ne.laurent

TL2 Moderator · Breda

Contributes reviews on supplier material. Based in Breda.

Joined 3 October 2024 · last posted 1d

93 posts, newest first. Showing up to 150.

Pooling trials with different estimands Replied, post #132 · Evidence › Meta-analyses · 27 Jul 2026 · 4 likes Study quality and weighting: some meta-analyses weight all studies equally; others weight by study size or study quality. The choice affects the result and should be…
Selection into a registry and what it does to the estimate — a second dataset Replied, post #24 · Evidence › Study critique · 20 Jul 2026 · 3 likes Publication bias: a single published positive trial is weaker evidence than multiple published trials with consistent results. Asking whether there are unpublished…
eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #16 · Clinical › Bloodwork · 19 Jul 2026 · 0 likes Liver enzymes: elevation does not specify cause. ALT and AST can rise from many things. Bilirubin helps narrow down the cause. Multiple markers together are more…
Follow-up: Sleep quality changes during weight loss Replied, post #73 · Wellbeing › Sleep · 18 Jul 2026 · 4 likes Worth separating two things that post #69 runs together. Stimulants and sleep: if supplementing with caffeine or other stimulants for energy during weight loss, timing…
Request: a per-category review queue Replied, post #103 · Meta › Feature requests · 14 Jul 2026 · 2 likes Picking up post #100: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
Electrolyte supplements: which ones do anything Replied, post #52 · Nutrition & Training › Hydration & electrolytes · 10 Jul 2026 · 10 likes Magnesium: deficiency during weight loss is common and symptoms (fatigue, muscle cramps) are nonspecific. Supplementation is inexpensive and low-risk if needed.
Sleep quality changes during weight loss Replied, post #14 · Wellbeing › Sleep · 10 Jul 2026 · 3 likes Sleep apnoea improvement: as weight is lost, sleep apnoea usually improves. The timeframe is weeks to months, not immediate. Improvement often is gradual rather than…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #129 · Sourcing › Logistics · 10 Jul 2026 · 9 likes Documentation after arrival: photograph the parcel and its contents on arrival. If something later turns out wrong (damage, loss, wrong item) you have evidence of the…
I joined for one answer and stayed for a year — what changed my mind Replied, post #63 · Start Here › Welcome · 5 Jul 2026 · 1 like Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
What a good consultation looks like from the other side Replied, post #55 · Clinical › Prescriber conversations · 2 Jul 2026 · 3 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Pooling trials with different estimands Replied, post #49 · Evidence › Meta-analyses · 25 Jun 2026 · 17 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
[2026 update] Temperature indicator cards: worth asking for? Replied, post #8 · Sourcing › Logistics · 19 Jun 2026 · 1 like Picking up post #5: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #43 · Analytics › HPLC & UHPLC · 17 Jun 2026 · 6 likes On post #39 — agreed on the reasoning, with one qualification. Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and higher…
A site rotation scheme that is easy enough to actually follow Replied, post #83 · Practice › Administration · 8 Jun 2026 · 26 likes A genuinely late dose: the labelling generally says that if the next dose is more than a couple of days away, take it as soon as you notice. If the next dose is close,…
Insomnia at a dose step: reported experiences — the long version Replied, post #28 · Wellbeing › Sleep · 31 May 2026 · 0 likes Picking up post #25: that is the part I would want checked first. Sleep hygiene: basics (cool dark room, consistent sleep time, no screens before bed) matter more…
Revisiting: Mean kinetic temperature explained without the mathematics Replied, post #22 · Practice › Storage & stability · 30 May 2026 · 0 likes post #21 answers the question as asked. The question underneath it is different. Dating prepared solutions: write the date reconstitution on the vial in permanent…
Chain of custody for a sample you posted yourself — one year on Replied, post #21 · Sourcing › Independent verification · 28 May 2026 · 14 likes Picking up post #18: that is the part I would want checked first. Cost and turnaround: different services have different pricing and turnaround times. Janoshik's…
Rotating between abdomen, thigh and upper arm: absorption differences — one year on Replied, post #66 · Practice › Administration · 22 May 2026 · 0 likes A site rotation scheme that actually works: abdomen, outer thigh, back of arm, outer hip. Rotate through them in order, move a minimum 2 cm between consecutive sites,…
Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #35 · Safety › Contraindications · 11 May 2026 · 14 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #61 · Data & Tools › Datasets · 6 May 2026 · 12 likes Limitations of datasets: all community-collected data has limitations. The population is self-selected (people in this community are not representative of all people…
When a dose reduction is the correct response to a side effect Replied, post #15 · Practice › Dosing & titration · 25 Apr 2026 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Validating a calculator against hand arithmetic Replied, post #18 · Data & Tools › Calculators · 15 Apr 2026 · 6 likes Reconstitution calculator: enter vial mass, final volume target, and the calculator tells you concentration and syringe mark for a given dose. Useful for…
Sample handling between despatch and injection Replied, post #23 · Analytics › Method validation · 7 Apr 2026 · 0 likes Coming back to post #21, because the follow-up matters more than the original answer. Transfer between laboratories: a method can be transferred from one lab to…
Follow-up: State-level differences that actually matter Replied, post #53 · Regional › North America · 6 Apr 2026 · 0 likes post #52 is right about the mechanism and I think understates the practical bit. Indigenous healthcare systems: different indigenous healthcare systems have different…
The anatomy of a question that gets answered within an hour Replied, post #12 · Start Here › How to Ask · 6 Apr 2026 · 1 like Coming back to post #10, because the follow-up matters more than the original answer. Arithmetic questions: write out the steps. "I have a 10 mg vial, I added 2 mL, I…
Cold solution and stinging: the simplest fix Replied, post #11 · Practice › Administration · 28 Mar 2026 · 0 likes Air bubbles in a subcutaneous injection: the honest risk assessment is low. Tiny air bubbles in subcutaneous tissue do not behave like an air embolism in a blood…
Stability of BPC-157 in solution: what has been measured — one year on Replied, post #27 · Compounds › Repair & healing peptides · 25 Mar 2026 · 24 likes TB-500 is usually the 7-residue actin-binding fragment of thymosin beta-4, not the full 43-residue protein. The two are routinely conflated in supplier documentation…
Revisiting: Can a home kit substitute for a laboratory report? A careful no Replied, post #2 · Analytics › Home & field testing · 24 Mar 2026 · 20 likes This follows the opening post rather than contradicting it. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
Request declined, with reasoning — what changed since Replied, post #23 · Meta › Feature requests · 23 Mar 2026 · 26 likes Deprecation requests: if you think a feature should be removed or changed, that is also a request. Explain why you think it would improve the site.
[2026 update] Are there stupid questions here? A staff answer, at length Replied, post #26 · Start Here › Welcome · 21 Mar 2026 · 24 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #88 · Pharmacology › Pharmacokinetics · 20 Feb 2026 · 0 likes Picking up post #85: that is the part I would want checked first. Hepatic metabolism: the degree to which each compound is hepatically metabolised versus renally…
Second pass at: What to keep a record of at the point of payment Replied, post #11 · Sourcing › Payments · 17 Feb 2026 · 13 likes Bank transfer and finality: once a bank transfer is sent, it is final. The money is gone. There is no recourse with the bank if the supplier disappears. That is why…
Resolution and tailing factor: real acceptance criteria Started this topic · Analytics › HPLC & UHPLC · 12 Feb 2026 · 47 likes Resolution and tailing factor: real acceptance criteria Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand…
Trifluoroacetate content and its consequences Replied, post #132 · Analytics › Impurities & related substances · 11 Feb 2026 · 1 like Picking up post #129: that is the part I would want checked first. Incomplete deprotection: mass higher by the protecting group mass. Usually markedly later eluting. A…
How to read a phase 2 result without treating it as a phase 3 result — what changed since Replied, post #34 · Compounds › Retatrutide · 25 Jan 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Heterogeneity as information rather than as a nuisance Replied, post #61 · Evidence › Meta-analyses · 14 Jan 2026 · 0 likes Picking up post #58: that is the part I would want checked first. Publication bias: what did not get published? Small studies with negative results are less likely to…
Distinguishing expected GI effects from something that needs urgent attention Replied, post #70 · Practice › Side effects · 10 Jan 2026 · 0 likes Gallbladder complications: rapid weight loss increases the risk of gallstone formation. The mechanism is not specific to this drug class. The risk is greatest in the…
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long… Replied, post #51 · Pharmacology › Receptor biology · 10 Jan 2026 · 0 likes I read post #49 twice before replying, because I had assumed the opposite. Bias and desensitisation: receptors can be biased (preferentially activating some downstream…
Revisiting: Review: an evidence digest and the citation check that delayed it Replied, post #46 · Documentation › Doc review · 4 Jan 2026 · 0 likes post #45 answers the question as asked. The question underneath it is different. Citation checking: if a maintained page cites a paper, the citation should match what…
[2026 update] Reflux appearing for the first time at a dose step Replied, post #2 · Practice › Side effects · 1 Jan 2026 · 3 likes On the opening post — agreed on the reasoning, with one qualification. Vomiting: when it is expected (first-dose reactions or early titration) and when it is a reason…
Follow-up: The decimal-point error, and the habit that catches it Replied, post #131 · Practice › Reconstitution · 30 Dec 2025 · 0 likes Arithmetic step by step: a 5 mg vial with 2 mL of diluent gives (5 mg) / (2 mL) = 2.5 mg/mL. On a U-100 syringe at that concentration, 100 units = 1 mL = 2.5 mg, so…
Tracking a preprint to publication: a worked example Replied, post #91 · Evidence › Preprints · 9 Dec 2025 · 1 like post #90 is right about the mechanism and I think understates the practical bit. Discussing preprints in this community: bring them in for early discussion, label them…
Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a… Replied, post #45 · Analytics › Method validation · 6 Dec 2025 · 15 likes Picking up post #42: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
Reference intervals: how they are constructed and why one in twenty flags Replied, post #14 · Clinical › Bloodwork · 22 Nov 2025 · 19 likes Reference intervals: constructed to contain the central 95% of a reference population, which means one in twenty healthy people falls outside one by definition. Add…
Pen dose counters: what a click does and does not guarantee Replied, post #88 · Devices › Pens & autoinjectors · 18 Nov 2025 · 0 likes Priming: most pens require priming before the first use (injecting a small amount to fill the needle and line). Not priming can result in no dose being delivered on the…
Stepping down deliberately, and how to do it without losing progress Replied, post #9 · Practice › Dosing & titration · 30 Oct 2025 · 0 likes I read post #7 twice before replying, because I had assumed the opposite. Reaching a dose and staying there for a year: the question of whether a stable dose remains…
The anatomy of a question that gets answered within an hour — the long version Replied, post #16 · Start Here › How to Ask · 22 Oct 2025 · 4 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Payment mechanics and the recovery options that do not exist Replied, post #59 · Sourcing › Payments · 21 Oct 2025 · 15 likes post #58 is right about the mechanism and I think understates the practical bit. Fraud and scams: if a supplier demands payment upfront with no recourse if delivery…
The headache that turns out to be dehydration Replied, post #20 · Nutrition & Training › Hydration & electrolytes · 11 Oct 2025 · 0 likes Lab testing: if symptoms are severe or persistent, checking electrolytes and minerals (sodium, potassium, magnesium, calcium) and interpreting them in context of losses…
Oral semaglutide bioavailability and its variability between people Replied, post #8 · Compounds › Oral incretins · 7 Oct 2025 · 0 likes I read post #6 twice before replying, because I had assumed the opposite. Two things before anyone answers the substance. First, the context in the first post is clear…
Why semaglutide solutions can look faintly opalescent and when that matters Replied, post #21 · Compounds › Semaglutide · 3 Oct 2025 · 0 likes Semaglutide versus liraglutide in STEP 8: semaglutide produced greater weight reduction and the discontinuation rates differed. But the trial was open-label for the…
About the Prescriber conversations category Replied, post #8 · Clinical › Prescriber conversations · 29 Sep 2025 · 27 likes Prescription logistics: confirm whether it will be filled locally, requires mail order, or will be prescribed off-label and needs a compounding pharmacy. Different…
Lipase elevation without symptoms: the interpretation problem Replied, post #9 · Clinical › Bloodwork · 26 Sep 2025 · 0 likes Analytical imprecision: any measurement has an error margin. A small difference in consecutive tests is usually measurement noise, not a real change. Knowing the…
How to read a phase 2 result without treating it as a phase 3 result — what changed since Replied, post #5 · Compounds › Retatrutide · 20 Sep 2025 · 0 likes The phase 2 obesity paper reported dose-dependent weight reduction of a magnitude that attracted attention. It also reported dose-dependent heart-rate increases. The…
High-resolution MS on aggregates and what it can see Replied, post #70 · Analytics › Mass spectrometry · 17 Sep 2025 · 13 likes Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and its mass is predictable from the base mass.
Follow-up: Why appetite effects are mostly central Replied, post #41 · Pharmacology › Receptor biology · 15 Sep 2025 · 17 likes Cross-reactivity and selectivity: the compounds are not perfectly selective for their target receptors. Semaglutide has some activity on other receptors; tirzepatide…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #132 · Wellbeing › Mental health · 13 Sep 2025 · 0 likes I read post #130 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
Warfarin and altered intake: the monitoring argument — the long version Replied, post #14 · Practice › Interactions · 9 Sep 2025 · 8 likes Anticoagulants: no direct interaction with the compounds in this class. Weight loss and body composition changes might affect the clearance or effect of warfarin if you…
The nausea timeline across the first four weeks, with a tabulated log Replied, post #42 · Practice › Side effects · 6 Sep 2025 · 4 likes post #41 answers the question as asked. The question underneath it is different. Hair shedding: telogen effluvium associated with rapid weight loss is reported. The…
Follow-up: History of disordered eating and why it changes the conversation Replied, post #74 · Clinical › Special populations · 4 Sep 2025 · 0 likes Medullary thyroid carcinoma history: an absolute contraindication because of the preclinical findings in rodent toxicology. The history (personal or family, especially…
When a preprint is the best available evidence and we say so Replied, post #116 · Evidence › Preprints · 30 Aug 2025 · 0 likes Coming back to post #114, because the follow-up matters more than the original answer. Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on…
Thyroid function tests during substantial weight change Replied, post #34 · Clinical › Bloodwork · 18 Aug 2025 · 9 likes A single value outside interval: usually uninformative on a single draw. What makes a result interesting: a trend across multiple draws, a magnitude well beyond the…
When a preprint is the best available evidence and we say so Replied, post #59 · Evidence › Preprints · 15 Aug 2025 · 6 likes Unrefereed work is not worthless. A great deal of it survives review substantially unchanged. It is also the case that the version appearing in a journal frequently has…
Follow-up: Journal club: orforglipron phase 2 and the non-peptide question Replied, post #17 · Evidence › Journal club · 13 Aug 2025 · 33 likes TRIUMPH (ongoing): Retatrutide phase 3. No results yet. Nothing should be attributed to it because it has not finished. When it does, this discussion will return to it.
Pinch or no pinch, and how needle length changes the answer Replied, post #2 · Practice › Administration · 27 Jul 2025 · 14 likes the opening post answers the question as asked. The question underneath it is different. Leak-back after withdrawal: a small amount of liquid on the skin after…
Canadian access and provincial variation — one year on Replied, post #24 · Regional › North America · 24 Jul 2025 · 18 likes United States: FDA licenses compounds. Prescribing and pharmacy practice are state-regulated. Compounds are prescription-only. Coverage is decided by individual plans,…
Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #142 · Compounds › Cagrilintide & amylin analogues · 28 Jun 2025 · 30 likes Coming back to post #140, because the follow-up matters more than the original answer. The CagriSema phase 2 paper: a fixed combination of the two components in one…
Reading an MS report that only gives you a single number Replied, post #106 · Analytics › Mass spectrometry · 13 Jun 2025 · 21 likes This follows post #103 rather than contradicting it. Quantitation by MS: most quantitation is done by LC-UV detection at 214 nm, not by MS, because extinction…
[2026 update] An appeal that failed, and what I would do differently Replied, post #12 · Access › Insurance & coverage · 7 Jun 2025 · 18 likes Picking up post #9: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
[2026 update] Clearance pathways and what renal impairment changes Replied, post #22 · Pharmacology › Pharmacokinetics · 31 May 2025 · 1 like Albumin binding: semaglutide binds albumin through a fatty side chain, which sequesters the free form and extends the half-life. Tirzepatide also has albumin binding…
Second pass at: Two scans six weeks apart on different machines: a cautionary tale Started this topic · Outcomes › Body composition · 18 May 2025 · 41 likes Second pass at: Two scans six weeks apart on different machines: a cautionary tale Writing it up because I had to work it out twice and would rather nobody else did.…
Comparators chosen for regulatory reasons rather than clinical ones — one year on Replied, post #32 · Evidence › Trials · 17 May 2025 · 0 likes Risk of bias: structured appraisal of internal validity. Key things to assess: randomisation method (was it truly random or could someone predict the next assignment),…
Coming back to: Oxidation and deamidation mass shifts, tabulated Replied, post #8 · Analytics › Mass spectrometry · 16 May 2025 · 0 likes Mass accuracy is expressed in parts per million. It is the difference between observed and theoretical mass divided by theoretical mass, multiplied by a million. A…
Dizziness on standing: the ordinary explanation first Replied, post #5 · Nutrition & Training › Hydration & electrolytes · 22 Apr 2025 · 13 likes post #4 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
Talking to a therapist about this specifically — does this still hold? Replied, post #46 · Wellbeing › Mental health · 16 Apr 2025 · 11 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Reading a chromatogram someone posted without axes Replied, post #20 · Analytics › HPLC & UHPLC · 11 Apr 2025 · 3 likes Detection wavelength: 214 nm detects the peptide bond and is relatively insensitive to composition. 280 nm detects aromatic residues and is strongly…
Scheduled maintenance and what will be unavailable Replied, post #102 · Meta › Announcements · 8 Apr 2025 · 1 like Archives: older announcements are archived by date. Checking archives is useful if you want to know what changed when.
Research-use-only labelling: what it means and what it does not — the long version Replied, post #121 · Sourcing › Regulatory · 4 Apr 2025 · 31 likes Coming back to post #119, because the follow-up matters more than the original answer. Preclinical versus clinical: compounds with strong preclinical data can fail in…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #26 · Sourcing › Regulatory · 28 Feb 2025 · 15 likes Picking up post #23: that is the part I would want checked first. Compounding and pharmacy rules: some jurisdictions allow a pharmacy to compound a drug that is not on…
Why mass spectrometry cannot tell you about an epimer Replied, post #72 · Analytics › Mass spectrometry · 28 Feb 2025 · 0 likes Coming back to post #70, because the follow-up matters more than the original answer. Sample matrix effects: if a sample is dissolved in a complex matrix, other…
Coming back to: Recording a dissent on a document rather than suppressing it Replied, post #40 · Documentation › Doc review · 25 Feb 2025 · 22 likes Promoted topic withdrawal: if a promoted topic becomes outdated or inaccurate and the maintainer does not update, requesting withdrawal is appropriate.
Distinguishing a deletion sequence by mass alone Replied, post #116 · Analytics › Mass spectrometry · 21 Feb 2025 · 19 likes Picking up post #113: that is the part I would want checked first. Quantitation by MS: most quantitation is done by LC-UV detection at 214 nm, not by MS, because…
Revisiting: Bug report: the reconstitution calculator and a rounding edge case Replied, post #68 · Data & Tools › Calculators · 28 Jan 2025 · 3 likes post #67 answers the question as asked. The question underneath it is different. Reconstitution calculator: enter vial mass, final volume target, and the calculator…
Revisiting: Moderation log format change Replied, post #59 · Meta › Announcements · 8 Dec 2024 · 31 likes post #58 answers the question as asked. The question underneath it is different. For anyone arriving from a search: the marked solution above is the direct answer, and…
Washout with a one-week half-life: the arithmetic Replied, post #48 · Research Methods › N-of-1 designs · 1 Dec 2024 · 2 likes When to run an n-of-1: this design works when you want to know whether a treatment works for you, not whether it works in general. For that purpose, it is efficient.
Revisiting: Melanocortin agonists: mechanism and the documented adverse profile Replied, post #94 · Compounds › Other compounds · 5 Nov 2024 · 4 likes When "no data" is the complete and final answer: if there is no published human data on a compound, that is the state of knowledge. Hope is not a substitute and…
Time to steady state after a dose increase Replied, post #31 · Pharmacology › Pharmacokinetics · 3 Nov 2024 · 5 likes SNAC (the oral bioavailability enhancer): sodium N-(8-[2-hydroxybenzoyl]amino) caprylate transiently raises gastric pH and promotes absorption. Without it, oral…
Type 2 diabetes and the largest part of the evidence base — does this still hold? Replied, post #8 · Clinical › Comorbidities · 28 Sep 2024 · 0 likes This follows post #5 rather than contradicting it. PCOS and metabolic overlap: polycystic ovary syndrome has metabolic overlap with obesity and insulin resistance. Data…
Follow-up: A site rotation scheme that is easy enough to actually follow Replied, post #45 · Practice › Administration · 21 Sep 2024 · 0 likes Coming back to post #43, because the follow-up matters more than the original answer. Bleeding at the injection site: normal and usually minimal. A little blood at the…
Signs of dehydration worth acting on Replied, post #18 · Safety › Adverse events · 19 Sep 2024 · 4 likes Serious and unexpected events are the ones to document and report. Serious means hospitalization-level serious. Unexpected means not in the drug's known profile. Both…
Revisiting: Five questions in one post gets you one answer — how to split them Started this topic · Start Here › How to Ask · 6 Aug 2024 · 0 likes Revisiting: Five questions in one post gets you one answer — how to split them Writing it up because I had to work it out twice and would rather nobody else did.…
Second pass at: Journal club: LEADER as the historical anchor Replied, post #49 · Evidence › Journal club · 21 Jul 2024 · 8 likes post #48 is right about the mechanism and I think understates the practical bit. For anyone arriving from a search: the marked solution above is the direct answer, and…
Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #47 · Practice › Dosing & titration · 8 Jul 2024 · 3 likes Titrating on tolerability rather than on the calendar: some people escalate when they tolerate a dose well, others escalate on the prescribed schedule regardless. The…