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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 25 of 40

Topic	Participants	Replies	Views	Activity
Compounds this community declines to help with, and why Compounds › Other compounds research use only needs a source mislabelling custom synthesis Solved Wiki Compounds this community declines to help with, and why — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SCALE ( N Engl J Med , 2015) and…	+81	87	35k	10mo
Availability by country, dated, with primary sources Access › International EMA MHRA telehealth personal import On the subject in the title: Availability by country, dated, with primary sources Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+72	81	6.9k	8mo
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating pregnancy & planning pancreatitis delayed gastric emptying Revisiting: Absolute versus relative contraindications Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+11	15	22k	5mo
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset Sourcing › Independent verification Janoshik Analytical blind sampling PeptideMeter VendorInvestigate Solved How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. A logistics question, since the…	+42	46	46k	2mo
Interim analyses and stopping rules Evidence › Trials intention to treat surrogate endpoints open label discontinuation & dropout Interim analyses and stopping rules Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do not think…	+25	29	35k	16d
Why oral semaglutide needs an absorption enhancer at all — one year on Compounds › Oral incretins randomised trial SOUL trial oral semaglutide PIONEER programme Why oral semaglutide needs an absorption enhancer at all — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SCALE ( N Engl J Med , 2015) cited…	+11	15	17k	24d
Injection discomfort: needle gauge, volume, temperature, technique — one year on Practice › Administration missed dose aseptic technique injection site rotation needle gauge & length Posting this under the heading it deserves: Injection discomfort: needle gauge, volume, temperature, technique — one year on Everything below is what sits behind that. Practical question with the units…		2	102	9mo
About the Pharmacokinetics category Pharmacology › Pharmacokinetics semaglutide tirzepatide liraglutide Pinned Wiki Half-life, accumulation, steady state, albumin binding, and why weekly dosing works. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	32k	8mo
What a confidence interval means, from scratch — the long version Research Methods › Statistics effect size worked example confounding number needed to treat The question in the title: What a confidence interval means, from scratch — the long version I will give what I have already checked below so nobody repeats it. I have seen SURMOUNT-2 ( Lancet , 2023) cited…	+16	20	2.3k	8mo
An inter-laboratory comparison on one lot, tabulated Analytics › Method validation linearity LOD & LOQ precision & repeatability system suitability Closed On the subject in the title: An inter-laboratory comparison on one lot, tabulated Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. semaglutide has a…		3	17k	10mo
An inter-laboratory comparison on one lot, tabulated — what changed since Analytics › Method validation stability-indicating method LOD & LOQ system suitability precision & repeatability An inter-laboratory comparison on one lot, tabulated — what changed since — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I…	+24	28	3.3k	7mo
Revisiting: Power cut for eleven hours: how I assessed it afterwards Practice › Storage & stability storage freeze-thaw beyond-use date cloudy or discoloured solution Revisiting: Power cut for eleven hours: how I assessed it afterwards — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing…		4	195	9mo
Non-inferiority margins: how they are chosen and how they are abused Evidence › Trials open label surrogate endpoints estimand intention to treat Posting this under the heading it deserves: Non-inferiority margins: how they are chosen and how they are abused Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med , 2021) with…	+42	46	10k	5mo
Biological variation versus analytical imprecision — does this still hold? Clinical › Bloodwork HbA1c eGFR & renal function thyroid function lipid panel Solved Closed The question in the title: Biological variation versus analytical imprecision — does this still hold? I will give what I have already checked below so nobody repeats it. Asking about a population rather than…		2	1.8k	8mo
Waist circumference technique and its repeatability Outcomes › Progress reports data table long read effect size DXA Waist circumference technique and its repeatability — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes…	+55	60	11k	5mo
The headache that turns out to be dehydration Nutrition & Training › Hydration & electrolytes fatigue heart rate blood pressure The headache that turns out to be dehydration Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost nobody…	+143	158	7.8k	6mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies Clinical › Special populations chronic kidney disease bariatric surgery history older adults pregnancy & planning Older adults, sarcopenia risk, and the trade-off nobody quantifies — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published…	+103	109	12k	5mo
Personal import allowances, compared — a second dataset Access › International personal import telehealth MHRA EMA Wiki Personal import allowances, compared — a second dataset — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what…	+124	132	9.2k	2mo
Sleep quality changes during weight loss — what changed since Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Sleep quality changes during weight loss — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+68	74	10k	8mo
Storing in the door of the fridge is worse than you think Practice › Storage & stability cold chain beyond-use date storage freeze-thaw Solved Storing in the door of the fridge is worse than you think Writing it up because I had to work it out twice and would rather nobody else did. A question about technique rather than about dose. I have been…		2	8.3k	5mo
Coming back to: Where the integrator drew the baseline, and how much it moved the number Analytics › HPLC & UHPLC peak integration gradient method UV & DAD detection data table On the subject in the title: Where the integrator drew the baseline, and how much it moved the number Working notes rather than a conclusion. Posting the method first, because I know what the first three…	+20	24	2.7k	10mo
Reverse causation in a cohort study of weight and outcome — a second dataset Evidence › Study critique risk of bias observational data confounding Reverse causation in a cohort study of weight and outcome — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+112	131	1.5k	10mo
Payment method and the leverage it gives you, ranked Sourcing › Payments research use only payments documentation quality Solved Closed Posting this under the heading it deserves: Payment method and the leverage it gives you, ranked Everything below is what sits behind that. Structured report rather than an opinion, following the format the…	+71	76	56k	10mo
Documentation that materially improves an appeal's chances Access › Insurance & coverage insurance appeals formulary prior authorisation Documentation that materially improves an appeal's chances — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what…	+93	98	3.6k	8mo
Run-in periods and the population they select Evidence › Trials surrogate endpoints discontinuation & dropout estimand randomised trial On the subject in the title: Run-in periods and the population they select Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+130	142	7.3k	1mo
Bleeding at the injection site: normal, and what to do about it Practice › Administration injection site reaction aseptic technique subcutaneous injection injection site rotation Solved Bleeding at the injection site: normal, and what to do about it — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the…		3	59k	8mo
Severe abdominal pain: why this is not a forum question — one year on Safety › Adverse events pancreatitis delayed gastric emptying gallbladder vomiting Closed Severe abdominal pain: why this is not a forum question — one year on — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I…		2	49k	10mo
Dead volume across syringe and needle combinations Devices › Syringes & needles needle gauge & length subcutaneous injection dead volume syringe units On the subject in the title: Dead volume across syringe and needle combinations Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go wrong…	+72	80	28k	5mo
Documenting an adverse event properly Safety › Adverse events gallbladder delayed gastric emptying vomiting hypoglycaemia Wiki Closed On the subject in the title: Documenting an adverse event properly Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I would…	+6	10	2.8k	10mo
Dizziness on standing and the electrolyte explanation — does this still hold? Practice › Side effects vomiting hair shedding nausea constipation Solved The question in the title: Dizziness on standing and the electrolyte explanation — does this still hold? I will give what I have already checked below so nobody repeats it. I have read the maintained page on…	+89	94	18k	1mo