Latest topics page 48

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 48 of 52

Topic	Participants	Replies	Views	Activity
Renal impairment: what the labelling says about dose Clinical › Special populations disordered eating adolescents bariatric surgery history older adults Wiki On the subject in the title: Renal impairment: what the labelling says about dose Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference…		4	8.9k	19mo
Here for the analytics and not much else — one year on Lounge › Introductions beginner friendly onboarding On the subject in the title: Here for the analytics and not much else — one year on Working notes rather than a conclusion. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim.…	+6	10	10k	19mo
Oxidation pathways for methionine and tryptophan Analytics › Impurities & related substances counter-ion content data table HPLC water content Posting this under the heading it deserves: Oxidation pathways for methionine and tryptophan Everything below is what sits behind that. Working through the identity arithmetic and I would like it checked.…	+58	63	1k	19mo
People with a low starting BMI: where the evidence stops Clinical › Special populations pregnancy & planning chronic kidney disease older adults Posting this under the heading it deserves: People with a low starting BMI: where the evidence stops Everything below is what sits behind that. Asking about a population rather than about a person. The…	+23	27	5.8k	19mo
Oral semaglutide bioavailability and its variability between people — a second dataset Compounds › Oral incretins randomised trial PIONEER programme SOUL trial Closed Oral semaglutide bioavailability and its variability between people — a second dataset — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support…	+141	154	47k	19mo
Coming back to: When to suspect the method rather than the sample Analytics › Method validation precision & repeatability LOD & LOQ linearity recovery Solved Wiki When to suspect the method rather than the sample I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first three…	+116	135	42k	19mo
Second pass at: A field-by-field walk through a certificate of analysis Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers amino acid analysis Solved Second pass at: A field-by-field walk through a certificate of analysis Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical…	+149	164	36k	19mo
Body image changing more slowly than the body Wellbeing › Mental health beginner friendly disordered eating mood Body image changing more slowly than the body — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this class…	+118	136	1.5k	19mo
TB-500 and thymosin beta-4: the fragment versus the protein — does this still hold? Compounds › Repair & healing peptides TB-500 BPC-157 needs a source Closed TB-500 and thymosin beta-4: the fragment versus the protein — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing STEP 8 ( JAMA , 2022)…	+19	23	4.2k	19mo
Molecular mass of semaglutide and why the figure differs between sources — does this still hold? Compounds › Semaglutide effect size type 2 diabetes STEP programme SELECT trial Solved Closed Molecular mass of semaglutide and why the figure differs between sources — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 (…	+94	102	14k	19mo
Converting between mg/mL and units per dose, both directions Practice › Reconstitution concentration maths dead volume bacteriostatic water Solved Posting this under the heading it deserves: Converting between mg/mL and units per dose, both directions Everything below is what sits behind that. Practical question with the units stated, because I have…	+106	142	9.5k	19mo
What would change my mind about repair peptides: a specific answer — one year on Compounds › Repair & healing peptides needs a source observational data TB-500 preprint Closed What would change my mind about repair peptides: a specific answer — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: STEP 1 ( N Engl J Med…	+9	13	42k	19mo
[2026 update] How to read a forest plot, properly, from scratch Evidence › Trials estimand discontinuation & dropout surrogate endpoints Solved How to read a forest plot, properly, from scratch — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it before…	+49	53	643	19mo
Building a sensible monitoring schedule with your prescriber Clinical › Bloodwork HbA1c eGFR & renal function lipase & amylase lipid panel Building a sensible monitoring schedule with your prescriber — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…	+91	108	52k	19mo
Persistent vomiting and the threshold for seeking help — one year on Safety › Adverse events hypoglycaemia vomiting gallbladder delayed gastric emptying Persistent vomiting and the threshold for seeking help — one year on Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own…	+39	43	596	19mo
Promotion criteria, and the one that stops most nominations Documentation › Doc review citation check review date wiki post promoted to docs Closed Promotion criteria, and the one that stops most nominations — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic…	+135	146	17k	19mo
Injection-site reactions: describing them precisely enough to be useful Practice › Side effects nausea delayed gastric emptying vomiting fatigue Injection-site reactions: describing them precisely enough to be useful Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it, in…	+81	86	3.6k	19mo
Revisiting: Moderation log format change Meta › Announcements guidelines trust levels moderation site feedback Revisiting: Moderation log format change Writing it up because I had to work it out twice and would rather nobody else did. Process question about how this site works. I have read the guidelines and the…	+66	71	9.1k	19mo
Meeting a protein target on a suppressed appetite — does this still hold? Nutrition & Training › Protein & intake micronutrients fatigue constipation Asking directly, because I could not find a straight answer: Meeting a protein target on a suppressed appetite — does this still hold? Longitudinal report with the method stated, because a number without a…	+56	61	45k	19mo
Second pass at: Choosing a concentration on purpose rather than by accident Practice › Reconstitution worked example dead volume reconstitution Second pass at: Choosing a concentration on purpose rather than by accident Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because…	+44	48	1k	19mo
Request: a diff view for wiki revisions Meta › Feature requests site feedback wiki post translation Request: a diff view for wiki revisions — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps…	+26	30	3.1k	19mo
Second opinions: how to seek one without burning the first Clinical › Prescriber conversations telehealth prior authorisation beginner friendly type 2 diabetes Closed Second opinions: how to seek one without burning the first Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own care — I…	+1	5	33k	19mo
Asking about a compound your prescriber has not heard of — one year on Clinical › Prescriber conversations beginner friendly type 2 diabetes prior authorisation Solved Under review On the subject in the title: Asking about a compound your prescriber has not heard of — one year on Working notes rather than a conclusion. General question, not a request for advice about my own care — I…	+11	15	3.7k	19mo
Two sessions a week versus four: what the evidence supports Nutrition & Training › Resistance training fatigue DXA lean mass loss Wiki On the subject in the title: Two sessions a week versus four: what the evidence supports Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method…	+27	31	22k	20mo
Why "any advice?" is the least effective ending for a post Start Here › How to Ask worked example guidelines site feedback beginner friendly The question in the title: Why "any advice?" is the least effective ending for a post I will give what I have already checked below so nobody repeats it. I want to check my reasoning rather than get a…	+115	126	55k	20mo
Washout with a one-week half-life: the arithmetic Research Methods › N-of-1 designs effect size data table worked example Wiki Washout with a one-week half-life: the arithmetic — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim I do not think it…	+90	96	44k	20mo
Coming back to: Research-use-only labelling: what it means and what it does not Sourcing › Regulatory MHRA personal import research use only Solved Research-use-only labelling: what it means and what it does not — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…	+45	50	39k	20mo
Follow-up: Semaglutide versus liraglutide head to head: reading STEP 8 carefully Compounds › Semaglutide effect size randomised trial SELECT trial STEP programme Semaglutide versus liraglutide head to head: reading STEP 8 carefully — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim…	+1	5	11k	20mo
Tracking semaglutide's approved indications across jurisdictions, dated — does this still hold? Compounds › Semaglutide randomised trial type 2 diabetes STEP programme effect size Solved Tracking semaglutide's approved indications across jurisdictions, dated — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SCALE ( N…	+58	62	49k	20mo
Taste changes and food aversion, reported and discussed Practice › Side effects fatigue nausea hair shedding delayed gastric emptying Solved Closed Posting this under the heading it deserves: Taste changes and food aversion, reported and discussed Everything below is what sits behind that. I have read the maintained page on this and I still have a gap,…	+40	47	28k	20mo