The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Evidence · Meta-analyses · continued

Risk-of-bias tools and the judgement they conceal — does this still hold? posts 31–31

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

SG
s.grimaldiTL2 Moderator27 Jul 2026#31
f.danquah, post #15: Coming back to post #13, because the follow-up matters more than the original answer. Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

Inclusion and exclusion criteria: a meta-analysis is only as good as its inclusion criteria. If the criteria are too broad, apples and oranges get pooled. If they are too narrow, the meta-analysis answers a overly specific question.

0 likes in reply to #15 23h

Suggested topics

TopicParticipantsRepliesViewsActivity
Publication bias detection and its low power — does this still hold?
The question in the title: Publication bias detection and its low power — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER ( N Engl J Med , 2016)…
RCGAKDBSP+24 28 2.4k 3mo
Publication bias detection and its low power
On the subject in the title: Publication bias detection and its low power Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not think it…
MAZLKK 2 3.2k 1d
What pooling buys you and what it destroys
The question in the title: What pooling buys you and what it destroys I will give what I have already checked below so nobody repeats it. Comparing SURMOUNT-2 ( Lancet , 2023) with LEADER ( N Engl J Med ,…
MDEHDHPMNA+74 83 6.6k 8mo
Heterogeneity as information rather than as a nuisance
Posting this under the heading it deserves: Heterogeneity as information rather than as a nuisance Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…
DFRJMNAN+88 95 1.2k 6mo
Random versus fixed effects: choosing rather than defaulting
Random versus fixed effects: choosing rather than defaulting — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before posting;…
NPFSMLAJS+16 20 22k 13mo

Related topics — sharing the tags heterogeneity, risk of bias, effect size

TopicParticipantsRepliesViewsActivity
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on
Posting this under the heading it deserves: SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med…
GOGTMMDSRM+122 136 48k 9mo
Journal club: indirect comparison between two programmes, defended and attacked
Journal club: indirect comparison between two programmes, defended and attacked Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016)…
BPTTARNSET+122 131 5.2k just now
Retatrutide dose escalation in the published trials
Posting this under the heading it deserves: Retatrutide dose escalation in the published trials Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it…
RMCCYMRMJW+149 159 30k 15mo
Journal club: the CagriSema phase 2 combination paper
On the subject in the title: Journal club: the CagriSema phase 2 combination paper Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not…
PFKMM 2 329 21h
Coming back to: Nausea profile of amylin analogues compared with GLP-1 agonists
Posting this under the heading it deserves: Nausea profile of amylin analogues compared with GLP-1 agonists Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with FLOW ( N Engl…
NEKCMALC+48 53 31k 13mo