Ranked by engagement

Top topics — all time page 24

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 24 of 40

Topic	Participants	Replies	Views	Activity
Revisiting: Can a home kit substitute for a laboratory report? A careful no Analytics › Home & field testing ELISA LOD & LOQ documentation quality third-party testing Revisiting: Can a home kit substitute for a laboratory report? A careful no — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it…	+50	56	9.8k	1d
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Pharmacology › Receptor biology retatrutide amylin analogues semaglutide Posting this under the heading it deserves: Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long version Everything below is what sits behind that. I would like to understand…	+57	63	1k	6mo
Osteoarthritis and mechanical versus metabolic improvement — one year on Clinical › Comorbidities chronic kidney disease MASH / hepatic steatosis obstructive sleep apnoea blood pressure Under review On the subject in the title: Osteoarthritis and mechanical versus metabolic improvement — one year on Working notes rather than a conclusion. General question, not a request for advice about my own care — I…	+52	56	8.1k	15d
About the Vendor reports category Sourcing › Vendor reports certificate of analysis batch & lot numbers third-party testing Pinned Wiki Structured reports on named suppliers. Batch, date, method and document, or it stays in the unverified column. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…		4	65k	18mo
Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club randomised trial effect size journal club risk of bias Solved Posting this under the heading it deserves: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with SCALE ( N Engl J…	+47	51	617	16mo
Journal club: indirect comparison between two programmes, defended and attacked — one year on Evidence › Journal club randomised trial risk of bias effect size estimand Posting this under the heading it deserves: Journal club: indirect comparison between two programmes, defended and attacked — one year on Everything below is what sits behind that. Comparing SURPASS-2 ( N…	+45	50	3k	9mo
Interim analyses and stopping rules Evidence › Trials intention to treat surrogate endpoints open label discontinuation & dropout Interim analyses and stopping rules Writing it up because I had to work it out twice and would rather nobody else did. I have seen SUSTAIN 6 ( N Engl J Med , 2016) cited in support of a claim I do not think…	+25	29	35k	16d
Titles that describe the question, not the situation — what changed since Start Here › How to Ask beginner friendly site feedback worked example guidelines Posting this under the heading it deserves: Titles that describe the question, not the situation — what changed since Everything below is what sits behind that. Question in the title. Context below, and I…	+29	33	29k	10mo
AOD-9604 and the fragment hypothesis, revisited Compounds › Other compounds mislabelling research use only custom synthesis needs a source Posting this under the heading it deserves: AOD-9604 and the fragment hypothesis, revisited Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med , 2021) with SUSTAIN 6 ( N Engl J Med…	+40	44	2.8k	6mo
Residual solvents and scavengers: what is looked for Analytics › Impurities & related substances counter-ion content HPLC data table forced degradation Solved On the subject in the title: Residual solvents and scavengers: what is looked for Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will otherwise…	+19	23	39k	14mo
What a 2 ppm match establishes, and what it does not Analytics › Mass spectrometry high-resolution MS charge states LC-MS MALDI-TOF What a 2 ppm match establishes, and what it does not — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity arithmetic and I would like it…	+56	60	5.2k	9mo
[2026 update] How to read a forest plot, properly, from scratch Evidence › Trials estimand discontinuation & dropout surrogate endpoints Solved How to read a forest plot, properly, from scratch — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read it before…	+49	53	643	19mo
Hepatic effects of glucagon receptor agonism: the mechanistic worry Compounds › Retatrutide TRIUMPH programme effect size preprint randomised trial Solved Posting this under the heading it deserves: Hepatic effects of glucagon receptor agonism: the mechanistic worry Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read…	+51	56	700	22mo
Washout with a one-week half-life: the arithmetic — does this still hold? Research Methods › N-of-1 designs confounding data table worked example Solved Washout with a one-week half-life: the arithmetic — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021)…	+41	45	12k	1d
About the Other compounds category Compounds › Other compounds research use only custom synthesis needs a source Pinned Wiki Closed Anything not covered by a dedicated subcategory, including research-use-only material with no human data. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+8	12	51k	7mo
Second pass at: Choosing a concentration on purpose rather than by accident Practice › Reconstitution reconstitution syringe units concentration maths Second pass at: Choosing a concentration on purpose rather than by accident Writing it up because I had to work it out twice and would rather nobody else did. A question about technique rather than about…	+49	54	6k	4mo
A fridge failure and how I assessed the contents afterwards Devices › Cold chain cold chain storage temperature excursion A fridge failure and how I assessed the contents afterwards Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a gap,…	+14	18	46k	17h
[2026 update] Are there stupid questions here? A staff answer, at length Start Here › Welcome guidelines trust levels onboarding Solved Closed Are there stupid questions here? A staff answer, at length — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried to…	+36	40	2.4k	1mo
Revisiting: Maintainer handover: how it works Meta › Wiki maintenance maintainership review date wiki post moderation Solved Revisiting: Maintainer handover: how it works Writing it up because I had to work it out twice and would rather nobody else did. Process question about how this site works. I have read the guidelines and the…	+53	57	664	4mo
Why this subcategory is stricter about sourcing than most Compounds › Secretagogues & GH axis observational data tesamorelin needs a source GHRP class Wiki Asking directly, because I could not find a straight answer: Why this subcategory is stricter about sourcing than most Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+48	52	617	21d
Batch numbers that do not match the vial label Sourcing › Red flags mislabelling disputed moderation underdosing Solved Batch numbers that do not match the vial label — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal, separately from product…	+43	48	8.9k	2d
When a preprint is the best available evidence and we say so — a second dataset Evidence › Preprints preprint risk of bias needs a source Solved When a preprint is the best available evidence and we say so — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med ,…	+20	24	36k	14mo
About the Body composition category Outcomes › Body composition DXA bioimpedance lean mass loss Pinned Wiki DXA, BIA, ultrasound and the precision of each. Lean mass preservation during rapid loss. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…		5	64k	15mo
Robustness: the parameters worth deliberately varying Analytics › Method validation stability-indicating method linearity precision & repeatability Robustness: the parameters worth deliberately varying Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…	+53	57	664	8mo
[2026 update] Reverting an edit that had no revision note Meta › Wiki maintenance wiki post citation check maintainership Reverting an edit that had no revision note — setting out what I have, and where I think it stops being reliable. Process question about how this site works. I have read the guidelines and the trust-level…	+8	12	54k	12mo
Two sessions a week versus four: what the evidence supports Nutrition & Training › Resistance training fatigue DXA lean mass loss Wiki On the subject in the title: Two sessions a week versus four: what the evidence supports Working notes rather than a conclusion. Longitudinal report with the method stated, because a number without a method…	+27	31	22k	20mo
The anatomy of a question that gets answered within an hour — does this still hold? Start Here › How to Ask beginner friendly onboarding site feedback guidelines The anatomy of a question that gets answered within an hour — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context…	+19	23	40k	14d
Documenting a supplier's response to a discrepancy Sourcing › Vendor reports third-party testing documentation quality batch & lot numbers Solved On the subject in the title: Documenting a supplier's response to a discrepancy Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers asked…	+44	49	589	8h
Orforglipron as a non-peptide: what changes when the molecule is small Compounds › Oral incretins orforglipron SOUL trial PIONEER programme On the subject in the title: Orforglipron as a non-peptide: what changes when the molecule is small Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURMOUNT-4 ( JAMA ,…	+26	30	26k	23mo
Follow-up: Review cadence: how often is a page actually re-checked? Documentation › Doc review wiki post citation check maintainership promoted to docs Solved The question in the title: Review cadence: how often is a page actually re-checked? I will give what I have already checked below so nobody repeats it. Nominating something for promotion into the…		2	64k	16mo