Latest topics page 49

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 49 of 52

Topic	Participants	Replies	Views	Activity
Follow-up: Escalating every six weeks instead of four: what I observed over eight months Practice › Dosing & titration titration worked example tirzepatide dose reduction Escalating every six weeks instead of four: what I observed over eight months — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have…		4	164	20mo
A side-effect grading scheme this community uses, and its limits — the long version Practice › Side effects nausea vomiting hair shedding constipation Solved A side-effect grading scheme this community uses, and its limits — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in…	+19	23	29k	20mo
Why I ask for the gradient before I discuss the number Analytics › HPLC & UHPLC gradient method data table HPLC system suitability The question in the title: Why I ask for the gradient before I discuss the number I will give what I have already checked below so nobody repeats it. I would like to understand what this number means before I…	+35	39	4.9k	20mo
A revision dispute resolved on the topic rather than in the history — a second dataset Meta › Wiki maintenance moderation citation check maintainership wiki post Solved On the subject in the title: A revision dispute resolved on the topic rather than in the history — a second dataset Working notes rather than a conclusion. Process question about how this site works. I have…	+45	50	33k	20mo
Reading a preclinical wound-healing model and its relevance to a human tendon Compounds › Repair & healing peptides TB-500 preprint observational data Wiki Closed On the subject in the title: Reading a preclinical wound-healing model and its relevance to a human tendon Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019) cited in support…	+149	160	3.3k	20mo
Type 1 diabetes: off-label use and the evidence gap — what changed since Clinical › Special populations adolescents disordered eating older adults Solved Type 1 diabetes: off-label use and the evidence gap — what changed since — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The…	+68	77	31k	20mo
Revisiting: Melanocortin agonists: mechanism and the documented adverse profile Compounds › Other compounds custom synthesis mislabelling research use only Solved Posting this under the heading it deserves: Revisiting: Melanocortin agonists: mechanism and the documented adverse profile Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with…	+119	141	22k	20mo
Follow-up: Recovery when intake is low: what to cut first Nutrition & Training › Resistance training DXA lean mass loss fatigue Posting this under the heading it deserves: Recovery when intake is low: what to cut first Everything below is what sits behind that. Longitudinal report with the method stated, because a number without a…	+36	40	38k	20mo
How to ask for a dose change without antagonising anyone — what changed since Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes Solved How to ask for a dose change without antagonising anyone — what changed since — that is the question, and I have not found it answered plainly anywhere I have looked. General question, not a request for…	+81	92	10k	20mo
[2026 update] Insulin combinations and hypoglycaemia risk Practice › Interactions needs a source hypoglycaemia metformin Insulin combinations and hypoglycaemia risk Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how quickly these…		2	2.8k	20mo
Choosing which test to pay for, given a fixed budget — does this still hold? Sourcing › Independent verification PeptideMeter blind sampling Janoshik Analytical VendorInvestigate Choosing which test to pay for, given a fixed budget — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to talk about documentation…	+35	39	755	20mo
Training through a dose escalation week Nutrition & Training › Resistance training lean mass loss DXA fatigue Training through a dose escalation week — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes about. I have…		4	42k	20mo
EMA product information as a primary source — does this still hold? Regional › European Union EMA cost per milligram formulary personal import Solved Closed The question in the title: EMA product information as a primary source — does this still hold? I will give what I have already checked below so nobody repeats it. Documenting an access outcome, dated, because…	+127	150	41k	20mo
Revisiting: Five questions in one post gets you one answer — how to split them Start Here › How to Ask worked example guidelines beginner friendly site feedback Solved Revisiting: Five questions in one post gets you one answer — how to split them Writing it up because I had to work it out twice and would rather nobody else did. Question in the title. Context below, and I…	+2	6	13k	20mo
Merging two pages that cover the same ground — the long version Documentation › Wiki requests promoted to docs review date maintainership wiki post On the subject in the title: Merging two pages that cover the same ground — the long version Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and…	+5	9	209	20mo
Melanocortin agonists: mechanism and the documented adverse profile Compounds › Other compounds needs a source mislabelling research use only custom synthesis Melanocortin agonists: mechanism and the documented adverse profile — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURMOUNT-2 ( Lancet , 2023) and…	+7	11	5.5k	20mo
Chronic kidney disease and the FLOW result — a second dataset Clinical › Comorbidities MASH / hepatic steatosis blood pressure type 2 diabetes Chronic kidney disease and the FLOW result — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own care —…		2	2.3k	20mo
A well-designed study with a badly written abstract — does this still hold? Evidence › Study critique disputed confounding risk of bias Solved Closed A well-designed study with a badly written abstract — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J Med , 2021)…		2	28k	20mo
US compounding rules and how they changed Regional › North America FDA telehealth insurance Closed US compounding rules and how they changed — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the…	+62	68	1.4k	20mo
Transporting a vial for a weekend away Practice › Storage & stability temperature excursion freeze-thaw beyond-use date cloudy or discoloured solution Closed On the subject in the title: Transporting a vial for a weekend away Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go wrong without…	+39	45	35k	21mo
Second pass at: Reimbursement variation across member states Regional › European Union personal import formulary cost per milligram EMA On the subject in the title: Second pass at: Reimbursement variation across member states Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+23	28	45k	21mo
Time to steady state after a dose increase Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose On the subject in the title: Time to steady state after a dose increase Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+151	163	9.7k	21mo
[2026 update] Comparing tirzepatide and semaglutide is harder than the tables suggest Compounds › Tirzepatide effect size SURMOUNT programme tirzepatide randomised trial Comparing tirzepatide and semaglutide is harder than the tables suggest Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with SURMOUNT-1…		2	23k	21mo
Signs of dehydration worth acting on Safety › Adverse events gallbladder delayed gastric emptying pancreatitis vomiting Solved Signs of dehydration worth acting on — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this class mostly…	+34	38	5.9k	21mo
Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water storage Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+11	15	51k	21mo
Second pass at: Food noise reducing and the disorientation that can follow Wellbeing › Mental health beginner friendly disordered eating mood Closed Second pass at: Food noise reducing and the disorientation that can follow — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The…	+55	59	965	21mo
Irish differences from the UK position Regional › UK & Ireland MHRA cost per milligram NHS Solved Posting this under the heading it deserves: Irish differences from the UK position Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this category expires.…	+62	66	993	21mo
Hypertension improvement and when medication needs revisiting — a second dataset Clinical › Comorbidities blood pressure type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis Posting this under the heading it deserves: Hypertension improvement and when medication needs revisiting — a second dataset Everything below is what sits behind that. General question, not a request for…	+126	133	22k	21mo
Second pass at: Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water Wiki Second pass at: Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I…	+24	28	1.5k	21mo
Relative retention time as a better inter-laboratory comparator — does this still hold? Analytics › Method validation LOD & LOQ precision & repeatability stability-indicating method recovery Solved Wiki Relative retention time as a better inter-laboratory comparator — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A documentation question…	+11	15	21k	21mo