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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 31 of 40

Topic	Participants	Replies	Views	Activity
Coming back to: Resolution and tailing factor: real acceptance criteria Analytics › HPLC & UHPLC peak integration data table UV & DAD detection Posting this under the heading it deserves: Resolution and tailing factor: real acceptance criteria Everything below is what sits behind that. Posting the method first, because I know what the first three…	+93	112	5.7k	9mo
[2026 update] What we do not know about retatrutide, listed explicitly Compounds › Retatrutide TRIUMPH programme preprint effect size randomised trial Wiki What we do not know about retatrutide, listed explicitly — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SCALE ( N Engl J Med , 2015) with STEP 2 ( Lancet ,…	+79	83	952	11mo
Freeze-thaw and why one cycle is not the same as five — a second dataset Practice › Storage & stability storage beyond-use date freeze-thaw Freeze-thaw and why one cycle is not the same as five — a second dataset — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+47	55	46k	10mo
Adolescents: a distinct evidence base — one year on Clinical › Special populations bariatric surgery history disordered eating pregnancy & planning adolescents Pinned Wiki Posting this under the heading it deserves: Adolescents: a distinct evidence base — one year on Everything below is what sits behind that. General question, not a request for advice about my own care — I know…	+78	88	9.3k	3mo
Pooling trials with different estimands — what changed since Evidence › Meta-analyses publication bias risk of bias meta-analysis effect size Pooling trials with different estimands — what changed since — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURPASS-4 ( Lancet , 2021) and finding…	+57	64	12k	7mo
Journal club: how we handle discontinuation in obesity trials Evidence › Journal club randomised trial effect size number needed to treat Solved Closed On the subject in the title: Journal club: how we handle discontinuation in obesity trials Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…		2	1.9k	12mo
Critiquing an observational claim about a class effect — one year on Evidence › Study critique observational data disputed risk of bias Pinned Critiquing an observational claim about a class effect — one year on — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim…	+5	9	3.2k	8mo
Revisiting: Food effects on oral incretin absorption: what is documented Compounds › Oral incretins oral semaglutide PIONEER programme SOUL trial orforglipron Under review Revisiting: Food effects on oral incretin absorption: what is documented — setting out what I have, and where I think it stops being reliable. Session topic: SURMOUNT-2 ( Lancet , 2023). Please read it before…	+6	10	51k	13mo
Second pass at: Robustness: the parameters worth deliberately varying Analytics › Method validation linearity LOD & LOQ recovery system suitability On the subject in the title: Second pass at: Robustness: the parameters worth deliberately varying Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+61	66	9.5k	3mo
[2026 update] Cold solution and stinging: the simplest fix Practice › Administration subcutaneous injection needle gauge & length aseptic technique injection site reaction Cold solution and stinging: the simplest fix — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful to anyone…	+6	10	496	11mo
Persistent vomiting and the threshold for seeking help Safety › Adverse events vomiting hypoglycaemia gallbladder pancreatitis On the subject in the title: Persistent vomiting and the threshold for seeking help Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference…	+82	88	31k	7mo
Pricing far outside the range, in either direction Sourcing › Red flags disputed mislabelling underdosing moderation Solved Posting this under the heading it deserves: Pricing far outside the range, in either direction Everything below is what sits behind that. Structured report rather than an opinion, following the format the…	+3	7	27k	7mo
About the Side effects category Practice › Side effects nausea constipation vomiting Pinned Wiki Closed Recognition, grading, timeline, and management. Adverse events that need urgent attention belong in Safety. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	7.1k	13mo
[2026 update] Scheduled maintenance and what will be unavailable Meta › Announcements trust levels site feedback guidelines Posting this under the heading it deserves: Scheduled maintenance and what will be unavailable Everything below is what sits behind that. Process question about how this site works. I have read the guidelines…	+18	22	400	8mo
How to read a forest plot, properly, from scratch Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Solved The question in the title: How to read a forest plot, properly, from scratch I will give what I have already checked below so nobody repeats it. Session topic: STEP 4 ( JAMA , 2021). Please read it before…	+73	81	17k	7mo
Pages past their review date, listed Meta › Wiki maintenance wiki post maintainership review date moderation Pages past their review date, listed Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation commons. The topic in question…	+26	30	6.4k	10mo
About the Dosing & titration category Practice › Dosing & titration titration dose reduction worked example Pinned Wiki Schedules, escalation intervals, dose reductions, and the arithmetic that connects a vial to a syringe mark. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	350	4mo
"Greater than or equal to 99%" as a specification rather than a result Analytics › COA interpretation reference standards documentation quality batch & lot numbers amino acid analysis Solved "Greater than or equal to 99%" as a specification rather than a result Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would…	+132	146	47k	5mo
Second pass at: Import rules for personal quantities, by jurisdiction, dated Sourcing › Regulatory research use only personal import FDA MHRA Second pass at: Import rules for personal quantities, by jurisdiction, dated Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are…		2	5k	11mo
About the Administration category Practice › Administration subcutaneous injection injection site rotation needle gauge & length Pinned Wiki Closed Technique, needle selection, site rotation, injection discomfort, and what to do about a missed or partial dose. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+5	9	3.1k	12mo
Comparing the STEP programme populations: who was actually enrolled — the long version Compounds › Semaglutide STEP programme randomised trial type 2 diabetes On the subject in the title: Comparing the STEP programme populations: who was actually enrolled — the long version Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with…		4	7.7k	11mo
Area percent versus weight percent: the confusion that causes most arguments — what changed since Analytics › HPLC & UHPLC gradient method data table HPLC Area percent versus weight percent: the confusion that causes most arguments — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first,…	+30	34	40k	13mo
About the Tirzepatide category Compounds › Tirzepatide tirzepatide SURMOUNT programme SURPASS programme Pinned Wiki Dual GIP/GLP-1 receptor agonist. SURPASS and SURMOUNT programme data, titration, and comparative discussion. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+2	6	132	13mo
Interim analyses and stopping rules — does this still hold? Evidence › Trials estimand discontinuation & dropout open label surrogate endpoints Solved Interim analyses and stopping rules — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SCALE ( N Engl J Med , 2015) with SURMOUNT-4 (…	+30	34	29k	13mo
AOD-9604 and the fragment hypothesis, revisited Compounds › Other compounds mislabelling research use only custom synthesis needs a source Posting this under the heading it deserves: AOD-9604 and the fragment hypothesis, revisited Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med , 2021) with SUSTAIN 6 ( N Engl J Med…	+40	44	2.8k	6mo
Why a compound being unapproved is not the same as being illegal to possess Sourcing › Regulatory FDA MHRA research use only EMA Why a compound being unapproved is not the same as being illegal to possess I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion,…	+72	78	23k	3mo
When to stop reading forums, including this one Wellbeing › Mental health mood disordered eating beginner friendly When to stop reading forums, including this one I have a specific reason for asking rather than idle curiosity, and the context is below. General question, not a request for advice about my own care — I know…	+78	86	47k	6mo
Coming back to: Why semaglutide solutions can look faintly opalescent and when that matters Compounds › Semaglutide SELECT trial randomised trial STEP programme Asking directly, because I could not find a straight answer: Why semaglutide solutions can look faintly opalescent and when that matters Comparing SELECT ( N Engl J Med , 2023) with PIONEER 6 ( N Engl J Med ,…	+16	20	17k	13mo
How this community escalates rather than diagnoses Safety › Adverse events delayed gastric emptying hypoglycaemia vomiting gallbladder Solved How this community escalates rather than diagnoses — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about a population rather than about a person. The published…		4	51k	8mo
Why semaglutide's albumin binding is the whole reason weekly dosing works Compounds › Semaglutide STEP programme SELECT trial randomised trial effect size Solved Closed Asking directly, because I could not find a straight answer: Why semaglutide's albumin binding is the whole reason weekly dosing works Session topic: SELECT ( N Engl J Med , 2023). Please read it before…		2	63k	5mo