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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 24 of 40

Topic	Participants	Replies	Views	Activity
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Compounds › Oral incretins oral semaglutide randomised trial PIONEER programme SOUL trial Solved Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SURPASS-4 ( Lancet , 2021)…	+130	135	11k	7mo
Follow-up: Constipation management, with a dietitian's contribution Practice › Side effects nausea fatigue hair shedding Closed Constipation management, with a dietitian's contribution — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the same…	+31	35	28k	8mo
Follow-up: Subcutaneous absorption kinetics and site differences Pharmacology › Pharmacokinetics semaglutide liraglutide worked example Subcutaneous absorption kinetics and site differences — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere. A…		4	9.9k	10mo
Reference intervals: how they are constructed and why one in twenty flags Clinical › Bloodwork HbA1c thyroid function eGFR & renal function lipase & amylase Under review Reference intervals: how they are constructed and why one in twenty flags — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I…	+104	119	30k	1mo
An orphaned page with no inbound links — the long version Meta › Wiki maintenance review date wiki post citation check Posting this under the heading it deserves: An orphaned page with no inbound links — the long version Everything below is what sits behind that. Process question about how this site works. I have read the…	+14	18	21k	10mo
[2026 update] A report I filed that turned out to be wrong, and the correction Sourcing › Vendor reports batch & lot numbers third-party testing documentation quality certificate of analysis On the subject in the title: A report I filed that turned out to be wrong, and the correction Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+15	19	18k	2d
Where to report an adverse event officially, by region — a second dataset Safety › Adverse events gallbladder delayed gastric emptying vomiting hypoglycaemia On the subject in the title: Where to report an adverse event officially, by region — a second dataset Working notes rather than a conclusion. Asking about a population rather than about a person. The…	+108	123	26k	8mo
Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide tirzepatide worked example Clearance pathways and what renal impairment changes Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+11	15	43k	2mo
Reconciling a supplier certificate with an independent result Sourcing › Vendor reports third-party testing Janoshik Analytical certificate of analysis Reconciling a supplier certificate with an independent result — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…	+18	24	347	9mo
Half-life, steady state, and accumulation worked through — a second dataset Pharmacology › Pharmacokinetics semaglutide worked example liraglutide Half-life, steady state, and accumulation worked through — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…	+110	126	14k	4mo
Warfarin and altered intake: the monitoring argument Practice › Interactions hypoglycaemia needs a source insulin Solved Warfarin and altered intake: the monitoring argument — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a gap, so I am asking rather…		2	11k	4mo
Micronutrient adequacy at low total intake — does this still hold? Nutrition & Training › Protein & intake fatigue lean mass loss micronutrients constipation Solved Closed Micronutrient adequacy at low total intake — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Longitudinal report with the method stated, because…	+21	25	45k	10mo
Hair shedding at month three: mechanism and time course Practice › Side effects delayed gastric emptying fatigue constipation hair shedding On the subject in the title: Hair shedding at month three: mechanism and time course Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful to…		2	47k	7mo
Why the titration planner refuses to produce a schedule below a floor Data & Tools › Calculators syringe units site feedback concentration maths Solved Asking directly, because I could not find a straight answer: Why the titration planner refuses to produce a schedule below a floor I would like to understand what this number means before I repeat it…	+76	83	53k	2mo
A genuinely late dose: what the labelling says and what people do — what changed since Practice › Administration subcutaneous injection missed dose needle gauge & length injection site rotation Solved A genuinely late dose: what the labelling says and what people do — what changed since — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still…	+9	13	474	6mo
Stepping down deliberately, and how to do it without losing progress Practice › Dosing & titration worked example semaglutide tirzepatide dose reduction Stepping down deliberately, and how to do it without losing progress — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+98	102	26k	3mo
Request: export my own posts — one year on Meta › Feature requests site feedback wiki post translation Request: export my own posts — one year on — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps…	+66	70	14k	4mo
Cagrilintide's dosing interval and the pharmacokinetics behind it Compounds › Cagrilintide & amylin analogues effect size randomised trial amylin analogues cagrisema Solved Cagrilintide's dosing interval and the pharmacokinetics behind it — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SELECT ( N Engl J Med ,…	+98	105	24k	10mo
Publishing an inconvenient result: a case study — the long version Sourcing › Independent verification Janoshik Analytical PeptideMeter Medutest blind sampling Publishing an inconvenient result: a case study — the long version Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+68	74	12k	7mo
Choosing a concentration on purpose rather than by accident Practice › Reconstitution concentration maths worked example syringe units Solved On the subject in the title: Choosing a concentration on purpose rather than by accident Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful…		2	719	1mo
What "marked as solution" means and who gets to mark it — does this still hold? Start Here › Welcome onboarding beginner friendly guidelines Solved What "marked as solution" means and who gets to mark it — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather…	+69	74	2.4k	3mo
Coming back to: Semaglutide in people without diabetes: what the evidence base looks like Compounds › Semaglutide effect size randomised trial SELECT trial On the subject in the title: Semaglutide in people without diabetes: what the evidence base looks like Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before…	+41	46	1.2k	4mo
Moderation log format change Meta › Announcements trust levels guidelines site feedback moderation Posting this under the heading it deserves: Moderation log format change Everything below is what sits behind that. Process question about how this site works. I have read the guidelines and the trust-level…	+53	57	4.8k	2mo
Absence of evidence and evidence of absence Research Methods › Statistics effect size worked example number needed to treat Absence of evidence and evidence of absence Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med , 2024). Please read it before…	+16	20	3.9k	5mo
Citing a preprint in a maintained document: our rule and its reasoning — does this still hold? Evidence › Preprints preprint needs a source effect size Solved Under review The question in the title: Citing a preprint in a maintained document: our rule and its reasoning — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER…	+103	115	24k	10mo
Pen mechanics when the cartridge is nearly empty — does this still hold? Devices › Pens & autoinjectors storage subcutaneous injection missed dose dead volume Asking directly, because I could not find a straight answer: Pen mechanics when the cartridge is nearly empty — does this still hold? Practical question with the units stated, because I have seen how quickly…	+37	47	61k	6mo
Second pass at: Circumference measurements as a poor man's composition estimate Outcomes › Body composition DXA lean mass loss data table Second pass at: Circumference measurements as a poor man's composition estimate — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a…	+64	68	13k	4mo
About the Statistics category Research Methods › Statistics effect size number needed to treat heterogeneity Pinned Wiki Effect sizes, intervals, multiplicity, and the difference between absent and undetected. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+4	8	2.3k	7mo
About the North America category Regional › North America FDA compounding insurance Pinned Wiki US and Canadian regulation, compounding, and coverage. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a note. If the scope…	+3	7	43k	9mo
Second pass at: Asking a follow-up: new topic or new reply? Start Here › How to Ask guidelines site feedback worked example beginner friendly Solved Wiki The question in the title: Second pass at: Asking a follow-up: new topic or new reply? I will give what I have already checked below so nobody repeats it. I want to check my reasoning rather than get a…		4	81	8mo