Latest topics page 41

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1,535 topics · page 41 of 52

Topic	Participants	Replies	Views	Activity
Pregnancy as an absolute contraindication — the long version Safety › Contraindications disordered eating pregnancy & planning delayed gastric emptying Under review On the subject in the title: Pregnancy as an absolute contraindication — the long version Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…		2	5.3k	14mo
A claim built entirely on a subgroup analysis Evidence › Study critique risk of bias observational data confounding disputed Solved A claim built entirely on a subgroup analysis Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do…	+71	80	1.1k	14mo
Why oral semaglutide needs an absorption enhancer at all — what changed since Compounds › Oral incretins randomised trial PIONEER programme SOUL trial Solved Asking directly, because I could not find a straight answer: Why oral semaglutide needs an absorption enhancer at all — what changed since Session topic: STEP 2 ( Lancet , 2021). Please read it before…		2	61k	14mo
Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions metformin needs a source hypoglycaemia Solved Wiki On the subject in the title: Delayed gastric emptying and oral medication absorption: which drugs matter Working notes rather than a conclusion. Reporting something rather than asking about it, in case the…	+110	116	43k	14mo
How to bring a laboratory report to an appointment usefully Clinical › Bloodwork thyroid function lipase & amylase lipid panel eGFR & renal function How to bring a laboratory report to an appointment usefully — that is the question, and I have not found it answered plainly anywhere I have looked. General question, not a request for advice about my own…		2	41k	14mo
Why we hide unevidenced fraud accusations and log the hiding Sourcing › Red flags underdosing mislabelling disputed moderation Solved Why we hide unevidenced fraud accusations and log the hiding — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to talk about documentation quality as a…	+97	106	63k	14mo
Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics semaglutide liraglutide worked example tirzepatide Albumin binding and how it produces a long half-life — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere. A…	+38	44	6.6k	14mo
An orphaned page with no inbound links Meta › Wiki maintenance wiki post maintainership citation check moderation An orphaned page with no inbound links — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps…	+44	48	7.5k	14mo
Pre-registering a personal experiment, seriously Research Methods › N-of-1 designs worked example data table effect size confounding Pre-registering a personal experiment, seriously — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SUSTAIN 6 ( N Engl J Med , 2016) and finding the…	+96	119	58k	14mo
A well-designed study with a badly written abstract Evidence › Study critique disputed effect size risk of bias observational data Posting this under the heading it deserves: A well-designed study with a badly written abstract Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with LEADER ( N Engl J Med ,…	+117	128	7.2k	14mo
Documenting an adverse event properly — the long version Safety › Adverse events delayed gastric emptying pancreatitis hypoglycaemia gallbladder Posting this under the heading it deserves: Documenting an adverse event properly — the long version Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+1	5	4.8k	14mo
Cost per milligram, computed honestly across formats — the long version Access › Pricing cost per milligram compounding formulary data table Cost per milligram, computed honestly across formats — the long version Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail…	+111	124	24k	14mo
Shakes versus food: a pragmatic assessment — the long version Nutrition & Training › Protein & intake micronutrients fatigue constipation On the subject in the title: Shakes versus food: a pragmatic assessment — the long version Working notes rather than a conclusion. Maintenance rather than loss, which is the part of this that almost nobody…	+36	41	28k	14mo
Excipient function in a licensed injectable Pharmacology › Formulation chemistry bacteriostatic water cloudy or discoloured solution sterile water Solved Wiki Closed Excipient function in a licensed injectable Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+3	7	36k	14mo
[2026 update] Building a sensible monitoring schedule with your prescriber Clinical › Bloodwork thyroid function HbA1c lipid panel lipase & amylase Closed Posting this under the heading it deserves: Building a sensible monitoring schedule with your prescriber Everything below is what sits behind that. General question, not a request for advice about my own care…	+22	26	5.1k	14mo
DXA precision and the least significant change for lean mass — the long version Outcomes › Body composition bioimpedance lean mass loss data table On the subject in the title: DXA precision and the least significant change for lean mass — the long version Working notes rather than a conclusion. Maintenance rather than loss, which is the part of this…	+97	111	22k	14mo
HbA1c lag and what it can and cannot tell you at eight weeks Clinical › Bloodwork HbA1c lipid panel thyroid function lipase & amylase Solved HbA1c lag and what it can and cannot tell you at eight weeks Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own care — I…	+14	18	2.6k	14mo
Reading a trial's population section before its results — does this still hold? Evidence › Trials randomised trial open label intention to treat discontinuation & dropout Closed Reading a trial's population section before its results — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen STEP 1 ( N Engl J Med ,…	+140	154	5.4k	14mo
Requesting a translation of an existing page Documentation › Wiki requests wiki post maintainership review date Requesting a translation of an existing page — setting out what I have, and where I think it stops being reliable. Process question about how this site works. I have read the guidelines and the trust-level…	+16	20	7.1k	14mo
Domestic fridge temperature mapping: a cheap experiment Devices › Cold chain cold chain temperature excursion storage freeze-thaw Domestic fridge temperature mapping: a cheap experiment Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a gap, so I…		2	182	14mo
Second pass at: Obstructive sleep apnoea and a hard endpoint in this class Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis chronic kidney disease Second pass at: Obstructive sleep apnoea and a hard endpoint in this class — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The…		2	726	14mo
UK access routes, dated and sourced — a second dataset Regional › UK & Ireland MHRA NHS cost per milligram personal import Posting this under the heading it deserves: UK access routes, dated and sourced — a second dataset Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…	+76	82	25k	14mo
Follow-up: Is "synergy" the right word for the combination data? Compounds › Cagrilintide & amylin analogues cagrilintide cagrisema amylin analogues effect size Solved Under review Is "synergy" the right word for the combination data? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…		2	41k	14mo
One lot is one lot: when a report becomes a pattern Sourcing › Vendor reports documentation quality certificate of analysis batch & lot numbers disputed Solved Posting this under the heading it deserves: One lot is one lot: when a report becomes a pattern Everything below is what sits behind that. Structured report rather than an opinion, following the format the…		2	19k	14mo
What SELECT changed about how semaglutide is discussed, and what it did not Compounds › Semaglutide STEP programme type 2 diabetes randomised trial Solved Asking directly, because I could not find a straight answer: What SELECT changed about how semaglutide is discussed, and what it did not Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+120	132	2k	14mo
Coverage for the indication versus for the drug Access › Insurance & coverage insurance formulary appeals prior authorisation Coverage for the indication versus for the drug — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the…	+70	79	18k	14mo
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence Compounds › Secretagogues & GH axis CJC-1295 needs a source tesamorelin observational data Posting this under the heading it deserves: Tesamorelin has an approved indication — what that changes about the evidence Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with…	+63	68	18k	14mo
Telehealth prescribing models in the US Regional › North America FDA compounding insurance telehealth Telehealth prescribing models in the US Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is what determines…	+95	102	6.1k	14mo
When to stop reading forums, including this one — the long version Wellbeing › Mental health disordered eating beginner friendly mood Solved Asking directly, because I could not find a straight answer: When to stop reading forums, including this one — the long version General question, not a request for advice about my own care — I know the…	+23	27	8.3k	14mo
Talking to a therapist about this specifically — does this still hold? Wellbeing › Mental health mood disordered eating beginner friendly Solved The question in the title: Talking to a therapist about this specifically — does this still hold? I will give what I have already checked below so nobody repeats it. Asking about a population rather than…	+59	65	13k	14mo

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Liraglutide — referenceUpdated 25 Jul 2026 · reviewed by 8 Mar 2027
Water content by Karl Fischer titrationUpdated 17 Jul 2026 · reviewed by 7 Apr 2027
SURMOUNT-1 — trial digestUpdated 15 Jul 2026 · reviewed by 21 May 2027
CJC-1295 — referenceUpdated 12 Jul 2026 · reviewed by 7 Jan 2027
SURPASS-2 — trial digestUpdated 9 Jul 2026 · reviewed by 1 Sep 2026
LEADER — trial digestUpdated 9 Jul 2026 · reviewed by 27 Mar 2027
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