k.radich

TL2 Moderator · Graz

Contributes reviews on supplier material. Based in Graz.

Joined 14 November 2024 · last posted 3d

89 posts, newest first. Showing up to 150.

Common supplements people ask about, assessed one at a time Replied, post #95 · Practice › Interactions · 25 Jul 2026 · 1 like Picking up post #92: that is the part I would want checked first. Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which…
Seven-day rolling means and why weekly readings mislead Replied, post #77 · Outcomes › Progress reports · 21 Jul 2026 · 23 likes post #76 is right about the mechanism and I think understates the practical bit. Seasonal patterns: some people report weight loss is slower in winter than summer. Body…
Reading order for a first week here, and what to skip until later — what changed since Replied, post #63 · Start Here › Welcome · 20 Jul 2026 · 0 likes Trust levels accumulate over time and they give you access to small things like the ability to edit your own posts without a timestamp. They are not a status symbol and…
Submitting a sample: the process end to end Replied, post #61 · Sourcing › Independent verification · 6 Jul 2026 · 19 likes post #60 is right about the mechanism and I think understates the practical bit. Janoshik Analytical: chromatographic purity and mass-spectrometric identity on…
[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #5 · Analytics › HPLC & UHPLC · 1 Jul 2026 · 13 likes I read post #3 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #30 · Analytics › Home & field testing · 26 Jun 2026 · 1 like post #29 is right about the mechanism and I think understates the practical bit. Thank you for the correction. I have edited my earlier post with a note rather than…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #13 · Compounds › Retatrutide · 23 Jun 2026 · 0 likes Why this subcategory is more cautious than elsewhere: retatrutide is investigational, phase 3 is ongoing, and the heart-rate signal in phase 2 is not negligible.…
Micronutrient adequacy at low total intake Replied, post #30 · Nutrition & Training › Protein & intake · 8 Jun 2026 · 0 likes Picking up post #27: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
A checklist for reading a certificate in under two minutes Replied, post #36 · Analytics › COA interpretation · 8 Jun 2026 · 12 likes Counter-ion form is crucial: peptides are isolated as salts, most often trifluoroacetate from reversed-phase purification or acetate after salt exchange. The…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #91 · Outcomes › Body composition · 8 Jun 2026 · 2 likes Ultrasound: thickness of subcutaneous fat at specific sites. Less standardised than DXA and operator-dependent. Useful as a supplementary measure but not as a primary…
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #84 · Sourcing › Red flags · 6 Jun 2026 · 0 likes Patterns that reliably precede a problem: underdosing (less active material than stated, documented by independent testing), mislabelling (wrong compound, wrong…
Injecting into an area that has become firm: why not to Replied, post #19 · Practice › Administration · 5 Jun 2026 · 23 likes Angle of injection: 90 degrees into pinched tissue ensures subcutaneous placement. It is not always necessary and shallower angles can work, but 90 degrees into a small…
Bariatric surgery history: altered anatomy, altered expectations Replied, post #26 · Clinical › Special populations · 27 May 2026 · 1 like Adolescents: a distinct evidence base exists. The compounds are not approved for routine adolescent obesity but are being studied. Adolescent physiology and psychology…
CJC-1295 with and without DAC: what the modification does Replied, post #66 · Compounds › Secretagogues & GH axis · 25 May 2026 · 0 likes Ipamorelin selectivity claims originate in preclinical characterisation and are reasonably well supported for what they claim: less effect on cortisol and prolactin…
[2026 update] A vial that will not fully dissolve: what to check and in what order Replied, post #59 · Practice › Reconstitution · 18 May 2026 · 27 likes Arithmetic step by step: a 5 mg vial with 2 mL of diluent gives (5 mg) / (2 mL) = 2.5 mg/mL. On a U-100 syringe at that concentration, 100 units = 1 mL = 2.5 mg, so…
Tracking a shortage from primary sources rather than rumour Replied, post #7 · Access › Shortages · 12 May 2026 · 28 likes Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.
Splitting an overlong document into two Replied, post #16 · Documentation › Wiki requests · 30 Apr 2026 · 23 likes Cross-referencing: if you notice two pages that should reference each other but do not, suggest the cross-reference.
Prescription portability between countries Replied, post #17 · Access › International · 26 Apr 2026 · 9 likes Language barriers: if you need to communicate with a supplier, clinician, or regulator in a language not your first language, misunderstanding is possible. Clarify when…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #117 · Clinical › Special populations · 20 Apr 2026 · 20 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
[2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #45 · Devices › Syringes & needles · 20 Apr 2026 · 7 likes Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it…
Five questions in one post gets you one answer — how to split them Replied, post #59 · Start Here › How to Ask · 19 Apr 2026 · 21 likes Context that matters: compound, how long in, current dose, relevant history. Context that does not matter: how you feel, your hopes for the outcome, your medical…
Foaming during reconstitution and whether it matters — the long version Replied, post #104 · Practice › Reconstitution · 19 Apr 2026 · 0 likes How much of the diluent volume the powder itself displaces: for a small peptide vial, the powder volume is negligible. For a larger vial or a kit with multiple…
The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #87 · Compounds › Tirzepatide · 18 Apr 2026 · 28 likes On post #83 — agreed on the reasoning, with one qualification. SURMOUNT-OSA is notable because it used an objective physiological endpoint, the apnoea-hypopnoea index,…
Blinding yourself: practical methods and their limits Replied, post #18 · Research Methods › N-of-1 designs · 15 Apr 2026 · 15 likes Objective versus subjective measures: subjective measures (how you feel) are vulnerable to bias. Objective measures (weight, strength on a specific exercise) are less…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #2 · Evidence › Journal club · 11 Apr 2026 · 7 likes SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective physiological endpoint. Notable because soft endpoints are avoided. Two…
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #9 · Wellbeing › Sleep · 5 Apr 2026 · 5 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Why the timeline is on the right and not the left — what changed since Replied, post #13 · Meta › Site feedback · 30 Mar 2026 · 9 likes This follows post #10 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
The "under review" status pill and when a moderator applies it Replied, post #37 · Evidence › Preprints · 25 Mar 2026 · 5 likes I read post #35 twice before replying, because I had assumed the opposite. Two things before anyone answers the substance. First, the context in the first post is clear…
Sample handling between despatch and injection Started this topic · Analytics › Method validation · 25 Mar 2026 · 19 likes Sample handling between despatch and injection Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I…
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Replied, post #69 · Practice › Storage & stability · 21 Mar 2026 · 16 likes Beyond-use dating: the date after which a prepared solution should not be used. It is an estimate based on how fast the solution degrades under stated storage, not on…
Splitting a weekly dose in two: the pharmacokinetic argument against Replied, post #15 · Practice › Dosing & titration · 8 Mar 2026 · 0 likes This follows post #12 rather than contradicting it. Dose equivalence between different incretin analogues is a weak concept. The molecules differ in structure,…
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #50 · Analytics › Mass spectrometry · 26 Feb 2026 · 0 likes Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and its mass is predictable from the base mass.
Anaesthesia and elective surgery: the aspiration question Replied, post #31 · Practice › Interactions · 24 Feb 2026 · 0 likes Metformin: commonly co-administered and relevant to gastrointestinal tolerability. Gastrointestinal side effects can overlap and additive. Taking them separately or…
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #132 · Practice › Dosing & titration · 22 Feb 2026 · 7 likes Dose equivalence between different incretin analogues is a weak concept. The molecules differ in structure, half-life, receptor selectivity, and in what has been…
Managing an unplanned gap in supply Replied, post #17 · Access › Shortages · 29 Jan 2026 · 22 likes Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and…
Personal import allowances, compared — a second dataset Replied, post #58 · Access › International · 26 Jan 2026 · 0 likes On post #54 — agreed on the reasoning, with one qualification. Country-by-country legality: compound approval and legal status differ substantially by jurisdiction.…
Reading an interaction checker output critically Replied, post #76 · Practice › Interactions · 26 Dec 2025 · 3 likes Alcohol: no absolute contraindication but it raises gastrointestinal irritation risk and this drug class already does that. The conservative position during titration…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #27 · Clinical › Bloodwork · 12 Dec 2025 · 9 likes Picking up post #24: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
[2026 update] Storing lyophilised material long term: what governs the shelf life Replied, post #28 · Practice › Storage & stability · 27 Nov 2025 · 0 likes Refrigeration slows degradation. Repeated warming and cooling is worse than continuous refrigeration. Light exposure is worth avoiding. The concentration matters…
Severe gastroparesis and why this class is a poor fit — one year on Replied, post #9 · Safety › Contraindications · 21 Nov 2025 · 7 likes Coming back to post #7, because the follow-up matters more than the original answer. History of pancreatitis: these compounds can rarely trigger pancreatitis. History…
[2026 update] Reporting a disappointing outcome, and why it belongs here Started this topic · Outcomes › Progress reports · 18 Nov 2025 · 17 likes On the subject in the title: Reporting a disappointing outcome, and why it belongs here Working notes rather than a conclusion. Longitudinal report with the method…
A comparison of home results against a laboratory result on the same vial Replied, post #60 · Analytics › Home & field testing · 8 Nov 2025 · 26 likes Lateral-flow devices: like a rapid COVID test. They have a reagent strip and produce a colour result. They are quick but not precise and not intended for quantitative…
Pharmaceutical compounding rules, summarised from primary sources — a second dataset Replied, post #17 · Sourcing › Regulatory · 5 Nov 2025 · 0 likes Worth separating two things that post #13 runs together. Import restrictions vary by compound and by jurisdiction: what is a controlled substance in one place is legal…
Tirzepatide molecular mass and the charge states you would expect on ESI — does this… Replied, post #4 · Compounds › Tirzepatide · 16 Oct 2025 · 23 likes On post #3 — agreed on the reasoning, with one qualification. Dual agonism versus dose: how much of tirzepatide's effect is the GIP component and how much is simply…
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #21 · Start Here › How to Ask · 8 Oct 2025 · 0 likes Questions you cannot explain: "I cannot say why I am asking this, but is this compound stable at room temperature?" is more productive than no question at all. People…
Meeting a protein target on a suppressed appetite Replied, post #24 · Nutrition & Training › Protein & intake · 26 Sep 2025 · 0 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Payment method and the leverage it gives you, ranked Replied, post #65 · Sourcing › Payments · 24 Sep 2025 · 0 likes Cryptocurrency for payment: offers less fraud protection than credit cards and is final like bank transfer. Advantage: no geographic restrictions and no intermediary…
Hypertension improvement and when medication needs revisiting Replied, post #58 · Clinical › Comorbidities · 13 Sep 2025 · 21 likes Comorbidity control: if a comorbidity (high blood pressure, high lipids) is not adequately controlled, the decision about adding compounds in this class depends on the…
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Replied, post #54 · Compounds › Semaglutide · 7 Sep 2025 · 10 likes The STEP programme populations were selected: enrollment criteria required baseline body mass index over 30, no recent blood pressure crisis, no recent retinopathy, no…
Tirzepatide molecular mass and the charge states you would expect on ESI Replied, post #33 · Compounds › Tirzepatide · 29 Aug 2025 · 0 likes post #32 is right about the mechanism and I think understates the practical bit. The 2.5 mg starting dose is not a therapeutic dose in the sense that weight loss is…
The nausea timeline across the first four weeks, with a tabulated log Replied, post #9 · Practice › Side effects · 22 Aug 2025 · 0 likes Recognition and grading: nausea ranges from "noticeable" to "limiting". Constipation ranges from mild to severe. Having language to describe the magnitude helps you…
Coming back to: Oxidation and deamidation mass shifts, tabulated Replied, post #22 · Analytics › Mass spectrometry · 20 Jul 2025 · 9 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #141 · Devices › Cold chain · 12 Jul 2025 · 19 likes Light protection: avoid direct sunlight and UV exposure. Amber vials or opaque containers reduce light exposure. For short-term storage, keeping the vial in its…
Gauge and length selection for subcutaneous injection Replied, post #8 · Devices › Syringes & needles · 29 Jun 2025 · 0 likes This follows post #5 rather than contradicting it. Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous…
A claim built entirely on a subgroup analysis Replied, post #71 · Evidence › Study critique · 2 Jun 2025 · 13 likes Bias towards the null and bias away from the null: different criticisms have different directions. Differential dropout might bias away from null; conservative…
Second pass at: Pen dose counters: what a click does and does not guarantee Replied, post #47 · Devices › Pens & autoinjectors · 23 May 2025 · 3 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
A report I filed that turned out to be wrong, and the correction Replied, post #61 · Sourcing › Vendor reports · 19 May 2025 · 17 likes Testing service selection: Janoshik gives purity with chromatogram. Medutest gives combined purity and identity. PeptideMeter gives verification records as well as…
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Replied, post #35 · Evidence › Journal club · 19 May 2025 · 0 likes SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg dose is not the highest available, which is the central and…
Pregnancy as an absolute contraindication Replied, post #74 · Safety › Contraindications · 19 May 2025 · 3 likes Coming back to post #72, because the follow-up matters more than the original answer. Allergy to the specific compound: true allergy is rare but possible. Any prior…
A claim built entirely on a subgroup analysis Replied, post #39 · Evidence › Study critique · 17 May 2025 · 13 likes Defending a paper against criticism: if the authors respond, they might clarify something the paper explained poorly. Their response might also miss your point. Either…
Criticising the method without criticising the authors Replied, post #62 · Evidence › Study critique · 6 May 2025 · 0 likes post #61 is right about the mechanism and I think understates the practical bit. Defending a paper against criticism: if the authors respond, they might clarify…
Asking about a compound your prescriber has not heard of Replied, post #29 · Clinical › Prescriber conversations · 1 May 2025 · 21 likes Worth separating two things that post #25 runs together. How to ask for what you need: rather than "should I take this", frame it as "I understand the evidence for this…
Reading a trial's population section before its results — does this still hold? Replied, post #19 · Evidence › Trials · 18 Apr 2025 · 22 likes Dropout is information: high dropout rates can indicate tolerability problems or lower efficacy than the summary suggests. Where the analysis handled dropouts matters.…
Carryover and the ghost peak from last week's standard Replied, post #86 · Analytics › HPLC & UHPLC · 11 Apr 2025 · 26 likes Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and higher efficiency than larger particles (3.5 μm or 5 μm), at the cost of…
Reading order for a first week here, and what to skip until later Replied, post #65 · Start Here › Welcome · 3 Apr 2025 · 19 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Requesting a translation of an existing page Replied, post #4 · Documentation › Wiki requests · 24 Mar 2025 · 30 likes post #3 answers the question as asked. The question underneath it is different. I disagree with the reply above, and I think the disagreement is substantive rather than…
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence Replied, post #30 · Compounds › Secretagogues & GH axis · 24 Mar 2025 · 9 likes Evidence quality in the secretagogue literature is honestly weaker than in the incretin literature. Large randomised controlled trials are rare. Most evidence is…
Maintainer handover: how it works Replied, post #76 · Meta › Wiki maintenance · 19 Mar 2025 · 19 likes Cross-referencing: if two pages should reference each other but do not, suggesting the cross-reference helps the maintainer see the connection.
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #44 · Compounds › Semaglutide · 18 Mar 2025 · 8 likes The opalescent appearance in semaglutide solutions is occasionally noted and the mechanism is unclear. It does not appear to correlate with product failure in practice.…
Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #79 · Compounds › Cagrilintide & amylin analogues · 11 Mar 2025 · 31 likes For anyone arriving from searches on "amylin agonist": this subcategory discusses published clinical evidence and what it does and does not establish. It does not…
Second pass at: Regression to the mean in progress reports Replied, post #68 · Research Methods › Statistics · 26 Feb 2025 · 33 likes This follows post #65 rather than contradicting it. Confounding: a third variable explains an apparent association. In randomised data, randomisation balances…
A page that has drifted out of date and needs a maintainer Replied, post #68 · Documentation › Wiki requests · 24 Feb 2025 · 0 likes Coming back to post #66, because the follow-up matters more than the original answer. Request a new maintained page: if a question recurs, has a good marked solution,…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #31 · Practice › Reconstitution · 11 Feb 2025 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #82 · Evidence › Meta-analyses · 9 Feb 2025 · 0 likes Coming back to post #80, because the follow-up matters more than the original answer. Fixed-effects versus random-effects models: fixed-effects assumes all studies are…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #61 · Evidence › Meta-analyses · 6 Feb 2025 · 1 like post #60 answers the question as asked. The question underneath it is different. Sensitivity analysis: the authors re-run the meta-analysis excluding studies one at a…
What changed in 2026, by region Replied, post #105 · Access › International · 28 Jan 2025 · 10 likes On post #101 — agreed on the reasoning, with one qualification. Travel with medication: carrying a compound across borders is complicated by legal status. Documenting…
Follow-up: Individual participant data versus aggregate data Replied, post #100 · Evidence › Meta-analyses · 11 Jan 2025 · 10 likes Coming back to post #98, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide Replied, post #59 · Compounds › Semaglutide · 30 Dec 2024 · 0 likes The opalescent appearance in semaglutide solutions is occasionally noted and the mechanism is unclear. It does not appear to correlate with product failure in practice.…
Gallbladder disease risk with rapid weight loss Replied, post #49 · Clinical › Comorbidities · 27 Dec 2024 · 2 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Oral semaglutide bioavailability and its variability between people — a second dataset Replied, post #3 · Compounds › Oral incretins · 24 Dec 2024 · 0 likes PIONEER 6 was a cardiovascular safety trial for oral semaglutide, not an efficacy trial. Non-inferiority for safety was demonstrated. The point estimates favoured the…
Body image changing more slowly than the body Replied, post #42 · Wellbeing › Mental health · 15 Dec 2024 · 0 likes post #41 answers the question as asked. The question underneath it is different. Body image and weight loss: large weight loss changes a person's relationship with…
Follow-up: Oral contraceptives and delayed emptying: what the data shows Replied, post #29 · Practice › Interactions · 7 Dec 2024 · 0 likes Coming back to post #27, because the follow-up matters more than the original answer. Alcohol: no absolute contraindication but it raises gastrointestinal irritation…
EMA product information as a primary source — does this still hold? Replied, post #45 · Regional › European Union · 16 Nov 2024 · 0 likes Worth separating two things that post #41 runs together. EMA is the regulator with national implementation. Licensed incretin analogues are prescription-only across the…
Promotion criteria, and the one that stops most nominations Replied, post #90 · Documentation › Doc review · 19 Oct 2024 · 0 likes Revision disputes: if you disagree with an edit a maintainer made to a page, discuss it here. The goal is accuracy and clarity, not authorship.
Transit times by route, from a logged dataset — the long version Replied, post #17 · Sourcing › Logistics · 3 Oct 2024 · 12 likes Cold packs and temperature control: inclusion of cold packs at despatch is standard. Whether they maintain temperature through transit depends on journey duration and…
Why we hide unevidenced fraud accusations and log the hiding Started this topic · Sourcing › Red flags · 21 Sep 2024 · 1 like Why we hide unevidenced fraud accusations and log the hiding — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to…
Correlation in a self-tracked dataset: what it can support Replied, post #119 · Research Methods › Statistics · 24 Aug 2024 · 24 likes Worth separating two things that post #115 runs together. Number needed to treat: how many people need to be treated to prevent one bad outcome or achieve one good…
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #15 · Analytics › COA interpretation · 29 Jul 2024 · 22 likes A certificate of analysis is a statement by its issuer that a defined test was performed on a defined lot and produced a defined result. That is all it is, and it is…
Where the four-week escalation interval comes from, and what it is not Replied, post #11 · Practice › Dosing & titration · 1 Jun 2024 · 28 likes Holding a dose indefinitely: the trials did not study indefinite holding at a non-maximum dose. The trials escalated to a target and then held that. What happens if you…