Topic summary

[2026 update] Journal club: PIONEER 6 as a safety trial

Evidence › Journal club journal club number needed to treat estimand

This is a generated summary. It shows the 5 most-liked posts from a topic of 19, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

VPoulsenTL3Regular20 Feb 2026 · edited#3

k.asante, post #2: SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective physiological endpoint. Notable because soft endpoints are avoided. Two parallel trials addressed the confounder directly. Go to post

I read the opening post twice before replying, because I had assumed the opposite.

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

23 likes in reply to #2 5mo

buffer_sheetTL3Regular23 Feb 2026#7

i.wojcik, post #6: Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your population to apply the results? (4) What was the absolute effect, not just the relative one? (5) What are the two strongest criticisms available? Go to post

SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower and more variable than injectable.

16 likes in reply to #6 5mo

bench_notesTL4 Moderator26 Feb 2026#11

Staff post. Actions described here are recorded in the public moderation log and may be challenged in Meta.

Session format: read the paper before posting. The discussion is much better when everyone has. Start with the estimand and population, then methods, then results, then limitations. That order makes critique coherent.

24 likes 5mo

s.mbekiTL2 Moderator27 Feb 2026#14

SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical thresholds carefully — they can exaggerate separation.

11 likes 5mo

n.abernathyTL3Analytical chemist28 Feb 2026#15

17 likes 5mo

Read the full topic (19 posts)

This topic was referenced in

Journal club: indirect comparison between two programmes, defended and attackedEvidence › Journal club · 131 replies

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