Evidence · Journal club · continued

Revisiting: Journal club: SURMOUNT-1, read without the press release posts 61–63

Evidence › Journal club number needed to treat effect size risk of bias journal club Solved

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

ni.kravchenkoTL2 Moderator26 Jun 2026 · edited#61

r.serrano, post #42: STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most subsequent comparison. Mean weight reduction was substantially larger than anything previously achieved pharmacologically. Go to post

post #60 is right about the mechanism and I think understates the practical bit.

Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up.

4 likes in reply to #42 1mo

r.jhannsdttirTL3Regular29 Jun 2026#62

Worth separating two things that post #58 runs together.

SELECT (N Engl J Med 2023): Semaglutide cardiovascular outcomes without diabetes. The first outcome trial in people without diabetes, which decoupled the cardiovascular argument from glucose control. Read the absolute numbers, not just the relative reduction.

13 likes 29d

a.vermeulenTL22 Jul 2026#63

Collapsed as off-topic by two members at trust level 3 or above

FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is essential because the components differ in how patient-important they are.

This topic was referenced in

Journal club: is percentage weight change the right endpoint?Evidence › Journal club · 120 replies

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