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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 20 of 40

Topic	Participants	Replies	Views	Activity
Filter needles: when they help and what they cost you Devices › Syringes & needles needle gauge & length subcutaneous injection dead volume On the subject in the title: Filter needles: when they help and what they cost you Working notes rather than a conclusion. A question about technique rather than about dose. I have been doing the same thing…	+45	50	19k	5mo
Severe abdominal pain: why this is not a forum question Safety › Adverse events vomiting pancreatitis delayed gastric emptying gallbladder Posting this under the heading it deserves: Severe abdominal pain: why this is not a forum question Everything below is what sits behind that. General question, not a request for advice about my own care — I…		2	17k	3mo
Second pass at: What pooling buys you and what it destroys Evidence › Meta-analyses risk of bias meta-analysis heterogeneity Posting this under the heading it deserves: Second pass at: What pooling buys you and what it destroys Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim…	+32	36	19k	4mo
A plateau that disappeared when I changed how I measured Outcomes › Progress reports DXA long read effect size Posting this under the heading it deserves: A plateau that disappeared when I changed how I measured Everything below is what sits behind that. Longitudinal report with the method stated, because a number…	+27	31	7.2k	3mo
How the published trials escalated, tabulated side by side Practice › Dosing & titration worked example semaglutide titration dose reduction Solved Closed The question in the title: How the published trials escalated, tabulated side by side I will give what I have already checked below so nobody repeats it. A question about technique rather than about dose. I…	+4	8	4.2k	5mo
Travelling with an injectable: documentation and practicalities Access › International NHS personal import EMA MHRA Posting this under the heading it deserves: Travelling with an injectable: documentation and practicalities Everything below is what sits behind that. Documenting an access outcome, dated, because everything…	+37	42	2.1k	1d
Injection volume, overload, and peak distortion — one year on Analytics › HPLC & UHPLC system suitability peak integration gradient method data table Under review Injection volume, overload, and peak distortion — one year on Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have…	+4	8	1.2k	4mo
Revisiting: Language barriers in accessing a prescription abroad Access › International EMA telehealth personal import MHRA Posting this under the heading it deserves: Revisiting: Language barriers in accessing a prescription abroad Everything below is what sits behind that. Documenting an access outcome, dated, because everything…	+131	148	28k	5mo
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Pharmacology › Receptor biology retatrutide amylin analogues semaglutide Posting this under the heading it deserves: Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Everything below is what sits behind that. I would like to understand…	+57	63	1k	6mo
Revisiting: Journal club: SURMOUNT-1, read without the press release Evidence › Journal club number needed to treat effect size risk of bias journal club Solved On the subject in the title: Revisiting: Journal club: SURMOUNT-1, read without the press release Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+54	62	1.5k	26d
Follow-up: What a statistical analysis plan adds that the paper does not Evidence › Trials randomised trial estimand open label surrogate endpoints What a statistical analysis plan adds that the paper does not I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in…		2	7.2k	3mo
Coming back to: Payment mechanics and the recovery options that do not exist Sourcing › Payments research use only payments documentation quality Under review On the subject in the title: Payment mechanics and the recovery options that do not exist Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers…	+7	11	2.6k	7mo
Amylin receptor signalling and satiety — what changed since Pharmacology › Receptor biology tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…	+73	78	3.5k	2mo
What the published dose-response for semaglutide actually looks like above 2.4 mg Compounds › Semaglutide STEP programme type 2 diabetes effect size SELECT trial Solved What the published dose-response for semaglutide actually looks like above 2.4 mg — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA ,…		2	10k	3mo
Why tirzepatide titration schedules have more steps than semaglutide's Compounds › Tirzepatide SURMOUNT programme SURPASS programme randomised trial tirzepatide Solved Wiki Asking directly, because I could not find a straight answer: Why tirzepatide titration schedules have more steps than semaglutide's Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…		4	8.4k	7mo
Hepatic steatosis: what the MASH trial evidence supports — one year on Clinical › Comorbidities MASH / hepatic steatosis obstructive sleep apnoea chronic kidney disease blood pressure Solved On the subject in the title: Hepatic steatosis: what the MASH trial evidence supports — one year on Working notes rather than a conclusion. General question, not a request for advice about my own care — I…		2	4.1k	6mo
Publication bias detection and its low power — does this still hold? Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: Publication bias detection and its low power — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER ( N Engl J Med , 2016)…	+24	28	2.4k	3mo
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long version Compounds › Tirzepatide SURMOUNT programme randomised trial effect size tirzepatide Closed On the subject in the title: Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long version Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med ,…	+85	90	13k	7mo
About the Preprints category Evidence › Preprints preprint risk of bias needs a source Pinned Wiki Unrefereed work, clearly labelled as such, with the usual caveats stated once and taken seriously. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+3	7	14k	3mo
Tracking a preprint to publication: a worked example Evidence › Preprints preprint risk of bias needs a source Tracking a preprint to publication: a worked example Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…	+133	147	15k	7mo
Journal club: semaglutide in MASH, and surrogate endpoints Evidence › Journal club randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: semaglutide in MASH, and surrogate endpoints Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with SURMOUNT-2 (…	+24	28	17k	15h
Second pass at: Fasting versus non-fasting and which tests care Clinical › Bloodwork lipase & amylase liver enzymes lipid panel HbA1c On the subject in the title: Second pass at: Fasting versus non-fasting and which tests care Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…	+20	25	21k	3mo
Follow-up: A supplier that answers analytical questions with restated claims Sourcing › Red flags documentation quality disputed mislabelling moderation A supplier that answers analytical questions with restated claims — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+74	82	2.8k	6mo
[2026 update] Does a peptide degrade silently, with no visual change? Practice › Storage & stability temperature excursion storage freeze-thaw cold chain Does a peptide degrade silently, with no visual change? — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have a gap,…	+82	86	24k	15d
Named, unnamed and unspecified impurities as regulatory categories Analytics › Impurities & related substances counter-ion content endotoxin testing water content On the subject in the title: Named, unnamed and unspecified impurities as regulatory categories Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked.…	+10	14	504	3mo
Water content on a certificate and why it changes the arithmetic — what changed since Analytics › COA interpretation documentation quality batch & lot numbers reference standards certificate of analysis On the subject in the title: Water content on a certificate and why it changes the arithmetic — what changed since Working notes rather than a conclusion. A documentation question rather than an analytical…		3	801	8mo
Reconstitution volumes that produce round numbers, tabulated Practice › Reconstitution reconstitution syringe units bacteriostatic water worked example Reconstitution volumes that produce round numbers, tabulated — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how quickly…	+103	112	1.7k	3mo
Coming back to: A community side-effect dataset, with its response rate and biases Data & Tools › Datasets observational data site feedback data table Solved Posting this under the heading it deserves: A community side-effect dataset, with its response rate and biases Everything below is what sits behind that. Working through the identity arithmetic and I would…	+96	101	33k	2d
Injection discomfort: needle gauge, volume, temperature, technique Practice › Administration subcutaneous injection injection site reaction needle gauge & length aseptic technique Injection discomfort: needle gauge, volume, temperature, technique — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+66	71	14k	2mo
Follow-up: Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis CJC-1295 ipamorelin tesamorelin needs a source On the subject in the title: Evidence quality in the secretagogue literature: an honest assessment Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with LEADER ( N Engl J Med…	+20	24	18k	4mo