d.bakker

TL2 Moderator · Faro

Contributes reviews on supplier material. Based in Faro.

Joined 12 May 2025 · last posted 3d

79 posts, newest first. Showing up to 150.

Revisiting: How this community labels and discusses unrefereed work Replied, post #34 · Evidence › Preprints · 25 Jul 2026 · 1 like Preprints for speed: some important preliminary findings are posted as preprints to disseminate quickly. That speed is useful but comes at the cost of not yet having…
Common supplements people ask about, assessed one at a time Replied, post #67 · Practice › Interactions · 19 Jul 2026 · 4 likes Worth separating two things that post #63 runs together. Two things before anyone answers the substance. First, the context in the first post is clear and specific.…
What to bring: records that a clinician can actually use — a second dataset Replied, post #48 · Clinical › Prescriber conversations · 18 Jul 2026 · 16 likes Understanding stopping rules: what would prompt stopping the compound? Adverse effect, lack of benefit after a defined time, or other reasons? Knowing in advance is…
What I would want from a home test that does not exist yet Replied, post #35 · Analytics › Home & field testing · 12 Jul 2026 · 4 likes post #34 answers the question as asked. The question underneath it is different. Enzyme assays: if you have an enzyme that reacts specifically with your compound, an…
Seven-day rolling means and why weekly readings mislead Replied, post #8 · Outcomes › Progress reports · 10 Jul 2026 · 4 likes Rate of change: reporting progress as "lost 5 kg in 12 weeks" is more useful than "currently at 82 kg" because the rate tells you whether the change is steady,…
Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #95 · Safety › Contraindications · 2 Jul 2026 · 4 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Deletion sequences: expected mass shifts by residue — the long version Started this topic · Analytics › Impurities & related substances · 1 Jul 2026 · 3 likes On the subject in the title: Deletion sequences: expected mass shifts by residue — the long version Working notes rather than a conclusion. Working through the identity…
Ultrasound and skinfolds: operator dependence in practice Replied, post #27 · Outcomes › Body composition · 23 Jun 2026 · 18 likes Lean mass loss during rapid weight reduction: depends on protein intake, resistance training volume, and total energy deficit. Adequate protein and maintaining training…
Follow-up: Reconciling a label claim with a content assay Replied, post #26 · Analytics › COA interpretation · 18 Jun 2026 · 1 like Sterility testing is separate: chromatographic purity, mass spectrometry, and endotoxin testing all say nothing about whether a solution is sterile. If sterility…
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just… Replied, post #116 · Compounds › Tirzepatide · 2 Jun 2026 · 0 likes SURMOUNT-4 used a randomised withdrawal design: everyone titrated, then those on maintenance were randomised to continue or placebo. Continuation maintained effect;…
Five questions in one post gets you one answer — how to split them Replied, post #82 · Start Here › How to Ask · 16 May 2026 · 4 likes Disagreement-style questions: "I read this and it contradicts what I heard here, which is right?" is answerable. "Is this a bad idea?" without giving the context is not.
Second pass at: Metformin co-administration and additive GI effects Replied, post #98 · Practice › Interactions · 4 May 2026 · 1 like Supplements and herbs: many have no established interaction. Some do. If you are taking something unusual, checking a reference (like a pharmacist) is more useful than…
Validating a method you did not develop Replied, post #15 · Analytics › Method validation · 1 May 2026 · 16 likes Worth separating two things that post #11 runs together. Accuracy: the method measures what you intend to measure. For purity methods, this is tested by…
Review: a draft on reconstitution arithmetic, with objections — one year on Replied, post #4 · Documentation › Doc review · 23 Apr 2026 · 0 likes Multilingual versions: if a maintained page should exist in another language, suggesting it here with your willingness to help translate can make it happen.
Second pass at: Where impurities in solid-phase peptide synthesis come from Replied, post #2 · Analytics › Impurities & related substances · 18 Apr 2026 · 4 likes Dimer and higher-order multimers: two or more peptide molecules bonded together. They appear at double the mass and higher. They may or may not separate from the…
[2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #37 · Devices › Syringes & needles · 17 Apr 2026 · 0 likes Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged…
Official shortage notices and what they authorise Replied, post #9 · Access › Shortages · 16 Apr 2026 · 7 likes Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are and following their communication is useful.
The "under review" status pill and when a moderator applies it Replied, post #64 · Evidence › Preprints · 9 Apr 2026 · 31 likes Worth separating two things that post #60 runs together. Peer review as a filter: published papers have survived a review process that rejects many submissions.…
What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still… Replied, post #13 · Compounds › Retatrutide · 8 Apr 2026 · 7 likes Coming back to post #11, because the follow-up matters more than the original answer. Mass and identity: a report on retatrutide should state the mass detected by…
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #127 · Pharmacology › Pharmacokinetics · 8 Apr 2026 · 0 likes Hepatic metabolism: the degree to which each compound is hepatically metabolised versus renally cleared is known but varies. Severe liver disease changes clearance.
Spike-and-recover accuracy for a peptide assay Replied, post #19 · Analytics › Method validation · 7 Apr 2026 · 16 likes Robustness: the method gives consistent results when minor parameters vary. Tested by deliberately varying pH, temperature, flow rate, and mobile phase composition…
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #57 · Analytics › Mass spectrometry · 5 Apr 2026 · 6 likes Purity and identity are different questions: LC-MS establishes that the species at a retention time has the expected mass. It does not establish how much of the sample…
Anaesthesia and elective surgery: the aspiration question Replied, post #70 · Practice › Interactions · 1 Apr 2026 · 15 likes Alcohol: no absolute contraindication but it raises gastrointestinal irritation risk and this drug class already does that. The conservative position during titration…
Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #16 · Outcomes › Progress reports · 7 Mar 2026 · 0 likes Measurement noise: day-to-day body mass varies by more than a kilogram on hydration, glycogen, and gut contents alone. A weekly reading is a single noisy sample of a…
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #33 · Pharmacology › Pharmacokinetics · 4 Feb 2026 · 3 likes I read post #31 twice before replying, because I had assumed the opposite. Accumulation at steady state: with a week-long half-life, steady-state concentration is…
Reading an interaction checker output critically Replied, post #107 · Practice › Interactions · 31 Jan 2026 · 14 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #26 · Clinical › Special populations · 28 Jan 2026 · 1 like Coming back to post #24, because the follow-up matters more than the original answer. Hepatic impairment: less is known about dosing in significant liver disease than…
Foaming during reconstitution and whether it matters — the long version Replied, post #11 · Practice › Reconstitution · 18 Jan 2026 · 7 likes Picking up post #8: that is the part I would want checked first. Over-dilution: if your target dose is 0.25 mg and your syringe is a 1 mL insulin syringe, you need a…
Cost per delivered dose, which is the number that matters Replied, post #37 · Access › Pricing · 8 Jan 2026 · 21 likes International pricing: the same compound costs very different amounts in different countries because healthcare systems and regulatory frameworks differ. Generally, US…
Second pass at: The topic list is dense — is that deliberate? Replied, post #38 · Meta › Site feedback · 7 Jan 2026 · 11 likes Navigation problems: if you cannot find something you expected to exist, or the path to it is unclear, report it. Site architecture affects usability.
Revisiting: Language barriers in accessing a prescription abroad Replied, post #41 · Access › International · 5 Jan 2026 · 19 likes post #40 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
Packaging that arrived damaged: documenting it properly — a second dataset Replied, post #15 · Sourcing › Logistics · 31 Dec 2025 · 0 likes I read post #13 twice before replying, because I had assumed the opposite. Customs outcomes are not predictable at the level of an individual parcel. What is…
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #70 · Wellbeing › Mental health · 31 Dec 2025 · 2 likes post #69 is right about the mechanism and I think understates the practical bit. When to involve a professional: if mood changes are persistent, deepen over weeks, or…
Substitution between formats during a shortage Replied, post #116 · Access › Shortages · 15 Dec 2025 · 0 likes Communication from suppliers: a supplier having supply problems usually communicates them. If a supplier goes silent, that is itself information.
The headache that turns out to be dehydration Replied, post #80 · Nutrition & Training › Hydration & electrolytes · 3 Dec 2025 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #20 · Clinical › Bloodwork · 1 Dec 2025 · 6 likes A single value outside interval: usually uninformative on a single draw. What makes a result interesting: a trend across multiple draws, a magnitude well beyond the…
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #24 · Pharmacology › Pharmacokinetics · 23 Nov 2025 · 22 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Pharmaceutical compounding rules, summarised from primary sources — a second dataset Replied, post #34 · Sourcing › Regulatory · 17 Nov 2025 · 14 likes Picking up post #31: that is the part I would want checked first. Why this category is maintained as documentation, not as recommendations: the goal is factual accuracy…
The anatomy of a question that gets answered within an hour — the long version Replied, post #95 · Start Here › How to Ask · 14 Nov 2025 · 0 likes Avoid "any advice?" at the end. It is so generic that people do not know which part of the post it refers to. Pick the specific part and ask that specific question…
Older adults, sarcopenia risk, and the trade-off nobody quantifies Replied, post #31 · Clinical › Special populations · 14 Nov 2025 · 1 like post #30 answers the question as asked. The question underneath it is different. Medullary thyroid carcinoma history: an absolute contraindication because of the…
The anatomy of a question that gets answered within an hour — the long version Replied, post #76 · Start Here › How to Ask · 9 Nov 2025 · 0 likes I read post #74 twice before replying, because I had assumed the opposite. Chromatogram questions: describe the method first. Column type, gradient, wavelength,…
Where to report an adverse event officially, by region — a second dataset Replied, post #107 · Safety › Adverse events · 8 Nov 2025 · 12 likes Medullary thyroid carcinoma is the reason these compounds are contraindicated in people with personal or family history of MTC or multiple endocrine neoplasia type 2.…
Where impurities in solid-phase peptide synthesis come from Replied, post #17 · Analytics › Impurities & related substances · 1 Nov 2025 · 5 likes Oxidation at methionine and tryptophan: adds 16 per oxygen. Usually elutes earlier. Oxidation is common in storage, especially if the solution is exposed to light or if…
Follow-up: What a seizure notice actually says Replied, post #31 · Sourcing › Logistics · 26 Oct 2025 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
What a purity-only report leaves out Replied, post #53 · Sourcing › Independent verification · 20 Oct 2025 · 23 likes Cost and turnaround: different services have different pricing and turnaround times. Janoshik's turnaround is weeks by mail; VendorInvestigate documentation review is…
Coming back to: Over-dilution: when your dose falls below one readable graduation Replied, post #66 · Practice › Reconstitution · 10 Oct 2025 · 10 likes post #65 answers the question as asked. The question underneath it is different. Foaming during reconstitution: bubbles in the solution are usually just air…
Documentation that appears only after payment Replied, post #35 · Sourcing › Red flags · 28 Sep 2025 · 0 likes Unresponsiveness: a supplier that does not reply to reasonable requests for documentation or clarification is showing you something about how they operate.
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #86 · Analytics › HPLC & UHPLC · 28 Sep 2025 · 0 likes Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and higher efficiency than larger particles (3.5 μm or 5 μm), at the cost of…
Reading a rodent study on a secretagogue without over-extrapolating Replied, post #47 · Compounds › Secretagogues & GH axis · 13 Sep 2025 · 28 likes This follows post #44 rather than contradicting it. Reading a rodent study on a secretagogue without over-extrapolating: rodent studies can show a mechanism is…
When a preprint is the best available evidence and we say so Replied, post #39 · Evidence › Preprints · 9 Aug 2025 · 0 likes Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on these servers are time-stamped and have DOIs even if they are later published elsewhere.…
A ten-fold dose error caught before injection Replied, post #78 · Devices › Syringes & needles · 7 Aug 2025 · 4 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Coming back to: What published stability data actually covers, and what it does not Replied, post #95 · Practice › Storage & stability · 24 Jul 2025 · 21 likes Picking up post #92: that is the part I would want checked first. Container choice matters: the material of the vial, the rubber closure, the fill volume all affect how…
Coming back to: Official shortage notices and what they authorise Replied, post #60 · Access › Shortages · 17 Jul 2025 · 22 likes Worth separating two things that post #56 runs together. Allocation and rationing: during severe shortages, suppliers might ration allocation to prescribers.…
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #6 · Analytics › HPLC & UHPLC · 11 Jul 2025 · 16 likes Worth separating two things that post #2 runs together. System suitability testing: injections run before and during the sample run to establish whether the instrument,…
Repeatability versus intermediate precision Replied, post #57 · Analytics › Method validation · 25 Jun 2025 · 33 likes Accuracy: the method measures what you intend to measure. For purity methods, this is tested by spike-and-recover experiments: add a known amount of impurity to a…
Lipase elevation without symptoms: the interpretation problem — a second dataset Replied, post #16 · Clinical › Bloodwork · 17 Jun 2025 · 0 likes This follows post #13 rather than contradicting it. A single value outside interval: usually uninformative on a single draw. What makes a result interesting: a trend…
Needle changes between doses on a reusable pen — does this still hold? Replied, post #6 · Devices › Pens & autoinjectors · 13 Jun 2025 · 2 likes post #5 answers the question as asked. The question underneath it is different. Off-label dosing with a pen: if you want to deliver a dose different from the pen's…
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Replied, post #26 · Evidence › Journal club · 5 Jun 2025 · 9 likes FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is…
Lipase elevation without symptoms: the interpretation problem — a second dataset Replied, post #9 · Clinical › Bloodwork · 4 Jun 2025 · 0 likes post #8 answers the question as asked. The question underneath it is different. Liver enzymes: elevation does not specify cause. ALT and AST can rise from many things.…
An orphaned page with no inbound links Replied, post #46 · Meta › Wiki maintenance · 28 May 2025 · 3 likes Cross-referencing: if two pages should reference each other but do not, suggesting the cross-reference helps the maintainer see the connection.
Second pass at: Designing a personal experiment that could change your mind Replied, post #33 · Research Methods › N-of-1 designs · 20 May 2025 · 0 likes When to run an n-of-1: this design works when you want to know whether a treatment works for you, not whether it works in general. For that purpose, it is efficient.
DXA precision and the least significant change for lean mass — the long version Replied, post #52 · Outcomes › Body composition · 16 May 2025 · 1 like post #51 is right about the mechanism and I think understates the practical bit. Bioelectric impedance analysis: less precise than DXA and strongly affected by…
Certificates issued by the seller versus by a laboratory Replied, post #36 · Analytics › COA interpretation · 8 Apr 2025 · 0 likes What fields matter on a certificate: lot number matching the vial, test date, the analytical method stated specifically, the measured result as a number, and the…
Revisiting: Aggregate verification data across the directory, with caveats Replied, post #3 · Sourcing › Independent verification · 6 Feb 2025 · 1 like Service differences on vendor pages: Janoshik and Medutest results are measurements on vials. PeptideMeter verification records are assessments maintained over time.…
Why the Start Here categories exist, and what they are not for — one year on Started this topic · Start Here › Welcome · 26 Jan 2025 · 60 likes Why the Start Here categories exist, and what they are not for — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. I…
Talking to a therapist about this specifically — does this still hold? Replied, post #5 · Wellbeing › Mental health · 13 Jan 2025 · 0 likes Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor…
About the Wiki requests category Replied, post #7 · Documentation › Wiki requests · 23 Dec 2024 · 0 likes Format suggestions: if you think a maintained page could be clearer in its presentation (different section structure, different examples, added graphics) suggest the…
UK access routes, dated and sourced — a second dataset Replied, post #17 · Regional › UK & Ireland · 18 Dec 2024 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Coming back to: When to suspect the method rather than the sample Replied, post #89 · Analytics › Method validation · 17 Dec 2024 · 13 likes I read post #87 twice before replying, because I had assumed the opposite. Range: the concentration range over which the method has been validated. Going outside the…
Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #15 · Devices › Cold chain · 29 Nov 2024 · 5 likes Reconstituted solutions: once reconstituted, solutions are less stable than lyophilised powder. Refrigerate prepared solutions immediately after preparation. Most…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #59 · Clinical › Special populations · 24 Nov 2024 · 26 likes Pancreatitis history: the compounds can rarely trigger pancreatitis. A history of pancreatitis makes monitoring for recurrence more important during titration.
Follow-up: Recovery when intake is low: what to cut first Replied, post #25 · Nutrition & Training › Resistance training · 15 Nov 2024 · 21 likes Volume: the number of sets per muscle group per week that supports muscle maintenance is roughly 12 to 18 hard sets. That varies by individual but gives a target range.
Second pass at: Pharmacy supply in the UK and the questions you will be asked Started this topic · Regional › UK & Ireland · 13 Nov 2024 · 35 likes Second pass at: Pharmacy supply in the UK and the questions you will be asked Writing it up because I had to work it out twice and would rather nobody else did. A…
Time to steady state after a dose increase Replied, post #51 · Pharmacology › Pharmacokinetics · 3 Nov 2024 · 18 likes Albumin binding: semaglutide binds albumin through a fatty side chain, which sequesters the free form and extends the half-life. Tirzepatide also has albumin binding…
Pancreatitis history and the risk calculus — a second dataset Replied, post #8 · Safety › Contraindications · 24 Sep 2024 · 29 likes Picking up post #5: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
Identical chromatograms across two different lots Replied, post #25 · Sourcing › Red flags · 14 Sep 2024 · 0 likes Documentation quality as a signal: a supplier that reports method identifiers, distinguishes specification from result, and states the counter-ion form is telling you…
Orforglipron as a non-peptide: what changes when the molecule is small Replied, post #4 · Compounds › Oral incretins · 25 Aug 2024 · 1 like Fasting instructions are not optional advice. Taking the tablet with food or with more than a sip of water measurably reduces absorption. This is the one compound in…
Progressive overload when the scale is falling — one year on Replied, post #4 · Nutrition & Training › Resistance training · 25 Aug 2024 · 32 likes Cardio and resistance: the interaction between energy-intense cardiovascular training and resistance training is real. Moderate cardio is fine; excessive endurance…
Circumference measurements as a poor man's composition estimate Replied, post #73 · Outcomes › Body composition · 17 Aug 2024 · 15 likes Lean mass loss during rapid weight reduction: depends on protein intake, resistance training volume, and total energy deficit. Adequate protein and maintaining training…