Recently active

Unread page 8

On the live site this tab tracks what you have not read. In this static rendering it shows every topic with activity in the last 45 days, which is the closest honest equivalent — we would rather explain the difference than pretend a static page knows your reading history.

414 topics · page 8 of 14

Topic	Participants	Replies	Views	Activity
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions hypoglycaemia metformin insulin needs a source Solved Delayed gastric emptying and oral medication absorption: which drugs matter Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+63	74	11k	1d
Gradient steepness and apparent purity: a worked comparison — the long version Analytics › HPLC & UHPLC HPLC system suitability gradient method Gradient steepness and apparent purity: a worked comparison — the long version — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I…		2	32k	1d
[2026 update] Temperature indicator cards: worth asking for? Sourcing › Logistics shipping packaging customs temperature excursion Temperature indicator cards: worth asking for? I have a specific reason for asking rather than idle curiosity, and the context is below. A logistics question, since the answers here are usually better than…	+21	26	4.5k	1d
Cleaning a self-reported dataset and what you throw away Data & Tools › Datasets confounding site feedback data table observational data Cleaning a self-reported dataset and what you throw away — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in…		2	28k	1d
Washout with a one-week half-life: the arithmetic — does this still hold? Research Methods › N-of-1 designs confounding data table worked example Solved Washout with a one-week half-life: the arithmetic — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021)…	+41	45	12k	1d
[2026 update] Documenting an adverse event properly Safety › Adverse events pancreatitis vomiting gallbladder Documenting an adverse event properly Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published trials in this…	+18	22	4.3k	1d
Why the Start Here categories exist, and what they are not for Start Here › Welcome guidelines trust levels onboarding beginner friendly Solved Why the Start Here categories exist, and what they are not for — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried…	+40	44	32k	1d
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Compounds › Semaglutide STEP programme type 2 diabetes randomised trial SELECT trial Posting this under the heading it deserves: Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Everything below is what sits behind that. I have seen SCALE ( N Engl J Med…	+115	122	2.6k	1d
Sulphur-smelling eructation: mechanism and what helps Practice › Side effects vomiting delayed gastric emptying nausea Sulphur-smelling eructation: mechanism and what helps — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful to…		2	58	1d
Muscle cramps: the ordinary causes before the exotic ones — a second dataset Practice › Side effects constipation delayed gastric emptying fatigue hair shedding Solved Posting this under the heading it deserves: Muscle cramps: the ordinary causes before the exotic ones — a second dataset Everything below is what sits behind that. Reporting something rather than asking about…	+65	77	39k	1d
Publication bias detection and its low power Evidence › Meta-analyses heterogeneity publication bias effect size On the subject in the title: Publication bias detection and its low power Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not think it…		2	3.2k	1d
Insomnia at a dose step: reported experiences — the long version Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Solved Pinned Insomnia at a dose step: reported experiences — the long version Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+47	51	31k	1d
Conditions that change the calculus rather than forbidding it Safety › Contraindications disordered eating pregnancy & planning pancreatitis delayed gastric emptying Conditions that change the calculus rather than forbidding it Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+28	32	6.1k	1d
Type 1 diabetes: off-label use and the evidence gap Clinical › Special populations pregnancy & planning bariatric surgery history disordered eating Solved On the subject in the title: Type 1 diabetes: off-label use and the evidence gap Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference…		2	2.3k	1d
Splitting an overlong document into two Documentation › Wiki requests promoted to docs review date wiki post Posting this under the heading it deserves: Splitting an overlong document into two Everything below is what sits behind that. Nominating something for promotion into the documentation commons. The topic in…	+30	34	6.2k	1d
What is genuinely unknown about long-term amylin agonism Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema amylin analogues Solved What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing STEP 8 ( JAMA , 2022) with SURMOUNT-1 ( N Engl J Med…	+83	91	46k	1d
Why the absence of controlled human data on BPC-157 matters more than people admit Compounds › Repair & healing peptides needs a source BPC-157 preprint Solved Why the absence of controlled human data on BPC-157 matters more than people admit — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing STEP 8 ( JAMA , 2022) with…	+60	66	16k	1d
Pinch or no pinch, and how needle length changes the answer — what changed since Practice › Administration missed dose aseptic technique injection site rotation Solved Posting this under the heading it deserves: Pinch or no pinch, and how needle length changes the answer — what changed since Everything below is what sits behind that. I have read the maintained page on this…	+58	62	16k	1d
System suitability injections: if they failed, the run did not happen — the long version Analytics › HPLC & UHPLC gradient method UV & DAD detection system suitability peak integration System suitability injections: if they failed, the run did not happen — the long version — setting out what I have, and where I think it stops being reliable. A documentation question rather than an…	+2	6	6.2k	1d
Revisiting: How this community labels and discusses unrefereed work Evidence › Preprints needs a source risk of bias preprint effect size Solved Revisiting: How this community labels and discusses unrefereed work Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited in…	+31	35	7k	1d
Peak-to-trough ratio at steady state for a weekly agent — the long version Pharmacology › Pharmacokinetics semaglutide missed dose tirzepatide worked example Under review Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means…	+57	61	708	1d
What published stability data actually covers, and what it does not Practice › Storage & stability cloudy or discoloured solution freeze-thaw beyond-use date Solved Asking directly, because I could not find a straight answer: What published stability data actually covers, and what it does not Reporting something rather than asking about it, in case the pattern is useful…	+8	12	435	1d
Journal club: SUSTAIN 6 and its retinopathy signal Evidence › Journal club estimand effect size risk of bias journal club Under review On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I do not think it…	+110	122	46k	1d
Revisiting: The report format the maintainers ask for, and why each field is there Sourcing › Vendor reports batch & lot numbers Janoshik Analytical documentation quality third-party testing Posting this under the heading it deserves: Revisiting: The report format the maintainers ask for, and why each field is there Everything below is what sits behind that. Structured report rather than an…	+100	108	57k	1d
Distinguishing a red flag from an inconvenience — a second dataset Sourcing › Red flags moderation documentation quality disputed On the subject in the title: Distinguishing a red flag from an inconvenience — a second dataset Working notes rather than a conclusion. A logistics question, since the answers here are usually better than…	+8	12	9.6k	1d
Athletes in weight-category sports: a different risk calculus Clinical › Special populations older adults adolescents disordered eating chronic kidney disease Solved Athletes in weight-category sports: a different risk calculus — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…	+38	42	6.6k	1d
The five documentation pages worth reading before you post anything — a second dataset Start Here › Welcome beginner friendly trust levels guidelines onboarding Solved On the subject in the title: The five documentation pages worth reading before you post anything — a second dataset Working notes rather than a conclusion. Question in the title. Context below, and I have…		2	24k	1d
Research-use-only status: what it means legally and practically Compounds › Other compounds research use only custom synthesis needs a source mislabelling Research-use-only status: what it means legally and practically Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited in…	+72	81	44k	1d
Does a peptide degrade silently, with no visual change? Practice › Storage & stability beyond-use date cold chain temperature excursion freeze-thaw Solved Does a peptide degrade silently, with no visual change? I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this and I still have a…	+73	79	1.3k	1d
PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities chronic kidney disease MASH / hepatic steatosis obstructive sleep apnoea type 2 diabetes On the subject in the title: PCOS and metabolic overlap: what is and is not studied Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in this…		3	6.6k	1d