Latest topics page 45

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 45 of 52

Topic	Participants	Replies	Views	Activity
Coming back to: Recording a dissent on a document rather than suppressing it Documentation › Doc review promoted to docs review date wiki post maintainership Posting this under the heading it deserves: Recording a dissent on a document rather than suppressing it Everything below is what sits behind that. Process question about how this site works. I have read the…	+43	47	11k	16mo
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Compounds › Secretagogues & GH axis GHRP class ipamorelin CJC-1295 needs a source Closed GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021)…	+9	13	249	17mo
Anaesthesia and elective surgery: the aspiration question — does this still hold? Practice › Interactions needs a source hypoglycaemia metformin Solved Anaesthesia and elective surgery: the aspiration question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Practical question with the units…	+23	27	5.6k	17mo
Why side effects reset at each escalation and that is not a failure — the long version Practice › Side effects nausea vomiting fatigue delayed gastric emptying The question in the title: Why side effects reset at each escalation and that is not a failure — the long version I will give what I have already checked below so nobody repeats it. Reporting something rather…		2	46k	17mo
Consistent declarations and why they matter more than clever ones Sourcing › Logistics packaging temperature excursion shipping customs Consistent declarations and why they matter more than clever ones — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+146	164	2k	17mo
What a seizure notice actually says Sourcing › Logistics shipping packaging customs Solved What a seizure notice actually says I have a specific reason for asking rather than idle curiosity, and the context is below. A logistics question, since the answers here are usually better than anywhere else…	+36	40	568	17mo
Revisiting: Bug report: the reconstitution calculator and a rounding edge case Data & Tools › Calculators worked example site feedback syringe units Revisiting: Bug report: the reconstitution calculator and a rounding edge case — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…	+109	122	5.8k	17mo
Why mass spectrometry cannot tell you about an epimer Analytics › Mass spectrometry LC-MS mass error (ppm) high-resolution MS charge states Why mass spectrometry cannot tell you about an epimer I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first three…	+75	82	4k	17mo
Prior authorisation: what the criteria usually require Access › Insurance & coverage prior authorisation formulary appeals insurance Solved On the subject in the title: Prior authorisation: what the criteria usually require Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+9	13	3.2k	17mo
Revisiting: Aggregate verification data across the directory, with caveats Sourcing › Independent verification PeptideMeter third-party testing blind sampling Medutest Closed Revisiting: Aggregate verification data across the directory, with caveats — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal,…	+22	26	23k	17mo
Titrating on tolerability rather than on the calendar — the long version Practice › Dosing & titration worked example missed dose titration tirzepatide Titrating on tolerability rather than on the calendar — the long version Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it, in…		2	7.7k	17mo
Retatrutide's phase 2 heart-rate signal and how to think about it — the long version Compounds › Retatrutide effect size randomised trial TRIUMPH programme Solved Retatrutide's phase 2 heart-rate signal and how to think about it — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med…		2	103	17mo
Pharmaceutical compounding rules, summarised from primary sources Sourcing › Regulatory MHRA EMA research use only Closed Pharmaceutical compounding rules, summarised from primary sources — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…	+135	163	46k	17mo
Second pass at: Regression to the mean in progress reports Research Methods › Statistics effect size worked example heterogeneity Second pass at: Regression to the mean in progress reports Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with STEP 4 ( JAMA ,…	+71	75	4k	17mo
Second pass at: Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics missed dose worked example semaglutide Posting this under the heading it deserves: Second pass at: Albumin binding and how it produces a long half-life Everything below is what sits behind that. I would like to understand what this number means…	+7	11	31k	17mo
Specification in the result column: why that is a meaningful error — the long version Analytics › COA interpretation batch & lot numbers documentation quality certificate of analysis reference standards Specification in the result column: why that is a meaningful error — the long version Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I…	+14	18	12k	17mo
Coming back to: How to tell whether your question is already answered on a maintained page Start Here › Welcome onboarding guidelines beginner friendly trust levels How to tell whether your question is already answered on a maintained page I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I…		2	808	17mo
SNAC and the mechanism of oral peptide absorption Compounds › Oral incretins orforglipron randomised trial PIONEER programme oral semaglutide On the subject in the title: SNAC and the mechanism of oral peptide absorption Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURPASS-4 ( Lancet , 2021) and finding the…	+13	17	14k	17mo
What we do not know about retatrutide, listed explicitly Compounds › Retatrutide retatrutide effect size preprint TRIUMPH programme The question in the title: What we do not know about retatrutide, listed explicitly I will give what I have already checked below so nobody repeats it. Comparing FLOW ( N Engl J Med , 2024) with SURMOUNT-OSA…	+106	113	4.8k	17mo
Coming back to: Official shortage notices and what they authorise Access › Shortages shortage FDA formulary Solved Closed Official shortage notices and what they authorise — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines…	+39	43	510	17mo
A request that was declined, and the reasoning Documentation › Wiki requests promoted to docs maintainership review date On the subject in the title: A request that was declined, and the reasoning Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the trust-level…		2	33k	17mo
Isotope patterns and why the monoisotopic peak is not the tallest Analytics › Mass spectrometry LC-MS MALDI-TOF mass error (ppm) high-resolution MS Isotope patterns and why the monoisotopic peak is not the tallest — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked.…	+12	16	7.5k	17mo
Distinguishing a deletion sequence by mass alone Analytics › Mass spectrometry mass error (ppm) high-resolution MS LC-MS MALDI-TOF Solved Distinguishing a deletion sequence by mass alone Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+121	129	25k	17mo
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand randomised trial number needed to treat effect size Journal club: SURPASS-2 and the semaglutide 1 mg comparator Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please read it before…	+126	138	31k	17mo
Revisiting: Heart failure with preserved ejection fraction: symptom endpoints Clinical › Comorbidities chronic kidney disease blood pressure obstructive sleep apnoea On the subject in the title: Revisiting: Heart failure with preserved ejection fraction: symptom endpoints Working notes rather than a conclusion. General question, not a request for advice about my own care…	+4	8	43k	17mo
Biased agonism: a real phenomenon, an over-used explanation — what changed since Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Biased agonism: a real phenomenon, an over-used explanation — what changed since — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I…	+49	56	47k	17mo
Semaglutide in people without diabetes: what the evidence base looks like Compounds › Semaglutide semaglutide effect size STEP programme randomised trial Semaglutide in people without diabetes: what the evidence base looks like Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SUSTAIN 6 ( N Engl J Med , 2016).…	+2	6	18k	17mo
Follow-up: Attributing a new peak: degradation product or excipient? Analytics › Impurities & related substances water content HPLC forced degradation endotoxin testing Solved Attributing a new peak: degradation product or excipient? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first…	+15	19	671	17mo
Amylin and gastric emptying: overlapping mechanisms with incretins Compounds › Cagrilintide & amylin analogues cagrisema amylin analogues randomised trial On the subject in the title: Amylin and gastric emptying: overlapping mechanisms with incretins Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting;…		2	50k	17mo
Coming back to: Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses meta-analysis publication bias heterogeneity risk of bias Reading a meta-analysis you disagree with, fairly Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…	+30	34	9.3k	17mo