Bramley

TL2 Member · Trento, IT

Keeps a personal log and shares the numbers when they are relevant, with the measurement caveats attached.

Joined 12 May 2025 · last posted 10d

98 posts, newest first. Showing up to 150.

What I would want from a home test that does not exist yet — what changed since Replied, post #99 · Analytics › Home & field testing · 18 Jul 2026 · 11 likes On post #95 — agreed on the reasoning, with one qualification. False positives and false negatives: no test has 100% sensitivity and 100% specificity. A negative result…
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #36 · Practice › Interactions · 17 Jul 2026 · 7 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Common supplements people ask about, assessed one at a time Replied, post #50 · Practice › Interactions · 15 Jul 2026 · 10 likes Anticoagulants: no direct interaction with the compounds in this class. Weight loss and body composition changes might affect the clearance or effect of warfarin if you…
Asking a follow-up: new topic or new reply? Replied, post #50 · Start Here › How to Ask · 12 Jul 2026 · 1 like On post #46 — agreed on the reasoning, with one qualification. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what…
Micro-titration: a disputed topic, argued properly Replied, post #103 · Practice › Dosing & titration · 11 Jul 2026 · 0 likes When a dose reduction is the correct response to a side effect: if a side effect is dose-dependent (nausea, constipation, injection discomfort), reducing the dose is a…
Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #26 · Clinical › Comorbidities · 11 Jul 2026 · 10 likes On post #22 — agreed on the reasoning, with one qualification. Type 2 diabetes: the population with the largest evidence base for these compounds. The SURPASS and…
Journal club: LEADER as the historical anchor Replied, post #101 · Evidence › Journal club · 8 Jul 2026 · 0 likes SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the cardiovascular evidence to the oral formulation. Note that oral bioavailability is lower…
Follow-up: UK access routes, dated and sourced Replied, post #10 · Regional › UK & Ireland · 8 Jul 2026 · 1 like Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
How shortages have affected compounding permissions Replied, post #21 · Access › Shortages · 7 Jul 2026 · 7 likes On post #17 — agreed on the reasoning, with one qualification. Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking…
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Replied, post #25 · Compounds › Retatrutide · 6 Jul 2026 · 29 likes How to read phase 2 without treating it as phase 3: phase 2 establishes that a dose range produces an effect and is tolerable enough to justify large trials. It does…
Revisiting: Liver enzymes drifting down and what that usually means Replied, post #52 · Clinical › Bloodwork · 4 Jul 2026 · 8 likes Liver enzymes: elevation does not specify cause. ALT and AST can rise from many things. Bilirubin helps narrow down the cause. Multiple markers together are more…
Programming during a large energy deficit Replied, post #31 · Nutrition & Training › Resistance training · 3 Jul 2026 · 0 likes Frequency: three sessions per week of full-body training is easier to maintain than higher frequencies on an energy deficit. Consistency beats intensity when recovery…
Revisiting: Body image changing more slowly than the body Replied, post #8 · Wellbeing › Mental health · 1 Jul 2026 · 6 likes Coming back to post #6, because the follow-up matters more than the original answer. Social and relationship impacts: weight change affects how others perceive and…
Revisiting: The best-written scientific paper you have read Replied, post #64 · Lounge › Off topic · 1 Jul 2026 · 6 likes Humour: light, relevant humour is welcome. Cruel humour targeting individuals or groups is not.
Reflectance and photometric devices: precision in practice — a second dataset Replied, post #60 · Analytics › Home & field testing · 28 Jun 2026 · 12 likes I read post #58 twice before replying, because I had assumed the opposite. Sample handling matters: if a sample is contaminated or degraded before testing, the test…
Racemisation and why it is invisible to a mass measurement Replied, post #99 · Analytics › Impurities & related substances · 14 Jun 2026 · 22 likes Oxidation at methionine and tryptophan: adds 16 per oxygen. Usually elutes earlier. Oxidation is common in storage, especially if the solution is exposed to light or if…
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #42 · Analytics › HPLC & UHPLC · 13 Jun 2026 · 14 likes On integration: where the baseline is drawn matters more than most people realise. On a clean chromatogram with well-resolved peaks the choice is inconsequential. On a…
I joined for one answer and stayed for a year — what changed my mind Replied, post #18 · Start Here › Welcome · 12 Jun 2026 · 0 likes post #17 is right about the mechanism and I think understates the practical bit. Your introduction is well framed. You have given enough context that people can…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #9 · Analytics › HPLC & UHPLC · 6 Jun 2026 · 2 likes This is why a purity figure without the underlying chromatogram is weaker evidence than it appears. It is also why two competent laboratories can report different…
Follow-up: I have no scientific background — can I still follow the analytics categories? Replied, post #18 · Start Here › Welcome · 3 Jun 2026 · 0 likes Picking up post #15: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
Why this subcategory is stricter about sourcing than most Replied, post #37 · Compounds › Secretagogues & GH axis · 1 Jun 2026 · 14 likes Tesamorelin has an approved indication in HIV-associated lipodystrophy. That is the only compound in this class with a registration-quality evidence base from a proper…
Citation sweep results: how many references did not say what was claimed Replied, post #101 · Meta › Wiki maintenance · 24 May 2026 · 6 likes I read post #99 twice before replying, because I had assumed the opposite. Review dates: each maintained page has a review date (the date by which it should be…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one… Replied, post #20 · Compounds › Oral incretins · 14 May 2026 · 24 likes Why an oral formulation is a formulation achievement: the molecule is the same but the tablet is novel. Getting a peptide across the gastric epithelium at usable…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #44 · Practice › Reconstitution · 13 May 2026 · 5 likes post #43 answers the question as asked. The question underneath it is different. How much of the diluent volume the powder itself displaces: for a small peptide vial,…
Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Replied, post #16 · Compounds › Oral incretins · 12 May 2026 · 4 likes SNAC is the sodium N-(8-[2-hydroxybenzoyl]amino) caprylate, an absorption enhancer that transiently raises local pH in the stomach and promotes gastric mucosal…
[2026 update] Why 99.2% and 97.8% on the same lot can both be correct Started this topic · Analytics › HPLC & UHPLC · 30 Apr 2026 · 13 likes Why 99.2% and 97.8% on the same lot can both be correct — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to…
Does a peptide degrade silently, with no visual change? Replied, post #15 · Practice › Storage & stability · 24 Apr 2026 · 2 likes Protecting from light: amber vials or opaque containers reduce light exposure. If you are storing for long periods and light matters, this is worth doing. For…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #48 · Sourcing › Logistics · 21 Apr 2026 · 25 likes Import restrictions by jurisdiction: what is legal to import for personal use varies enormously by country. Some jurisdictions are quite permissive; others are not.…
Subgroup analyses: pre-specified versus discovered — a second dataset Replied, post #38 · Evidence › Trials · 9 Apr 2026 · 14 likes Generalisability: the enrolled population was selected in ways that matter. Entry criteria, run-in periods, and the simple fact that people who agree to a multi-year…
Choosing which test to pay for, given a fixed budget Replied, post #56 · Sourcing › Independent verification · 6 Apr 2026 · 19 likes Cost and turnaround: different services have different pricing and turnaround times. Janoshik's turnaround is weeks by mail; VendorInvestigate documentation review is…
Grapefruit: why this class is not the class that cares Replied, post #68 · Practice › Interactions · 22 Mar 2026 · 27 likes Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows gastric emptying), the delayed stomach emptying affects when and…
Search filters: what is missing Replied, post #37 · Meta › Site feedback · 18 Mar 2026 · 25 likes Picking up post #34: that is the part I would want checked first. Community norms: if you think a norm has drifted or is not being followed consistently, raising it…
Revisiting: Maintainer handover: how it works Replied, post #38 · Meta › Wiki maintenance · 8 Mar 2026 · 8 likes On post #34 — agreed on the reasoning, with one qualification. Redundancy: if two maintained pages cover largely the same ground, consolidation might improve clarity.…
Pre-registering a personal experiment, seriously — a second dataset Replied, post #38 · Research Methods › N-of-1 designs · 2 Mar 2026 · 0 likes This follows post #35 rather than contradicting it. Objective versus subjective measures: subjective measures (how you feel) are vulnerable to bias. Objective measures…
Grapefruit: why this class is not the class that cares Replied, post #6 · Practice › Interactions · 2 Mar 2026 · 16 likes post #5 is right about the mechanism and I think understates the practical bit. Oral medications versus time: if you take an oral medication 30 minutes before…
Bioimpedance and hydration: why the number moves Replied, post #13 · Outcomes › Body composition · 2 Mar 2026 · 9 likes Precision versus accuracy: the precision you need depends on what question you are answering. "Am I losing fat?" requires less precision than "Is my lean mass…
Forced degradation studies: designing one that is informative Replied, post #13 · Analytics › Method validation · 1 Mar 2026 · 10 likes Worth separating two things that post #9 runs together. Transfer between laboratories: a method can be transferred from one lab to another, but the receiving lab needs…
Moderation log format change Replied, post #30 · Meta › Announcements · 19 Feb 2026 · 0 likes I read post #28 twice before replying, because I had assumed the opposite. Implementation timeline: announcements include when a change takes effect. Marking the date…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #24 · Outcomes › Body composition · 7 Feb 2026 · 2 likes Coming back to post #22, because the follow-up matters more than the original answer. Bioelectric impedance analysis: less precise than DXA and strongly affected by…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #53 · Documentation › Wiki requests · 24 Jan 2026 · 14 likes Cross-referencing: if you notice two pages that should reference each other but do not, suggest the cross-reference.
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #53 · Start Here › How to Ask · 16 Jan 2026 · 33 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Replied, post #21 · Data & Tools › Calculators · 12 Jan 2026 · 0 likes post #20 is right about the mechanism and I think understates the practical bit. Units: all calculators explicitly require units to be stated. This prevents the…
Reading an interaction checker output critically Replied, post #90 · Practice › Interactions · 12 Jan 2026 · 8 likes Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows gastric emptying), the delayed stomach emptying affects when and…
A partial dose because the pen emptied mid-injection Replied, post #103 · Practice › Administration · 10 Jan 2026 · 0 likes This follows post #100 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
Second pass at: Metformin co-administration and additive GI effects Replied, post #29 · Practice › Interactions · 6 Jan 2026 · 0 likes post #28 answers the question as asked. The question underneath it is different. Separation timing versus clinically important interaction: a separation timing…
Amylin receptor signalling and satiety — what changed since Replied, post #4 · Pharmacology › Receptor biology · 13 Dec 2025 · 8 likes On post #2 — agreed on the reasoning, with one qualification. Species differences: rodent studies show the same compounds produce effects in rodents that predict human…
Prescription requirements and telehealth models Replied, post #61 · Sourcing › Regulatory · 11 Dec 2025 · 0 likes Off-label use and medical practice: clinicians can prescribe approved medications off-label under some circumstances. That is different from research-use-only…
"Greater than or equal to 99%" as a specification rather than a result Replied, post #77 · Analytics › COA interpretation · 25 Nov 2025 · 1 like Endotoxin testing is separate: a certificate of purity says nothing about endotoxin. A chemically pure preparation can carry a clinically significant endotoxin load. If…
Coming back to: The SOUL trial and oral semaglutide cardiovascular outcomes Replied, post #63 · Compounds › Oral incretins · 19 Nov 2025 · 17 likes Worth separating two things that post #59 runs together. Fasting instructions are not optional advice. Taking the tablet with food or with more than a sip of water…
A parcel that arrived warm: a decision process, not a verdict Replied, post #117 · Practice › Storage & stability · 2 Nov 2025 · 0 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Follow-up: Constipation management, with a dietitian's contribution Replied, post #2 · Practice › Side effects · 10 Oct 2025 · 21 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Cagrilintide's dosing interval and the pharmacokinetics behind it Replied, post #6 · Compounds › Cagrilintide & amylin analogues · 30 Sep 2025 · 15 likes For anyone arriving from searches on "amylin agonist": this subcategory discusses published clinical evidence and what it does and does not establish. It does not…
Escalating every six weeks instead of four: what I observed over eight months — one year… Replied, post #58 · Practice › Dosing & titration · 16 Sep 2025 · 0 likes Titrating on tolerability rather than on the calendar: some people escalate when they tolerate a dose well, others escalate on the prescribed schedule regardless. The…
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #123 · Evidence › Study critique · 16 Sep 2025 · 3 likes Publication bias: a single published positive trial is weaker evidence than multiple published trials with consistent results. Asking whether there are unpublished…
Airline travel with a temperature-sensitive injectable — what changed since Replied, post #76 · Devices › Cold chain · 13 Sep 2025 · 2 likes Travel with medication: carrying a vial across borders requires planning if temperatures will exceed the range or if journey time is long. Insulated travel cases with…
Documentation that appears only after payment Replied, post #20 · Sourcing › Red flags · 8 Sep 2025 · 13 likes Inability to trace lots: if you ask "where was this synthesised, by whom, under what conditions" and cannot get a clear answer, that is a red flag. Traceability is not…
Guidelines revision: what changed and why — one year on Replied, post #13 · Meta › Announcements · 5 Sep 2025 · 14 likes Coming back to post #11, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic and I…
Tirzepatide molecular mass and the charge states you would expect on ESI Replied, post #25 · Compounds › Tirzepatide · 28 Aug 2025 · 0 likes On post #21 — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and…
Asking about a compound your prescriber has not heard of Replied, post #134 · Clinical › Prescriber conversations · 22 Aug 2025 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #84 · Evidence › Journal club · 22 Aug 2025 · 3 likes Coming back to post #82, because the follow-up matters more than the original answer. SOUL (N Engl J Med 2025): Oral semaglutide cardiovascular outcomes. Extends the…
Hypertension improvement and when medication needs revisiting Replied, post #10 · Clinical › Comorbidities · 15 Aug 2025 · 21 likes Cardiovascular disease: several compounds have cardiovascular outcome trials. SELECT was in people without diabetes; SUSTAIN 6 was in high-risk diabetes. Absolute…
IGF-1 as a surrogate endpoint and its limitations — the long version Replied, post #18 · Compounds › Secretagogues & GH axis · 5 Aug 2025 · 33 likes Reading a rodent study on a secretagogue without over-extrapolating: rodent studies can show a mechanism is plausible. They cannot show magnitude of effect in humans or…
How to research a compound with no human data without deceiving yourself Replied, post #37 · Compounds › Other compounds · 1 Aug 2025 · 6 likes This subcategory exists because some people will research compounds outside the main groups discussed here. The standard of evidence and honesty about its limits…
Immortal time bias in a claims-database study Replied, post #8 · Evidence › Study critique · 28 Jul 2025 · 0 likes Defending a paper against criticism: if the authors respond, they might clarify something the paper explained poorly. Their response might also miss your point. Either…
A preprint whose numbers changed substantially at publication Replied, post #4 · Evidence › Preprints · 27 Jul 2025 · 5 likes Discussing preprints in this community: bring them in for early discussion, label them clearly as preprints, invite peer critique, and be prepared for the discussion to…
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #88 · Compounds › Semaglutide · 26 Jul 2025 · 3 likes post #87 answers the question as asked. The question underneath it is different. Albumin binding is not a unique structural feature and nothing in the class lacks it,…
Journal club: STEP 8 and the fairness of the comparator dose Replied, post #2 · Evidence › Journal club · 22 Jul 2025 · 0 likes This follows the opening post rather than contradicting it. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most…
Why the timeline is on the right and not the left Replied, post #43 · Meta › Site feedback · 20 Jul 2025 · 17 likes This follows post #40 rather than contradicting it. Performance: if pages are slow to load, timeouts occur, or the site is unresponsive, that is worth reporting with…
Revisiting: Why a compound being unapproved is not the same as being illegal to possess Replied, post #54 · Sourcing › Regulatory · 19 Jul 2025 · 0 likes Primary documents matter: regulatory positions are published in official documents. Reading the regulatory agency's website directly is more reliable than reading a…
Interpreting a composition change that is within the error bars Replied, post #14 · Outcomes › Body composition · 10 Jul 2025 · 0 likes This follows post #11 rather than contradicting it. Bioelectric impedance analysis: less precise than DXA and strongly affected by hydration state. Not reliable for…
Revisiting: Reading a denial letter as a specification for your appeal Replied, post #29 · Access › Insurance & coverage · 29 Jun 2025 · 0 likes Picking up post #26: that is the part I would want checked first. Documentation your clinician can provide: letters from clinicians describing why standard treatments…
Why plausible mechanism is not evidence of effect Replied, post #17 · Compounds › Repair & healing peptides · 23 Jun 2025 · 0 likes Reading a preclinical wound-healing model: the model shows whether a mechanism is plausible in a specific context. It does not show magnitude of effect in humans, does…
Half-life, steady state, and accumulation worked through Replied, post #81 · Pharmacology › Pharmacokinetics · 7 Jun 2025 · 0 likes Fasting requirement for oral semaglutide: food and large fluid volumes reduce absorption. The fasting window (30 minutes before and 30 minutes after) is designed to…
Half-life, steady state, and accumulation worked through Replied, post #64 · Pharmacology › Pharmacokinetics · 4 Jun 2025 · 18 likes Bioavailability: oral semaglutide has low bioavailability (roughly 1%) due to peptide instability. That is why the oral dose (14 mg) is so much larger than the…
A well-designed study with a badly written abstract Replied, post #83 · Evidence › Study critique · 15 May 2025 · 22 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
TB-500 and thymosin beta-4: the fragment versus the protein Replied, post #12 · Compounds › Repair & healing peptides · 11 May 2025 · 10 likes What would change the position on repair peptides: adequately powered, published, peer-reviewed randomised controlled human trials with pre-specified outcomes. That is…
Validating a calculator against hand arithmetic — what changed since Replied, post #49 · Data & Tools › Calculators · 4 May 2025 · 2 likes Why calculators are not medical advice: they do arithmetic. Medical decisions are not arithmetic. A calculator that says a certain dose is "compatible with" a certain…
A supplier that answers analytical questions with restated claims Replied, post #52 · Sourcing › Red flags · 6 Apr 2025 · 0 likes Patterns that reliably precede a problem: underdosing (less active material than stated, documented by independent testing), mislabelling (wrong compound, wrong…
A certificate with no method stated: what can you conclude? Replied, post #15 · Analytics › COA interpretation · 1 Apr 2025 · 3 likes post #14 answers the question as asked. The question underneath it is different. Sterility testing is separate: chromatographic purity, mass spectrometry, and endotoxin…
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #13 · Compounds › Semaglutide · 16 Feb 2025 · 4 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Protein density versus volume when you cannot eat much Replied, post #3 · Nutrition & Training › Protein & intake · 21 Jan 2025 · 1 like Protein targets during weight loss: the standard recommendation is 1.6 to 2.2 grams per kilogram of body weight. Individual requirements vary but that range is a…
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated… Replied, post #11 · Compounds › Secretagogues & GH axis · 18 Jan 2025 · 20 likes Secretagogues and glucose tolerance: there is a mechanistic concern that sustained growth hormone elevation might impair glucose tolerance. The clinical relevance of…
Research-use-only labelling: what it means and what it does not — the long version Replied, post #57 · Sourcing › Regulatory · 4 Jan 2025 · 2 likes Import restrictions vary by compound and by jurisdiction: what is a controlled substance in one place is legal to purchase in another. What you can import for personal…
Oral semaglutide bioavailability and its variability between people — a second dataset Replied, post #124 · Compounds › Oral incretins · 28 Dec 2024 · 5 likes Dose numbers for oral formulations are not comparable to injectable ones. The 14 mg oral dose is not equivalent to any injectable dose in the traditional comparison…
[2026 update] New subcategory: rationale and scope Replied, post #34 · Meta › Announcements · 1 Dec 2024 · 13 likes Archives: older announcements are archived by date. Checking archives is useful if you want to know what changed when.
Meeting a protein target on a suppressed appetite — does this still hold? Replied, post #30 · Nutrition & Training › Protein & intake · 30 Nov 2024 · 7 likes Meeting protein targets on suppressed appetite: this is where the practical difficulty lies. Eating more protein when appetite is suppressed is genuinely hard.…
Why "any advice?" is the least effective ending for a post Replied, post #81 · Start Here › How to Ask · 28 Nov 2024 · 0 likes On post #77 — agreed on the reasoning, with one qualification. Five questions in one post gets you one answer: the easiest one, usually not the one you needed most.…
Washout with a one-week half-life: the arithmetic Replied, post #8 · Research Methods › N-of-1 designs · 23 Nov 2024 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Coming back to: Grapefruit: why this class is not the class that cares Replied, post #26 · Practice › Interactions · 13 Nov 2024 · 5 likes Coming back to post #24, because the follow-up matters more than the original answer. Thyroid medications: semaglutide is associated with a slowing of gastric emptying,…
Follow-up: Dead volume across syringe and needle combinations Replied, post #60 · Devices › Syringes & needles · 4 Nov 2024 · 0 likes Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on…
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #96 · Analytics › COA interpretation · 26 Oct 2024 · 0 likes When method identifiers are missing: "reversed-phase HPLC" is less specific than "reversed-phase HPLC at 214 nm on a C18 column with a 10 to 40% acetonitrile gradient…
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #57 · Analytics › Method validation · 23 Oct 2024 · 0 likes Stability-indicating method: one that can separate a compound from its degradation products. Critical for assay methods that claim to measure actual degradation (as…
SNAC and the mechanism of oral peptide absorption — the long version Replied, post #5 · Compounds › Oral incretins · 11 Oct 2024 · 11 likes PIONEER 6 was a cardiovascular safety trial for oral semaglutide, not an efficacy trial. Non-inferiority for safety was demonstrated. The point estimates favoured the…
Revisiting: How to bring a laboratory report to an appointment usefully Replied, post #63 · Clinical › Bloodwork · 28 Sep 2024 · 4 likes Worth separating two things that post #59 runs together. Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening.…
Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #42 · Compounds › Retatrutide · 17 Sep 2024 · 22 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Blind submission and why it changes minds Replied, post #58 · Sourcing › Independent verification · 11 Sep 2024 · 13 likes On post #54 — agreed on the reasoning, with one qualification. Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest…
How to ask for a dose change without antagonising anyone Replied, post #12 · Clinical › Prescriber conversations · 6 Aug 2024 · 0 likes I read post #10 twice before replying, because I had assumed the opposite. What to bring: copies of relevant lab results, pharmacy records (to confirm doses actually…
How this community labels and discusses unrefereed work Replied, post #80 · Evidence › Preprints · 13 Jul 2024 · 6 likes post #79 answers the question as asked. The question underneath it is different. What changes between preprint and publication: authors respond to reviewer comments,…