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Devices · Syringes & needles

Fixed versus detachable needles: the trade-offs

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Solved by k.fonseca in post #6
On post #2 — agreed on the reasoning, with one qualification. Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

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HN
h.nwosuTL2 Moderator10 Nov 2024#1

Posting this under the heading it deserves: Fixed versus detachable needles: the trade-offs Everything below is what sits behind that.

I have read the maintained page on this and I still have a gap, so I am asking rather than guessing.

Context: semaglutide, 26 weeks in, currently at a dose I reached by the standard four-week steps. Everything below is my own record rather than anything a clinician told me.

The specific question is the one in the title. What I have already checked: the labelling summary on the relevant documentation page, the two most-linked topics in this subcategory, and my own notes from the last 12 weeks. What I could not find is whether the answer changes at higher doses or whether it is the same arithmetic throughout.

If the answer is "it depends", I would rather know what it depends on than be given a number.

50 likes 21mo
AV
a.vukovicTL2 Moderator11 Nov 2024#2

Worth separating two things that the opening post runs together.

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

0 likes 21mo
PW
PharmNotes_WhitfieldTL4Pharmacist12 Nov 2024#3

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

4 likes 20mo
SM
s.mbekiTL2 Moderator14 Nov 2024#4

Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses.

13 likes 20mo
RD
r.danquahTL2 Moderator15 Nov 2024#5

post #4 answers the question as asked. The question underneath it is different.

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

0 likes 20mo
KF
k.fonsecaTL2 Moderator Solution15 Nov 2024#6

On post #2 — agreed on the reasoning, with one qualification.

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

7 likes 20mo
KV
k.vanheckeTL2 Moderator16 Nov 2024#7
s.mbeki, post #4: Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses. Go to post

Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up.

8 likes in reply to #4 20mo
VB
v.baptistaTL2 Moderator17 Nov 2024#8

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

19 likes 20mo
JW
journalclub_wrenTL3Regular18 Nov 2024#9

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

14 likes 20mo
NC
n.cabreraTL2 Moderator19 Nov 2024#10

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

28 likes 20mo
PN
p.novakTL2 Moderator20 Nov 2024#11

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

9 likes 20mo
TK
t.kulkarniTL3Regular20 Nov 2024 · edited#12

This follows post #9 rather than contradicting it.

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

2 likes 20mo
AV
a.vermeulenTL2 Moderator21 Nov 2024#13

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

0 likes 20mo
RJ
r.jhannsdttirTL3Regular22 Nov 2024#14
journalclub_wren, post #9: Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice. Go to post

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

29 likes in reply to #9 20mo
NK
ni.kravchenkoTL2 Moderator23 Nov 2024#15

Coming back to post #13, because the follow-up matters more than the original answer.

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

14 likes 20mo
IS
isotonic_sheetTL3Regular23 Nov 2024#16

Picking up post #13: that is the part I would want checked first.

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

5 likes 20mo
PK
p.krastevTL2 Moderator24 Nov 2024#17
h.nwosu, post #1: Posting this under the heading it deserves: Fixed versus detachable needles: the trade-offs Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so I am asking rather than guessing. Context: semaglutide, 26 weeks in, currently at a dose I reached by the standard four-week steps.… Go to post

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

0 likes in reply to #1 20mo
RV
r.venkatesanTL3Wiki editor25 Nov 2024#18
r.jhannsdttir, post #14: Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose. Go to post

Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up.

0 likes in reply to #14 20mo
FD
f.danquahTL2 Moderator25 Nov 2024 · edited#19
p.novak, post #11: Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less. Go to post

I read post #17 twice before replying, because I had assumed the opposite.

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

3 likes in reply to #11 20mo
MM
maintenance_modeTL3Regular26 Nov 2024#20

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

0 likes 20mo
RR
r.restrepoTL2 Moderator27 Nov 2024#21
journalclub_wren, post #9: Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice. Go to post

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

21 likes in reply to #9 20mo
CC
c.correiaTL2 Moderator27 Nov 2024#22
r.jhannsdttir, post #14: Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose. Go to post

Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses.

0 likes in reply to #14 20mo
MM
m.malinowskiTL228 Nov 2024#23
ML
m.lindqvistTL2 Moderator29 Nov 2024#24

Worth separating two things that post #20 runs together.

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

9 likes 20mo
DF
d.fontaineTL2 Moderator29 Nov 2024#25

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

29 likes 20mo
FS
f.sjobergTL2 Moderator30 Nov 2024#26
f.danquah, post #19: I read post #17 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had been repeating something I had not checked carefully enough. Go to post

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

0 likes in reply to #19 20mo
ME
me.eriksenTL2 Moderator1 Dec 2024#27

post #26 answers the question as asked. The question underneath it is different.

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

5 likes 20mo
KS
k.salinasTL2 Moderator1 Dec 2024#28

On post #24 — agreed on the reasoning, with one qualification.

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

14 likes 20mo
SK
s.karlsen_rphTL3Pharmacist2 Dec 2024#29

This follows post #26 rather than contradicting it.

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

0 likes 20mo
OV
o.vukovicTL2 Moderator3 Dec 2024#30
a.vermeulen, post #13: Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had been repeating something I had not checked carefully enough. Go to post

I read post #28 twice before replying, because I had assumed the opposite.

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

0 likes in reply to #13 20mo