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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 26 of 40

Topic	Participants	Replies	Views	Activity
Revisiting: Sample size in a voluntary survey: the selection problem Data & Tools › Datasets data table confounding site feedback observational data Solved Revisiting: Sample size in a voluntary survey: the selection problem — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies…		2	56k	9mo
Freeze-thaw and why one cycle is not the same as five Practice › Storage & stability beyond-use date freeze-thaw cloudy or discoloured solution storage On the subject in the title: Freeze-thaw and why one cycle is not the same as five Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking rather…	+21	25	41k	8mo
[2026 update] Storing lyophilised material long term: what governs the shelf life Practice › Storage & stability beyond-use date freeze-thaw cold chain cloudy or discoloured solution Storing lyophilised material long term: what governs the shelf life — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing…	+122	133	35k	1mo
Batch date after test date, and other internal inconsistencies Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers documentation quality Batch date after test date, and other internal inconsistencies — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+27	31	4.9k	7mo
Titles that describe the question, not the situation — what changed since Start Here › How to Ask beginner friendly site feedback worked example guidelines Posting this under the heading it deserves: Titles that describe the question, not the situation — what changed since Everything below is what sits behind that. Question in the title. Context below, and I…	+29	33	29k	10mo
Aggregated purity results across four services, with caveats — a second dataset Data & Tools › Datasets data table confounding site feedback observational data Closed Aggregated purity results across four services, with caveats — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like…	+127	151	42k	10mo
Second pass at: Counter-ion content and its effect on measured mass Analytics › Mass spectrometry mass error (ppm) counter-ion content MALDI-TOF charge states Solved Second pass at: Counter-ion content and its effect on measured mass Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like…		4	16k	4mo
Sample size calculations, read backwards from the published number Evidence › Trials intention to treat surrogate endpoints randomised trial Sample size calculations, read backwards from the published number Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SUSTAIN 6 ( N Engl J Med , 2016). Please…		2	8.1k	6mo
Mood changes: monitoring, and when to involve a professional — what changed since Wellbeing › Mental health beginner friendly disordered eating mood Solved Mood changes: monitoring, and when to involve a professional — what changed since Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice…	+6	10	45k	25d
Follow-up: Why "dose equivalence" between different incretin analogues is a weak concept Practice › Dosing & titration dose reduction worked example tirzepatide missed dose Solved Asking directly, because I could not find a straight answer: Why "dose equivalence" between different incretin analogues is a weak concept Reporting something rather than asking about it, in case the pattern…	+7	11	26k	9mo
MHRA statements, read directly Regional › UK & Ireland NHS MHRA personal import Solved Pinned MHRA statements, read directly Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is what determines the…	+93	101	2.2k	5mo
Second pass at: Programming during a large energy deficit Nutrition & Training › Resistance training fatigue lean mass loss DXA On the subject in the title: Second pass at: Programming during a large energy deficit Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is…	+94	100	1.2k	8mo
[2026 update] A certificate with no method stated: what can you conclude? Analytics › COA interpretation reference standards certificate of analysis documentation quality batch & lot numbers Solved A certificate with no method stated: what can you conclude? — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to understand what this number means before I…		2	82	11mo
Getting a referral rather than a refusal Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes Getting a referral rather than a refusal — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the difference and I would…	+8	12	32k	2mo
Airline travel with a temperature-sensitive injectable Devices › Cold chain freeze-thaw cold chain temperature excursion storage Posting this under the heading it deserves: Airline travel with a temperature-sensitive injectable Everything below is what sits behind that. A question about technique rather than about dose. I have been…	+19	23	4.9k	7mo
IGF-1 as a surrogate endpoint and its limitations Compounds › Secretagogues & GH axis GHRP class needs a source observational data tesamorelin IGF-1 as a surrogate endpoint and its limitations Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I do not…	+5	9	35k	4mo
Reading an interaction checker output critically Practice › Interactions metformin delayed gastric emptying needs a source On the subject in the title: Reading an interaction checker output critically Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking rather than…	+144	152	3k	4mo
Tag proliferation and whether we should prune Meta › Site feedback guidelines site feedback moderation Closed On the subject in the title: Tag proliferation and whether we should prune Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the trust-level…		2	11k	11mo
Discussing something you have already been doing Clinical › Prescriber conversations prior authorisation type 2 diabetes beginner friendly telehealth Solved Under review On the subject in the title: Discussing something you have already been doing Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I…	+10	14	3.4k	10mo
Reading SURMOUNT-1 without the press release Compounds › Tirzepatide SURMOUNT programme effect size randomised trial SURPASS programme Posting this under the heading it deserves: Reading SURMOUNT-1 without the press release Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA , 2024) cited in support of a claim I do not…	+103	121	7k	7mo
Journal club: STEP-HFpEF and symptom endpoints Evidence › Journal club journal club effect size estimand risk of bias Journal club: STEP-HFpEF and symptom endpoints — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURMOUNT-1 ( N Engl J Med , 2022) and finding…	+18	22	2.5k	11mo
Confounding by indication, explained with a concrete example Evidence › Study critique confounding observational data disputed On the subject in the title: Confounding by indication, explained with a concrete example Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-2 ( N Engl J Med ,…	+21	25	21k	11mo
Tirzepatide and nausea: is the profile genuinely different or just differently reported? Compounds › Tirzepatide SURMOUNT programme randomised trial SURPASS programme tirzepatide Asking directly, because I could not find a straight answer: Tirzepatide and nausea: is the profile genuinely different or just differently reported? Comparing PIONEER 6 ( N Engl J Med , 2019) with STEP 8 (…	+18	22	37k	8mo
[2026 update] Are there stupid questions here? A staff answer, at length Start Here › Welcome guidelines trust levels onboarding Solved Closed Are there stupid questions here? A staff answer, at length — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried to…	+36	40	2.4k	1mo
Vagal afferents and the gut-brain pathway — one year on Pharmacology › Receptor biology amylin analogues long read semaglutide retatrutide Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…		2	136	11mo
Second pass at: MALDI versus ESI for a quick identity check Analytics › Mass spectrometry MALDI-TOF mass error (ppm) high-resolution MS counter-ion content Solved Second pass at: MALDI versus ESI for a quick identity check Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it…		2	18k	7mo
Retatrutide's phase 2 heart-rate signal and how to think about it Compounds › Retatrutide randomised trial preprint TRIUMPH programme retatrutide On the subject in the title: Retatrutide's phase 2 heart-rate signal and how to think about it Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019) cited in support of a claim…	+19	23	20k	7mo
What a purity-only report leaves out Sourcing › Independent verification Medutest VendorInvestigate third-party testing PeptideMeter Solved What a purity-only report leaves out — that is the question, and I have not found it answered plainly anywhere I have looked. Structured report rather than an opinion, following the format the maintainers…	+92	105	4k	8mo
About the Site feedback category Meta › Site feedback site feedback moderation guidelines Pinned Wiki Closed Bugs, friction, and the parts of the site that do not work the way you expected. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and…		4	54k	10mo
[2026 update] Hello from a laboratory that does not do peptides Lounge › Introductions onboarding beginner friendly Hello from a laboratory that does not do peptides Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still applies if anyone makes a…		2	49k	4mo