Intersection · Evidence × effect size

Evidence topics tagged effect size

Topics in Evidence carrying the tag effect size. Magnitude, not just direction or significance.

84 topics

Topic	Participants	Replies	Views	Activity
Journal club: indirect comparison between two programmes, defended and attacked journal club randomised trial number needed to treat risk of bias Journal club: indirect comparison between two programmes, defended and attacked Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016)…	+122	131	5.2k	just now
Journal club: LEADER as the historical anchor estimand number needed to treat journal club effect size Pinned Journal club: LEADER as the historical anchor Writing it up because I had to work it out twice and would rather nobody else did. Comparing STEP 1 ( N Engl J Med , 2021) with SURMOUNT-4 ( JAMA , 2024) and…	+103	110	8.1k	2h
When a network meta-analysis is defensible and when it is not effect size heterogeneity publication bias Solved When a network meta-analysis is defensible and when it is not I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with LEADER (…		2	27k	4h
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset risk of bias journal club effect size estimand Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med ,…	+18	22	656	13h
Journal club: semaglutide in MASH, and surrogate endpoints randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: semaglutide in MASH, and surrogate endpoints Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with SURMOUNT-2 (…	+24	28	17k	15h
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? randomised trial risk of bias effect size journal club Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Comparing STEP 2 ( Lancet , 2021) with SURPASS-2 ( N Engl J Med ,…	+70	76	4.8k	15h
A structured critique template this community uses — a second dataset observational data effect size confounding Solved On the subject in the title: A structured critique template this community uses — a second dataset Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before…	+47	51	16k	15h
A critique that turned out to be unfair, retracted by its author confounding risk of bias effect size observational data Wiki Posting this under the heading it deserves: A critique that turned out to be unfair, retracted by its author Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it…	+34	38	20k	17h
Revisiting: What pooling buys you and what it destroys heterogeneity effect size publication bias Solved On the subject in the title: Revisiting: What pooling buys you and what it destroys Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+97	107	4k	19h
Journal club: the CagriSema phase 2 combination paper randomised trial estimand effect size On the subject in the title: Journal club: the CagriSema phase 2 combination paper Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not…		2	329	21h
Immortal time bias in a claims-database study — one year on effect size risk of bias confounding Solved Posting this under the heading it deserves: Immortal time bias in a claims-database study — one year on Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med , 2021) with SURMOUNT-1 (…	+41	46	3.7k	22h
Journal club: what we got wrong in an earlier session number needed to treat effect size randomised trial journal club On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before posting; the…	+114	125	2.5k	23h
Risk-of-bias tools and the judgement they conceal — does this still hold? heterogeneity risk of bias effect size publication bias Solved Risk-of-bias tools and the judgement they conceal — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021)…	+26	30	5.8k	23h
Pooling trials with different estimands publication bias risk of bias effect size meta-analysis Solved On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURMOUNT-1 ( N Engl J Med , 2022) and finding the…	+120	132	2.3k	1d
A structured critique template this community uses observational data effect size risk of bias A structured critique template this community uses — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURPASS-4 ( Lancet , 2021) and finding the…		2	18k	1d
Selection into a registry and what it does to the estimate — a second dataset confounding risk of bias effect size disputed Solved Posting this under the heading it deserves: Selection into a registry and what it does to the estimate — a second dataset Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024).…	+28	32	1.3k	1d
[2026 update] Journal club: what we got wrong in an earlier session journal club effect size estimand number needed to treat Solved Journal club: what we got wrong in an earlier session — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not think it…	+5	9	4.2k	1d
Publication bias detection and its low power heterogeneity publication bias effect size On the subject in the title: Publication bias detection and its low power Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not think it…		2	3.2k	1d
Revisiting: How this community labels and discusses unrefereed work needs a source risk of bias preprint effect size Solved Revisiting: How this community labels and discusses unrefereed work Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited in…	+31	35	7k	1d
Journal club: SUSTAIN 6 and its retinopathy signal estimand effect size risk of bias journal club Under review On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I do not think it…	+110	122	46k	1d
A pooled estimate that changed when one trial was added meta-analysis publication bias effect size Solved A pooled estimate that changed when one trial was added — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…	+24	28	3.5k	2d
Coming back to: Why a preprint's supplementary material is often the best part risk of bias effect size preprint Under review Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021) with STEP 4 (…	+109	116	36k	2d
Revisiting: Journal club: SURMOUNT-1, read without the press release number needed to treat effect size risk of bias journal club Solved On the subject in the title: Revisiting: Journal club: SURMOUNT-1, read without the press release Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+54	62	1.5k	26d
Journal club: STEP 3 and the intensive behavioural therapy floor randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: STEP 3 and the intensive behavioural therapy floor Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with STEP 4 (…	+6	10	13k	28d
Journal club: SELECT, absolute risk, and how it was reported journal club estimand randomised trial effect size Journal club: SELECT, absolute risk, and how it was reported Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med , 2024). Please read…		2	52k	1mo
Second pass at: A pooled estimate that changed when one trial was added effect size risk of bias publication bias meta-analysis Wiki On the subject in the title: Second pass at: A pooled estimate that changed when one trial was added Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before…	+26	30	22k	1mo
Journal club: SELECT, absolute risk, and how it was reported — a second dataset risk of bias effect size randomised trial journal club On the subject in the title: Journal club: SELECT, absolute risk, and how it was reported — a second dataset Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SELECT ( N…		4	1.3k	1mo
How this community labels and discusses unrefereed work — the long version needs a source effect size risk of bias Asking directly, because I could not find a straight answer: How this community labels and discusses unrefereed work — the long version I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a…	+18	23	21k	2mo
The "under review" status pill and when a moderator applies it risk of bias effect size preprint Posting this under the heading it deserves: The "under review" status pill and when a moderator applies it Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it…	+96	119	17k	3mo
Coming back to: Measurement error in a self-reported exposure risk of bias observational data effect size disputed Measurement error in a self-reported exposure — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+23	27	49k	3mo

Sponsored Janoshik Analytical — independent third-party testingHPLC purity and mass-spectrometric identity on submitted samples, reported with the method stated. The laboratory most often cited in this community’s verification records.Independent testing → Sponsored GL Biochem (Shanghai) Ltd. — synthesis, directFounded 1998. ISO 9001 and cGMP certified, over 1,500 staff and 200-plus patents. Custom peptide synthesis and amino acid derivatives, with a batch certificate on every order.Custom synthesis →