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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 30 of 40

Topic	Participants	Replies	Views	Activity
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Clinical › Special populations older adults chronic kidney disease adolescents disordered eating Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a…	+64	69	15k	7mo
A friction point in the promotion workflow Meta › Site feedback guidelines moderation site feedback A friction point in the promotion workflow — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps…	+4	8	491	11mo
Immortal time bias in a claims-database study Evidence › Study critique risk of bias observational data disputed confounding Closed Immortal time bias in a claims-database study — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+29	34	28k	11mo
Follow-up: Why appetite effects are mostly central Pharmacology › Receptor biology tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A documentation question rather than an analytical one. I have a certificate in front of me that reports a…	+86	90	61k	9mo
Rewriting my first post: a before-and-after, with commentary Start Here › How to Ask worked example beginner friendly onboarding Closed Rewriting my first post: a before-and-after, with commentary Writing it up because I had to work it out twice and would rather nobody else did. I want to check my reasoning rather than get a conclusion. My…		3	2.7k	4mo
Follow-up: Why we hide unevidenced fraud accusations and log the hiding Sourcing › Red flags mislabelling disputed moderation underdosing The question in the title: Why we hide unevidenced fraud accusations and log the hiding I will give what I have already checked below so nobody repeats it. Structured report rather than an opinion, following…	+12	16	17k	12mo
Why catalogue breadth is not evidence of anything — what changed since Compounds › Other compounds custom synthesis mislabelling needs a source research use only Asking directly, because I could not find a straight answer: Why catalogue breadth is not evidence of anything — what changed since Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+62	66	26k	10mo
A field-by-field walk through a certificate of analysis Analytics › COA interpretation documentation quality amino acid analysis certificate of analysis batch & lot numbers Solved Posting this under the heading it deserves: A field-by-field walk through a certificate of analysis Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+136	147	1.8k	12mo
Appeal templates and why they are deliberately unemotional — one year on Access › Insurance & coverage insurance appeals prior authorisation formulary Closed Appeal templates and why they are deliberately unemotional — one year on Writing it up because I had to work it out twice and would rather nobody else did. Documenting an access outcome, dated, because…		2	4.1k	11mo
A calculator that gives a right answer to the wrong question — does this still hold? Data & Tools › Calculators worked example concentration maths syringe units site feedback Solved Under review A calculator that gives a right answer to the wrong question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what…	+23	27	62k	8mo
Measurement error in home scales, with a worked standard deviation — a second dataset Research Methods › Statistics effect size confounding heterogeneity number needed to treat Solved Measurement error in home scales, with a worked standard deviation — a second dataset — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with SURPASS-2…		2	13k	7mo
Second pass at: What "verified" means on our vendor pages, stated narrowly Sourcing › Vendor reports Janoshik Analytical documentation quality third-party testing batch & lot numbers Solved Second pass at: What "verified" means on our vendor pages, stated narrowly — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better…	+94	102	20k	3mo
Revisiting: Review: an evidence digest and the citation check that delayed it Documentation › Doc review citation check review date maintainership Solved Closed Revisiting: Review: an evidence digest and the citation check that delayed it — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation…	+54	58	8.2k	5mo
Theoretical plates: useful number or ritual? Analytics › HPLC & UHPLC system suitability data table HPLC UV & DAD detection Solved Theoretical plates: useful number or ritual? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I repeat it…		2	284	9mo
Guidelines revision: what changed and why — one year on Meta › Announcements trust levels moderation site feedback guidelines Pinned On the subject in the title: Guidelines revision: what changed and why — one year on Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the…	+75	81	3.9k	4mo
About the Trials category Evidence › Trials randomised trial estimand intention to treat Pinned Wiki Individual randomised trials: design, population, endpoints, results, and limitations. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+6	10	27k	12mo
Angle of injection and whether 90 degrees is always right Practice › Administration aseptic technique missed dose injection site reaction On the subject in the title: Angle of injection and whether 90 degrees is always right Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful to…	+105	116	5.4k	4mo
Second pass at: How to ask a question when you cannot say why you are asking it Start Here › How to Ask onboarding worked example guidelines Solved Second pass at: How to ask a question when you cannot say why you are asking it — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to…	+73	81	16k	4mo
The nausea timeline across the first four weeks, with a tabulated log — what changed since Practice › Side effects constipation delayed gastric emptying fatigue nausea On the subject in the title: The nausea timeline across the first four weeks, with a tabulated log — what changed since Working notes rather than a conclusion. I have read the maintained page on this and I…	+24	29	2.8k	6mo
Why semaglutide solutions can look faintly opalescent and when that matters Compounds › Semaglutide semaglutide SELECT trial randomised trial effect size Solved The question in the title: Why semaglutide solutions can look faintly opalescent and when that matters I will give what I have already checked below so nobody repeats it. Comparing LEADER ( N Engl J Med ,…	+73	79	2k	4mo
Revisiting: Early satiety becoming a problem rather than a benefit Practice › Side effects hair shedding fatigue delayed gastric emptying nausea Closed On the subject in the title: Revisiting: Early satiety becoming a problem rather than a benefit Working notes rather than a conclusion. A question about technique rather than about dose. I have been doing the…		2	14k	12mo
[2026 update] A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipase & amylase liver enzymes lipid panel Solved Closed On the subject in the title: A single out-of-range value on an otherwise normal panel Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…	+15	19	53k	9mo
Coming back to: A community side-effect dataset, with its response rate and biases Data & Tools › Datasets observational data site feedback confounding data table On the subject in the title: A community side-effect dataset, with its response rate and biases Working notes rather than a conclusion. Posting the method first, because I know what the first three replies…	+27	31	46k	9mo
Dose numbers across compounds are not on the same scale Practice › Dosing & titration titration worked example tirzepatide missed dose Dose numbers across compounds are not on the same scale — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a gap, so I am asking…		2	1.6k	9mo
DXA precision and the least significant change for lean mass — what changed since Outcomes › Body composition DXA data table lean mass loss bioimpedance Solved DXA precision and the least significant change for lean mass — what changed since — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this…		2	56k	11mo
Trust level 3 requirements: a clarification Meta › Announcements guidelines site feedback moderation Trust level 3 requirements: a clarification — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps…	+10	14	7k	9mo
Thyroid function tests during substantial weight change Clinical › Bloodwork lipase & amylase HbA1c liver enzymes eGFR & renal function Closed Posting this under the heading it deserves: Thyroid function tests during substantial weight change Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+136	149	3.3k	8mo
Coming back to: Nausea profile of amylin analogues compared with GLP-1 agonists Compounds › Cagrilintide & amylin analogues effect size cagrilintide cagrisema amylin analogues Posting this under the heading it deserves: Nausea profile of amylin analogues compared with GLP-1 agonists Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with FLOW ( N Engl…	+48	53	31k	13mo
Discussing something you have already been doing — the long version Clinical › Prescriber conversations telehealth prior authorisation beginner friendly type 2 diabetes Solved Discussing something you have already been doing — the long version Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+14	18	58k	12mo
Second pass at: Coverage in the US: a map of the usual obstacles Regional › North America insurance telehealth compounding FDA On the subject in the title: Second pass at: Coverage in the US: a map of the usual obstacles Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…		4	62k	9mo