p.novotny

TL2 Regular · Prague, CZ

Lifter. Interested in preserving what I spent a decade building while losing fat.

Joined 3 June 2025 · last posted 4d

102 posts, newest first. Showing up to 150.

[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #106 · Access › International · 24 Jul 2026 · 4 likes Currency and exchange rates: paying in different currencies has different costs and risks. Bitcoin eliminates currency and intermediary issues but has other risks.
Restarting after a long gap: what the labelling implies Replied, post #37 · Practice › Dosing & titration · 21 Jul 2026 · 3 likes The four-week escalation interval is a convention from the pivotal trials, not a pharmacological constant. The pharmacological argument is that with a week-long…
Follow-up: How compounding permissions changed when supply normalised Replied, post #24 · Sourcing › Regulatory · 15 Jul 2026 · 0 likes Regulatory positions change: a compound's status today might differ from its status a year from now. Citing a regulatory position is worth doing only with a date…
Follow-up: Signs of dehydration worth acting on Replied, post #25 · Safety › Adverse events · 15 Jul 2026 · 0 likes Serious and unexpected events are the ones to document and report. Serious means hospitalization-level serious. Unexpected means not in the drug's known profile. Both…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #60 · Practice › Dosing & titration · 13 Jul 2026 · 8 likes Titrating on tolerability rather than on the calendar: some people escalate when they tolerate a dose well, others escalate on the prescribed schedule regardless. The…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #57 · Compounds › Retatrutide · 12 Jul 2026 · 2 likes I read post #55 twice before replying, because I had assumed the opposite. Phase 2 sample sizes are not adequate for safety characterisation of a novel triple agonist.…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #52 · Analytics › Impurities & related substances · 6 Jul 2026 · 13 likes I read post #50 twice before replying, because I had assumed the opposite. Truncation products: fragments from incomplete synthesis or from degradation. They elute…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #111 · Evidence › Journal club · 5 Jul 2026 · 20 likes Coming back to post #109, because the follow-up matters more than the original answer. SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the…
Submitting a sample: the process end to end Replied, post #58 · Sourcing › Independent verification · 4 Jul 2026 · 29 likes This follows post #55 rather than contradicting it. Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a…
NHS criteria and how they are applied in practice Replied, post #8 · Regional › UK & Ireland · 21 Jun 2026 · 2 likes post #7 is right about the mechanism and I think understates the practical bit. Compounding pharmacies: UK allows compounding under specific conditions when a licensed…
Racemisation and why it is invisible to a mass measurement Replied, post #123 · Analytics › Impurities & related substances · 15 Jun 2026 · 0 likes Deletion sequences (incomplete coupling during synthesis): lower in mass by one residue. Chromatographically they usually elute earlier or later depending on the…
Fixed versus detachable needles: the trade-offs — does this still hold? Replied, post #7 · Devices › Syringes & needles · 13 Jun 2026 · 0 likes I read post #5 twice before replying, because I had assumed the opposite. Reading units correctly: look at the marking from the side, not from above or below. The…
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #105 · Practice › Storage & stability · 9 Jun 2026 · 22 likes Container choice matters: the material of the vial, the rubber closure, the fill volume all affect how quickly the contents degrade. Smaller fill volumes lose less to…
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just… Replied, post #123 · Compounds › Tirzepatide · 3 Jun 2026 · 1 like post #122 is right about the mechanism and I think understates the practical bit. Half-life difference: tirzepatide is about 5 days versus semaglutide's week-long.…
Electrolyte supplements: which ones do anything Replied, post #22 · Nutrition & Training › Hydration & electrolytes · 3 Jun 2026 · 0 likes Orthostatic symptoms: dizziness on standing after lying down can indicate dehydration or electrolyte depletion. Increasing fluids, salt, and potassium usually resolves…
Revisiting: Mean kinetic temperature explained without the mathematics Replied, post #52 · Practice › Storage & stability · 1 Jun 2026 · 10 likes Refrigeration slows degradation. Repeated warming and cooling is worse than continuous refrigeration. Light exposure is worth avoiding. The concentration matters…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #19 · Compounds › Oral incretins · 29 May 2026 · 22 likes post #18 answers the question as asked. The question underneath it is different. Trial adherence in an oral trial with strict administration requirements is genuinely…
Research-use-only status: what it means legally and practically Replied, post #42 · Compounds › Other compounds · 14 May 2026 · 2 likes Research-use-only status is a legal classification, not a safety classification. It means the compound is sold for laboratory use and not for human consumption or…
Sample handling between despatch and injection Replied, post #55 · Analytics › Method validation · 20 Apr 2026 · 7 likes Accuracy: the method measures what you intend to measure. For purity methods, this is tested by spike-and-recover experiments: add a known amount of impurity to a…
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #4 · marked as the solution · Analytics › Home & field testing · 18 Apr 2026 · 7 likes What physical quantity does the device measure? A colorimetric or lateral-flow method typically responds to a class of chemistry rather than to a specific molecule. It…
The "under review" status pill and when a moderator applies it Replied, post #73 · Evidence › Preprints · 14 Apr 2026 · 2 likes Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having…
Journal club: SURMOUNT-4 and continuation versus withdrawal Replied, post #27 · Evidence › Journal club · 11 Apr 2026 · 5 likes Worth separating two things that post #23 runs together. SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a…
A site rotation scheme that is easy enough to actually follow Replied, post #38 · Practice › Administration · 11 Apr 2026 · 12 likes post #37 answers the question as asked. The question underneath it is different. Angle of injection: 90 degrees into pinched tissue ensures subcutaneous placement. It…
Anaesthesia and elective surgery: the aspiration question Replied, post #75 · Practice › Interactions · 5 Apr 2026 · 26 likes On post #71 — agreed on the reasoning, with one qualification. Metformin: commonly co-administered and relevant to gastrointestinal tolerability. Gastrointestinal side…
Insomnia at a dose step: reported experiences — the long version Replied, post #8 · Wellbeing › Sleep · 3 Apr 2026 · 16 likes Obstructive sleep apnoea: pre-existing OSA can worsen with weight before it improves (apnoea-hypopnoea index goes up as soft tissue inflames before weight is lost).…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #115 · Clinical › Bloodwork · 30 Mar 2026 · 0 likes HbA1c and glucose: HbA1c reflects average glucose over months; a spot glucose measurement reflects the moment. Trending glucose downward while HbA1c stays flat is a…
Personal import allowances, compared — a second dataset Replied, post #94 · Access › International · 29 Mar 2026 · 0 likes Currency and exchange rates: paying in different currencies has different costs and risks. Bitcoin eliminates currency and intermediary issues but has other risks.
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #76 · Start Here › How to Ask · 21 Mar 2026 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #53 · Research Methods › N-of-1 designs · 9 Mar 2026 · 12 likes Generalisability: a robust n-of-1 result applies to you. It does not tell you much about whether the effect generalises to others similar to you, much less to people…
Reading an interaction checker output critically Replied, post #131 · Practice › Interactions · 26 Feb 2026 · 2 likes Separation timing versus clinically important interaction: a separation timing inconvenience (taking one medication 2 hours before or after another) is not the same as…
Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #129 · Compounds › Semaglutide · 26 Feb 2026 · 25 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Whether protein timing matters at a large deficit Replied, post #27 · Nutrition & Training › Protein & intake · 20 Feb 2026 · 22 likes Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as solid food. Using both together can help.
Revisiting: Maintainer handover: how it works Replied, post #7 · Meta › Wiki maintenance · 20 Feb 2026 · 5 likes Coming back to post #5, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #8 · Practice › Dosing & titration · 14 Feb 2026 · 27 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #39 · Clinical › Special populations · 11 Feb 2026 · 0 likes Worth separating two things that post #35 runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather…
Seven-day rolling means and why weekly readings mislead — one year on Replied, post #15 · Outcomes › Progress reports · 7 Feb 2026 · 29 likes Non-scale victories: muscle gain or maintenance, clothing fit, energy level, and capability (like climbing stairs without breathlessness) are measurements that…
Preprint servers and what screening they do Replied, post #27 · Evidence › Preprints · 17 Jan 2026 · 2 likes Worth separating two things that post #23 runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather…
Muscle cramps: the ordinary causes before the exotic ones Replied, post #36 · Practice › Side effects · 16 Jan 2026 · 0 likes Fatigue: commonly reported, frequently multifactorial. It is worth asking whether other factors have changed (sleep, training volume, diet adequacy, hydration) before…
Distinguishing expected GI effects from something that needs urgent attention Replied, post #20 · Practice › Side effects · 3 Jan 2026 · 16 likes On post #16 — agreed on the reasoning, with one qualification. Recognition and grading: nausea ranges from "noticeable" to "limiting". Constipation ranges from mild to…
Pre-registering a personal experiment, seriously — a second dataset Replied, post #15 · Research Methods › N-of-1 designs · 28 Dec 2025 · 10 likes I read post #13 twice before replying, because I had assumed the opposite. Confounding in personal experiments: other things change when you start a medication (season,…
Vomiting: when it is expected and when it is a reason to stop Replied, post #57 · Practice › Side effects · 28 Dec 2025 · 11 likes Worth separating two things that post #53 runs together. Pancreatitis: a rare but serious event with a specific presentation (epigastric pain, back pain, elevated…
Why "add 2 mL" is not an instruction Replied, post #22 · Practice › Reconstitution · 27 Dec 2025 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Reconciling a label claim with a content assay Replied, post #5 · Analytics › COA interpretation · 26 Dec 2025 · 1 like Sterility testing is separate: chromatographic purity, mass spectrometry, and endotoxin testing all say nothing about whether a solution is sterile. If sterility…
Publishing an inconvenient result: a case study — the long version Replied, post #48 · Sourcing › Independent verification · 24 Nov 2025 · 24 likes post #47 answers the question as asked. The question underneath it is different. Janoshik Analytical: chromatographic purity and mass-spectrometric identity on…
Interpreting a result that disagrees with the supplier's certificate Replied, post #18 · Sourcing › Independent verification · 20 Nov 2025 · 0 likes I read post #16 twice before replying, because I had assumed the opposite. Two things before anyone answers the substance. First, the context in the first post is clear…
The anatomy of a question that gets answered within an hour — the long version Replied, post #90 · Start Here › How to Ask · 13 Nov 2025 · 33 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
What a purity-only report leaves out Replied, post #81 · Sourcing › Independent verification · 10 Nov 2025 · 0 likes post #80 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
How to read a forest plot, properly, from scratch Replied, post #51 · Evidence › Trials · 6 Nov 2025 · 12 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #11 · Pharmacology › Pharmacokinetics · 30 Oct 2025 · 5 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Where to report an adverse event officially, by region — a second dataset Replied, post #66 · Safety › Adverse events · 28 Oct 2025 · 11 likes Severe gastrointestinal events: persistent vomiting, abdominal pain out of proportion, or signs of bowel obstruction warrant urgent evaluation. Mild nausea and…
What a purity-only report leaves out Replied, post #62 · Sourcing › Independent verification · 27 Oct 2025 · 4 likes I read post #60 twice before replying, because I had assumed the opposite. Two things before anyone answers the substance. First, the context in the first post is clear…
Why oral semaglutide needs an absorption enhancer at all Replied, post #42 · Compounds › Oral incretins · 17 Oct 2025 · 28 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
High-resolution MS on aggregates and what it can see Replied, post #90 · Analytics › Mass spectrometry · 11 Oct 2025 · 28 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
An orphaned page with no inbound links — the long version Replied, post #11 · Meta › Wiki maintenance · 10 Oct 2025 · 16 likes I read post #9 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so…
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #99 · Analytics › HPLC & UHPLC · 8 Oct 2025 · 0 likes System suitability testing: injections run before and during the sample run to establish whether the instrument, column and method were performing when the sample was…
Hypertension improvement and when medication needs revisiting Replied, post #65 · Clinical › Comorbidities · 17 Sep 2025 · 1 like Bariatric surgery history: altered anatomy after surgery affects absorption. That matters for oral medications and for reconstituted solutions. Discussing specific…
Payment method and the leverage it gives you, ranked Replied, post #18 · Sourcing › Payments · 16 Sep 2025 · 6 likes post #17 answers the question as asked. The question underneath it is different. Recurring billing: if a supplier sets up recurring billing by default, understanding…
Documentation that appears only after payment Replied, post #22 · Sourcing › Red flags · 10 Sep 2025 · 19 likes post #21 is right about the mechanism and I think understates the practical bit. Thank you for the correction. I have edited my earlier post with a note rather than…
Second pass at: LOD and LOQ: definitions people get wrong Replied, post #23 · Analytics › Method validation · 30 Aug 2025 · 19 likes post #22 is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct answer, and…
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #40 · Analytics › HPLC & UHPLC · 30 Aug 2025 · 0 likes Before anything else: what was the gradient, and at what wavelength? Area percent at different wavelengths is not the same number even on the same sample because…
A parcel that arrived warm: a decision process, not a verdict Replied, post #17 · Practice › Storage & stability · 29 Aug 2025 · 22 likes Picking up post #14: that is the part I would want checked first. Vial integrity: once a vial is entered with a needle repeatedly, the rubber closure degrades and the…
Thyroid function tests during substantial weight change Replied, post #44 · Clinical › Bloodwork · 28 Aug 2025 · 1 like Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #60 · Compounds › Oral incretins · 7 Jul 2025 · 26 likes Oral versus injectable exposure: comparing a 14 mg oral dose with a 0.5 mg injectable dose is comparing apples to a different fruit. The oral bioavailability is low…
Coming back to: Official shortage notices and what they authorise Replied, post #45 · Access › Shortages · 1 Jul 2025 · 9 likes I read post #43 twice before replying, because I had assumed the opposite. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write…
Repeatability versus intermediate precision Replied, post #41 · Analytics › Method validation · 22 Jun 2025 · 1 like Robustness: the method gives consistent results when minor parameters vary. Tested by deliberately varying pH, temperature, flow rate, and mobile phase composition…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #139 · Practice › Reconstitution · 19 Jun 2025 · 0 likes How much of the diluent volume the powder itself displaces: for a small peptide vial, the powder volume is negligible. For a larger vial or a kit with multiple…
Journal club: SURMOUNT-1, read without the press release Replied, post #139 · Evidence › Journal club · 17 Jun 2025 · 7 likes Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
TB-500 and thymosin beta-4: the fragment versus the protein Replied, post #30 · Compounds › Repair & healing peptides · 3 Jun 2025 · 12 likes post #29 answers the question as asked. The question underneath it is different. Oral versus injected administration claims for BPC-157: the preclinical work studied…
Validating a calculator against hand arithmetic — what changed since Replied, post #94 · Data & Tools › Calculators · 27 May 2025 · 0 likes Why calculators are not medical advice: they do arithmetic. Medical decisions are not arithmetic. A calculator that says a certain dose is "compatible with" a certain…
Second pass at: Designing a personal experiment that could change your mind Replied, post #24 · Research Methods › N-of-1 designs · 19 May 2025 · 30 likes Confounding in personal experiments: other things change when you start a medication (season, exercise, diet, stress). Documenting those confounders helps you…
Validating a calculator against hand arithmetic — what changed since Replied, post #77 · Data & Tools › Calculators · 19 May 2025 · 0 likes Coming back to post #75, because the follow-up matters more than the original answer. Precision and significant figures: the calculators do not round to match your…
Coverage for the indication versus for the drug Replied, post #61 · Access › Insurance & coverage · 11 May 2025 · 5 likes Coming back to post #59, because the follow-up matters more than the original answer. Appeals process: unemotional prose, the criterion quoted verbatim, evidence mapped…
DXA precision and the least significant change for lean mass — the long version Replied, post #23 · Outcomes › Body composition · 10 May 2025 · 25 likes This follows post #20 rather than contradicting it. Maintenance phase: tracking body composition during maintenance (weight stable) is different from tracking during…
Titles that describe the question, not the situation Replied, post #8 · Start Here › How to Ask · 9 May 2025 · 1 like Lab result questions: state the result, the reference interval, and what else is on the same panel. A single flag on a single draw is usually uninformative without…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #43 · Sourcing › Independent verification · 3 May 2025 · 1 like When results are inconclusive: if a testing service reports "insufficient to verify" on a documentation review, that is not a negative finding about the product. It…
Publishing an inconvenient result: a case study Replied, post #14 · Sourcing › Independent verification · 30 Apr 2025 · 0 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Why plausible mechanism is not evidence of effect — one year on Replied, post #2 · Compounds › Repair & healing peptides · 27 Apr 2025 · 6 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Metformin co-administration and additive GI effects Replied, post #12 · Practice › Interactions · 24 Apr 2025 · 5 likes Food interactions: most interactions are absorption interactions. Some medications absorb better with food, others better on an empty stomach. With an incretin agonist…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #44 · Evidence › Journal club · 19 Apr 2025 · 21 likes PIONEER 6 (N Engl J Med 2019): Cardiovascular safety trial for oral semaglutide, not efficacy. Non-inferiority for safety was met. The trial was not designed to…
Follow-up: Documentation that appears only after payment Replied, post #5 · Sourcing › Red flags · 17 Apr 2025 · 1 like post #4 answers the question as asked. The question underneath it is different. Pricing patterns: unusually low prices for what are otherwise consistent with market…
Fibre intake when total intake falls, and the constipation link Replied, post #48 · Nutrition & Training › Protein & intake · 2 Apr 2025 · 9 likes This follows post #45 rather than contradicting it. Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be as satiating as…
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #127 · Compounds › Semaglutide · 13 Mar 2025 · 6 likes Worth separating two things that post #123 runs together. Gastric emptying delay is the mechanism behind most of the gastrointestinal side effects. Slowing the stomach…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Replied, post #34 · Compounds › Tirzepatide · 7 Mar 2025 · 8 likes Coming back to post #32, because the follow-up matters more than the original answer. SURPASS-2 compared tirzepatide with semaglutide 1.0 mg, the licensed diabetes dose…
Why we hide unevidenced fraud accusations and log the hiding Replied, post #47 · Sourcing › Red flags · 2 Feb 2025 · 19 likes This follows post #44 rather than contradicting it. Unresponsiveness: a supplier that does not reply to reasonable requests for documentation or clarification is…
What we do not know about retatrutide, listed explicitly Replied, post #76 · Compounds › Retatrutide · 30 Jan 2025 · 0 likes Worth separating two things that post #72 runs together. Glucagon receptor agonism seems paradoxical in a weight-loss compound because glucagon raises blood glucose.…
Dose numbers for oral formulations are not comparable to injectable ones — a second… Replied, post #51 · Compounds › Oral incretins · 14 Jan 2025 · 0 likes Trial adherence in an oral trial with strict administration requirements is genuinely worse than trial-published data often suggests. That is why the exposure…
Follow-up: Individual participant data versus aggregate data Replied, post #16 · Evidence › Meta-analyses · 8 Jan 2025 · 28 likes Sensitivity analysis: the authors re-run the meta-analysis excluding studies one at a time, or by quality, to see whether the pooled estimate changes. Robust results…
Oxidation pathways for methionine and tryptophan Replied, post #6 · Analytics › Impurities & related substances · 25 Dec 2024 · 19 likes Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself or with other molecules. Under oxidising conditions multiple species…
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #82 · Compounds › Semaglutide · 24 Dec 2024 · 4 likes On post #78 — agreed on the reasoning, with one qualification. Semaglutide versus liraglutide in STEP 8: semaglutide produced greater weight reduction and the…
Follow-up: Dead volume across syringe and needle combinations Replied, post #79 · Devices › Syringes & needles · 9 Dec 2024 · 2 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Follow-up: Recovery when intake is low: what to cut first Replied, post #40 · Nutrition & Training › Resistance training · 23 Nov 2024 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #46 · Clinical › Special populations · 23 Nov 2024 · 4 likes Older adults: sarcopenia risk is higher, polypharmacy is common, and the clinical trials did not enroll many people over 75. Extrapolating to very old people is…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #38 · Evidence › Journal club · 21 Nov 2024 · 2 likes Worth separating two things that post #34 runs together. SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg dose is not…
Isotope patterns and why the monoisotopic peak is not the tallest Replied, post #3 · Analytics › Mass spectrometry · 18 Nov 2024 · 0 likes Worth separating two things that the opening post runs together. Resolution: "high resolution" commonly means
Why "any advice?" is the least effective ending for a post Replied, post #41 · Start Here › How to Ask · 16 Nov 2024 · 0 likes Disagreement-style questions: "I read this and it contradicts what I heard here, which is right?" is answerable. "Is this a bad idea?" without giving the context is not.
Revisiting: Moderation log format change Replied, post #26 · Meta › Announcements · 13 Nov 2024 · 7 likes post #25 is right about the mechanism and I think understates the practical bit. Scheduled maintenance: if the site is going offline for maintenance, advance notice…
Why "any advice?" is the least effective ending for a post Replied, post #7 · Start Here › How to Ask · 3 Nov 2024 · 0 likes The specific question in the title is more useful than you might think. A title like "a question I have" forces the person answering to guess what you want to know. A…
Requesting a page: what makes a good request — what changed since Replied, post #129 · Documentation › Wiki requests · 13 Oct 2024 · 0 likes Authority and authorship: if you think a maintained page needs input from someone with specific expertise (a clinician, an analytical chemist) suggest who might…
Second pass at: Food noise reducing and the disorientation that can follow Replied, post #29 · Wellbeing › Mental health · 13 Oct 2024 · 0 likes Coming back to post #27, because the follow-up matters more than the original answer. Two things before anyone answers the substance. First, the context in the first…
Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #10 · Compounds › Cagrilintide & amylin analogues · 12 Oct 2024 · 3 likes For anyone arriving from searches on "amylin agonist": this subcategory discusses published clinical evidence and what it does and does not establish. It does not…
Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #17 · Evidence › Journal club · 14 Aug 2024 · 0 likes FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is…
Journal club: FLOW and the renal composite, component by component Replied, post #69 · Evidence › Journal club · 15 Jul 2024 · 19 likes SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg dose is not the highest available, which is the central and…