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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 32 of 40

Topic	Participants	Replies	Views	Activity
Multiplicity when you track fifteen variables Research Methods › Statistics effect size heterogeneity confounding worked example Solved Multiplicity when you track fifteen variables — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-OSA ( N Engl J Med , 2024) and finding…		2	60k	11mo
Anxiety in the first weeks: drug, situation, or both — what changed since Wellbeing › Mental health mood disordered eating beginner friendly Anxiety in the first weeks: drug, situation, or both — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a…	+88	95	4.5k	5mo
Repeatability versus intermediate precision Analytics › Method validation precision & repeatability recovery LOD & LOQ linearity Solved Repeatability versus intermediate precision — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise be.…	+119	134	34k	13mo
Reading a denial letter as a specification for your appeal Access › Insurance & coverage appeals prior authorisation insurance Closed Reading a denial letter as a specification for your appeal Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that…		3	30k	12mo
Revisiting: What to include when your question involves arithmetic Start Here › How to Ask worked example site feedback onboarding beginner friendly Revisiting: What to include when your question involves arithmetic — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to include the…	+21	25	384	12mo
About the Method validation category Analytics › Method validation stability-indicating method linearity LOD & LOQ Pinned Wiki Specificity, linearity, precision, accuracy, robustness, system suitability, and why two labs disagree. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	468	5mo
Second pass at: Sleep tracking data and its considerable limitations Wellbeing › Sleep fatigue heart rate obstructive sleep apnoea Posting this under the heading it deserves: Second pass at: Sleep tracking data and its considerable limitations Everything below is what sits behind that. Asking about a population rather than about a…		2	59	12mo
Managing an unplanned gap in supply — what changed since Access › Shortages compounding FDA formulary On the subject in the title: Managing an unplanned gap in supply — what changed since Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+114	124	54k	8mo
Revisiting: Reading order for a first week here, and what to skip until later Start Here › Welcome guidelines trust levels onboarding Posting this under the heading it deserves: Revisiting: Reading order for a first week here, and what to skip until later Everything below is what sits behind that. I want to check my reasoning rather than…		2	60k	4mo
Temperature loggers worth the money — the long version Devices › Cold chain storage freeze-thaw temperature excursion Closed On the subject in the title: Temperature loggers worth the money — the long version Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful to…	+110	127	48k	6mo
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Practice › Dosing & titration missed dose tirzepatide dose reduction titration Solved Asking directly, because I could not find a straight answer: Reaching a dose and staying there for a year: a longitudinal note — does this still hold? I have read the maintained page on this and I still have…	+35	39	547	11mo
Whether an aggregate is worth publishing at all: a disputed topic Data & Tools › Datasets confounding site feedback observational data On the subject in the title: Whether an aggregate is worth publishing at all: a disputed topic Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+20	24	18k	13mo
Second pass at: Isotonicity and what happens when you get it wrong Pharmacology › Formulation chemistry counter-ion content storage bacteriostatic water sterile water Closed Second pass at: Isotonicity and what happens when you get it wrong — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked.…	+1	5	2.6k	11mo
Temperature loggers worth the money Devices › Cold chain cold chain storage freeze-thaw Temperature loggers worth the money — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful to anyone else. Over 10…	+46	50	8k	9mo
GIP receptor agonism and the argument about direction Pharmacology › Receptor biology tirzepatide long read amylin analogues semaglutide GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise…		2	867	10mo
Random versus fixed effects: choosing rather than defaulting Evidence › Meta-analyses effect size publication bias risk of bias heterogeneity Closed Random versus fixed effects: choosing rather than defaulting — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before posting;…	+16	20	22k	13mo
[2026 update] Gastro-oesophageal reflux: improving or worsening? Clinical › Comorbidities chronic kidney disease MASH / hepatic steatosis PCOS blood pressure Solved Asking directly, because I could not find a straight answer: Gastro-oesophageal reflux: improving or worsening? General question, not a request for advice about my own care — I know the difference and I would…		3	782	13mo
What a documentation review can and cannot tell you Sourcing › Independent verification Medutest VendorInvestigate Janoshik Analytical blind sampling Solved Wiki What a documentation review can and cannot tell you — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to talk about documentation quality as a signal,…	+79	83	950	11mo
About the Cagrilintide & amylin analogues category Compounds › Cagrilintide & amylin analogues cagrilintide cagrisema amylin analogues Pinned Wiki Long-acting amylin analogues alone and in combination. Mechanism, published data, and the open questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	1.8k	11mo
[2026 update] An appeal that failed, and what I would do differently Access › Insurance & coverage prior authorisation insurance formulary Posting this under the heading it deserves: An appeal that failed, and what I would do differently Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…	+152	159	2.5k	13mo
What this community means by "a source", in practical terms Start Here › Welcome beginner friendly trust levels guidelines Solved Asking directly, because I could not find a straight answer: What this community means by "a source", in practical terms Question in the title. Context below, and I have tried to include the things people…	+107	122	1.9k	10mo
Insulin combinations and hypoglycaemia risk Practice › Interactions metformin needs a source hypoglycaemia insulin Closed On the subject in the title: Insulin combinations and hypoglycaemia risk Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go wrong…	+18	22	7.8k	13mo
Coming back to: Lurking for two months before posting: was that the right call? Start Here › Welcome beginner friendly trust levels onboarding Solved The question in the title: Lurking for two months before posting: was that the right call? I will give what I have already checked below so nobody repeats it. I want to check my reasoning rather than get a…	+28	32	3.3k	11mo
A side-effect grading scheme this community uses, and its limits Practice › Side effects constipation hair shedding fatigue Posting this under the heading it deserves: A side-effect grading scheme this community uses, and its limits Everything below is what sits behind that. Reporting something rather than asking about it, in case…	+1	5	3.8k	12mo
Interpreting a composition change that is within the error bars Outcomes › Body composition bioimpedance data table lean mass loss On the subject in the title: Interpreting a composition change that is within the error bars Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a…	+18	22	5.8k	12mo
Cross-border purchase within the EU: the actual rules Access › International MHRA EMA telehealth NHS Solved Cross-border purchase within the EU: the actual rules Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is…	+6	10	41k	11mo
Refrigerated versus room temperature: the trade-off stated plainly — what changed since Practice › Storage & stability temperature excursion freeze-thaw storage cloudy or discoloured solution Closed Posting this under the heading it deserves: Refrigerated versus room temperature: the trade-off stated plainly — what changed since Everything below is what sits behind that. Practical question with the units…		2	2.7k	9mo
History of disordered eating and why it changes the conversation Clinical › Special populations older adults chronic kidney disease adolescents bariatric surgery history Closed History of disordered eating and why it changes the conversation Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+20	24	30k	8mo
The CagriSema phase 2 paper and what a fixed combination buys — the long version Compounds › Cagrilintide & amylin analogues amylin analogues cagrisema cagrilintide The CagriSema phase 2 paper and what a fixed combination buys — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021)…	+137	158	17k	13mo
Lipase elevation without symptoms: the interpretation problem Clinical › Bloodwork thyroid function lipase & amylase eGFR & renal function Pinned Closed Lipase elevation without symptoms: the interpretation problem Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+21	25	62k	5mo