Ranked by engagement

Top topics — all time page 20

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 20 of 40

Topic	Participants	Replies	Views	Activity
Taste changes and food aversion, reported and discussed Practice › Side effects fatigue nausea hair shedding delayed gastric emptying Solved Closed Posting this under the heading it deserves: Taste changes and food aversion, reported and discussed Everything below is what sits behind that. I have read the maintained page on this and I still have a gap,…	+40	47	28k	20mo
Coming back to: A community side-effect dataset, with its response rate and biases Data & Tools › Datasets observational data site feedback confounding data table On the subject in the title: A community side-effect dataset, with its response rate and biases Working notes rather than a conclusion. Posting the method first, because I know what the first three replies…	+27	31	46k	9mo
A checklist for reading a certificate in under two minutes — does this still hold? Analytics › COA interpretation documentation quality certificate of analysis amino acid analysis batch & lot numbers Solved A checklist for reading a certificate in under two minutes — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to understand what this…	+49	55	15k	9mo
[2026 update] People with a low starting BMI: where the evidence stops Clinical › Special populations chronic kidney disease adolescents pregnancy & planning bariatric surgery history People with a low starting BMI: where the evidence stops Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+19	23	62k	23mo
Criticising the method without criticising the authors — one year on Evidence › Study critique confounding effect size disputed risk of bias Solved Closed On the subject in the title: Criticising the method without criticising the authors — one year on Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting;…	+16	20	61k	11mo
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Compounds › Retatrutide retatrutide preprint randomised trial effect size Solved The question in the title: Why a glucagon receptor agonist in a weight-loss compound is not a contradiction I will give what I have already checked below so nobody repeats it. Comparing LEADER ( N Engl J Med…	+43	47	19k	2d
Revisiting: Primary endpoint hierarchies and why order matters Evidence › Trials estimand surrogate endpoints discontinuation & dropout intention to treat Posting this under the heading it deserves: Revisiting: Primary endpoint hierarchies and why order matters Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with SURPASS-2 ( N…	+21	25	46k	3mo
Packaging that arrived damaged: documenting it properly Sourcing › Logistics shipping customs temperature excursion cold chain Pinned Packaging that arrived damaged: documenting it properly Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than…	+43	49	26k	1d
Review: a draft on reconstitution arithmetic, with objections — one year on Documentation › Doc review maintainership citation check promoted to docs review date Review: a draft on reconstitution arithmetic, with objections — one year on Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the…	+46	51	11k	20h
Revisiting: Journal club: SURMOUNT-1, read without the press release Evidence › Journal club number needed to treat effect size risk of bias journal club Solved On the subject in the title: Revisiting: Journal club: SURMOUNT-1, read without the press release Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+54	62	1.5k	26d
[2026 update] Currency conversion and the cost you did not see Sourcing › Payments research use only payments documentation quality Solved Posting this under the heading it deserves: Currency conversion and the cost you did not see Everything below is what sits behind that. A logistics question, since the answers here are usually better than…	+21	26	52k	2d
EU-wide position versus national implementation — what changed since Regional › European Union EMA cost per milligram personal import formulary Pinned EU-wide position versus national implementation — what changed since Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included,…	+22	26	58k	2mo
Shakes versus food: a pragmatic assessment Nutrition & Training › Protein & intake lean mass loss micronutrients constipation Shakes versus food: a pragmatic assessment Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost nobody writes…	+22	26	53k	20h
Levothyroxine timing: a real interaction with a simple fix Practice › Interactions needs a source metformin hypoglycaemia delayed gastric emptying Levothyroxine timing: a real interaction with a simple fix Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it, in case the…	+20	24	60k	18mo
Revisiting: List price versus negotiated price versus what you pay Access › Pricing cost per milligram compounding data table formulary Revisiting: List price versus negotiated price versus what you pay — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is…	+24	28	50k	12mo
Oxidation pathways for methionine and tryptophan Analytics › Impurities & related substances counter-ion content data table HPLC water content Posting this under the heading it deserves: Oxidation pathways for methionine and tryptophan Everything below is what sits behind that. Working through the identity arithmetic and I would like it checked.…	+58	63	1k	19mo
Aggregates and why a purity assay may miss them entirely Analytics › Impurities & related substances water content counter-ion content forced degradation HPLC Aggregates and why a purity assay may miss them entirely Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…	+61	69	2.9k	6mo
Certificates issued by the seller versus by a laboratory Analytics › COA interpretation amino acid analysis certificate of analysis documentation quality Posting this under the heading it deserves: Certificates issued by the seller versus by a laboratory Everything below is what sits behind that. I would like to understand what this number means before I…	+58	65	1.2k	15mo
NHS criteria and how they are applied in practice Regional › UK & Ireland NHS cost per milligram personal import MHRA NHS criteria and how they are applied in practice — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines…	+37	42	31k	2d
The C-cell question: rodent findings and their human context — what changed since Compounds › Semaglutide effect size SELECT trial randomised trial type 2 diabetes Closed The C-cell question: rodent findings and their human context — what changed since — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support…	+61	65	1.3k	22mo
[2026 update] Area percent versus weight percent: the confusion that causes most arguments Analytics › HPLC & UHPLC gradient method UV & DAD detection peak integration data table On the subject in the title: Area percent versus weight percent: the confusion that causes most arguments Working notes rather than a conclusion. Posting the method first, because I know what the first three…	+65	70	1.1k	16d
What changed in 2026, by region — does this still hold? Access › International personal import MHRA EMA telehealth Solved What changed in 2026, by region — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Documenting an access outcome, dated, because everything in…	+20	25	50k	1d
An emergency department visit, described afterwards Safety › Adverse events gallbladder hypoglycaemia pancreatitis An emergency department visit, described afterwards Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+56	62	1.4k	11mo
Second pass at: Pharmacy supply in the UK and the questions you will be asked Regional › UK & Ireland personal import MHRA NHS Second pass at: Pharmacy supply in the UK and the questions you will be asked Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail…	+46	53	14k	12mo
A structured critique template this community uses — a second dataset Evidence › Study critique observational data effect size confounding Solved On the subject in the title: A structured critique template this community uses — a second dataset Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before…	+47	51	16k	15h
Revisiting: Completing a dose with a second syringe, and the dead-volume arithmetic Practice › Administration subcutaneous injection aseptic technique needle gauge & length injection site reaction Closed Revisiting: Completing a dose with a second syringe, and the dead-volume arithmetic Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this…	+16	20	56k	12mo
Second pass at: Robustness: the parameters worth deliberately varying Analytics › Method validation linearity LOD & LOQ recovery system suitability On the subject in the title: Second pass at: Robustness: the parameters worth deliberately varying Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+61	66	9.5k	3mo
Follow-up: A parcel that arrived warm: a decision process, not a verdict Practice › Storage & stability temperature excursion cloudy or discoloured solution beyond-use date Posting this under the heading it deserves: A parcel that arrived warm: a decision process, not a verdict Everything below is what sits behind that. A question about technique rather than about dose. I have…	+49	59	1.2k	2mo
Revisiting: Review: an evidence digest and the citation check that delayed it Documentation › Doc review citation check review date maintainership Solved Closed Revisiting: Review: an evidence digest and the citation check that delayed it — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation…	+54	58	8.2k	5mo
Ultrasound and skinfolds: operator dependence in practice Outcomes › Body composition DXA data table lean mass loss Ultrasound and skinfolds: operator dependence in practice — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody…	+72	76	2.7k	2d