Ranked by engagement

Top topics — all time page 26

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 26 of 40

Topic	Participants	Replies	Views	Activity
Residual solvents and scavengers: what is looked for — what changed since Analytics › Impurities & related substances forced degradation water content data table HPLC Solved Residual solvents and scavengers: what is looked for — what changed since — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three…	+37	41	7k	2mo
Electrolyte supplements: which ones do anything — a second dataset Nutrition & Training › Hydration & electrolytes fatigue heart rate blood pressure Electrolyte supplements: which ones do anything — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this…		2	59k	15mo
Second pass at: Submitting a sample: the process end to end Sourcing › Independent verification Janoshik Analytical PeptideMeter Medutest blind sampling Solved Second pass at: Submitting a sample: the process end to end Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better…	+12	16	41k	4mo
Enforcement priorities versus written rules Sourcing › Regulatory FDA personal import MHRA Enforcement priorities versus written rules — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal, separately from product quality.…		2	62k	15mo
Ultrasound and skinfolds: operator dependence in practice — what changed since Outcomes › Body composition data table DXA bioimpedance lean mass loss Posting this under the heading it deserves: Ultrasound and skinfolds: operator dependence in practice — what changed since Everything below is what sits behind that. Longitudinal report with the method…	+32	37	7.4k	3mo
When a dose reduction is the correct response to a side effect — a second dataset Practice › Dosing & titration worked example dose reduction titration tirzepatide When a dose reduction is the correct response to a side effect — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on…	+10	14	42k	2mo
A side-effect grading scheme this community uses, and its limits — the long version Practice › Side effects nausea vomiting hair shedding constipation Solved A side-effect grading scheme this community uses, and its limits — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in…	+19	23	29k	20mo
Bleeding at the injection site: normal, and what to do about it Practice › Administration injection site reaction aseptic technique subcutaneous injection injection site rotation Solved Bleeding at the injection site: normal, and what to do about it — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the…		3	59k	8mo
Pharmaceutical compounding rules, summarised from primary sources — a second dataset Sourcing › Regulatory MHRA research use only compounding Posting this under the heading it deserves: Pharmaceutical compounding rules, summarised from primary sources — a second dataset Everything below is what sits behind that. A logistics question, since the…	+50	56	780	8mo
Pen wastage and its effect on real cost Access › Pricing cost per milligram compounding formulary data table Pen wastage and its effect on real cost Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is what determines…	+29	33	19k	21mo
Sample size intuition for a personal experiment Research Methods › Statistics number needed to treat heterogeneity confounding effect size On the subject in the title: Sample size intuition for a personal experiment Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the discussion is…		4	62k	18mo
Why appetite effects are mostly central Pharmacology › Receptor biology amylin analogues tirzepatide semaglutide long read Why appetite effects are mostly central I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first three replies will…		2	56k	16mo
Immortal time bias in a claims-database study — one year on Evidence › Study critique effect size risk of bias confounding Solved Posting this under the heading it deserves: Immortal time bias in a claims-database study — one year on Everything below is what sits behind that. Comparing SURPASS-2 ( N Engl J Med , 2021) with SURMOUNT-1 (…	+41	46	3.7k	22h
History of disordered eating and why it changes the conversation Clinical › Special populations older adults chronic kidney disease adolescents bariatric surgery history Closed History of disordered eating and why it changes the conversation Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The…	+20	24	30k	8mo
Revisiting: Filing a first vendor report: a worked example Sourcing › Vendor reports batch & lot numbers documentation quality third-party testing disputed On the subject in the title: Revisiting: Filing a first vendor report: a worked example Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers…		2	60k	11mo
The most common factual error about semaglutide on the internet — what changed since Compounds › Semaglutide effect size randomised trial SELECT trial type 2 diabetes The most common factual error about semaglutide on the internet — what changed since — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 1 ( N…	+42	46	1.7k	5mo
Tracking a preprint to publication: a worked example — the long version Evidence › Preprints risk of bias preprint effect size Posting this under the heading it deserves: Tracking a preprint to publication: a worked example — the long version Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 2 (…	+38	47	560	22mo
Publication patterns in the BPC-157 literature, examined Compounds › Repair & healing peptides preprint BPC-157 TB-500 needs a source Solved Posting this under the heading it deserves: Publication patterns in the BPC-157 literature, examined Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of…	+40	45	3.4k	21h
A vial that will not fully dissolve: what to check and in what order Practice › Reconstitution reconstitution bacteriostatic water syringe units Solved A vial that will not fully dissolve: what to check and in what order — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+12	16	40k	15mo
Second pass at: Designing a personal experiment that could change your mind Research Methods › N-of-1 designs worked example effect size confounding data table Solved Second pass at: Designing a personal experiment that could change your mind Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please…	+39	44	632	14mo
Mood changes: monitoring, and when to involve a professional — what changed since Wellbeing › Mental health beginner friendly disordered eating mood Solved Mood changes: monitoring, and when to involve a professional — what changed since Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice…	+6	10	45k	25d
Revisiting: Filter needles: when they help and what they cost you Devices › Syringes & needles worked example needle gauge & length subcutaneous injection dead volume Closed Revisiting: Filter needles: when they help and what they cost you — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the…	+48	52	6.6k	11mo
[2026 update] US compounding rules and how they changed Regional › North America FDA compounding insurance Solved US compounding rules and how they changed Writing it up because I had to work it out twice and would rather nobody else did. Documenting an access outcome, dated, because everything in this category expires.…	+32	37	7.4k	10mo
Multiplicity when you track fifteen variables Research Methods › Statistics effect size heterogeneity confounding worked example Solved Multiplicity when you track fifteen variables — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-OSA ( N Engl J Med , 2024) and finding…		2	60k	11mo
About the Impurities & related substances category Analytics › Impurities & related substances forced degradation counter-ion content water content Pinned Wiki Deletion sequences, oxidation, deamidation, aggregates, residual solvents, and counter-ion content. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…	+6	10	50k	15h
What the GIP component of tirzepatide is thought to contribute, and how confident we can be — the long version Compounds › Tirzepatide SURMOUNT programme randomised trial effect size tirzepatide Solved Asking directly, because I could not find a straight answer: What the GIP component of tirzepatide is thought to contribute, and how confident we can be — the long version Comparing PIONEER 6 ( N Engl J Med ,…	+48	52	609	10mo
An orphaned page with no inbound links Meta › Wiki maintenance wiki post maintainership citation check moderation An orphaned page with no inbound links — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The topic in question keeps…	+44	48	7.5k	14mo
Guidelines revision: what changed and why — does this still hold? Meta › Announcements trust levels site feedback guidelines moderation Guidelines revision: what changed and why — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Process question about how this site works. I have…		2	58k	7mo
How this community escalates rather than diagnoses Safety › Adverse events delayed gastric emptying hypoglycaemia vomiting gallbladder Solved How this community escalates rather than diagnoses — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about a population rather than about a person. The published…		4	51k	8mo
When a red flag was a misunderstanding, and the retraction Sourcing › Red flags underdosing disputed mislabelling Pinned When a red flag was a misunderstanding, and the retraction — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to talk about documentation quality as a…	+34	38	8.3k	21mo