Ranked by engagement

Top topics — all time page 25

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

1,535 topics · page 25 of 40

Topic	Participants	Replies	Views	Activity
Coming back to: A newcomer's list of things that confused me, and the fixes Start Here › Welcome guidelines onboarding trust levels beginner friendly Posting this under the heading it deserves: A newcomer's list of things that confused me, and the fixes Everything below is what sits behind that. Question in the title. Context below, and I have tried to…	+4	8	57k	23d
Spreadsheets: an appreciation Lounge › Off topic beginner friendly long read On the subject in the title: Spreadsheets: an appreciation Working notes rather than a conclusion. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim. Something adjacent that I…	+26	30	25k	2.1y
Second pass at: A pooled estimate that changed when one trial was added Evidence › Meta-analyses effect size risk of bias publication bias meta-analysis Wiki On the subject in the title: Second pass at: A pooled estimate that changed when one trial was added Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before…	+26	30	22k	1mo
Athletes in weight-category sports: a different risk calculus — a second dataset Clinical › Special populations pregnancy & planning disordered eating bariatric surgery history Pinned On the subject in the title: Athletes in weight-category sports: a different risk calculus — a second dataset Working notes rather than a conclusion. General question, not a request for advice about my own…	+37	41	16k	20mo
Meeting a protein target on a suppressed appetite Nutrition & Training › Protein & intake constipation micronutrients lean mass loss fatigue Meeting a protein target on a suppressed appetite Writing it up because I had to work it out twice and would rather nobody else did. Longitudinal report with the method stated, because a number without a…	+39	44	11k	7mo
Second pass at: What pooling buys you and what it destroys Evidence › Meta-analyses risk of bias meta-analysis heterogeneity Posting this under the heading it deserves: Second pass at: What pooling buys you and what it destroys Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim…	+32	36	19k	4mo
Revisiting: Aggregates and why a purity assay may miss them entirely Analytics › Impurities & related substances endotoxin testing HPLC counter-ion content water content Solved Posting this under the heading it deserves: Revisiting: Aggregates and why a purity assay may miss them entirely Everything below is what sits behind that. I would like to understand what this number means…	+48	53	918	8mo
Revisiting: Patterns that reliably precede a problem, documented Sourcing › Red flags underdosing moderation mislabelling documentation quality Posting this under the heading it deserves: Revisiting: Patterns that reliably precede a problem, documented Everything below is what sits behind that. A logistics question, since the answers here are usually…	+16	20	36k	2mo
Tirzepatide and nausea: is the profile genuinely different or just differently reported? Compounds › Tirzepatide SURMOUNT programme randomised trial SURPASS programme tirzepatide Asking directly, because I could not find a straight answer: Tirzepatide and nausea: is the profile genuinely different or just differently reported? Comparing PIONEER 6 ( N Engl J Med , 2019) with STEP 8 (…	+18	22	37k	8mo
MS/MS sequence confirmation: what it costs and when it is worth it — what changed since Analytics › Mass spectrometry charge states LC-MS MALDI-TOF counter-ion content Closed Posting this under the heading it deserves: MS/MS sequence confirmation: what it costs and when it is worth it — what changed since Everything below is what sits behind that. Working through the identity…	+34	39	21k	1mo
Revisiting: Food effects on oral incretin absorption: what is documented Compounds › Oral incretins oral semaglutide PIONEER programme SOUL trial orforglipron Under review Revisiting: Food effects on oral incretin absorption: what is documented — setting out what I have, and where I think it stops being reliable. Session topic: SURMOUNT-2 ( Lancet , 2023). Please read it before…	+6	10	51k	13mo
Refrigerated versus room temperature: the trade-off stated plainly Practice › Storage & stability cold chain cloudy or discoloured solution storage beyond-use date Refrigerated versus room temperature: the trade-off stated plainly Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have…		2	66k	2y
Coming back to: Semaglutide in people without diabetes: what the evidence base looks like Compounds › Semaglutide effect size randomised trial SELECT trial On the subject in the title: Semaglutide in people without diabetes: what the evidence base looks like Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before…	+41	46	1.2k	4mo
Coming back to: The nausea timeline across the first four weeks, with a tabulated log Practice › Side effects constipation fatigue nausea delayed gastric emptying Wiki Posting this under the heading it deserves: The nausea timeline across the first four weeks, with a tabulated log Everything below is what sits behind that. Reporting something rather than asking about it, in…	+42	49	576	17mo
Revisiting: Why I ask for the gradient before I discuss the number Analytics › HPLC & UHPLC UV & DAD detection data table peak integration system suitability Posting this under the heading it deserves: Revisiting: Why I ask for the gradient before I discuss the number Everything below is what sits behind that. I would like to understand what this number means…	+15	19	43k	10mo
Dose numbers for oral formulations are not comparable to injectable ones Compounds › Oral incretins orforglipron PIONEER programme SOUL trial On the subject in the title: Dose numbers for oral formulations are not comparable to injectable ones Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it…	+19	23	39k	6mo
Coverage in the US: a map of the usual obstacles Regional › North America FDA insurance telehealth compounding Coverage in the US: a map of the usual obstacles — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the…	+46	50	7.9k	5mo
Follow-up: Signs of dehydration worth acting on Safety › Adverse events delayed gastric emptying pancreatitis hypoglycaemia Posting this under the heading it deserves: Signs of dehydration worth acting on Everything below is what sits behind that. General question, not a request for advice about my own care — I know the difference…	+35	39	9.8k	1d
[2026 update] Reading a supplementary appendix and finding the interesting part Evidence › Trials estimand intention to treat open label surrogate endpoints On the subject in the title: Reading a supplementary appendix and finding the interesting part Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with FLOW ( N Engl J Med , 2024)…	+39	44	8.2k	5mo
Second pass at: Programming during a large energy deficit Nutrition & Training › Resistance training DXA lean mass loss fatigue Posting this under the heading it deserves: Second pass at: Programming during a large energy deficit Everything below is what sits behind that. Longitudinal report with the method stated, because a number…	+44	48	632	30d
Second pass at: Where impurities in solid-phase peptide synthesis come from Analytics › Impurities & related substances counter-ion content data table endotoxin testing HPLC Closed Posting this under the heading it deserves: Second pass at: Where impurities in solid-phase peptide synthesis come from Everything below is what sits behind that. A documentation question rather than an…	+47	51	3.3k	5mo
Second pass at: The storage lookup and where its data comes from Data & Tools › Calculators concentration maths syringe units site feedback worked example On the subject in the title: Second pass at: The storage lookup and where its data comes from Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a…	+38	42	13k	19d
Buffers, pH and why a formulation is a formulation Pharmacology › Formulation chemistry counter-ion content cloudy or discoloured solution sterile water storage Buffers, pH and why a formulation is a formulation Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+11	15	51k	21mo
BPC-157: what the rodent literature actually shows, and what it does not Compounds › Repair & healing peptides observational data preprint BPC-157 needs a source BPC-157: what the rodent literature actually shows, and what it does not — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a…	+44	48	3k	10mo
The retatrutide phase 2 obesity paper, read closely Compounds › Retatrutide preprint effect size TRIUMPH programme Posting this under the heading it deserves: The retatrutide phase 2 obesity paper, read closely Everything below is what sits behind that. Session topic: STEP 8 ( JAMA , 2022). Please read it before posting;…		2	65k	10mo
Second pass at: Coverage in the US: a map of the usual obstacles Regional › North America insurance telehealth compounding FDA On the subject in the title: Second pass at: Coverage in the US: a map of the usual obstacles Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…		4	62k	9mo
Why semaglutide's albumin binding is the whole reason weekly dosing works Compounds › Semaglutide STEP programme SELECT trial randomised trial effect size Solved Closed Asking directly, because I could not find a straight answer: Why semaglutide's albumin binding is the whole reason weekly dosing works Session topic: SELECT ( N Engl J Med , 2023). Please read it before…		2	63k	5mo
Impurity thresholds: where the common numbers come from — what changed since Analytics › Impurities & related substances counter-ion content HPLC endotoxin testing water content Solved Posting this under the heading it deserves: Impurity thresholds: where the common numbers come from — what changed since Everything below is what sits behind that. A documentation question rather than an…		2	61k	3mo
Why oral semaglutide needs an absorption enhancer at all — what changed since Compounds › Oral incretins randomised trial PIONEER programme SOUL trial Solved Asking directly, because I could not find a straight answer: Why oral semaglutide needs an absorption enhancer at all — what changed since Session topic: STEP 2 ( Lancet , 2021). Please read it before…		2	61k	14mo
Racemisation and why it is invisible to a mass measurement — what changed since Analytics › Impurities & related substances forced degradation water content counter-ion content Racemisation and why it is invisible to a mass measurement — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I…	+11	15	42k	16d