Latest topics page 42

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 42 of 52

Topic	Participants	Replies	Views	Activity
Research-use-only labelling: what it means and what it does not — the long version Sourcing › Regulatory EMA research use only compounding Posting this under the heading it deserves: Research-use-only labelling: what it means and what it does not — the long version Everything below is what sits behind that. I would like to talk about…	+150	158	55k	14mo
Lean mass preservation: what the evidence supports Outcomes › Body composition lean mass loss bioimpedance DXA Lean mass preservation: what the evidence supports Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost nobody…	+23	27	347	14mo
Second pass at: Designing a personal experiment that could change your mind Research Methods › N-of-1 designs worked example effect size confounding data table Solved Second pass at: Designing a personal experiment that could change your mind Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please…	+39	44	632	14mo
Relative retention time as a better inter-laboratory comparator Analytics › Method validation linearity recovery precision & repeatability stability-indicating method On the subject in the title: Relative retention time as a better inter-laboratory comparator Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will…	+7	11	28k	14mo
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Sourcing › Independent verification blind sampling PeptideMeter Medutest third-party testing How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion, following…	+117	130	3.3k	14mo
Particulates in a reconstituted solution: identifying the likely source — what changed since Analytics › Impurities & related substances water content HPLC forced degradation counter-ion content Particulates in a reconstituted solution: identifying the likely source — what changed since — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what…		2	129	14mo
Pregnancy as an absolute contraindication Safety › Contraindications disordered eating delayed gastric emptying pregnancy & planning pancreatitis Solved Pregnancy as an absolute contraindication — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this class mostly…	+102	106	21k	14mo
A page that has drifted out of date and needs a maintainer Documentation › Wiki requests promoted to docs maintainership review date Solved On the subject in the title: A page that has drifted out of date and needs a maintainer Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic in…	+95	104	1.2k	14mo
Critiquing an observational claim about a class effect Evidence › Study critique disputed risk of bias effect size observational data Posting this under the heading it deserves: Critiquing an observational claim about a class effect Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…		2	6.9k	14mo
Follow-up: Documentation that appears only after payment Sourcing › Red flags disputed mislabelling underdosing documentation quality Wiki Posting this under the heading it deserves: Documentation that appears only after payment Everything below is what sits behind that. I would like to talk about documentation quality as a signal, separately…	+82	87	50k	14mo
Water content on a certificate and why it changes the arithmetic Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers Closed Water content on a certificate and why it changes the arithmetic — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+19	23	24k	14mo
Ipamorelin selectivity claims and where they came from — a second dataset Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin ipamorelin Posting this under the heading it deserves: Ipamorelin selectivity claims and where they came from — a second dataset Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021)…		2	27k	14mo
Residual solvents and scavengers: what is looked for Analytics › Impurities & related substances counter-ion content HPLC data table forced degradation Solved On the subject in the title: Residual solvents and scavengers: what is looked for Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will otherwise…	+19	23	39k	14mo
Micronutrient status when intake falls substantially — a second dataset Clinical › Bloodwork thyroid function eGFR & renal function lipid panel lipase & amylase Closed Micronutrient status when intake falls substantially — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person.…	+9	13	274	14mo
Coming back to: A critique that turned out to be unfair, retracted by its author Evidence › Study critique disputed observational data effect size confounding Closed A critique that turned out to be unfair, retracted by its author — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not…		2	1.3k	14mo
The five documentation pages worth reading before you post anything Start Here › Welcome onboarding beginner friendly trust levels Solved The five documentation pages worth reading before you post anything — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to include the…	+1	5	10k	14mo
Fibre intake when total intake falls, and the constipation link Nutrition & Training › Protein & intake lean mass loss fatigue constipation micronutrients Fibre intake when total intake falls, and the constipation link — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number without a…	+61	66	12k	15mo
Pages past their review date, listed — does this still hold? Meta › Wiki maintenance review date moderation citation check maintainership Solved Closed Pages past their review date, listed — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Nominating something for promotion into the documentation…	+27	31	52k	15mo
Adjudicated events and why the definition matters — the long version Evidence › Trials intention to treat estimand randomised trial discontinuation & dropout Adjudicated events and why the definition matters — the long version Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 4 ( JAMA…	+125	146	13k	15mo
A vial that will not fully dissolve: what to check and in what order Practice › Reconstitution reconstitution bacteriostatic water syringe units Solved A vial that will not fully dissolve: what to check and in what order — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+12	16	40k	15mo
Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset Compounds › Secretagogues & GH axis GHRP class ipamorelin tesamorelin Under review The question in the title: Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset I will give what I have already checked below so nobody repeats it. I have seen LEADER ( N…	+60	64	25k	15mo
Units, standards, and other things that quietly hold the world together Lounge › Off topic long read beginner friendly Closed Units, standards, and other things that quietly hold the world together — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if anyone…	+33	38	31k	15mo
Coming back to: Oxidation pathways for methionine and tryptophan Analytics › Impurities & related substances HPLC counter-ion content water content data table Oxidation pathways for methionine and tryptophan Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+1	5	36k	15mo
Criticising the method without criticising the authors Evidence › Study critique disputed observational data confounding effect size Criticising the method without criticising the authors Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim…	+55	61	60k	15mo
Bleeding at the injection site: normal, and what to do about it — does this still hold? Practice › Administration injection site rotation aseptic technique subcutaneous injection needle gauge & length Bleeding at the injection site: normal, and what to do about it — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Reporting something rather than…	+20	24	16k	15mo
Enforcement priorities versus written rules Sourcing › Regulatory FDA personal import MHRA Enforcement priorities versus written rules — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal, separately from product quality.…		2	62k	15mo
Reading order for a first week here, and what to skip until later Start Here › Welcome onboarding guidelines beginner friendly trust levels Reading order for a first week here, and what to skip until later Writing it up because I had to work it out twice and would rather nobody else did. I want to check my reasoning rather than get a conclusion.…	+112	117	3.1k	15mo
Deamidation and the close-eluting pair it produces Analytics › Impurities & related substances forced degradation HPLC water content data table Deamidation and the close-eluting pair it produces Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+33	37	46k	15mo
Metformin co-administration and additive GI effects Practice › Interactions insulin hypoglycaemia metformin delayed gastric emptying Metformin co-administration and additive GI effects Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it, in case the pattern is…	+28	32	2.1k	15mo
Revisiting: Oral versus injected administration claims for BPC-157 Compounds › Repair & healing peptides observational data needs a source TB-500 BPC-157 Solved On the subject in the title: Revisiting: Oral versus injected administration claims for BPC-157 Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I…	+23	27	7.7k	15mo