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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 22 of 40

Topic	Participants	Replies	Views	Activity
AOD-9604 and the fragment hypothesis, revisited — does this still hold? Compounds › Other compounds research use only needs a source mislabelling Solved The question in the title: AOD-9604 and the fragment hypothesis, revisited — does this still hold? I will give what I have already checked below so nobody repeats it. Comparing FLOW ( N Engl J Med , 2024)…	+7	11	31k	19h
A history of disordered eating: proceeding carefully Wellbeing › Mental health mood beginner friendly disordered eating A history of disordered eating: proceeding carefully Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+70	75	10k	6mo
Endotoxin and why it is a separate question from purity Analytics › Impurities & related substances water content counter-ion content forced degradation HPLC Endotoxin and why it is a separate question from purity Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…		2	22k	4mo
Adsorptive losses at low concentration, and why dilute solutions are fragile Practice › Storage & stability storage cold chain beyond-use date Adsorptive losses at low concentration, and why dilute solutions are fragile — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have…	+16	20	1.7k	4mo
Severe gastroparesis and why this class is a poor fit — one year on Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Closed Severe gastroparesis and why this class is a poor fit — one year on — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+19	23	23k	7mo
How to read a phase 2 result without treating it as a phase 3 result Compounds › Retatrutide randomised trial preprint effect size TRIUMPH programme The question in the title: How to read a phase 2 result without treating it as a phase 3 result I will give what I have already checked below so nobody repeats it. Session topic: FLOW ( N Engl J Med , 2024).…	+36	40	35k	7mo
Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Compounds › Tirzepatide tirzepatide SURPASS programme effect size randomised trial Closed Revisiting: Why tirzepatide titration schedules have more steps than semaglutide's Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med ,…	+89	101	32k	8mo
Constipation management, with a dietitian's contribution Practice › Side effects constipation nausea delayed gastric emptying vomiting Solved Posting this under the heading it deserves: Constipation management, with a dietitian's contribution Everything below is what sits behind that. Practical question with the units stated, because I have seen…	+79	88	27k	21d
Coming back to: Feature request: should a dose-equivalence tool exist at all? Data & Tools › Calculators syringe units concentration maths worked example site feedback Solved Feature request: should a dose-equivalence tool exist at all? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first…	+37	41	725	7mo
Prescription requirements and telehealth models Sourcing › Regulatory FDA compounding research use only MHRA Prescription requirements and telehealth models Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than anywhere…	+91	97	5.4k	7mo
[2026 update] What steady state means for the decision to escalate Practice › Dosing & titration tirzepatide worked example semaglutide missed dose The question in the title: What steady state means for the decision to escalate I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still have a…	+127	137	32k	8mo
Dizziness on standing and the electrolyte explanation Practice › Side effects hair shedding fatigue vomiting delayed gastric emptying On the subject in the title: Dizziness on standing and the electrolyte explanation Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking rather…	+3	7	147	4mo
Pre-registering a personal experiment, seriously — a second dataset Research Methods › N-of-1 designs data table worked example confounding Posting this under the heading it deserves: Pre-registering a personal experiment, seriously — a second dataset Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of…	+60	66	35k	3mo
Dose numbers for oral formulations are not comparable to injectable ones Compounds › Oral incretins orforglipron PIONEER programme SOUL trial On the subject in the title: Dose numbers for oral formulations are not comparable to injectable ones Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it…	+19	23	39k	6mo
Second pass at: Why semaglutide's albumin binding is the whole reason weekly dosing works Compounds › Semaglutide SELECT trial STEP programme effect size randomised trial Second pass at: Why semaglutide's albumin binding is the whole reason weekly dosing works Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet ,…		2	39k	6mo
Whether protein timing matters at a large deficit Nutrition & Training › Protein & intake micronutrients lean mass loss fatigue Posting this under the heading it deserves: Whether protein timing matters at a large deficit Everything below is what sits behind that. Longitudinal report with the method stated, because a number without a…	+29	33	7.7k	4mo
Micro-titration: a disputed topic, argued properly Practice › Dosing & titration titration dose reduction worked example tirzepatide Solved Wiki Micro-titration: a disputed topic, argued properly Writing it up because I had to work it out twice and would rather nobody else did. A question about technique rather than about dose. I have been doing the…	+99	110	61k	2d
Search filters: what is missing Meta › Site feedback site feedback moderation guidelines Search filters: what is missing — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps being…	+74	84	15k	3d
Long-time reader, first-time poster Lounge › Introductions beginner friendly onboarding On the subject in the title: Long-time reader, first-time poster Working notes rather than a conclusion. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim. Something adjacent…	+15	19	2.5k	8mo
About the Pens & autoinjectors category Devices › Pens & autoinjectors dead volume missed dose storage Pinned Wiki Pen mechanics, dose counters, priming, and what happens when a pen is used off its label. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+1	5	92	5mo
Journal club: LEADER as the historical anchor Evidence › Journal club estimand number needed to treat journal club effect size Pinned Journal club: LEADER as the historical anchor Writing it up because I had to work it out twice and would rather nobody else did. Comparing STEP 1 ( N Engl J Med , 2021) with SURMOUNT-4 ( JAMA , 2024) and…	+103	110	8.1k	2h
[2026 update] Currency conversion and the cost you did not see Sourcing › Payments research use only payments documentation quality Solved Posting this under the heading it deserves: Currency conversion and the cost you did not see Everything below is what sits behind that. A logistics question, since the answers here are usually better than…	+21	26	52k	2d
Interpreting a result that disagrees with the supplier's certificate Sourcing › Independent verification Janoshik Analytical Medutest PeptideMeter third-party testing Interpreting a result that disagrees with the supplier's certificate Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+129	153	7.3k	5mo
Second pass at: Metformin co-administration and additive GI effects Practice › Interactions hypoglycaemia delayed gastric emptying metformin needs a source On the subject in the title: Second pass at: Metformin co-administration and additive GI effects Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…	+131	142	56k	19d
Shoulders, tangent skims, and defensible integration — the long version Analytics › HPLC & UHPLC HPLC system suitability peak integration data table Shoulders, tangent skims, and defensible integration — the long version Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the…	+16	20	27k	3mo
When a dose reduction is the correct response to a side effect — a second dataset Practice › Dosing & titration worked example dose reduction titration tirzepatide When a dose reduction is the correct response to a side effect — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on…	+10	14	42k	2mo
Conference abstracts as evidence: the weakest common citation Evidence › Preprints risk of bias effect size needs a source On the subject in the title: Conference abstracts as evidence: the weakest common citation Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+1	5	2k	9mo
Citation sweep results: how many references did not say what was claimed Meta › Wiki maintenance moderation maintainership citation check wiki post On the subject in the title: Citation sweep results: how many references did not say what was claimed Working notes rather than a conclusion. Process question about how this site works. I have read the…	+92	101	2.9k	2mo
The most useful thing you learned here that was not the answer you came for Lounge › Off topic long read beginner friendly The most useful thing you learned here that was not the answer you came for Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still…	+54	61	57k	1d
Reused chromatograms across lots: how to spot it Analytics › COA interpretation batch & lot numbers amino acid analysis documentation quality certificate of analysis On the subject in the title: Reused chromatograms across lots: how to spot it Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of…	+53	60	9.5k	4h