s.vukovic

TL2 Moderator · Dijon

Contributes reviews on supplier material. Based in Dijon.

Joined 23 March 2025 · last posted 5d

93 posts, newest first. Showing up to 150.

Alcohol: what is documented and what is folklore Replied, post #128 · Practice › Interactions · 23 Jul 2026 · 6 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
A critique that turned out to be unfair, retracted by its author Replied, post #35 · Evidence › Study critique · 21 Jul 2026 · 12 likes What makes a methodological criticism substantive: it identifies a specific feature of the design that materially affects what the paper can conclude. "Small sample…
Deletion sequences: expected mass shifts by residue — the long version Replied, post #9 · Analytics › Impurities & related substances · 12 Jul 2026 · 0 likes Incomplete deprotection: mass higher by the protecting group mass. Usually markedly later eluting. A synthesis artifact from incomplete removal of protecting groups.
Second pass at: Which categories are strict and which are relaxed, honestly Replied, post #90 · Start Here › Welcome · 9 Jul 2026 · 6 likes Welcome. The orientation materials are pinned at the top of this category and they take about an hour. They answer most of the questions a new member has and they save…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #94 · Devices › Syringes & needles · 4 Jul 2026 · 30 likes On post #90 — agreed on the reasoning, with one qualification. Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #61 · Evidence › Journal club · 26 Jun 2026 · 10 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Follow-up: The most useful thing you learned here that was not the answer you came for Replied, post #11 · Lounge › Off topic · 21 Jun 2026 · 9 likes Science communication: if you come across an interesting science paper or article about peptides or metabolism, sharing it and discussing the idea is on-topic.
Fasting versus non-fasting and which tests care Replied, post #52 · Clinical › Bloodwork · 20 Jun 2026 · 7 likes Worth separating two things that post #48 runs together. Analytical imprecision: any measurement has an error margin. A small difference in consecutive tests is usually…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #87 · Practice › Reconstitution · 17 Jun 2026 · 0 likes Reconstituting a multi-strength kit: if a kit contains 5 mg, 10 mg, 15 mg vials and you are reconstituting all of them, writing the concentration on each vial in…
Racemisation and why it is invisible to a mass measurement Replied, post #54 · Analytics › Impurities & related substances · 11 Jun 2026 · 2 likes Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself or with other molecules. Under oxidising conditions multiple species…
Review: a draft on reconstitution arithmetic, with objections — what changed since Replied, post #19 · Documentation › Doc review · 7 Jun 2026 · 0 likes Review of promoted topics: when a topic is nominated for promotion to a maintained documentation page, the draft is posted here. Community review happens before…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #83 · Evidence › Journal club · 5 Jun 2026 · 15 likes Worth separating two things that post #79 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
Revisiting: Absolute versus relative contraindications Replied, post #78 · Safety › Contraindications · 29 Apr 2026 · 9 likes Severe hepatic impairment: less is known than for kidney disease. Extreme caution or contraindication depending on the specific degree of impairment.
Amylin receptor signalling and satiety — what changed since Replied, post #68 · Pharmacology › Receptor biology · 25 Apr 2026 · 3 likes I read post #66 twice before replying, because I had assumed the opposite. Glucagon receptor agonism: glucagon receptor agonism increases energy expenditure and…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #64 · Outcomes › Body composition · 24 Apr 2026 · 0 likes Lean mass loss during rapid weight reduction: depends on protein intake, resistance training volume, and total energy deficit. Adequate protein and maintaining training…
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #17 · Wellbeing › Sleep · 19 Apr 2026 · 0 likes Apnoea monitoring: if you have diagnosed or suspected sleep apnoea, periodic monitoring (annually) during weight loss is prudent because severity changes.
Reading U-100 graduations, with a conversion table Replied, post #21 · Devices › Syringes & needles · 12 Apr 2026 · 19 likes Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many…
[2026 update] What a purity-only report leaves out Replied, post #79 · Sourcing › Independent verification · 5 Apr 2026 · 0 likes Medutest: combined purity and identity reporting. Appears throughout vendor documentation. Where a submission has been blind we note it because blind results are worth…
What a certificate commits its issuer to — one year on Replied, post #41 · Analytics › COA interpretation · 31 Mar 2026 · 1 like post #40 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #39 · Analytics › Mass spectrometry · 29 Mar 2026 · 19 likes Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and its mass is predictable from the base mass.
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #109 · Pharmacology › Pharmacokinetics · 18 Mar 2026 · 24 likes Accumulation at steady state: with a week-long half-life, steady-state concentration is reached around 4 to 5 half-lives (about 4 to 5 weeks). Before that,…
Pinch or no pinch, and how needle length changes the answer — what changed since Replied, post #3 · Practice › Administration · 8 Mar 2026 · 0 likes Cold solution and stinging: warming the vial in your hands for a minute before injection reduces the stinging sensation substantially. This is the simplest thing to try…
CJC-1295 with and without DAC: what the modification does Replied, post #8 · Compounds › Secretagogues & GH axis · 5 Mar 2026 · 6 likes Evidence quality in the secretagogue literature is honestly weaker than in the incretin literature. Large randomised controlled trials are rare. Most evidence is…
Air bubbles in a subcutaneous injection: the honest risk assessment — does this still… Replied, post #3 · Practice › Administration · 24 Feb 2026 · 0 likes Cold solution and stinging: warming the vial in your hands for a minute before injection reduces the stinging sensation substantially. This is the simplest thing to try…
Pharmacy supply in the UK and the questions you will be asked Replied, post #52 · Regional › UK & Ireland · 23 Feb 2026 · 0 likes Occupational health screening: some UK occupations require medical checks. Disclosure of weight-loss medication might be relevant to employment screening; understand…
How the published trials escalated, tabulated side by side Replied, post #7 · Practice › Dosing & titration · 21 Feb 2026 · 0 likes When a dose reduction is the correct response to a side effect: if a side effect is dose-dependent (nausea, constipation, injection discomfort), reducing the dose is a…
Micro-titration: a disputed topic, argued properly Replied, post #35 · Practice › Dosing & titration · 16 Feb 2026 · 31 likes Picking up post #32: that is the part I would want checked first. Dose equivalence between different incretin analogues is a weak concept. The molecules differ in…
Stability of BPC-157 in solution: what has been measured — one year on Replied, post #9 · Compounds › Repair & healing peptides · 12 Feb 2026 · 0 likes Picking up post #6: that is the part I would want checked first. What would change the position on repair peptides: adequately powered, published, peer-reviewed…
Filter needles: when they help and what they cost you Replied, post #45 · Devices › Syringes & needles · 5 Feb 2026 · 0 likes Picking up post #42: that is the part I would want checked first. Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For…
Trifluoroacetate content and its consequences Replied, post #71 · Analytics › Impurities & related substances · 3 Feb 2026 · 21 likes post #70 answers the question as asked. The question underneath it is different. Incomplete deprotection: mass higher by the protecting group mass. Usually markedly…
Why the titration planner refuses to produce a schedule below a floor Replied, post #33 · Data & Tools › Calculators · 28 Jan 2026 · 1 like Worth separating two things that post #29 runs together. The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic,…
A partial dose because the pen emptied mid-injection Replied, post #24 · Practice › Administration · 7 Jan 2026 · 2 likes This follows post #21 rather than contradicting it. A genuinely late dose: the labelling generally says that if the next dose is more than a couple of days away, take…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #13 · Documentation › Wiki requests · 27 Dec 2025 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Comparing my trajectory with the trial curves, carefully Replied, post #93 · Outcomes › Progress reports · 20 Dec 2025 · 7 likes Longitudinal report with the method stated: same scale, same time of day, same conditions. A scale is a tool; use the same one each time. Consistency matters more than…
An inter-laboratory comparison on one lot, tabulated — what changed since Replied, post #24 · Analytics › Method validation · 10 Dec 2025 · 0 likes post #23 is right about the mechanism and I think understates the practical bit. Why two laboratories may disagree: after validating the same method, they may still…
[2026 update] What steady state means for the decision to escalate Replied, post #134 · Practice › Dosing & titration · 18 Nov 2025 · 15 likes Micro-titration: the concept of increments smaller than the labelled steps. It has no evidence base from trials but is described by some people. The downside is that…
Gauge and length selection for subcutaneous injection Replied, post #51 · Devices › Syringes & needles · 16 Nov 2025 · 1 like post #50 answers the question as asked. The question underneath it is different. Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are…
Freeze-thaw and why one cycle is not the same as five Replied, post #17 · Practice › Storage & stability · 31 Oct 2025 · 4 likes Coming back to post #15, because the follow-up matters more than the original answer. Refrigeration slows degradation. Repeated warming and cooling is worse than…
New subcategory: rationale and scope Replied, post #92 · Meta › Announcements · 22 Oct 2025 · 13 likes Archives: older announcements are archived by date. Checking archives is useful if you want to know what changed when.
Validating a method you did not develop Replied, post #4 · Analytics › Method validation · 22 Oct 2025 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
New subcategory: rationale and scope Replied, post #73 · Meta › Announcements · 20 Oct 2025 · 3 likes Staff announcements, policy changes, and scheduled maintenance. Read-only except for questions clarifying what was announced.
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #41 · Start Here › Welcome · 16 Oct 2025 · 1 like Trust levels accumulate over time and they give you access to small things like the ability to edit your own posts without a timestamp. They are not a status symbol and…
Compounds this community declines to help with, and why Replied, post #17 · Compounds › Other compounds · 26 Sep 2025 · 28 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #31 · Evidence › Study critique · 13 Sep 2025 · 18 likes This follows post #28 rather than contradicting it. When you change your mind: if a reply convinces you that your criticism was not well-founded, say so plainly. The…
[2026 update] Splitting an overlong document into two Replied, post #31 · Documentation › Wiki requests · 9 Sep 2025 · 32 likes Correction requests: if you spot an error in a maintained page, note it here with the specific correction. The maintainer will review and update if justified.
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #95 · Compounds › Oral incretins · 4 Sep 2025 · 0 likes On post #91 — agreed on the reasoning, with one qualification. Oral versus injectable exposure: comparing a 14 mg oral dose with a 0.5 mg injectable dose is comparing…
Enforcement priorities versus written rules — does this still hold? Replied, post #35 · Sourcing › Regulatory · 29 Aug 2025 · 0 likes Import restrictions vary by compound and by jurisdiction: what is a controlled substance in one place is legal to purchase in another. What you can import for personal…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #44 · Evidence › Journal club · 16 Aug 2025 · 0 likes I read post #42 twice before replying, because I had assumed the opposite. PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not…
Are there stupid questions here? A staff answer, at length Replied, post #77 · Start Here › Welcome · 16 Aug 2025 · 6 likes The FAQ link in the sidebar is maintained and worth ten hours of forum browsing. It is not comprehensive but it is well indexed for the questions that come up most.
How the vendor documentation pages are maintained, and by whom — what changed since Replied, post #39 · Sourcing › Vendor reports · 13 Aug 2025 · 7 likes I read post #37 twice before replying, because I had assumed the opposite. Blind submission is worth the effort: have someone else relabel the sample so neither you nor…
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Replied, post #24 · Practice › Dosing & titration · 11 Aug 2025 · 13 likes Steady state means the plasma concentration is stable from dose to dose. That happens around 4 to 5 half-lives. Before that, the concentration is rising with each dose.…
Second pass at: Why this subcategory is stricter about sourcing than most Replied, post #44 · Compounds › Secretagogues & GH axis · 7 Aug 2025 · 31 likes GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like CJC-1295) cause the pituitary to release growth…
A ten-fold dose error caught before injection — one year on Replied, post #43 · Devices › Syringes & needles · 2 Aug 2025 · 19 likes Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take…
Coming back to: When "no data" is the complete and final answer Replied, post #66 · Compounds › Other compounds · 31 Jul 2025 · 27 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #10 · Wellbeing › Mental health · 27 Jul 2025 · 4 likes post #9 answers the question as asked. The question underneath it is different. Support and community: some people process weight change through community (online or…
Angle of injection and whether 90 degrees is always right Replied, post #4 · Practice › Administration · 25 Jul 2025 · 0 likes Leak-back after withdrawal: a small amount of liquid on the skin after withdrawal is ordinary. Whether you lost a "meaningful" dose depends on concentration and your…
Trust level 3 requirements: a clarification Replied, post #2 · Meta › Announcements · 21 Jul 2025 · 14 likes This follows the opening post rather than contradicting it. When announcements are made: major policy changes, technical changes affecting site function, planned…
Area percent versus weight percent: the confusion that causes most arguments — what… Replied, post #35 · Analytics › HPLC & UHPLC · 26 Jun 2025 · 3 likes Method validation is the demonstration that a method can separate the compound from its degradation products and impurities reliably. A method that cannot resolve an…
The CagriSema phase 2 paper and what a fixed combination buys — the long version Replied, post #159 · Compounds › Cagrilintide & amylin analogues · 20 Jun 2025 · 0 likes Coming back to post #157, because the follow-up matters more than the original answer. The dosing interval: cagrilintide's half-life is roughly 7 to 8 days, suitable…
A supplier that answers analytical questions with restated claims Replied, post #95 · Sourcing › Red flags · 12 Jun 2025 · 24 likes Unresponsiveness: a supplier that does not reply to reasonable requests for documentation or clarification is showing you something about how they operate.
Airline travel with a temperature-sensitive injectable — what changed since Replied, post #37 · Devices › Cold chain · 10 Jun 2025 · 3 likes Assessing an excursion: if a package sat at room temperature for a time, visual inspection (cloudiness, discoloration, particles) can alert you to problems. Not visible…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #66 · Wellbeing › Mental health · 8 Jun 2025 · 10 likes Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan…
The CagriSema phase 2 paper and what a fixed combination buys — the long version Replied, post #15 · Compounds › Cagrilintide & amylin analogues · 4 Jun 2025 · 2 likes post #14 answers the question as asked. The question underneath it is different. Amylin signalling is distinct from GLP-1 signalling. Amylin slows gastric emptying and…
Pregnancy as an absolute contraindication Replied, post #35 · Safety › Contraindications · 18 May 2025 · 24 likes post #34 answers the question as asked. The question underneath it is different. Pregnancy: these compounds are not approved for pregnancy. The potential risks outweigh…
Reading a trial's population section before its results — does this still hold? Replied, post #103 · Evidence › Trials · 14 May 2025 · 5 likes Picking up post #100: that is the part I would want checked first. Intent-to-treat versus per-protocol: ITT includes everyone assigned regardless of whether they took…
A checklist for reading a certificate in under two minutes — does this still hold? Replied, post #5 · Analytics › COA interpretation · 14 May 2025 · 0 likes post #4 answers the question as asked. The question underneath it is different. Reading old certificates: if a certificate is dated years ago, the lot it describes…
A well-designed study with a badly written abstract Replied, post #78 · Evidence › Study critique · 12 May 2025 · 3 likes This follows post #75 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #102 · Devices › Cold chain · 12 May 2025 · 21 likes I read post #100 twice before replying, because I had assumed the opposite. Domestic refrigeration: most lyophilised peptides are stored at 2–8 °C (35–46 °F). That is…
About the Datasets category Replied, post #4 · Data & Tools › Datasets · 6 Apr 2025 · 22 likes Suggestion for the wiki post above: it would be worth linking the two or three most-referenced topics in this category directly, since new members reliably ask for…
Second pass at: Retatrutide mass and identity: what a report should show Replied, post #14 · Compounds › Retatrutide · 3 Apr 2025 · 0 likes Worth separating two things that post #10 runs together. Triple agonism: is the effect additive, synergistic, or neither? A phase 2 comparison of tirzepatide (dual) to…
Journal club: SURMOUNT-1, read without the press release Replied, post #84 · Evidence › Journal club · 25 Mar 2025 · 9 likes FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is…
One lot is one lot: when a report becomes a pattern — the long version Replied, post #125 · Sourcing › Vendor reports · 18 Mar 2025 · 6 likes post #124 is right about the mechanism and I think understates the practical bit. Pattern across lots: a single result is a data point. Three or four results from the…
Follow-up: Attributing a new peak: degradation product or excipient? Replied, post #14 · Analytics › Impurities & related substances · 17 Feb 2025 · 19 likes Incomplete deprotection: mass higher by the protecting group mass. Usually markedly later eluting. A synthesis artifact from incomplete removal of protecting groups.
Adducts: sodium, potassium, and the peak you did not expect Replied, post #5 · Analytics › Mass spectrometry · 6 Feb 2025 · 0 likes On the opening post — agreed on the reasoning, with one qualification. Sample matrix effects: if a sample is dissolved in a complex matrix, other compounds in the…
Oxidation and deamidation mass shifts, tabulated Replied, post #46 · Analytics › Mass spectrometry · 1 Feb 2025 · 1 like Worth separating two things that post #42 runs together. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #101 · Evidence › Journal club · 22 Jan 2025 · 0 likes SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical…
[2026 update] New subcategory: rationale and scope Replied, post #108 · Meta › Announcements · 31 Dec 2024 · 0 likes Worth separating two things that post #104 runs together. Staff-only posts: some announcements are visible only to staff (concerning internal operations). Members see…
What would change my mind about repair peptides: a specific answer — one year on Replied, post #14 · Compounds › Repair & healing peptides · 23 Dec 2024 · 20 likes I read post #12 twice before replying, because I had assumed the opposite. The distinction between "no evidence it works" and "evidence it does not work": we have the…
Building a sensible monitoring schedule with your prescriber Replied, post #15 · Clinical › Bloodwork · 18 Dec 2024 · 0 likes A single value outside interval: usually uninformative on a single draw. What makes a result interesting: a trend across multiple draws, a magnitude well beyond the…
[2026 update] New subcategory: rationale and scope Replied, post #74 · Meta › Announcements · 18 Dec 2024 · 12 likes Staff-only posts: some announcements are visible only to staff (concerning internal operations). Members see public announcements.
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #94 · Analytics › Method validation · 14 Dec 2024 · 13 likes Transfer between laboratories: a method can be transferred from one lab to another, but the receiving lab needs to demonstrate that they can achieve the same…
Asking about a compound your prescriber has not heard of — one year on Replied, post #11 · Clinical › Prescriber conversations · 3 Dec 2024 · 3 likes Worth separating two things that post #7 runs together. Discussing off-label dosing: if you want to dose differently than the label specifies (slower titration, higher…
Second pass at: How to research a compound with no human data without deceiving yourself Started this topic · Compounds › Other compounds · 22 Nov 2024 · 20 likes Second pass at: How to research a compound with no human data without deceiving yourself Writing it up because I had to work it out twice and would rather nobody else…
EMA product information as a primary source — does this still hold? Replied, post #129 · Regional › European Union · 18 Nov 2024 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
[2026 update] Step therapy requirements and how to satisfy them Replied, post #20 · Access › Insurance & coverage · 9 Nov 2024 · 10 likes Reimbursement changes: a compound covered one year might not be the next. A formulary decision in January can change by April. Checking again before refilling saves…
Journal club: STEP 4 and what a withdrawal design can prove — one year on Replied, post #2 · Evidence › Journal club · 21 Oct 2024 · 1 like the opening post is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct…
Requesting a page: what makes a good request — what changed since Replied, post #117 · Documentation › Wiki requests · 13 Oct 2024 · 4 likes post #116 answers the question as asked. The question underneath it is different. Cross-referencing: if you notice two pages that should reference each other but do…
Requesting a page: what makes a good request — what changed since Replied, post #98 · Documentation › Wiki requests · 12 Oct 2024 · 20 likes post #97 answers the question as asked. The question underneath it is different. Authority and authorship: if you think a maintained page needs input from someone with…
Second pass at: Sodium, potassium and magnesium when intake drops Replied, post #133 · Nutrition & Training › Hydration & electrolytes · 4 Oct 2024 · 12 likes The very ordinary causes of week-two malaise: inadequate hydration, low sodium intake, too-rapid calorie deficit, and inadequate sleep are more common causes of fatigue…
A page that has drifted out of date and needs a maintainer Replied, post #3 · Documentation › Wiki requests · 17 Aug 2024 · 0 likes Authority and authorship: if you think a maintained page needs input from someone with specific expertise (a clinician, an analytical chemist) suggest who might…
Follow-up: Where the four-week escalation interval comes from, and what it is not Replied, post #24 · Practice › Dosing & titration · 7 Jul 2024 · 13 likes This follows post #21 rather than contradicting it. Dose equivalence between different incretin analogues is a weak concept. The molecules differ in structure,…
Cold packs, phase-change material, and what survives ten days Replied, post #65 · Sourcing › Logistics · 3 Jul 2024 · 18 likes Packaging integrity on arrival: if a parcel arrives with compromised packaging, that is evidence of a handling problem in transit. The contents may or may not be…
Follow-up: Dead volume across syringe and needle combinations Replied, post #3 · Devices › Syringes & needles · 23 Jun 2024 · 8 likes Worth separating two things that the opening post runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly…