Ranked by engagement

Top topics — all time page 21

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 21 of 40

Topic	Participants	Replies	Views	Activity
Contributing data without breaching anyone's privacy Data & Tools › Datasets data table confounding observational data Solved Contributing data without breaching anyone's privacy Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…	+65	71	839	5mo
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people admit Compounds › Repair & healing peptides observational data TB-500 BPC-157 preprint Solved Revisiting: Why the absence of controlled human data on BPC-157 matters more than people admit Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet ,…	+50	55	7.8k	2d
Review: a draft on reconstitution arithmetic, with objections — what changed since Documentation › Doc review promoted to docs wiki post review date citation check Posting this under the heading it deserves: Review: a draft on reconstitution arithmetic, with objections — what changed since Everything below is what sits behind that. Nominating something for promotion…	+39	50	26k	22h
Second pass at: Absence of evidence and evidence of absence Research Methods › Statistics worked example confounding number needed to treat On the subject in the title: Second pass at: Absence of evidence and evidence of absence Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before posting;…	+50	55	18k	16h
Shakes versus food: a pragmatic assessment — the long version Nutrition & Training › Protein & intake micronutrients fatigue constipation On the subject in the title: Shakes versus food: a pragmatic assessment — the long version Working notes rather than a conclusion. Maintenance rather than loss, which is the part of this that almost nobody…	+36	41	28k	14mo
Area percent versus weight percent: the confusion that causes most arguments — what changed since Analytics › HPLC & UHPLC gradient method data table HPLC Area percent versus weight percent: the confusion that causes most arguments — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first,…	+30	34	40k	13mo
Step therapy requirements and how to satisfy them Access › Insurance & coverage prior authorisation insurance formulary Posting this under the heading it deserves: Step therapy requirements and how to satisfy them Everything below is what sits behind that. A coverage question with the paperwork detail included, since that is…	+21	25	49k	2mo
How to read a phase 2 result without treating it as a phase 3 result Compounds › Retatrutide randomised trial preprint effect size TRIUMPH programme The question in the title: How to read a phase 2 result without treating it as a phase 3 result I will give what I have already checked below so nobody repeats it. Session topic: FLOW ( N Engl J Med , 2024).…	+36	40	35k	7mo
A payment that went through twice: how it was resolved Sourcing › Payments payments research use only documentation quality Solved Closed A payment that went through twice: how it was resolved Writing it up because I had to work it out twice and would rather nobody else did. I would like to talk about documentation quality as a signal,…	+20	24	55k	3mo
Peak-to-trough ratio at steady state for a weekly agent — the long version Pharmacology › Pharmacokinetics semaglutide missed dose tirzepatide worked example Under review Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means…	+57	61	708	1d
What a good consultation looks like from the other side Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes beginner friendly What a good consultation looks like from the other side — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about a population rather than about a person. The…	+57	62	4.9k	22h
Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a second dataset Analytics › Method validation linearity LOD & LOQ recovery Closed On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a second dataset Working notes rather than a conclusion. Working through the identity…	+53	58	7.5k	6mo
Coming back to: Why the cheapest option is often not the cheapest Access › Pricing formulary cost per milligram data table compounding Why the cheapest option is often not the cheapest — that is the question, and I have not found it answered plainly anywhere I have looked. Documenting an access outcome, dated, because everything in this…	+21	25	55k	13mo
Coming back to: Reconciling a supplier certificate with an independent result Sourcing › Vendor reports documentation quality certificate of analysis batch & lot numbers Posting this under the heading it deserves: Reconciling a supplier certificate with an independent result Everything below is what sits behind that. Structured report rather than an opinion, following the…	+26	30	45k	16h
Why plausible mechanism is not evidence of effect Compounds › Repair & healing peptides TB-500 preprint observational data Solved Closed Asking directly, because I could not find a straight answer: Why plausible mechanism is not evidence of effect Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the discussion is much…	+14	18	57k	13mo
Follow-up: Recovery when intake is low: what to cut first Nutrition & Training › Resistance training DXA lean mass loss fatigue Posting this under the heading it deserves: Recovery when intake is low: what to cut first Everything below is what sits behind that. Longitudinal report with the method stated, because a number without a…	+36	40	38k	20mo
Second pass at: Trial registration and comparing the protocol with the paper Evidence › Trials estimand discontinuation & dropout randomised trial open label Posting this under the heading it deserves: Second pass at: Trial registration and comparing the protocol with the paper Everything below is what sits behind that. I have seen SCALE ( N Engl J Med , 2015)…	+30	34	33k	13mo
Temperature loggers worth the money Devices › Cold chain cold chain storage freeze-thaw Temperature loggers worth the money — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful to anyone else. Over 10…	+46	50	8k	9mo
Coming back to: Measurement error in a self-reported exposure Evidence › Study critique risk of bias observational data effect size disputed Measurement error in a self-reported exposure — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+23	27	49k	3mo
Chronic kidney disease and the FLOW result Clinical › Comorbidities PCOS blood pressure chronic kidney disease MASH / hepatic steatosis Solved Posting this under the heading it deserves: Chronic kidney disease and the FLOW result Everything below is what sits behind that. General question, not a request for advice about my own care — I know the…	+34	38	33k	23mo
Which fields on a certificate actually matter, ranked Analytics › COA interpretation reference standards certificate of analysis documentation quality batch & lot numbers Closed Which fields on a certificate actually matter, ranked — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first, because I know what the first three…	+25	29	46k	4mo
Filter needles: when they help and what they cost you Devices › Syringes & needles needle gauge & length subcutaneous injection dead volume On the subject in the title: Filter needles: when they help and what they cost you Working notes rather than a conclusion. A question about technique rather than about dose. I have been doing the same thing…	+45	50	19k	5mo
Vomiting: when it is expected and when it is a reason to stop — one year on Practice › Side effects nausea vomiting hair shedding Vomiting: when it is expected and when it is a reason to stop — one year on Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it,…	+19	23	49k	18h
Second pass at: Reimbursement variation across member states Regional › European Union personal import formulary cost per milligram EMA On the subject in the title: Second pass at: Reimbursement variation across member states Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+23	28	45k	21mo
Sample size intuition for a personal experiment — does this still hold? Research Methods › Statistics effect size heterogeneity number needed to treat Solved Sample size intuition for a personal experiment — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J Med , 2021) with…	+33	38	26k	23d
Escalating every six weeks instead of four: what I observed over eight months — one year on Practice › Dosing & titration missed dose semaglutide dose reduction titration On the subject in the title: Escalating every six weeks instead of four: what I observed over eight months — one year on Working notes rather than a conclusion. I have read the maintained page on this and I…	+55	59	9.1k	10mo
Micronutrient adequacy at low total intake — does this still hold? Nutrition & Training › Protein & intake fatigue lean mass loss micronutrients constipation Solved Closed Micronutrient adequacy at low total intake — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Longitudinal report with the method stated, because…	+21	25	45k	10mo
Reading a chromatogram someone posted without axes Analytics › HPLC & UHPLC HPLC UV & DAD detection gradient method data table Reading a chromatogram someone posted without axes — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in front…	+47	55	9.4k	13mo
Moderation log format change Meta › Announcements trust levels guidelines site feedback moderation Posting this under the heading it deserves: Moderation log format change Everything below is what sits behind that. Process question about how this site works. I have read the guidelines and the trust-level…	+53	57	4.8k	2mo
Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema effect size Posting this under the heading it deserves: Historical amylin analogues and what happened to them Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of a…	+29	36	31k	1d