Tags · Evidence

effect size

Magnitude, not just direction or significance.

214 topics 77 solved Group: Evidence

Compounds 89 Evidence 84 Research Methods 26 Outcomes 15

214 topics · page 7 of 8

Topic	Participants	Replies	Views	Activity
Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? Evidence › Journal club journal club effect size number needed to treat randomised trial The question in the title: Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen SURMOUNT-2 ( Lancet ,…	+60	66	12k	16mo
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Compounds › Semaglutide STEP programme type 2 diabetes randomised trial effect size Posting this under the heading it deserves: Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022)…	+125	132	39k	16mo
Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club randomised trial effect size journal club risk of bias Solved Posting this under the heading it deserves: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with SCALE ( N Engl J…	+47	51	617	16mo
Retatrutide's phase 2 heart-rate signal and how to think about it — the long version Compounds › Retatrutide effect size randomised trial TRIUMPH programme Solved Retatrutide's phase 2 heart-rate signal and how to think about it — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med…		2	103	17mo
Second pass at: Regression to the mean in progress reports Research Methods › Statistics effect size worked example heterogeneity Second pass at: Regression to the mean in progress reports Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with STEP 4 ( JAMA ,…	+71	75	4k	17mo
What we do not know about retatrutide, listed explicitly Compounds › Retatrutide retatrutide effect size preprint TRIUMPH programme The question in the title: What we do not know about retatrutide, listed explicitly I will give what I have already checked below so nobody repeats it. Comparing FLOW ( N Engl J Med , 2024) with SURMOUNT-OSA…	+106	113	4.8k	17mo
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand randomised trial number needed to treat effect size Journal club: SURPASS-2 and the semaglutide 1 mg comparator Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please read it before…	+126	138	31k	17mo
Semaglutide in people without diabetes: what the evidence base looks like Compounds › Semaglutide semaglutide effect size STEP programme randomised trial Semaglutide in people without diabetes: what the evidence base looks like Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SUSTAIN 6 ( N Engl J Med , 2016).…	+2	6	18k	17mo
A claim built entirely on a subgroup analysis — what changed since Evidence › Study critique disputed effect size observational data risk of bias Closed On the subject in the title: A claim built entirely on a subgroup analysis — what changed since Working notes rather than a conclusion. I have seen PIONEER 6 ( N Engl J Med , 2019) cited in support of a claim…		2	2k	18mo
Second pass at: Multiplicity when you track fifteen variables Research Methods › Statistics number needed to treat confounding effect size worked example Posting this under the heading it deserves: Second pass at: Multiplicity when you track fifteen variables Everything below is what sits behind that. I have seen SCALE ( N Engl J Med , 2015) cited in support…		2	12k	18mo
Second pass at: Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues amylin analogues effect size cagrilintide cagrisema Closed Second pass at: Historical amylin analogues and what happened to them — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim…	+15	19	22k	18mo
SURPASS-2 and the comparator dose question that will not go away Compounds › Tirzepatide SURPASS programme randomised trial effect size SURMOUNT programme SURPASS-2 and the comparator dose question that will not go away — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before…	+101	111	1.5k	18mo
Sample size intuition for a personal experiment Research Methods › Statistics number needed to treat heterogeneity confounding effect size On the subject in the title: Sample size intuition for a personal experiment Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the discussion is…		4	62k	18mo
Tirzepatide storage and stability: what is published versus what is assumed — does this still hold? Compounds › Tirzepatide tirzepatide SURPASS programme effect size The question in the title: Tirzepatide storage and stability: what is published versus what is assumed — does this still hold? I will give what I have already checked below so nobody repeats it. Comparing…	+15	19	930	18mo
Follow-up: Individual participant data versus aggregate data Evidence › Meta-analyses meta-analysis effect size publication bias heterogeneity Individual participant data versus aggregate data — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURPASS-4 ( Lancet , 2021) and finding the…	+101	111	23k	18mo
Follow-up: Tirzepatide's shorter half-life and its one practical consequence Compounds › Tirzepatide tirzepatide SURPASS programme SURMOUNT programme effect size Solved Tirzepatide's shorter half-life and its one practical consequence Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of…	+130	137	11k	19mo
Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide Compounds › Semaglutide effect size type 2 diabetes randomised trial Solved Posting this under the heading it deserves: Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA ,…	+72	77	7.2k	19mo
Molecular mass of semaglutide and why the figure differs between sources — does this still hold? Compounds › Semaglutide effect size type 2 diabetes STEP programme SELECT trial Solved Closed Molecular mass of semaglutide and why the figure differs between sources — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 (…	+94	102	14k	19mo
Washout with a one-week half-life: the arithmetic Research Methods › N-of-1 designs effect size data table worked example Wiki Washout with a one-week half-life: the arithmetic — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim I do not think it…	+90	96	44k	20mo
Follow-up: Semaglutide versus liraglutide head to head: reading STEP 8 carefully Compounds › Semaglutide effect size randomised trial SELECT trial STEP programme Semaglutide versus liraglutide head to head: reading STEP 8 carefully — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim…	+1	5	11k	20mo
Tracking semaglutide's approved indications across jurisdictions, dated — does this still hold? Compounds › Semaglutide randomised trial type 2 diabetes STEP programme effect size Solved Tracking semaglutide's approved indications across jurisdictions, dated — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SCALE ( N…	+58	62	49k	20mo
Second pass at: When a network meta-analysis is defensible and when it is not Evidence › Meta-analyses heterogeneity meta-analysis effect size publication bias Solved Pinned Posting this under the heading it deserves: Second pass at: When a network meta-analysis is defensible and when it is not Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with LEADER…		2	2.8k	21mo
[2026 update] Comparing tirzepatide and semaglutide is harder than the tables suggest Compounds › Tirzepatide effect size SURMOUNT programme tirzepatide randomised trial Comparing tirzepatide and semaglutide is harder than the tables suggest Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with SURMOUNT-1…		2	23k	21mo
Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand effect size risk of bias journal club Solved On the subject in the title: Journal club: SURPASS-2 and the semaglutide 1 mg comparator Working notes rather than a conclusion. Session topic: SELECT ( N Engl J Med , 2023). Please read it before posting;…	+71	76	52k	21mo
Tracking a preprint to publication: a worked example — the long version Evidence › Preprints risk of bias preprint effect size Posting this under the heading it deserves: Tracking a preprint to publication: a worked example — the long version Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with STEP 2 (…	+38	47	560	22mo
Coming back to: Prediction intervals and why they are more honest than confidence intervals Evidence › Meta-analyses publication bias heterogeneity effect size risk of bias Prediction intervals and why they are more honest than confidence intervals Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURMOUNT-OSA ( N Engl J Med , 2024)…		2	65	22mo
Why a preprint's supplementary material is often the best part Evidence › Preprints needs a source risk of bias preprint effect size Why a preprint's supplementary material is often the best part I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: SUSTAIN 6 ( N Engl J Med , 2016). Please…	+38	42	863	22mo
Hepatic effects of glucagon receptor agonism: the mechanistic worry Compounds › Retatrutide TRIUMPH programme effect size preprint randomised trial Solved Posting this under the heading it deserves: Hepatic effects of glucagon receptor agonism: the mechanistic worry Everything below is what sits behind that. Session topic: SURMOUNT-4 ( JAMA , 2024). Please read…	+51	56	700	22mo
The C-cell question: rodent findings and their human context — what changed since Compounds › Semaglutide effect size SELECT trial randomised trial type 2 diabetes Closed The C-cell question: rodent findings and their human context — what changed since — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support…	+61	65	1.3k	22mo
Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Posting this under the heading it deserves: Reading a meta-analysis you disagree with, fairly Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of a…	+7	13	2.5k	23mo