Ranked by engagement

Top topics — this month page 9

Ranked by replies, likes and views over this month, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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374 topics · page 9 of 13

Topic	Participants	Replies	Views	Activity
What a regulator's shortage notice actually authorises Sourcing › Regulatory personal import research use only EMA FDA Solved What a regulator's shortage notice actually authorises — that is the question, and I have not found it answered plainly anywhere I have looked. A logistics question, since the answers here are usually better…	+8	12	15k	17h
Compounds this community declines to help with, and why — does this still hold? Compounds › Other compounds custom synthesis research use only mislabelling Compounds this community declines to help with, and why — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SCALE ( N Engl J Med ,…	+3	7	26k	7h
Retatrutide mass and identity: what a report should show Compounds › Retatrutide TRIUMPH programme preprint retatrutide effect size Solved Posting this under the heading it deserves: Retatrutide mass and identity: what a report should show Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with STEP 4 ( JAMA , 2021)…	+22	27	872	22h
Reading a syringe in poor light, and how to avoid needing to — what changed since Devices › Syringes & needles dead volume subcutaneous injection syringe units needle gauge & length Posting this under the heading it deserves: Reading a syringe in poor light, and how to avoid needing to — what changed since Everything below is what sits behind that. I have read the maintained page on this…	+3	7	27k	27d
What to bring: records that a clinician can actually use Clinical › Prescriber conversations beginner friendly type 2 diabetes prior authorisation Solved Asking directly, because I could not find a straight answer: What to bring: records that a clinician can actually use Asking about a population rather than about a person. The published trials in this class…	+15	19	6.4k	1d
What would change my mind about repair peptides: a specific answer Compounds › Repair & healing peptides TB-500 needs a source preprint Under review What would change my mind about repair peptides: a specific answer — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 ( JAMA , 2024). Please…	+26	30	1.1k	23h
Joined after a search result and stayed Lounge › Introductions beginner friendly onboarding Posting this under the heading it deserves: Joined after a search result and stayed Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim.…	+5	9	26k	7h
[2026 update] Correlation in a self-tracked dataset: what it can support Research Methods › Statistics number needed to treat effect size worked example heterogeneity Posting this under the heading it deserves: Correlation in a self-tracked dataset: what it can support Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA , 2024) cited in support of a…		2	31k	6h
Purity assay versus content assay: two different numbers Analytics › COA interpretation documentation quality batch & lot numbers reference standards certificate of analysis On the subject in the title: Purity assay versus content assay: two different numbers Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A…	+6	10	24k	25d
Tesamorelin has an approved indication — what that changes about the evidence Compounds › Secretagogues & GH axis observational data tesamorelin GHRP class CJC-1295 Tesamorelin has an approved indication — what that changes about the evidence — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURMOUNT-1 ( N Engl J…	+23	27	3.4k	1d
An appeal that succeeded, with the letter structure Access › Insurance & coverage appeals formulary prior authorisation insurance On the subject in the title: An appeal that succeeded, with the letter structure Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+12	16	15k	1d
[2026 update] Temperature indicator cards: worth asking for? Sourcing › Logistics shipping packaging customs temperature excursion Temperature indicator cards: worth asking for? I have a specific reason for asking rather than idle curiosity, and the context is below. A logistics question, since the answers here are usually better than…	+21	26	4.5k	1d
Mass error in ppm: the arithmetic and the caveat — a second dataset Analytics › Mass spectrometry counter-ion content mass error (ppm) charge states LC-MS Solved On the subject in the title: Mass error in ppm: the arithmetic and the caveat — a second dataset Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked.…	+20	24	1.7k	1d
Naming conventions for research peptides and the confusion they cause Compounds › Other compounds custom synthesis mislabelling research use only needs a source Posting this under the heading it deserves: Naming conventions for research peptides and the confusion they cause Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 1 ( N…	+21	25	4.9k	22d
Review: an evidence digest and the citation check that delayed it Documentation › Doc review citation check review date promoted to docs wiki post On the subject in the title: Review: an evidence digest and the citation check that delayed it Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The…	+13	17	15k	2d
Revisiting: Theoretical plates: useful number or ritual? Analytics › HPLC & UHPLC system suitability UV & DAD detection gradient method data table Solved Asking directly, because I could not find a straight answer: Revisiting: Theoretical plates: useful number or ritual? I would like to understand what this number means before I repeat it anywhere. A…	+16	21	1.2k	1d
Why I now write the concentration on the vial in marker Practice › Reconstitution syringe units bacteriostatic water concentration maths Asking directly, because I could not find a straight answer: Why I now write the concentration on the vial in marker Practical question with the units stated, because I have seen how quickly these go wrong…	+1	5	30k	11d
[2026 update] Documenting an adverse event properly Safety › Adverse events pancreatitis vomiting gallbladder Documenting an adverse event properly Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published trials in this…	+18	22	4.3k	1d
Substitution between formats during a shortage — what changed since Access › Shortages shortage formulary FDA compounding Solved Substitution between formats during a shortage — what changed since — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is…	+17	21	2.7k	9d
Talking to a therapist about this specifically Wellbeing › Mental health disordered eating beginner friendly mood Solved Posting this under the heading it deserves: Talking to a therapist about this specifically Everything below is what sits behind that. Asking about a population rather than about a person. The published trials…	+20	24	855	14h
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Evidence › Journal club risk of bias journal club effect size estimand Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med ,…	+18	22	656	13h
GIP receptor agonism and the argument about direction — does this still hold? Pharmacology › Receptor biology long read amylin analogues retatrutide Solved GIP receptor agonism and the argument about direction — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity arithmetic…	+10	14	15k	16h
Type 2 diabetes and the largest part of the evidence base — does this still hold? Clinical › Comorbidities type 2 diabetes chronic kidney disease PCOS blood pressure Solved Type 2 diabetes and the largest part of the evidence base — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about a population rather…	+17	22	4.5k	1d
Rewriting my first post: a before-and-after, with commentary — what changed since Start Here › How to Ask site feedback onboarding beginner friendly worked example Posting this under the heading it deserves: Rewriting my first post: a before-and-after, with commentary — what changed since Everything below is what sits behind that. I want to check my reasoning rather…	+15	19	12k	13h
Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC system suitability peak integration gradient method data table Solved Why 99.2% and 97.8% on the same lot can both be correct I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I…	+16	20	3.1k	11h
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Compounds › Retatrutide retatrutide randomised trial effect size preprint Solved Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+10	14	8.4k	16h
Cleaning a self-reported dataset and what you throw away Data & Tools › Datasets confounding site feedback data table observational data Cleaning a self-reported dataset and what you throw away — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in…		2	28k	1d
Where to report an adverse event officially, by region Safety › Adverse events pancreatitis gallbladder vomiting hypoglycaemia Solved Where to report an adverse event officially, by region Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…		2	27k	1h
Deletion sequences: expected mass shifts by residue — the long version Analytics › Impurities & related substances water content endotoxin testing data table forced degradation On the subject in the title: Deletion sequences: expected mass shifts by residue — the long version Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked.…	+21	25	6.9k	10h
About the Mass spectrometry category Analytics › Mass spectrometry LC-MS high-resolution MS mass error (ppm) Pinned Wiki LC-MS and high-resolution MS, charge states, mass accuracy in ppm, and what identity confirmation does and does not establish. This post is a community wiki: any member at trust level 3 or above can edit it,…	+5	9	19k	6h