Ranked by engagement

Top topics — all time page 39

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 39 of 40

Topic	Participants	Replies	Views	Activity
Second pass at: Leak-back after withdrawal and whether you lost a meaningful dose Practice › Administration subcutaneous injection needle gauge & length missed dose Second pass at: Leak-back after withdrawal and whether you lost a meaningful dose — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case…	+18	22	2k	25d
The five documentation pages worth reading before you post anything — a second dataset Start Here › Welcome beginner friendly trust levels guidelines onboarding Solved On the subject in the title: The five documentation pages worth reading before you post anything — a second dataset Working notes rather than a conclusion. Question in the title. Context below, and I have…		2	24k	1d
Coming back to: "Greater than or equal to 99%" as a specification rather than a result Analytics › COA interpretation documentation quality amino acid analysis certificate of analysis batch & lot numbers Posting this under the heading it deserves: "Greater than or equal to 99%" as a specification rather than a result Everything below is what sits behind that. Working through the identity arithmetic and I…		2	31k	6mo
Reading a syringe in poor light, and how to avoid needing to Devices › Syringes & needles syringe units dead volume needle gauge & length worked example Solved Reading a syringe in poor light, and how to avoid needing to Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen…		2	22k	just now
What other technical communities get right that we do not Lounge › Off topic beginner friendly long read Wiki What other technical communities get right that we do not — that is the question, and I have not found it answered plainly anywhere I have looked. Lower-stakes topic, but the sourcing rule still applies if…	+2	6	23k	5h
Coming back to: Why our vendor pages link the storefront and mark it sponsored Sourcing › Vendor reports third-party testing batch & lot numbers certificate of analysis documentation quality Why our vendor pages link the storefront and mark it sponsored I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion, following the…		2	22k	8h
Heart failure with preserved ejection fraction: symptom endpoints Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis blood pressure Heart failure with preserved ejection fraction: symptom endpoints — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+19	23	311	12d
Cost per milligram, computed honestly across formats — a second dataset Access › Pricing cost per milligram formulary compounding Closed Cost per milligram, computed honestly across formats — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail…		2	27k	13mo
Reverse causation in a cohort study of weight and outcome Evidence › Study critique disputed observational data effect size On the subject in the title: Reverse causation in a cohort study of weight and outcome Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with FLOW ( N Engl J Med , 2024) and…	+10	14	11k	7mo
Journal club: STEP 3 and the intensive behavioural therapy floor Evidence › Journal club randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: STEP 3 and the intensive behavioural therapy floor Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with STEP 4 (…	+6	10	13k	28d
[2026 update] Scheduled maintenance and what will be unavailable Meta › Announcements trust levels site feedback guidelines Posting this under the heading it deserves: Scheduled maintenance and what will be unavailable Everything below is what sits behind that. Process question about how this site works. I have read the guidelines…	+18	22	400	8mo
Fibre intake when total intake falls, and the constipation link — one year on Nutrition & Training › Protein & intake micronutrients lean mass loss fatigue Posting this under the heading it deserves: Fibre intake when total intake falls, and the constipation link — one year on Everything below is what sits behind that. Longitudinal report with the method stated,…	+9	13	16k	16h
Follow-up: A partial dose because the pen emptied mid-injection Practice › Administration injection site reaction subcutaneous injection injection site rotation aseptic technique Posting this under the heading it deserves: A partial dose because the pen emptied mid-injection Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so I…	+10	14	10k	23mo
Journal club: STEP-HFpEF and symptom endpoints Evidence › Journal club journal club effect size estimand risk of bias Journal club: STEP-HFpEF and symptom endpoints — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURMOUNT-1 ( N Engl J Med , 2022) and finding…	+18	22	2.5k	11mo
Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Analytics › Method validation LOD & LOQ system suitability linearity stability-indicating method Asking directly, because I could not find a straight answer: Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Working through the identity arithmetic and I would like it…	+10	14	13k	5mo
Subgroup analyses: pre-specified versus discovered Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Subgroup analyses: pre-specified versus discovered — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURPASS-4 ( Lancet , 2021) and finding the…		2	27k	1d
Follow-up: The topic list is dense — is that deliberate? Meta › Site feedback site feedback guidelines moderation Solved The question in the title: The topic list is dense — is that deliberate? I will give what I have already checked below so nobody repeats it. Nominating something for promotion into the documentation commons.…		4	23k	12mo
Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis ipamorelin observational data GHRP class tesamorelin Solved Evidence quality in the secretagogue literature: an honest assessment Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024) with STEP…		2	25k	9d
About the Off topic category Lounge › Off topic long read beginner friendly Pinned Wiki Anything adjacent and interesting. Not a rules-free zone, just a relaxed one. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…	+1	5	20k	21mo
HbA1c lag and what it can and cannot tell you at eight weeks Clinical › Bloodwork HbA1c lipid panel thyroid function lipase & amylase Solved HbA1c lag and what it can and cannot tell you at eight weeks Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own care — I…	+14	18	2.6k	14mo
Discussing something you have already been doing Clinical › Prescriber conversations prior authorisation type 2 diabetes beginner friendly telehealth Solved Under review On the subject in the title: Discussing something you have already been doing Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I…	+10	14	3.4k	10mo
Reading a combination trial: attributing effect to components Compounds › Cagrilintide & amylin analogues cagrisema amylin analogues effect size cagrilintide Closed On the subject in the title: Reading a combination trial: attributing effect to components Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…		4	19k	11mo
About the Doc review category Documentation › Doc review wiki post promoted to docs citation check Pinned Wiki Review of drafts and revisions before and after promotion. Every promotion is discussed in public. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	25k	4mo
Foaming during reconstitution and whether it matters Practice › Reconstitution concentration maths bacteriostatic water reconstitution syringe units Posting this under the heading it deserves: Foaming during reconstitution and whether it matters Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so I…	+19	24	466	11mo
Reference intervals: how they are constructed and why one in twenty flags — does this still hold? Clinical › Bloodwork thyroid function liver enzymes lipid panel HbA1c Solved Asking directly, because I could not find a straight answer: Reference intervals: how they are constructed and why one in twenty flags — does this still hold? General question, not a request for advice about…	+18	22	281	2h
Follow-up: Reporting a discrepancy without making an allegation Sourcing › Vendor reports certificate of analysis disputed third-party testing Janoshik Analytical Reporting a discrepancy without making an allegation Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the format the…		2	24k	19mo
Reverting an edit that had no revision note Meta › Wiki maintenance citation check moderation review date maintainership Posting this under the heading it deserves: Reverting an edit that had no revision note Everything below is what sits behind that. Nominating something for promotion into the documentation commons. The topic…	+17	21	4.5k	12mo
About the N-of-1 designs category Research Methods › N-of-1 designs worked example confounding effect size Pinned Wiki Designing a personal experiment that could actually change your mind, including washouts and blinding. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	22k	14h
Assessing a warm arrival: the decision process Sourcing › Logistics temperature excursion cold chain shipping Closed Posting this under the heading it deserves: Assessing a warm arrival: the decision process Everything below is what sits behind that. A logistics question, since the answers here are usually better than…	+15	19	3.3k	16mo
Aggregated purity results across four services, with caveats Data & Tools › Datasets observational data site feedback data table Posting this under the heading it deserves: Aggregated purity results across four services, with caveats Everything below is what sits behind that. Working through the identity arithmetic and I would like it…		3	24k	9mo