k.redgrave

TL2 Member · Aachen, DE

Based in the EU. Tracks what is available and funded locally, and dates every claim.

Joined 6 June 2025 · last posted 14d · groups: regional-eu

96 posts, newest first. Showing up to 150.

A critique that turned out to be unfair, retracted by its author Replied, post #30 · Evidence › Study critique · 14 Jul 2026 · 14 likes Bias towards the null and bias away from the null: different criticisms have different directions. Differential dropout might bias away from null; conservative…
Why we ask for units every single time, with three examples of what goes wrong Replied, post #114 · Start Here › How to Ask · 10 Jul 2026 · 0 likes Chromatogram questions: describe the method first. Column type, gradient, wavelength, detection method. Everything else follows from method. A chromatogram without…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #118 · Practice › Reconstitution · 10 Jul 2026 · 25 likes How much of the diluent volume the powder itself displaces: for a small peptide vial, the powder volume is negligible. For a larger vial or a kit with multiple…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #56 · Analytics › Impurities & related substances · 7 Jul 2026 · 19 likes Aggregates: multiples of the monomer mass. May not elute at all under a standard reversed-phase method. A species that does not come off the column does not appear in…
Journal club: what we got wrong in an earlier session Replied, post #26 · Evidence › Journal club · 24 Jun 2026 · 10 likes SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical…
Research-use-only status: what it means legally and practically Replied, post #59 · Compounds › Other compounds · 16 Jun 2026 · 4 likes Naming conventions for research peptides cause confusion because suppliers do not follow a standard. The same compound gets different names from different suppliers. If…
CJC-1295 with and without DAC: what the modification does Replied, post #85 · Compounds › Secretagogues & GH axis · 16 Jun 2026 · 0 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Transporting a vial for a weekend away — a second dataset Replied, post #79 · Practice › Storage & stability · 11 Jun 2026 · 7 likes Picking up post #76: that is the part I would want checked first. Freeze-thaw: some peptide solutions tolerate freezing poorly because ice crystals damage protein…
What steady state means for the decision to escalate Replied, post #11 · Practice › Dosing & titration · 9 Jun 2026 · 6 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
Analytical identity of BPC-157: a 15-mer with a simple mass — does this still hold? Replied, post #30 · Compounds › Repair & healing peptides · 8 Jun 2026 · 0 likes Analytical identity of BPC-157: a 15-residue peptide with an unambiguous mass (≈1419.5 Da). Identity confirmation by LC-MS is trivially easy, which means there is no…
Tracking a shortage from primary sources rather than rumour Replied, post #41 · Access › Shortages · 8 Jun 2026 · 6 likes Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.
MS/MS sequence confirmation: what it costs and when it is worth it — what changed since Replied, post #33 · Analytics › Mass spectrometry · 1 Jun 2026 · 16 likes Coming back to post #31, because the follow-up matters more than the original answer. Calibration matters: a high-resolution instrument out of calibration can report…
Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #2 · Compounds › Cagrilintide & amylin analogues · 28 May 2026 · 0 likes On the opening post — agreed on the reasoning, with one qualification. Is synergy the right word for the combination data? A phase 2 trial cannot establish whether…
A site rotation scheme that is easy enough to actually follow Replied, post #63 · Practice › Administration · 14 May 2026 · 12 likes This follows post #60 rather than contradicting it. Bleeding at the injection site: normal and usually minimal. A little blood at the needle site after withdrawal is…
[2026 update] Does a peptide degrade silently, with no visual change? Replied, post #59 · Practice › Storage & stability · 13 May 2026 · 33 likes Temperature excursions: if a vial sat at room temperature for a time, the question is whether the excursion was long enough to cause damage. Hours at room temperature…
Fixed versus detachable needles: the trade-offs — does this still hold? Replied, post #3 · Devices › Syringes & needles · 8 May 2026 · 18 likes Coming back to the opening post, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic…
Revisiting: A field-by-field walk through a certificate of analysis Replied, post #31 · Analytics › COA interpretation · 3 May 2026 · 0 likes Amino acid analysis gives content: it hydrolyses the peptide and quantifies the residues. It measures the peptide content independent of chromatographic purity. Very…
[2026 update] Storing lyophilised material long term: what governs the shelf life Replied, post #105 · Practice › Storage & stability · 26 Apr 2026 · 5 likes Refrigeration slows degradation. Repeated warming and cooling is worse than continuous refrigeration. Light exposure is worth avoiding. The concentration matters…
Sample handling between despatch and injection Replied, post #68 · Analytics › Method validation · 25 Apr 2026 · 31 likes Picking up post #65: that is the part I would want checked first. Stability-indicating method: one that can separate a compound from its degradation products. Critical…
Sulfonylureas: the interaction most worth taking seriously Replied, post #5 · Practice › Interactions · 24 Apr 2026 · 6 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #109 · Analytics › Mass spectrometry · 24 Apr 2026 · 0 likes Coming back to post #107, because the follow-up matters more than the original answer. What mass accuracy establishes: the measured mass is consistent with a specific…
Anaesthesia and elective surgery: the aspiration question Replied, post #92 · Practice › Interactions · 19 Apr 2026 · 20 likes Picking up post #89: that is the part I would want checked first. Supplements and herbs: many have no established interaction. Some do. If you are taking something…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #147 · Access › Pricing · 15 Apr 2026 · 11 likes Discount programmes and coupons: manufacturers often offer coupons that reduce out-of-pocket costs if insurance is not covering or is covering at a high copay. These…
Fasting versus non-fasting and which tests care Replied, post #6 · marked as the solution · Clinical › Bloodwork · 1 Apr 2026 · 8 likes Biological variation: the person-to-person variation in a biomarker for a healthy person is larger than most people realize. Comparing your result to the reference…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #57 · Research Methods › N-of-1 designs · 22 Mar 2026 · 18 likes Washout periods: after stopping a medication, how long does it take for the effect to wash out? For compounds with a week-long half-life, roughly a month is needed to…
Introducing myself: pharmacist, sceptic, reluctant participant — one year on Replied, post #97 · Lounge › Introductions · 17 Mar 2026 · 22 likes Welcome: the response to introductions is usually welcome. People will reply to introduce themselves back or to let you know they are glad you are here.
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #72 · Start Here › How to Ask · 10 Mar 2026 · 0 likes On post #68 — agreed on the reasoning, with one qualification. Units. Everything needs units. This is why we ask every single time. I have seen the same arithmetic done…
Reading a regulatory notice rather than an article about it Replied, post #2 · Sourcing › Regulatory · 23 Feb 2026 · 0 likes On the opening post — agreed on the reasoning, with one qualification. Off-label use and medical practice: clinicians can prescribe approved medications off-label under…
Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #125 · Compounds › Semaglutide · 21 Feb 2026 · 0 likes The SELECT trial changed the positioning because it was the first cardiovascular outcome trial in people without diabetes. That decoupled the cardiovascular argument…
Micro-titration: a disputed topic, argued properly — one year on Replied, post #2 · Practice › Dosing & titration · 1 Feb 2026 · 7 likes The arithmetic of an intermediate dose: if the label says 1.0 mg and 2.0 mg, a dose strictly between them is off-label by definition. Some people compute it anyway. The…
[2026 update] Confounding by indication, explained with a concrete example Replied, post #10 · Evidence › Study critique · 28 Jan 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Revisiting: Language barriers in accessing a prescription abroad Replied, post #60 · Access › International · 17 Jan 2026 · 27 likes This follows post #57 rather than contradicting it. Import rules for personal use: what you can import for personal use depends on your country's rules, not on where it…
Muscle cramps: the ordinary causes before the exotic ones Replied, post #43 · Practice › Side effects · 16 Jan 2026 · 10 likes On post #39 — agreed on the reasoning, with one qualification. Nausea: the most common side effect and the most dose- and titration-dependent one. It is usually most…
Why oral semaglutide needs an absorption enhancer at all Replied, post #59 · Compounds › Oral incretins · 17 Dec 2025 · 0 likes post #58 answers the question as asked. The question underneath it is different. The SOUL trial: cardiovascular outcomes trial for oral semaglutide in people with type…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long… Replied, post #91 · Compounds › Tirzepatide · 13 Dec 2025 · 5 likes Storage and stability: published data on licensed tirzepatide formulations exists and is worth reading directly rather than through summarised claims. Reconstituted…
Journal club: LEADER as the historical anchor Replied, post #5 · Evidence › Journal club · 19 Nov 2025 · 4 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Waist circumference technique and its repeatability Replied, post #17 · Outcomes › Progress reports · 17 Nov 2025 · 0 likes Seasonal patterns: some people report weight loss is slower in winter than summer. Body composition and activity changes might contribute. Noting the season is useful…
Older adults, sarcopenia risk, and the trade-off nobody quantifies Replied, post #30 · Clinical › Special populations · 12 Nov 2025 · 7 likes Pancreatitis history: the compounds can rarely trigger pancreatitis. A history of pancreatitis makes monitoring for recurrence more important during titration.
Where the integrator drew the baseline, and how much it moved the number Replied, post #19 · Analytics › HPLC & UHPLC · 10 Nov 2025 · 20 likes Picking up post #16: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the…
Coming back to: Feature request: should a dose-equivalence tool exist at all? Replied, post #4 · Data & Tools › Calculators · 9 Nov 2025 · 18 likes This follows post #3 rather than contradicting it. For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add…
Where to report an adverse event officially, by region — a second dataset Replied, post #70 · Safety › Adverse events · 29 Oct 2025 · 2 likes Serious and unexpected events are the ones to document and report. Serious means hospitalization-level serious. Unexpected means not in the drug's known profile. Both…
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #137 · Compounds › Tirzepatide · 25 Oct 2025 · 27 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Follow-up: Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #12 · Practice › Dosing & titration · 16 Oct 2025 · 3 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #102 · Evidence › Study critique · 15 Sep 2025 · 5 likes What makes a methodological criticism substantive: it identifies a specific feature of the design that materially affects what the paper can conclude. "Small sample…
Payment method and the leverage it gives you, ranked Replied, post #14 · Sourcing › Payments · 15 Sep 2025 · 3 likes Currency conversion: payment in your local currency often involves a conversion fee. Paying in the supplier's native currency sometimes saves money, sometimes costs…
About the Site feedback category Replied, post #5 · Meta › Site feedback · 14 Sep 2025 · 1 like Display issues: broken layouts, images not loading, text overlapping — report with the browser and device you were using. Display bugs are platform-specific.
Aggregated purity results across four services, with caveats — a second dataset Replied, post #150 · Data & Tools › Datasets · 11 Sep 2025 · 4 likes Coming back to post #148, because the follow-up matters more than the original answer. How to contribute: if you have longitudinal data you want to add, the format is…
Second pass at: LOD and LOQ: definitions people get wrong Replied, post #27 · Analytics › Method validation · 2 Sep 2025 · 26 likes post #26 answers the question as asked. The question underneath it is different. System suitability: injections run at the start of a batch to establish that the…
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #20 · Wellbeing › Mental health · 28 Aug 2025 · 12 likes Worth separating two things that post #16 runs together. Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift…
Distinguishing a deletion sequence by mass alone — the long version Replied, post #43 · Analytics › Mass spectrometry · 24 Aug 2025 · 17 likes post #42 answers the question as asked. The question underneath it is different. Resolution: "high resolution" commonly means
[2026 update] Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Replied, post #3 · Compounds › Tirzepatide · 21 Aug 2025 · 0 likes SURPASS-2 compared tirzepatide with semaglutide 1.0 mg, the licensed diabetes dose at that time. It did not compare with semaglutide 2.4 mg, the highest approved dose.…
What a documentation review can and cannot tell you Replied, post #80 · Sourcing › Independent verification · 19 Aug 2025 · 7 likes Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and…
Which panel is worth repeating and which is worth ignoring Replied, post #86 · Clinical › Bloodwork · 16 Aug 2025 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
A request that was declined, and the reasoning — a second dataset Replied, post #57 · Documentation › Wiki requests · 11 Aug 2025 · 11 likes Format suggestions: if you think a maintained page could be clearer in its presentation (different section structure, different examples, added graphics) suggest the…
Coming back to: When "no data" is the complete and final answer Replied, post #79 · Compounds › Other compounds · 10 Aug 2025 · 0 likes This follows post #76 rather than contradicting it. When "no data" is the complete and final answer: if there is no published human data on a compound, that is the…
Follow-up: Why appetite effects are mostly central Replied, post #13 · Pharmacology › Receptor biology · 7 Aug 2025 · 15 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
A request that was declined, and the reasoning — a second dataset Replied, post #17 · Documentation › Wiki requests · 6 Aug 2025 · 10 likes This follows post #14 rather than contradicting it. Format suggestions: if you think a maintained page could be clearer in its presentation (different section…
Antibiotics and a course of something with delayed emptying Replied, post #99 · Practice › Interactions · 24 Jul 2025 · 4 likes Picking up post #96: that is the part I would want checked first. Food interactions: most interactions are absorption interactions. Some medications absorb better with…
About the Datasets category Replied, post #11 · Data & Tools › Datasets · 18 Jul 2025 · 22 likes post #10 answers the question as asked. The question underneath it is different. Using data in discussions: datasets are useful as reference points when someone claims…
A field-by-field walk through a certificate of analysis Replied, post #101 · Analytics › COA interpretation · 17 Jul 2025 · 1 like On post #97 — agreed on the reasoning, with one qualification. Amino acid analysis gives content: it hydrolyses the peptide and quantifies the residues. It measures the…
Coming back to: Over-dilution: when your dose falls below one readable graduation Replied, post #30 · Practice › Reconstitution · 10 Jul 2025 · 0 likes post #29 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
Comparators chosen for regulatory reasons rather than clinical ones — one year on Replied, post #66 · Evidence › Trials · 1 Jul 2025 · 18 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Forced degradation studies: designing one that is informative — does this still hold? Replied, post #26 · Analytics › Method validation · 29 Jun 2025 · 0 likes Why two laboratories may disagree: after validating the same method, they may still report different purity on the same sample due to integration differences, column…
[2026 update] An appeal that failed, and what I would do differently Replied, post #109 · Access › Insurance & coverage · 14 Jun 2025 · 2 likes On post #105 — agreed on the reasoning, with one qualification. Prior authorisation: pre-approval requirements and how to satisfy them. Most denials cite specific…
Validating a calculator against hand arithmetic — what changed since Replied, post #98 · Data & Tools › Calculators · 29 May 2025 · 32 likes Precision and significant figures: the calculators do not round to match your input precision. If you input values to one decimal place, the output might have more. Use…
Travel coolers and how long they really hold — the long version Started this topic · Devices › Cold chain · 17 May 2025 · 23 likes Travel coolers and how long they really hold — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than…
Coverage for the indication versus for the drug Replied, post #65 · Access › Insurance & coverage · 14 May 2025 · 8 likes I read post #63 twice before replying, because I had assumed the opposite. Prior authorisation: pre-approval requirements and how to satisfy them. Most denials cite…
Payment mechanics and the recovery options that do not exist — what changed since Replied, post #7 · Sourcing › Payments · 2 May 2025 · 12 likes post #6 answers the question as asked. The question underneath it is different. No payment facilitation: this site does not handle payments and does not connect buyers…
Titles that describe the question, not the situation Replied, post #4 · Start Here › How to Ask · 30 Apr 2025 · 0 likes the opening post is right about the mechanism and I think understates the practical bit. Avoid "any advice?" at the end. It is so generic that people do not know which…
A report I filed that turned out to be wrong, and the correction Replied, post #21 · Sourcing › Vendor reports · 20 Apr 2025 · 26 likes Lot matching: confirm the lot number on the certificate matches the lot number on the vial. A result from a different lot is not evidence about your vial.
Vagal afferents and the gut-brain pathway Started this topic · Pharmacology › Receptor biology · 7 Apr 2025 · 36 likes On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. A documentation question rather than an analytical one. I…
Adjudicated events and why the definition matters — the long version Replied, post #79 · Evidence › Trials · 3 Apr 2025 · 31 likes This follows post #76 rather than contradicting it. Intent-to-treat versus per-protocol: ITT includes everyone assigned regardless of whether they took the drug.…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #144 · Sourcing › Regulatory · 5 Mar 2025 · 5 likes Research-use-only status is a legal classification, not a safety classification. It means the compound is sold for laboratory use and not for human consumption. The…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #21 · Evidence › Meta-analyses · 29 Jan 2025 · 0 likes Pooled estimates and heterogeneity: when trials differ in population, duration, or comparator, a pooled estimate answers a question that no individual trial asked. High…
Second pass at: Certificates issued by the seller versus by a laboratory Replied, post #65 · Analytics › COA interpretation · 27 Jan 2025 · 0 likes When method identifiers are missing: "reversed-phase HPLC" is less specific than "reversed-phase HPLC at 214 nm on a C18 column with a 10 to 40% acetonitrile gradient…
Why we hide unevidenced fraud accusations and log the hiding Replied, post #43 · Sourcing › Red flags · 24 Jan 2025 · 13 likes Documentation quality as a signal: a supplier that reports method identifiers, distinguishes specification from result, and states the counter-ion form is telling you…
Biased agonism: a real phenomenon, an over-used explanation — what changed since Replied, post #23 · Pharmacology › Receptor biology · 11 Jan 2025 · 17 likes Species differences: rodent studies show the same compounds produce effects in rodents that predict human effects reasonably well for semaglutide and tirzepatide. The…
Follow-up: Individual participant data versus aggregate data Replied, post #12 · Evidence › Meta-analyses · 8 Jan 2025 · 0 likes Coming back to post #10, because the follow-up matters more than the original answer. Inclusion and exclusion criteria: a meta-analysis is only as good as its inclusion…
UK access routes, dated and sourced — a second dataset Replied, post #22 · Regional › UK & Ireland · 1 Jan 2025 · 19 likes I read post #20 twice before replying, because I had assumed the opposite. Ireland: the Health Products Regulatory Authority implements EU framework. Prescription-only.…
What the published dose-response for semaglutide actually looks like above 2.4 mg — a… Replied, post #10 · Compounds › Semaglutide · 28 Dec 2024 · 24 likes Coming back to post #8, because the follow-up matters more than the original answer. The SELECT trial changed the positioning because it was the first cardiovascular…
Oxidation pathways for methionine and tryptophan Replied, post #10 · Analytics › Impurities & related substances · 26 Dec 2024 · 0 likes Aggregates: multiples of the monomer mass. May not elute at all under a standard reversed-phase method. A species that does not come off the column does not appear in…
Coming back to: Oxidation pathways for methionine and tryptophan Replied, post #3 · Analytics › Impurities & related substances · 18 Dec 2024 · 5 likes Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself or with other molecules. Under oxidising conditions multiple species…
Washout with a one-week half-life: the arithmetic Replied, post #34 · Research Methods › N-of-1 designs · 29 Nov 2024 · 20 likes When to run an n-of-1: this design works when you want to know whether a treatment works for you, not whether it works in general. For that purpose, it is efficient.
Coming back to: Research-use-only labelling: what it means and what it does not Replied, post #41 · Sourcing › Regulatory · 28 Nov 2024 · 0 likes Compounding and pharmacy rules: some jurisdictions allow a pharmacy to compound a drug that is not on the market under specific conditions. The conditions are strict…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #42 · Clinical › Special populations · 23 Nov 2024 · 1 like Pregnancy and planning: these compounds are not approved for use in pregnancy. Planning windows (how long to wait before attempting pregnancy) are not formally…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #2 · Clinical › Special populations · 18 Nov 2024 · 3 likes Picking up the opening post: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the…
Buffers, pH and why a formulation is a formulation Replied, post #13 · Pharmacology › Formulation chemistry · 30 Oct 2024 · 25 likes Picking up post #10: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
Tracking semaglutide's approved indications across jurisdictions, dated — does this… Replied, post #3 · Compounds › Semaglutide · 28 Oct 2024 · 0 likes This follows post #2 rather than contradicting it. The SELECT trial changed the positioning because it was the first cardiovascular outcome trial in people without…
Irish differences from the UK position Replied, post #58 · Regional › UK & Ireland · 25 Oct 2024 · 0 likes post #57 answers the question as asked. The question underneath it is different. Thank you for the correction. I have edited my earlier post with a note rather than…
Why I ask for the gradient before I discuss the number Replied, post #24 · Analytics › HPLC & UHPLC · 30 Sep 2024 · 26 likes post #23 answers the question as asked. The question underneath it is different. Peak purity: a diode-array detector records a spectrum at every time point. If a peak…
Telehealth prescribing models in the US Replied, post #3 · Regional › North America · 7 Sep 2024 · 2 likes Coming back to the opening post, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from…
Reporting a discrepancy without making an allegation Replied, post #18 · Sourcing › Vendor reports · 7 Aug 2024 · 29 likes Dosing and purity: a vial that is 99% pure might contain 80% of its label claim if the other mass is water, counter-ion, and excipient. Purity and content are…
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated… Replied, post #3 · Compounds › Secretagogues & GH axis · 4 Aug 2024 · 0 likes IGF-1 as a surrogate: it is a better integrated measure than a spot growth hormone level and it is still a surrogate, with all the caveats that come with surrogates.…
Guidelines revision: what changed and why Replied, post #120 · Meta › Announcements · 28 Jul 2024 · 22 likes When announcements are made: major policy changes, technical changes affecting site function, planned downtime, and changes to guidelines all get announced here.
Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #119 · Practice › Dosing & titration · 10 Jul 2024 · 28 likes Holding a dose indefinitely: the trials did not study indefinite holding at a non-maximum dose. The trials escalated to a target and then held that. What happens if you…
Two sessions a week versus four: what the evidence supports — a second dataset Replied, post #14 · Nutrition & Training › Resistance training · 20 Jun 2024 · 3 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…