Tags · Status

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90 topics 27 solved Group: Status

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90 topics · page 3 of 3

Topic	Participants	Replies	Views	Activity
The "under review" status pill and when a moderator applies it — a second dataset Evidence › Preprints needs a source risk of bias preprint effect size The "under review" status pill and when a moderator applies it — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021)…	+50	54	1.4k	11mo
BPC-157: what the rodent literature actually shows, and what it does not — a second dataset Compounds › Repair & healing peptides TB-500 preprint observational data needs a source Solved On the subject in the title: BPC-157: what the rodent literature actually shows, and what it does not — a second dataset Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019)…	+77	84	54k	11mo
Coming back to: When "no data" is the complete and final answer Compounds › Other compounds research use only needs a source custom synthesis When "no data" is the complete and final answer I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…	+77	82	12k	11mo
IGF-1 as a surrogate endpoint and its limitations — the long version Compounds › Secretagogues & GH axis CJC-1295 observational data ipamorelin needs a source Solved Closed On the subject in the title: IGF-1 as a surrogate endpoint and its limitations — the long version Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of a claim I do…	+14	18	53k	12mo
How to research a compound with no human data without deceiving yourself Compounds › Other compounds needs a source mislabelling custom synthesis research use only Solved Asking directly, because I could not find a straight answer: How to research a compound with no human data without deceiving yourself Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the…	+107	119	11k	12mo
Sequence verification for an obscure compound: how it is done Compounds › Other compounds needs a source custom synthesis research use only mislabelling Sequence verification for an obscure compound: how it is done Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with SURMOUNT-1 ( N…	+104	114	10k	12mo
Antibiotics and a course of something with delayed emptying Practice › Interactions insulin hypoglycaemia needs a source metformin Antibiotics and a course of something with delayed emptying — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful…	+99	108	1.4k	12mo
Why plausible mechanism is not evidence of effect — one year on Compounds › Repair & healing peptides needs a source preprint BPC-157 Solved Closed The question in the title: Why plausible mechanism is not evidence of effect — one year on I will give what I have already checked below so nobody repeats it. Session topic: STEP 4 ( JAMA , 2021). Please read…	+3	7	3.6k	13mo
Second pass at: How to research a compound with no human data without deceiving yourself Compounds › Other compounds research use only custom synthesis needs a source mislabelling Second pass at: How to research a compound with no human data without deceiving yourself Writing it up because I had to work it out twice and would rather nobody else did. Comparing STEP 1 ( N Engl J Med ,…	+64	71	2.5k	13mo
Insulin combinations and hypoglycaemia risk Practice › Interactions metformin needs a source hypoglycaemia insulin Closed On the subject in the title: Insulin combinations and hypoglycaemia risk Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go wrong…	+18	22	7.8k	13mo
When a preprint is the best available evidence and we say so — a second dataset Evidence › Preprints preprint risk of bias needs a source Solved When a preprint is the best available evidence and we say so — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med ,…	+20	24	36k	14mo
Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions metformin needs a source hypoglycaemia Solved Wiki On the subject in the title: Delayed gastric emptying and oral medication absorption: which drugs matter Working notes rather than a conclusion. Reporting something rather than asking about it, in case the…	+110	116	43k	14mo
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence Compounds › Secretagogues & GH axis CJC-1295 needs a source tesamorelin observational data Posting this under the heading it deserves: Tesamorelin has an approved indication — what that changes about the evidence Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with…	+63	68	18k	14mo
Ipamorelin selectivity claims and where they came from — a second dataset Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin ipamorelin Posting this under the heading it deserves: Ipamorelin selectivity claims and where they came from — a second dataset Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021)…		2	27k	14mo
Revisiting: Oral versus injected administration claims for BPC-157 Compounds › Repair & healing peptides observational data needs a source TB-500 BPC-157 Solved On the subject in the title: Revisiting: Oral versus injected administration claims for BPC-157 Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I…	+23	27	7.7k	15mo
When "no data" is the complete and final answer Compounds › Other compounds custom synthesis mislabelling needs a source research use only Solved Asking directly, because I could not find a straight answer: When "no data" is the complete and final answer I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not think it…	+154	165	6.3k	15mo
Research-use-only status: what it means legally and practically — a second dataset Compounds › Other compounds research use only mislabelling needs a source custom synthesis Solved Research-use-only status: what it means legally and practically — a second dataset — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with SURPASS-2 (…	+109	125	2k	16mo
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Compounds › Secretagogues & GH axis GHRP class ipamorelin CJC-1295 needs a source Closed GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021)…	+9	13	249	17mo
Anaesthesia and elective surgery: the aspiration question — does this still hold? Practice › Interactions needs a source hypoglycaemia metformin Solved Anaesthesia and elective surgery: the aspiration question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Practical question with the units…	+23	27	5.6k	17mo
Revisiting: What a well-designed human trial of a secretagogue would look like Compounds › Secretagogues & GH axis CJC-1295 observational data needs a source GHRP class On the subject in the title: Revisiting: What a well-designed human trial of a secretagogue would look like Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it…	+69	74	25k	18mo
Levothyroxine timing: a real interaction with a simple fix Practice › Interactions needs a source metformin hypoglycaemia delayed gastric emptying Levothyroxine timing: a real interaction with a simple fix Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it, in case the…	+20	24	60k	18mo
Coming back to: Grapefruit: why this class is not the class that cares Practice › Interactions metformin needs a source insulin Posting this under the heading it deserves: Grapefruit: why this class is not the class that cares Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so…	+44	48	12k	18mo
Follow-up: Oral contraceptives and delayed emptying: what the data shows Practice › Interactions hypoglycaemia delayed gastric emptying needs a source Closed Oral contraceptives and delayed emptying: what the data shows — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is…	+31	35	13k	18mo
TB-500 and thymosin beta-4: the fragment versus the protein — does this still hold? Compounds › Repair & healing peptides TB-500 BPC-157 needs a source Closed TB-500 and thymosin beta-4: the fragment versus the protein — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing STEP 8 ( JAMA , 2022)…	+19	23	4.2k	19mo
What would change my mind about repair peptides: a specific answer — one year on Compounds › Repair & healing peptides needs a source observational data TB-500 preprint Closed What would change my mind about repair peptides: a specific answer — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: STEP 1 ( N Engl J Med…	+9	13	42k	19mo
[2026 update] Insulin combinations and hypoglycaemia risk Practice › Interactions needs a source hypoglycaemia metformin Insulin combinations and hypoglycaemia risk Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how quickly these…		2	2.8k	20mo
Melanocortin agonists: mechanism and the documented adverse profile Compounds › Other compounds needs a source mislabelling research use only custom synthesis Melanocortin agonists: mechanism and the documented adverse profile — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURMOUNT-2 ( Lancet , 2023) and…	+7	11	5.5k	20mo
Why a preprint's supplementary material is often the best part Evidence › Preprints needs a source risk of bias preprint effect size Why a preprint's supplementary material is often the best part I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: SUSTAIN 6 ( N Engl J Med , 2016). Please…	+38	42	863	22mo
Naming conventions for research peptides and the confusion they cause — one year on Compounds › Other compounds research use only mislabelling needs a source Naming conventions for research peptides and the confusion they cause — one year on — setting out what I have, and where I think it stops being reliable. I have seen SURMOUNT-2 ( Lancet , 2023) cited in…	+1	5	181	2y
How this community labels and discusses unrefereed work Evidence › Preprints risk of bias effect size preprint needs a source How this community labels and discusses unrefereed work — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SCALE ( N Engl J Med , 2015) cited in support of a…	+112	119	1.3k	2y