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1,535 topics · page 27 of 40

Topic	Participants	Replies	Views	Activity
About the Home & field testing category Analytics › Home & field testing ELISA third-party testing LOD & LOQ Pinned Wiki What consumer-accessible tests can and cannot tell you. Mostly a subcategory about limitations. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…		4	51k	11mo
Journal club: SELECT, absolute risk, and how it was reported — a second dataset Evidence › Journal club risk of bias effect size randomised trial journal club On the subject in the title: Journal club: SELECT, absolute risk, and how it was reported — a second dataset Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SELECT ( N…		4	1.3k	1mo
Tirzepatide molecular mass and the charge states you would expect on ESI — does this still hold? Compounds › Tirzepatide SURMOUNT programme SURPASS programme effect size tirzepatide Asking directly, because I could not find a straight answer: Tirzepatide molecular mass and the charge states you would expect on ESI — does this still hold? Comparing STEP 2 ( Lancet , 2021) with…	+7	11	281	6mo
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since Compounds › Semaglutide semaglutide SELECT trial type 2 diabetes STEP programme Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile — what changed since — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA ,…	+6	10	6.1k	8mo
Tirzepatide molecular mass and the charge states you would expect on ESI Compounds › Tirzepatide effect size SURPASS programme SURMOUNT programme randomised trial Tirzepatide molecular mass and the charge states you would expect on ESI Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited…	+36	40	44k	11mo
Semaglutide half-life: where the 165 to 184 hour figure comes from Compounds › Semaglutide semaglutide effect size randomised trial type 2 diabetes Wiki Semaglutide half-life: where the 165 to 184 hour figure comes from — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with STEP 4 ( JAMA , 2021) and…	+128	145	3k	4mo
How to read a phase 2 result without treating it as a phase 3 result — what changed since Compounds › Retatrutide TRIUMPH programme randomised trial preprint Solved Asking directly, because I could not find a straight answer: How to read a phase 2 result without treating it as a phase 3 result — what changed since Session topic: STEP 2 ( Lancet , 2021). Please read it…	+25	35	568	6mo
Can a home kit substitute for a laboratory report? A careful no Analytics › Home & field testing third-party testing documentation quality LOD & LOQ ELISA Solved Asking directly, because I could not find a straight answer: Can a home kit substitute for a laboratory report? A careful no I would like to understand what this number means before I repeat it anywhere. A…	+122	131	1.7k	5mo
About the Feature requests category Meta › Feature requests site feedback wiki post translation Pinned Wiki Closed Requests for platform and documentation features, with the reasoning that justifies them. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…		4	28k	9mo
The most useful thing you learned here that was not the answer you came for — a second dataset Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: The most useful thing you learned here that was not the answer you came for — a second dataset Everything below is what sits behind that. Lower-stakes topic, but…	+111	121	6.6k	9mo
How to tell whether your question is already answered on a maintained page Start Here › Welcome guidelines onboarding trust levels Solved How to tell whether your question is already answered on a maintained page — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I…	+5	9	30k	3mo
Why most self-reports here are not experiments, and that is fine Research Methods › N-of-1 designs confounding worked example data table effect size Closed Why most self-reports here are not experiments, and that is fine — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in…		2	46k	11mo
What published stability data actually covers, and what it does not — what changed since Practice › Storage & stability freeze-thaw storage temperature excursion cloudy or discoloured solution Solved What published stability data actually covers, and what it does not — what changed since — that is the question, and I have not found it answered plainly anywhere I have looked. Practical question with the…		3	43k	6mo
EU-wide position versus national implementation — what changed since Regional › European Union EMA cost per milligram personal import formulary Pinned EU-wide position versus national implementation — what changed since Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included,…	+22	26	58k	2mo
Coming back to: Why most self-reports here are not experiments, and that is fine Research Methods › N-of-1 designs worked example data table effect size Solved Closed The question in the title: Why most self-reports here are not experiments, and that is fine I will give what I have already checked below so nobody repeats it. Comparing LEADER ( N Engl J Med , 2016) with…	+56	62	11k	4mo
The nausea timeline across the first four weeks, with a tabulated log Practice › Side effects nausea fatigue vomiting The nausea timeline across the first four weeks, with a tabulated log — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern…	+118	134	1.8k	10mo
Request: show the solution author in the topic list Meta › Feature requests translation site feedback wiki post Pinned Posting this under the heading it deserves: Request: show the solution author in the topic list Everything below is what sits behind that. Nominating something for promotion into the documentation commons.…		2	2.4k	10mo
Oral semaglutide bioavailability and its variability between people Compounds › Oral incretins SOUL trial oral semaglutide randomised trial Posting this under the heading it deserves: Oral semaglutide bioavailability and its variability between people Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA , 2024) cited in…	+44	48	574	3mo
NHS criteria and how they are applied in practice — the long version Regional › UK & Ireland cost per milligram NHS MHRA Posting this under the heading it deserves: NHS criteria and how they are applied in practice — the long version Everything below is what sits behind that. A coverage question with the paperwork detail…	+11	15	11k	9mo
[2026 update] Does dual agonism explain the effect size, or is it dose? Compounds › Tirzepatide SURMOUNT programme randomised trial SURPASS programme effect size Solved Asking directly, because I could not find a straight answer: Does dual agonism explain the effect size, or is it dose? Session topic: SELECT ( N Engl J Med , 2023). Please read it before posting; the…	+58	63	40k	9mo
Second pass at: LOD and LOQ: definitions people get wrong Analytics › Method validation recovery precision & repeatability linearity LOD & LOQ Posting this under the heading it deserves: Second pass at: LOD and LOQ: definitions people get wrong Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+47	51	40k	10mo
Second pass at: The mass-error checker and its intended scope Data & Tools › Calculators site feedback worked example concentration maths Solved Pinned Posting this under the heading it deserves: Second pass at: The mass-error checker and its intended scope Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+70	74	1.7k	8mo
Journal club: STEP-HFpEF and symptom endpoints — a second dataset Evidence › Journal club estimand risk of bias randomised trial journal club On the subject in the title: Journal club: STEP-HFpEF and symptom endpoints — a second dataset Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with STEP 4 ( JAMA , 2021) and…	+11	15	4k	10mo
A parcel that arrived warm: a decision process, not a verdict Practice › Storage & stability cold chain beyond-use date storage freeze-thaw Solved A parcel that arrived warm: a decision process, not a verdict Writing it up because I had to work it out twice and would rather nobody else did. A question about technique rather than about dose. I have been…	+130	140	12k	8mo
Cross-border purchase rules within the EU Regional › European Union personal import formulary cost per milligram EMA On the subject in the title: Cross-border purchase rules within the EU Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what determines the answer.…	+45	49	15k	8mo
The "under review" status pill and when a moderator applies it — a second dataset Evidence › Preprints needs a source risk of bias preprint effect size The "under review" status pill and when a moderator applies it — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021)…	+50	54	1.4k	11mo
[2026 update] Journal club: is percentage weight change the right endpoint? Evidence › Journal club effect size risk of bias randomised trial Journal club: is percentage weight change the right endpoint? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021) with…	+105	118	18k	11mo
Hypertension improvement and when medication needs revisiting Clinical › Comorbidities type 2 diabetes MASH / hepatic steatosis chronic kidney disease Closed Hypertension improvement and when medication needs revisiting Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+74	79	1.1k	10mo
Particulates in a reconstituted solution: identifying the likely source Analytics › Impurities & related substances counter-ion content data table HPLC water content Posting this under the heading it deserves: Particulates in a reconstituted solution: identifying the likely source Everything below is what sits behind that. Posting the method first, because I know what the…	+15	19	13k	9mo
Enforcement priorities versus written rules — does this still hold? Sourcing › Regulatory EMA MHRA compounding FDA Solved Under review Enforcement priorities versus written rules — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Structured report rather than an opinion, following…	+36	40	37k	11mo