Ranked by engagement

Top topics — this quarter page 10

Ranked by replies, likes and views over this quarter, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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515 topics · page 10 of 14

Topic	Participants	Replies	Views	Activity
Revisiting: How this community labels and discusses unrefereed work Evidence › Preprints needs a source risk of bias preprint effect size Solved Revisiting: How this community labels and discusses unrefereed work Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited in…	+31	35	7k	1d
Lipid changes during rapid weight loss: the expected trajectory Clinical › Bloodwork liver enzymes thyroid function lipid panel lipase & amylase Solved Posting this under the heading it deserves: Lipid changes during rapid weight loss: the expected trajectory Everything below is what sits behind that. General question, not a request for advice about my own…	+11	15	34k	11h
Bariatric surgery history: altered anatomy, altered expectations Clinical › Special populations pregnancy & planning disordered eating older adults adolescents Solved Posting this under the heading it deserves: Bariatric surgery history: altered anatomy, altered expectations Everything below is what sits behind that. General question, not a request for advice about my own…	+35	39	486	2mo
Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry cloudy or discoloured solution storage counter-ion content Solubility limits and what a cloudy solution is telling you — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate…	+11	15	34k	20h
Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Compounds › Oral incretins randomised trial oral semaglutide SOUL trial PIONEER programme Posting this under the heading it deserves: Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022)…	+27	31	17k	25d
Journal club: semaglutide in MASH, and surrogate endpoints Evidence › Journal club randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: semaglutide in MASH, and surrogate endpoints Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with SURMOUNT-2 (…	+24	28	17k	15h
Risk-of-bias tools and the judgement they conceal — does this still hold? Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Risk-of-bias tools and the judgement they conceal — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021)…	+26	30	5.8k	23h
Semaglutide formulation: what is in the licensed product besides the peptide Compounds › Semaglutide SELECT trial type 2 diabetes semaglutide Semaglutide formulation: what is in the licensed product besides the peptide — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-1 ( N…	+29	35	4.4k	1h
Reading U-100 graduations, with a conversion table Devices › Syringes & needles dead volume worked example subcutaneous injection needle gauge & length Posting this under the heading it deserves: Reading U-100 graduations, with a conversion table Everything below is what sits behind that. Practical question with the units stated, because I have seen how…	+35	41	2k	1d
Sulfonylureas: the interaction most worth taking seriously Practice › Interactions needs a source metformin insulin Sulfonylureas: the interaction most worth taking seriously Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+4	8	38k	6h
Two scans six weeks apart on different machines: a cautionary tale Outcomes › Body composition lean mass loss data table bioimpedance DXA Solved On the subject in the title: Two scans six weeks apart on different machines: a cautionary tale Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a…	+18	26	9.4k	2mo
A revision dispute resolved on the topic rather than in the history Meta › Wiki maintenance wiki post maintainership moderation citation check A revision dispute resolved on the topic rather than in the history Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation…	+11	15	40k	16h
About the Syringes & needles category Devices › Syringes & needles syringe units dead volume needle gauge & length Pinned Wiki Insulin syringe graduations, dead volume, gauge and length selection, and reading units correctly. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	45k	1mo
What the GIP component of tirzepatide is thought to contribute, and how confident we can be Compounds › Tirzepatide tirzepatide SURPASS programme SURMOUNT programme effect size Solved What the GIP component of tirzepatide is thought to contribute, and how confident we can be I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl…	+16	20	23k	19h
What a certificate commits its issuer to — the long version Analytics › COA interpretation batch & lot numbers amino acid analysis reference standards certificate of analysis Asking directly, because I could not find a straight answer: What a certificate commits its issuer to — the long version A documentation question rather than an analytical one. I have a certificate in front…	+20	26	21k	2d
Request declined, with reasoning — what changed since Meta › Feature requests wiki post site feedback translation Posting this under the heading it deserves: Request declined, with reasoning — what changed since Everything below is what sits behind that. Process question about how this site works. I have read the…	+34	38	9.4k	2mo
Why cagrilintide alone is discussed so much less than in combination — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide effect size Solved Under review Why cagrilintide alone is discussed so much less than in combination — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4…	+27	31	1.2k	22h
Recording a dissent on a document rather than suppressing it Documentation › Doc review maintainership promoted to docs citation check Solved Recording a dissent on a document rather than suppressing it Writing it up because I had to work it out twice and would rather nobody else did. Process question about how this site works. I have read the…	+15	19	25k	1mo
Personal or family history of medullary thyroid carcinoma Safety › Contraindications thyroid C-cell question pancreatitis pregnancy & planning Personal or family history of medullary thyroid carcinoma Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+31	37	709	26d
AOD-9604 and the fragment hypothesis, revisited — does this still hold? Compounds › Other compounds research use only needs a source mislabelling Solved The question in the title: AOD-9604 and the fragment hypothesis, revisited — does this still hold? I will give what I have already checked below so nobody repeats it. Comparing FLOW ( N Engl J Med , 2024)…	+7	11	31k	19h
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one year on Compounds › Oral incretins PIONEER programme SOUL trial orforglipron Solved Asking directly, because I could not find a straight answer: Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one year on I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited…	+16	20	18k	2mo
About the Receptor biology category Pharmacology › Receptor biology amylin analogues semaglutide tirzepatide Pinned Wiki GLP-1, GIP, glucagon and amylin receptor signalling, bias, desensitisation and central versus peripheral action. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+6	10	34k	20d
How this community labels and discusses unrefereed work — the long version Evidence › Preprints needs a source effect size risk of bias Asking directly, because I could not find a straight answer: How this community labels and discusses unrefereed work — the long version I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a…	+18	23	21k	2mo
I have no scientific background — can I still follow the analytics categories? Start Here › Welcome onboarding beginner friendly trust levels The question in the title: I have no scientific background — can I still follow the analytics categories? I will give what I have already checked below so nobody repeats it. I want to check my reasoning…	+29	40	1.4k	12d
Introducing myself: pharmacist, sceptic, reluctant participant Lounge › Introductions onboarding beginner friendly Introducing myself: pharmacist, sceptic, reluctant participant Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still applies if…	+13	17	23k	2mo
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — does this still hold? Sourcing › Independent verification PeptideMeter VendorInvestigate third-party testing Janoshik Analytical Asking directly, because I could not find a straight answer: How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — does this still hold? Structured report rather than an opinion, following the…	+24	28	8k	1mo
Travelling with an injectable: documentation and practicalities Access › International NHS personal import EMA MHRA Posting this under the heading it deserves: Travelling with an injectable: documentation and practicalities Everything below is what sits behind that. Documenting an access outcome, dated, because everything…	+37	42	2.1k	1d
Validating a calculator against hand arithmetic Data & Tools › Calculators syringe units concentration maths worked example Solved Validating a calculator against hand arithmetic Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+17	21	12k	3mo
Follow-up: UK access routes, dated and sourced Regional › UK & Ireland personal import cost per milligram MHRA Solved On the subject in the title: UK access routes, dated and sourced Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As of May 2026, in…	+10	14	27k	2d
Coming back to: Swirling versus inverting versus leaving it alone Practice › Reconstitution reconstitution concentration maths syringe units Solved Swirling versus inverting versus leaving it alone Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how quickly…	+20	24	16k	26d