98	104	3k	8mo
Cross-border purchase rules within the EU Regional › European Union personal import formulary cost per milligram EMA On the subject in the title: Cross-border purchase rules within the EU Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what determines the answer.…	+45	49	15k	8mo
Second pass at: A reconstituted vial's beyond-use date and the reasoning behind common figures Practice › Storage & stability beyond-use date cold chain temperature excursion freeze-thaw Solved Second pass at: A reconstituted vial's beyond-use date and the reasoning behind common figures Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the…	+4	8	20k	8mo
What pooling buys you and what it destroys Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: What pooling buys you and what it destroys I will give what I have already checked below so nobody repeats it. Comparing SURMOUNT-2 ( Lancet , 2023) with LEADER ( N Engl J Med ,…	+74	83	6.6k	8mo
A preprint whose numbers changed substantially at publication — what changed since Evidence › Preprints risk of bias effect size needs a source On the subject in the title: A preprint whose numbers changed substantially at publication — what changed since Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it…	+3	7	125	8mo
Journal club: how we handle discontinuation in obesity trials — what changed since Evidence › Journal club number needed to treat estimand risk of bias randomised trial Solved Journal club: how we handle discontinuation in obesity trials — what changed since — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it…	+14	18	35k	8mo
Oral versus injectable exposure: comparing apples to a different fruit Compounds › Oral incretins oral semaglutide SOUL trial PIONEER programme randomised trial Oral versus injectable exposure: comparing apples to a different fruit — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURMOUNT-4 ( JAMA ,…	+19	23	332	8mo
Absolute versus relative contraindications Safety › Contraindications pregnancy & planning delayed gastric emptying pancreatitis On the subject in the title: Absolute versus relative contraindications Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I would…	+4	8	23k	8mo
History of disordered eating and why it changes the conversation Clinical › Special populations older adults chronic kidney disease adolescents bariatric surgery history Closed History of disordered eating and why it changes the conversation Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+20	24	30k	8mo
Gauge and length selection for subcutaneous injection Devices › Syringes & needles syringe units needle gauge & length worked example subcutaneous injection Solved Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+50	55	1.3k	8mo
Pharmaceutical compounding rules, summarised from primary sources — a second dataset Sourcing › Regulatory MHRA research use only compounding Posting this under the heading it deserves: Pharmaceutical compounding rules, summarised from primary sources — a second dataset Everything below is what sits behind that. A logistics question, since the…	+50	56	780	8mo
Availability by country, dated, with primary sources Access › International EMA MHRA telehealth personal import On the subject in the title: Availability by country, dated, with primary sources Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+72	81	6.9k	8mo
Second pass at: Two scans six weeks apart on different machines: a cautionary tale Outcomes › Body composition DXA bioimpedance lean mass loss data table Second pass at: Two scans six weeks apart on different machines: a cautionary tale Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the…	+1	5	34k	8mo
Follow-up: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Compounds › Retatrutide retatrutide effect size TRIUMPH programme preprint Retatrutide phase 2 in type 2 diabetes: the Lancet paper Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…	+1	5	31k	8mo
Second pass at: Programming during a large energy deficit Nutrition & Training › Resistance training fatigue lean mass loss DXA On the subject in the title: Second pass at: Programming during a large energy deficit Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is…	+94	100	1.2k	8mo
What a purity-only report leaves out Sourcing › Independent verification Medutest VendorInvestigate third-party testing PeptideMeter Solved What a purity-only report leaves out — that is the question, and I have not found it answered plainly anywhere I have looked. Structured report rather than an opinion, following the format the maintainers…	+92	105	4k	8mo
Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Compounds › Tirzepatide SURMOUNT programme tirzepatide randomised trial effect size Posting this under the heading it deserves: Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Everything below is what sits behind that. I have seen SCALE ( N Engl J Med , 2015) cited in support…	+4	8	14k	8mo
Follow-up: Constipation management, with a dietitian's contribution Practice › Side effects nausea fatigue hair shedding Closed Constipation management, with a dietitian's contribution — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the same…	+31	35	28k	8mo

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Liraglutide — referenceUpdated 25 Jul 2026 · reviewed by 8 Mar 2027
Water content by Karl Fischer titrationUpdated 17 Jul 2026 · reviewed by 7 Apr 2027
SURMOUNT-1 — trial digestUpdated 15 Jul 2026 · reviewed by 21 May 2027
CJC-1295 — referenceUpdated 12 Jul 2026 · reviewed by 7 Jan 2027
SURPASS-2 — trial digestUpdated 9 Jul 2026 · reviewed by 1 Sep 2026
LEADER — trial digestUpdated 9 Jul 2026 · reviewed by 27 Mar 2027
PeptideMeter — what its reports establishUpdated 5 Jul 2026 · reviewed by 28 Oct 2026

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