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1,535 topics · page 29 of 40

Topic	Participants	Replies	Views	Activity
About the How to Ask category Start Here › How to Ask onboarding beginner friendly guidelines Pinned Wiki Framing a question so that it can actually be answered: what to include, what to leave out, and why we ask for units. This post is a community wiki: any member at trust level 3 or above can edit it, and every…	+6	10	11k	4mo
When a preprint is the best available evidence and we say so Evidence › Preprints risk of bias effect size preprint Solved When a preprint is the best available evidence and we say so — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in…	+148	160	31k	11mo
A preprint whose numbers changed substantially at publication — what changed since Evidence › Preprints risk of bias effect size needs a source On the subject in the title: A preprint whose numbers changed substantially at publication — what changed since Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it…	+3	7	125	8mo
Pinch or no pinch, and how needle length changes the answer Practice › Administration injection site reaction aseptic technique needle gauge & length missed dose Pinch or no pinch, and how needle length changes the answer Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a gap,…	+118	126	11k	9mo
Reading U-100 graduations, with a conversion table — what changed since Devices › Syringes & needles worked example dead volume syringe units subcutaneous injection Reading U-100 graduations, with a conversion table — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I…		2	10k	2mo
Tracking that stops updating and then resumes — the long version Sourcing › Logistics packaging cold chain shipping Tracking that stops updating and then resumes — the long version — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+61	69	27k	6mo
Injecting into an area that has become firm: why not to — does this still hold? Practice › Administration injection site rotation aseptic technique missed dose subcutaneous injection Asking directly, because I could not find a straight answer: Injecting into an area that has become firm: why not to — does this still hold? I have read the maintained page on this and I still have a gap, so…		2	49k	9mo
Insurance and replacement policies, compared — the long version Sourcing › Logistics shipping cold chain packaging temperature excursion Insurance and replacement policies, compared — the long version — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal, separately…	+29	33	4.9k	9mo
Follow-up: Sodium, potassium and magnesium when intake drops Nutrition & Training › Hydration & electrolytes blood pressure fatigue heart rate On the subject in the title: Sodium, potassium and magnesium when intake drops Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is not a…	+8	12	335	7mo
Hepatic impairment and the absence of data Clinical › Special populations older adults adolescents chronic kidney disease disordered eating Hepatic impairment and the absence of data — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this class mostly…	+30	35	32k	10mo
Column chemistry choices for a 40-residue peptide Analytics › HPLC & UHPLC gradient method system suitability HPLC peak integration Column chemistry choices for a 40-residue peptide — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise be.…	+39	43	1.1k	10mo
A preprint whose numbers changed substantially at publication Evidence › Preprints preprint needs a source effect size Wiki Closed A preprint whose numbers changed substantially at publication — setting out what I have, and where I think it stops being reliable. Session topic: SURMOUNT-2 ( Lancet , 2023). Please read it before posting;…	+90	95	21k	9mo
Liver enzymes drifting down and what that usually means Clinical › Bloodwork HbA1c liver enzymes eGFR & renal function Solved Closed Liver enzymes drifting down and what that usually means — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this…	+66	72	12k	4mo
Journal club: STEP 8 and the fairness of the comparator dose Evidence › Journal club estimand number needed to treat journal club Journal club: STEP 8 and the fairness of the comparator dose — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 8 ( JAMA , 2022) and finding…	+2	6	39k	12mo
Fatigue in the first month: how much is the drug and how much is intake — what changed since Practice › Side effects nausea constipation hair shedding Closed Fatigue in the first month: how much is the drug and how much is intake — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page…	+77	82	1.2k	11mo
Impurity thresholds: where the common numbers come from — what changed since Analytics › Impurities & related substances counter-ion content HPLC endotoxin testing water content Solved Posting this under the heading it deserves: Impurity thresholds: where the common numbers come from — what changed since Everything below is what sits behind that. A documentation question rather than an…		2	61k	3mo
About the Mental health category Wellbeing › Mental health mood disordered eating beginner friendly Pinned Wiki Mood, anxiety, disordered eating history, and knowing when to involve a professional. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+4	8	34k	9mo
Are there stupid questions here? A staff answer, at length Start Here › Welcome beginner friendly guidelines onboarding trust levels Solved Are there stupid questions here? A staff answer, at length I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…	+122	153	50k	11mo
Second pass at: Why this subcategory is stricter about sourcing than most Compounds › Secretagogues & GH axis observational data ipamorelin tesamorelin needs a source Second pass at: Why this subcategory is stricter about sourcing than most — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-4 ( JAMA ,…	+120	129	61k	11mo
Cagrilintide molecular characteristics and analytical considerations Compounds › Cagrilintide & amylin analogues cagrilintide randomised trial amylin analogues cagrisema Cagrilintide molecular characteristics and analytical considerations — setting out what I have, and where I think it stops being reliable. I have seen SURMOUNT-2 ( Lancet , 2023) cited in support of a claim I…		4	41k	12mo
What to include when your question involves arithmetic Start Here › How to Ask beginner friendly onboarding site feedback guidelines Solved Closed What to include when your question involves arithmetic — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried to…		2	3.1k	7mo
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction — one year on Compounds › Retatrutide retatrutide preprint randomised trial Solved Closed The question in the title: Why a glucagon receptor agonist in a weight-loss compound is not a contradiction — one year on I will give what I have already checked below so nobody repeats it. Comparing STEP 4 (…		4	3.7k	10mo
Power cut for eleven hours: how I assessed it afterwards Practice › Storage & stability beyond-use date freeze-thaw storage cloudy or discoloured solution Posting this under the heading it deserves: Power cut for eleven hours: how I assessed it afterwards Everything below is what sits behind that. Practical question with the units stated, because I have seen…	+102	109	1.4k	9mo
Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? Evidence › Journal club journal club effect size number needed to treat Solved The question in the title: Journal club: STEP 3 and the intensive behavioural therapy floor — does this still hold? I will give what I have already checked below so nobody repeats it. Session topic: STEP 4 (…		2	15k	10mo
[2026 update] Long-time reader, first-time poster Lounge › Introductions onboarding beginner friendly Solved Long-time reader, first-time poster — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim. Something adjacent…	+46	50	23k	5mo
Canadian access and provincial variation — one year on Regional › North America FDA compounding insurance Canadian access and provincial variation — one year on Writing it up because I had to work it out twice and would rather nobody else did. Documenting an access outcome, dated, because everything in this…	+43	47	964	12mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? Clinical › Special populations disordered eating chronic kidney disease pregnancy & planning Solved Asking directly, because I could not find a straight answer: Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? General question, not a request for advice about my own…		2	22k	11mo
Insomnia at a dose step: reported experiences Wellbeing › Sleep fatigue obstructive sleep apnoea heart rate Solved On the subject in the title: Insomnia at a dose step: reported experiences Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I…	+20	24	18k	8mo
[2026 update] Reverting an edit that had no revision note Meta › Wiki maintenance wiki post citation check maintainership Reverting an edit that had no revision note — setting out what I have, and where I think it stops being reliable. Process question about how this site works. I have read the guidelines and the trust-level…	+8	12	54k	12mo
Coming back to: Amylin analogue mechanism: satiety signalling separate from GLP-1 Compounds › Cagrilintide & amylin analogues cagrisema effect size randomised trial cagrilintide On the subject in the title: Amylin analogue mechanism: satiety signalling separate from GLP-1 Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I…	+27	31	671	12mo