m.lindqvist

TL2 Moderator · Ibadan

Contributes reviews on supplier material. Based in Ibadan.

Joined 21 August 2025 · last posted just now

82 posts, newest first. Showing up to 150.

Journal club: indirect comparison between two programmes, defended and attacked Replied, post #132 · Evidence › Journal club · 28 Jul 2026 · 4 likes post #131 answers the question as asked. The question underneath it is different. Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #124 · Analytics › Home & field testing · 25 Jul 2026 · 3 likes Enzyme assays: if you have an enzyme that reacts specifically with your compound, an enzyme-based assay can work. These are sometimes available commercially but are…
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #120 · Compounds › Semaglutide · 25 Jul 2026 · 1 like Semaglutide versus liraglutide in STEP 8: semaglutide produced greater weight reduction and the discontinuation rates differed. But the trial was open-label for the…
Completing a dose with a second syringe, and the dead-volume arithmetic Replied, post #69 · Practice › Administration · 12 Jul 2026 · 0 likes Picking up post #66: that is the part I would want checked first. Leak-back after withdrawal: a small amount of liquid on the skin after withdrawal is ordinary. Whether…
[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #29 · Practice › Interactions · 10 Jul 2026 · 12 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with… Replied, post #62 · Analytics › Method validation · 22 Jun 2026 · 19 likes Range: the concentration range over which the method has been validated. Going outside the validated range is going outside the method's demonstrated performance.
How shortages have affected compounding permissions — does this still hold? Replied, post #14 · Access › Shortages · 17 Jun 2026 · 2 likes post #13 is right about the mechanism and I think understates the practical bit. Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are…
Insomnia at a dose step: reported experiences — the long version Replied, post #34 · Wellbeing › Sleep · 15 Jun 2026 · 0 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Micronutrient adequacy at low total intake Replied, post #5 · Nutrition & Training › Protein & intake · 5 Jun 2026 · 1 like Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
System suitability injections: if they failed, the run did not happen — the long version Replied, post #4 · Analytics › HPLC & UHPLC · 28 May 2026 · 2 likes post #2 is right about the mechanism and I think understates the practical bit. Detection wavelength: 214 nm detects the peptide bond and is relatively insensitive to…
Run-in periods and the population they select Replied, post #124 · Evidence › Trials · 25 May 2026 · 0 likes This follows post #121 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
Reconstituting a multi-strength kit without mixing yourself up — what changed since Replied, post #18 · Practice › Reconstitution · 23 May 2026 · 20 likes Foaming during reconstitution: bubbles in the solution are usually just air incorporated during mixing. They usually resolve with gentle warming and time. Persistent…
Manufacturer assistance programmes and their eligibility rules Replied, post #27 · Access › Pricing · 20 May 2026 · 0 likes Price variation between pharmacies: identical prescriptions can cost different amounts at different pharmacies because pharmacies negotiate individually with insurers…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #58 · Evidence › Journal club · 16 May 2026 · 6 likes Session format: read the paper before posting. The discussion is much better when everyone has. Start with the estimand and population, then methods, then results, then…
[2026 update] Area percent versus weight percent: the confusion that causes most arguments Replied, post #35 · Analytics › HPLC & UHPLC · 26 Apr 2026 · 30 likes Area percent is not mass percent. It is a proportion of absorbance, weighted by each species' extinction coefficient. For closely related impurities the approximation…
Blind submission and why it changes minds — the long version Replied, post #34 · Sourcing › Independent verification · 21 Apr 2026 · 3 likes PeptideMeter: purity analysis plus structured, dated supplier verification records. Produces both individual analytical results and verification records assessed over…
Revisiting: The report format the maintainers ask for, and why each field is there Replied, post #45 · Sourcing › Vendor reports · 3 Apr 2026 · 0 likes post #44 is right about the mechanism and I think understates the practical bit. Multiple services on one lot: agreement across two independent laboratories is stronger…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #85 · Clinical › Special populations · 25 Mar 2026 · 0 likes post #84 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
An ABAB design with a data table and honest limitations — a second dataset Replied, post #90 · Research Methods › N-of-1 designs · 22 Mar 2026 · 9 likes Coming back to post #88, because the follow-up matters more than the original answer. Confounding in personal experiments: other things change when you start a…
Coming back to: Time to steady state after a dose increase Replied, post #17 · Pharmacology › Pharmacokinetics · 20 Mar 2026 · 21 likes This follows post #14 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
Second pass at: What pooling buys you and what it destroys Replied, post #28 · Evidence › Meta-analyses · 17 Mar 2026 · 18 likes Subgroup analysis: sometimes a meta-analysis reports separate pooled estimates for different subgroups (e.g., by baseline body mass index or by trial duration). Be…
Reading a preclinical wound-healing model and its relevance to a human tendon — a second… Replied, post #37 · Compounds › Repair & healing peptides · 11 Mar 2026 · 0 likes Picking up post #34: that is the part I would want checked first. Stability of BPC-157 in solution: what has been measured in published work covers specific…
The lowest dose that does anything: is that a real question? Replied, post #18 · Practice › Dosing & titration · 2 Mar 2026 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Coming back to: Training through a dose escalation week Replied, post #41 · Nutrition & Training › Resistance training · 1 Mar 2026 · 0 likes Picking up post #38: that is the part I would want checked first. Cardio and resistance: the interaction between energy-intense cardiovascular training and resistance…
Second pass at: Identical chromatograms across two different lots Replied, post #17 · Sourcing › Red flags · 20 Feb 2026 · 0 likes Worth separating two things that post #13 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
Interpreting a result that disagrees with the supplier's certificate Replied, post #124 · Sourcing › Independent verification · 16 Feb 2026 · 5 likes On post #120 — agreed on the reasoning, with one qualification. Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest…
The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #5 · Compounds › Tirzepatide · 1 Feb 2026 · 0 likes On the opening post — agreed on the reasoning, with one qualification. SURMOUNT-4 used a randomised withdrawal design: everyone titrated, then those on maintenance were…
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Replied, post #55 · Clinical › Special populations · 23 Jan 2026 · 17 likes Pancreatitis history: the compounds can rarely trigger pancreatitis. A history of pancreatitis makes monitoring for recurrence more important during titration.
Second pass at: Which categories are strict and which are relaxed, honestly Replied, post #4 · Start Here › Welcome · 20 Jan 2026 · 0 likes The moderation log is public. Every staff action is logged with the rule cited and the reasoning stated. If you get moderated, the explanation is there and it is worth…
Adsorption to container surfaces and to plastics Replied, post #5 · Pharmacology › Formulation chemistry · 10 Jan 2026 · 27 likes Picking up post #2: that is the part I would want checked first. Fill volume and headspace: the amount of solution in a vial and the air above it affect how much the…
Liver enzymes drifting down and what that usually means Replied, post #43 · Clinical › Bloodwork · 4 Jan 2026 · 6 likes Liver enzymes: elevation does not specify cause. ALT and AST can rise from many things. Bilirubin helps narrow down the cause. Multiple markers together are more…
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Replied, post #2 · Data & Tools › Calculators · 11 Dec 2025 · 0 likes Coming back to the opening post, because the follow-up matters more than the original answer. Titration planning: a calculator that shows you the escalation schedule…
[2026 update] Whether protein timing matters at a large deficit Replied, post #2 · Nutrition & Training › Protein & intake · 10 Dec 2025 · 6 likes Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as solid food. Using both together can help.
Batch date after test date, and other internal inconsistencies Replied, post #10 · Analytics › COA interpretation · 20 Oct 2025 · 0 likes What fields matter on a certificate: lot number matching the vial, test date, the analytical method stated specifically, the measured result as a number, and the…
Pooling trials with different estimands — what changed since Replied, post #38 · Evidence › Meta-analyses · 17 Oct 2025 · 10 likes Inclusion and exclusion criteria: a meta-analysis is only as good as its inclusion criteria. If the criteria are too broad, apples and oranges get pooled. If they are…
Temperature loggers worth the money Replied, post #42 · Devices › Cold chain · 15 Oct 2025 · 25 likes post #41 answers the question as asked. The question underneath it is different. Temperature excursions: brief excursions above 8 °C are tolerable for most compounds.…
Why "add 2 mL" is not an instruction Started this topic · Practice › Reconstitution · 15 Oct 2025 · 56 likes The question in the title: Why "add 2 mL" is not an instruction I will give what I have already checked below so nobody repeats it. A question about technique rather…
Compounds this community declines to help with, and why Replied, post #54 · Compounds › Other compounds · 3 Oct 2025 · 0 likes Melanocortin agonists: mechanism involves the melanocortin-4 receptor pathway that regulates appetite. The documented adverse profile includes blood pressure elevation…
A preprint whose numbers changed substantially at publication Replied, post #74 · Evidence › Preprints · 1 Oct 2025 · 6 likes I read post #72 twice before replying, because I had assumed the opposite. Unrefereed work is not worthless. A great deal of it survives review substantially unchanged.…
Cagrilintide's dosing interval and the pharmacokinetics behind it Replied, post #12 · Compounds › Cagrilintide & amylin analogues · 1 Oct 2025 · 0 likes Coming back to post #10, because the follow-up matters more than the original answer. Nausea profile of amylin analogues: the historical agent pramlintide required…
Column chemistry choices for a 40-residue peptide Replied, post #36 · Analytics › HPLC & UHPLC · 14 Sep 2025 · 0 likes System suitability testing: injections run before and during the sample run to establish whether the instrument, column and method were performing when the sample was…
AOD-9604 and the fragment hypothesis, revisited Replied, post #11 · Compounds › Other compounds · 27 Aug 2025 · 20 likes I read post #9 twice before replying, because I had assumed the opposite. This subcategory exists because some people will research compounds outside the main groups…
Request: a diff view for wiki revisions — the long version Replied, post #35 · Meta › Feature requests · 27 Aug 2025 · 0 likes Worth separating two things that post #31 runs together. Alternatives: if you have thought of a way the current site might already serve your need, mention it. It helps…
Power cut for eleven hours: how I assessed it afterwards Replied, post #30 · Practice › Storage & stability · 21 Aug 2025 · 22 likes Container choice matters: the material of the vial, the rubber closure, the fill volume all affect how quickly the contents degrade. Smaller fill volumes lose less to…
How to research a compound with no human data without deceiving yourself Replied, post #114 · Compounds › Other compounds · 4 Aug 2025 · 8 likes When "no data" is the complete and final answer: if there is no published human data on a compound, that is the state of knowledge. Hope is not a substitute and…
Hepatic impairment and the absence of data Replied, post #2 · Clinical › Special populations · 25 Jul 2025 · 2 likes Renal impairment: the compounds are cleared renally to some degree. Dose adjustments might be needed in severe renal impairment. Consulting with a clinician familiar…
Canadian access and provincial variation — one year on Replied, post #15 · Regional › North America · 22 Jul 2025 · 9 likes post #14 answers the question as asked. The question underneath it is different. Provincial formularies in Canada are published and are the correct source for coverage…
Sodium, potassium and magnesium when intake drops Replied, post #70 · Nutrition & Training › Hydration & electrolytes · 21 Jul 2025 · 12 likes On post #66 — agreed on the reasoning, with one qualification. Water intoxication: drinking excessive water (more than a few liters per day for extended time) without…
Why "any advice?" is the least effective ending for a post — the long version Replied, post #24 · Start Here › How to Ask · 13 Jul 2025 · 18 likes Avoid "any advice?" at the end. It is so generic that people do not know which part of the post it refers to. Pick the specific part and ask that specific question…
Pooling trials with different estimands — what changed since Replied, post #3 · Evidence › Meta-analyses · 12 Jul 2025 · 32 likes Worth separating two things that the opening post runs together. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what…
Interim analyses and stopping rules — does this still hold? Replied, post #32 · Evidence › Trials · 4 Jul 2025 · 8 likes Generalisability: the enrolled population was selected in ways that matter. Entry criteria, run-in periods, and the simple fact that people who agree to a multi-year…
Insulin combinations and hypoglycaemia risk Replied, post #15 · Practice › Interactions · 21 Jun 2025 · 15 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Coming back to: Sample size calculations, read backwards from the published number Replied, post #42 · Evidence › Trials · 18 Jun 2025 · 0 likes Population narrowness: most trials in this class enrolled fairly specific groups. Baseline body mass index ranges, exclusion of renal disease, exclusion of certain…
Hepatic steatosis: what the MASH trial evidence supports Replied, post #62 · Clinical › Comorbidities · 11 Jun 2025 · 0 likes This follows post #59 rather than contradicting it. PCOS and metabolic overlap: polycystic ovary syndrome has metabolic overlap with obesity and insulin resistance.…
Follow-up: What other technical communities get right that we do not Replied, post #126 · Lounge › Off topic · 10 Jun 2025 · 16 likes I read post #124 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
Follow-up: Tracking intake honestly when appetite is absent Replied, post #37 · Nutrition & Training › Protein & intake · 7 Jun 2025 · 0 likes post #36 is right about the mechanism and I think understates the practical bit. Meeting protein targets on suppressed appetite: this is where the practical difficulty…
DXA precision and the least significant change for lean mass — the long version Replied, post #102 · Outcomes › Body composition · 26 May 2025 · 5 likes Precision versus accuracy: the precision you need depends on what question you are answering. "Am I losing fat?" requires less precision than "Is my lean mass…
Talking to a therapist about this specifically — does this still hold? Replied, post #59 · Wellbeing › Mental health · 11 May 2025 · 1 like Picking up post #56: that is the part I would want checked first. Support and community: some people process weight change through community (online or in-person).…
Retatrutide dose escalation in the published trials Replied, post #101 · Compounds › Retatrutide · 7 Apr 2025 · 4 likes TRIUMPH is phase 3 and it is ongoing. No phase 3 results exist. Nothing should be attributed to TRIUMPH because the trial has not finished. When it does, this page will…
Individual participant data versus aggregate data Replied, post #25 · Evidence › Meta-analyses · 3 Apr 2025 · 0 likes Why forest plots are more informative than pooled numbers: they show the variation across studies, which tells you whether the effect is consistent or heterogeneous. A…
Obstructive sleep apnoea and a hard endpoint in this class Replied, post #45 · Clinical › Comorbidities · 29 Mar 2025 · 0 likes Multiple comorbidities: a person with diabetes, kidney disease, and cardiovascular disease is outside the studied populations in most trials. Extrapolating to that…
Coming back to: Over-dilution: when your dose falls below one readable graduation Started this topic · Practice › Reconstitution · 27 Mar 2025 · 27 likes Over-dilution: when your dose falls below one readable graduation Writing it up because I had to work it out twice and would rather nobody else did. I have read the…
Albumin binding and how it produces a long half-life Replied, post #10 · Pharmacology › Pharmacokinetics · 1 Mar 2025 · 0 likes This follows post #7 rather than contradicting it. Accumulation at steady state: with a week-long half-life, steady-state concentration is reached around 4 to 5…
Requesting a page: what makes a good request Replied, post #5 · Documentation › Wiki requests · 21 Feb 2025 · 33 likes Suggesting content for a page: if you know a maintained page is missing something important, post a suggestion with specific content you think should be added.
Coming back to: Official shortage notices and what they authorise Replied, post #13 · Access › Shortages · 11 Feb 2025 · 7 likes Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long the gap will be and how that affects your condition. Discussing with your…
Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? Replied, post #34 · Evidence › Journal club · 30 Jan 2025 · 0 likes FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is…
Coming back to: Column chemistry choices for a 40-residue peptide Started this topic · Analytics › HPLC & UHPLC · 10 Jan 2025 · 1 like On the subject in the title: Column chemistry choices for a 40-residue peptide Working notes rather than a conclusion. Posting the method first, because I know what the…
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #80 · Compounds › Semaglutide · 8 Jan 2025 · 1 like The SELECT trial changed the positioning because it was the first cardiovascular outcome trial in people without diabetes. That decoupled the cardiovascular argument…
Recovery when intake is low: what to cut first Started this topic · Nutrition & Training › Resistance training · 8 Jan 2025 · 0 likes Recovery when intake is low: what to cut first Writing it up because I had to work it out twice and would rather nobody else did. Longitudinal report with the method…
Follow-up: Reporting a discrepancy without making an allegation Replied, post #3 · Sourcing › Vendor reports · 6 Jan 2025 · 1 like Coming back to the opening post, because the follow-up matters more than the original answer. Two things before anyone answers the substance. First, the context in the…
When "no data" is the complete and final answer Replied, post #33 · Compounds › Other compounds · 2 Dec 2024 · 6 likes Melanocortin agonists: mechanism involves the melanocortin-4 receptor pathway that regulates appetite. The documented adverse profile includes blood pressure elevation…
Fixed versus detachable needles: the trade-offs Replied, post #24 · Devices › Syringes & needles · 29 Nov 2024 · 9 likes Worth separating two things that post #20 runs together. Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your…
Requesting a page: what makes a good request — what changed since Replied, post #53 · Documentation › Wiki requests · 11 Oct 2024 · 8 likes On post #49 — agreed on the reasoning, with one qualification. Translation suggestions: if a maintained page should exist in another language, suggesting it here helps…
Progressive overload when the scale is falling — one year on Replied, post #109 · Nutrition & Training › Resistance training · 30 Sep 2024 · 17 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #52 · Evidence › Journal club · 23 Sep 2024 · 0 likes Session format: read the paper before posting. The discussion is much better when everyone has. Start with the estimand and population, then methods, then results, then…
Revisiting: How to bring a laboratory report to an appointment usefully Replied, post #37 · Clinical › Bloodwork · 18 Sep 2024 · 1 like Picking up post #34: that is the part I would want checked first. Analytical imprecision: any measurement has an error margin. A small difference in consecutive tests…
Correlation in a self-tracked dataset: what it can support Replied, post #96 · Research Methods › Statistics · 24 Aug 2024 · 20 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Correlation in a self-tracked dataset: what it can support Replied, post #75 · Research Methods › Statistics · 23 Aug 2024 · 19 likes Number needed to treat: how many people need to be treated to prevent one bad outcome or achieve one good outcome. More intuitive than relative risk reduction.
Coming back to: Purity assay versus content assay: two different numbers Replied, post #36 · Analytics › COA interpretation · 10 Aug 2024 · 2 likes Amino acid analysis gives content: it hydrolyses the peptide and quantifies the residues. It measures the peptide content independent of chromatographic purity. Very…
Oral contraceptives and delayed emptying: what the data shows Replied, post #71 · Practice › Interactions · 19 Jul 2024 · 25 likes Worth separating two things that post #67 runs together. Separation timing versus clinically important interaction: a separation timing inconvenience (taking one…
PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one —… Replied, post #3 · Compounds › Oral incretins · 9 Jul 2024 · 0 likes This follows post #2 rather than contradicting it. Why an oral formulation is a formulation achievement: the molecule is the same but the tablet is novel. Getting a…
Assessing a warm arrival: the decision process — one year on Replied, post #71 · Sourcing › Logistics · 31 May 2024 · 3 likes Picking up post #68: that is the part I would want checked first. Documentation after arrival: photograph the parcel and its contents on arrival. If something later…