Latest topics page 46

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 46 of 52

Topic	Participants	Replies	Views	Activity
Contributing data without breaching anyone's privacy — what changed since Data & Tools › Datasets observational data confounding site feedback data table On the subject in the title: Contributing data without breaching anyone's privacy — what changed since Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a…		2	58k	17mo
Coming back to: The nausea timeline across the first four weeks, with a tabulated log Practice › Side effects constipation fatigue nausea delayed gastric emptying Wiki Posting this under the heading it deserves: The nausea timeline across the first four weeks, with a tabulated log Everything below is what sits behind that. Reporting something rather than asking about it, in…	+42	49	576	17mo
Reading a supplementary appendix and finding the interesting part Evidence › Trials open label discontinuation & dropout intention to treat estimand Reading a supplementary appendix and finding the interesting part — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do…	+87	92	1.1k	17mo
Coming back to: Adsorption to container surfaces and to plastics Pharmacology › Formulation chemistry bacteriostatic water counter-ion content storage sterile water Adsorption to container surfaces and to plastics — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise be.…		2	459	17mo
[2026 update] Lipid changes during rapid weight loss: the expected trajectory Clinical › Bloodwork thyroid function eGFR & renal function lipid panel lipase & amylase Lipid changes during rapid weight loss: the expected trajectory Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+51	56	7.1k	17mo
Random versus fixed effects: choosing rather than defaulting — a second dataset Evidence › Meta-analyses heterogeneity risk of bias publication bias On the subject in the title: Random versus fixed effects: choosing rather than defaulting — a second dataset Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it…	+95	106	20k	17mo
Canadian access and provincial variation Regional › North America compounding telehealth FDA insurance Posting this under the heading it deserves: Canadian access and provincial variation Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this category…	+74	80	7.7k	18mo
Protein density versus volume when you cannot eat much Nutrition & Training › Protein & intake constipation fatigue micronutrients On the subject in the title: Protein density versus volume when you cannot eat much Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method is not…	+89	105	20k	18mo
Cost per milligram, computed honestly across formats Access › Pricing formulary cost per milligram data table Posting this under the heading it deserves: Cost per milligram, computed honestly across formats Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…		2	47k	18mo
Identical chromatograms across two different lots Sourcing › Red flags mislabelling underdosing documentation quality Identical chromatograms across two different lots Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than…	+80	87	58k	18mo
Coming back to: Renal impairment: what the labelling says about dose Clinical › Special populations chronic kidney disease adolescents disordered eating pregnancy & planning Renal impairment: what the labelling says about dose — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this…	+30	34	48k	18mo
Revisiting: What a well-designed human trial of a secretagogue would look like Compounds › Secretagogues & GH axis CJC-1295 observational data needs a source GHRP class On the subject in the title: Revisiting: What a well-designed human trial of a secretagogue would look like Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it…	+69	74	25k	18mo
Feature request: should a dose-equivalence tool exist at all? Data & Tools › Calculators site feedback worked example concentration maths syringe units Closed Feature request: should a dose-equivalence tool exist at all? — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first, because I know what the first…	+21	25	4.8k	18mo
What changed in 2026, by region Access › International EMA NHS personal import Solved What changed in 2026, by region — that is the question, and I have not found it answered plainly anywhere I have looked. Documenting an access outcome, dated, because everything in this category expires. As…	+110	122	1.4k	18mo
Units, standards, and other things that quietly hold the world together — one year on Lounge › Off topic beginner friendly long read Solved On the subject in the title: Units, standards, and other things that quietly hold the world together — one year on Working notes rather than a conclusion. Lower-stakes topic, but the sourcing rule still…		2	91	18mo
Second pass at: A pen that felt like it delivered nothing: diagnosing it afterwards Devices › Pens & autoinjectors dead volume storage subcutaneous injection missed dose Second pass at: A pen that felt like it delivered nothing: diagnosing it afterwards — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I…	+9	13	829	18mo
Attributing a new peak: degradation product or excipient? Analytics › Impurities & related substances counter-ion content HPLC data table forced degradation Solved Closed Asking directly, because I could not find a straight answer: Attributing a new peak: degradation product or excipient? Posting the method first, because I know what the first three replies will otherwise be.…		2	15k	18mo
A claim built entirely on a subgroup analysis — what changed since Evidence › Study critique disputed effect size observational data risk of bias Closed On the subject in the title: A claim built entirely on a subgroup analysis — what changed since Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019) cited in support of a claim…		2	2k	18mo
Second pass at: Multiplicity when you track fifteen variables Research Methods › Statistics number needed to treat confounding effect size worked example Posting this under the heading it deserves: Second pass at: Multiplicity when you track fifteen variables Everything below is what sits behind that. I have seen SCALE ( N Engl J Med , 2015) cited in support…		2	12k	18mo
The topic list is dense — is that deliberate? Meta › Site feedback guidelines site feedback moderation Solved The topic list is dense — is that deliberate? — that is the question, and I have not found it answered plainly anywhere I have looked. Nominating something for promotion into the documentation commons. The…	+83	91	49k	18mo
Why our vendor pages link the storefront and mark it sponsored Sourcing › Vendor reports batch & lot numbers Janoshik Analytical certificate of analysis disputed Solved Why our vendor pages link the storefront and mark it sponsored — that is the question, and I have not found it answered plainly anywhere I have looked. A logistics question, since the answers here are usually…	+17	21	335	18mo
Second pass at: Certificates issued by the seller versus by a laboratory Analytics › COA interpretation certificate of analysis amino acid analysis batch & lot numbers Second pass at: Certificates issued by the seller versus by a laboratory — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+81	92	20k	18mo
Reporting a good result: why nobody bothers and why they should — one year on Sourcing › Vendor reports batch & lot numbers certificate of analysis documentation quality disputed Wiki Posting this under the heading it deserves: Reporting a good result: why nobody bothers and why they should — one year on Everything below is what sits behind that. Structured report rather than an opinion,…	+19	27	4.7k	18mo
Why the Start Here categories exist, and what they are not for — one year on Start Here › Welcome onboarding beginner friendly guidelines Solved Why the Start Here categories exist, and what they are not for — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather than…	+11	15	566	18mo
Gallbladder disease risk with rapid weight loss Clinical › Comorbidities obstructive sleep apnoea type 2 diabetes chronic kidney disease Solved Posting this under the heading it deserves: Gallbladder disease risk with rapid weight loss Everything below is what sits behind that. General question, not a request for advice about my own care — I know the…	+56	63	34k	18mo
Reading an MS report that only gives you a single number — the long version Analytics › Mass spectrometry mass error (ppm) counter-ion content LC-MS high-resolution MS Reading an MS report that only gives you a single number — the long version — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I…		2	47k	18mo
Levothyroxine timing: a real interaction with a simple fix Practice › Interactions needs a source metformin hypoglycaemia delayed gastric emptying Levothyroxine timing: a real interaction with a simple fix Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it, in case the…	+20	24	60k	18mo
Revisiting: Holding a dose indefinitely: is there a documented downside? Practice › Dosing & titration titration tirzepatide worked example missed dose Solved The question in the title: Revisiting: Holding a dose indefinitely: is there a documented downside? I will give what I have already checked below so nobody repeats it. A question about technique rather than…	+26	30	4.5k	18mo
Follow-up: Why this community will not facilitate a group purchase Sourcing › Payments documentation quality research use only payments Why this community will not facilitate a group purchase I have a specific reason for asking rather than idle curiosity, and the context is below. A logistics question, since the answers here are usually…		2	19k	18mo
Escalating every six weeks instead of four: what I observed over eight months Practice › Dosing & titration titration worked example dose reduction Escalating every six weeks instead of four: what I observed over eight months Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+27	31	432	18mo