Ranked by engagement

Top topics — this quarter page 13

Ranked by replies, likes and views over this quarter, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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515 topics · page 13 of 14

Topic	Participants	Replies	Views	Activity
[2026 update] Documenting an adverse event properly Safety › Adverse events pancreatitis vomiting gallbladder Documenting an adverse event properly Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published trials in this…	+18	22	4.3k	1d
Substitution between formats during a shortage — what changed since Access › Shortages shortage formulary FDA compounding Solved Substitution between formats during a shortage — what changed since — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is…	+17	21	2.7k	9d
Talking to a therapist about this specifically Wellbeing › Mental health disordered eating beginner friendly mood Solved Posting this under the heading it deserves: Talking to a therapist about this specifically Everything below is what sits behind that. Asking about a population rather than about a person. The published trials…	+20	24	855	14h
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Evidence › Journal club risk of bias journal club effect size estimand Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med ,…	+18	22	656	13h
GIP receptor agonism and the argument about direction — does this still hold? Pharmacology › Receptor biology long read amylin analogues retatrutide Solved GIP receptor agonism and the argument about direction — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity arithmetic…	+10	14	15k	16h
Type 2 diabetes and the largest part of the evidence base — does this still hold? Clinical › Comorbidities type 2 diabetes chronic kidney disease PCOS blood pressure Solved Type 2 diabetes and the largest part of the evidence base — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about a population rather…	+17	22	4.5k	1d
Rewriting my first post: a before-and-after, with commentary — what changed since Start Here › How to Ask site feedback onboarding beginner friendly worked example Posting this under the heading it deserves: Rewriting my first post: a before-and-after, with commentary — what changed since Everything below is what sits behind that. I want to check my reasoning rather…	+15	19	12k	13h
Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC system suitability peak integration gradient method data table Solved Why 99.2% and 97.8% on the same lot can both be correct I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I…	+16	20	3.1k	11h
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Compounds › Retatrutide retatrutide randomised trial effect size preprint Solved Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+10	14	8.4k	16h
Second pass at: I joined for one answer and stayed for a year — what changed my mind Start Here › Welcome onboarding trust levels beginner friendly Solved Second pass at: I joined for one answer and stayed for a year — what changed my mind — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have…		4	25k	2mo
Cleaning a self-reported dataset and what you throw away Data & Tools › Datasets confounding site feedback data table observational data Cleaning a self-reported dataset and what you throw away — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in…		2	28k	1d
Where to report an adverse event officially, by region Safety › Adverse events pancreatitis gallbladder vomiting hypoglycaemia Solved Where to report an adverse event officially, by region Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…		2	27k	1h
Deletion sequences: expected mass shifts by residue — the long version Analytics › Impurities & related substances water content endotoxin testing data table forced degradation On the subject in the title: Deletion sequences: expected mass shifts by residue — the long version Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked.…	+21	25	6.9k	10h
About the Mass spectrometry category Analytics › Mass spectrometry LC-MS high-resolution MS mass error (ppm) Pinned Wiki LC-MS and high-resolution MS, charge states, mass accuracy in ppm, and what identity confirmation does and does not establish. This post is a community wiki: any member at trust level 3 or above can edit it,…	+5	9	19k	6h
Coming back to: Batch date after test date, and other internal inconsistencies Analytics › COA interpretation reference standards amino acid analysis documentation quality certificate of analysis On the subject in the title: Batch date after test date, and other internal inconsistencies Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+21	27	420	3h
HbA1c lag and what it can and cannot tell you at eight weeks — one year on Clinical › Bloodwork liver enzymes lipase & amylase lipid panel thyroid function Posting this under the heading it deserves: HbA1c lag and what it can and cannot tell you at eight weeks — one year on Everything below is what sits behind that. General question, not a request for advice…	+18	22	655	13h
Semaglutide and alcohol: what is actually documented Compounds › Semaglutide STEP programme randomised trial type 2 diabetes SELECT trial Posting this under the heading it deserves: Semaglutide and alcohol: what is actually documented Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim I do…	+14	18	10k	2d
Tracking semaglutide's approved indications across jurisdictions, dated Compounds › Semaglutide semaglutide effect size SELECT trial Tracking semaglutide's approved indications across jurisdictions, dated Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited…	+15	19	2.8k	1d
When a network meta-analysis is defensible and when it is not Evidence › Meta-analyses effect size heterogeneity publication bias Solved When a network meta-analysis is defensible and when it is not I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with LEADER (…		2	27k	4h
Why the cheapest option is often not the cheapest Access › Pricing compounding formulary cost per milligram data table Solved Wiki Why the cheapest option is often not the cheapest I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated, because everything in this…	+19	23	1.2k	12h
Language barriers in accessing a prescription abroad Access › International personal import telehealth EMA Solved Language barriers in accessing a prescription abroad Writing it up because I had to work it out twice and would rather nobody else did. Documenting an access outcome, dated, because everything in this…		2	22k	1h
Second pass at: Leak-back after withdrawal and whether you lost a meaningful dose Practice › Administration subcutaneous injection needle gauge & length missed dose Second pass at: Leak-back after withdrawal and whether you lost a meaningful dose — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case…	+18	22	2k	25d
The five documentation pages worth reading before you post anything — a second dataset Start Here › Welcome beginner friendly trust levels guidelines onboarding Solved On the subject in the title: The five documentation pages worth reading before you post anything — a second dataset Working notes rather than a conclusion. Question in the title. Context below, and I have…		2	24k	1d
Reading a syringe in poor light, and how to avoid needing to Devices › Syringes & needles syringe units dead volume needle gauge & length worked example Solved Reading a syringe in poor light, and how to avoid needing to Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen…		2	22k	just now
What other technical communities get right that we do not Lounge › Off topic beginner friendly long read Wiki What other technical communities get right that we do not — that is the question, and I have not found it answered plainly anywhere I have looked. Lower-stakes topic, but the sourcing rule still applies if…	+2	6	23k	5h
Coming back to: Why our vendor pages link the storefront and mark it sponsored Sourcing › Vendor reports third-party testing batch & lot numbers certificate of analysis documentation quality Why our vendor pages link the storefront and mark it sponsored I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion, following the…		2	22k	8h
Heart failure with preserved ejection fraction: symptom endpoints Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis blood pressure Heart failure with preserved ejection fraction: symptom endpoints — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+19	23	311	12d
Journal club: STEP 3 and the intensive behavioural therapy floor Evidence › Journal club randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: STEP 3 and the intensive behavioural therapy floor Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with STEP 4 (…	+6	10	13k	28d
Fibre intake when total intake falls, and the constipation link — one year on Nutrition & Training › Protein & intake micronutrients lean mass loss fatigue Posting this under the heading it deserves: Fibre intake when total intake falls, and the constipation link — one year on Everything below is what sits behind that. Longitudinal report with the method stated,…	+9	13	16k	16h
Subgroup analyses: pre-specified versus discovered Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Subgroup analyses: pre-specified versus discovered — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURPASS-4 ( Lancet , 2021) and finding the…		2	27k	1d