Ranked by engagement

Top topics — all time page 17

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

1,535 topics · page 17 of 40

Topic	Participants	Replies	Views	Activity
Lurking for two months before posting: was that the right call? Start Here › Welcome guidelines trust levels beginner friendly Asking directly, because I could not find a straight answer: Lurking for two months before posting: was that the right call? Question in the title. Context below, and I have tried to include the things people…	+67	71	11k	8mo
How much context is too much context in a first post? Start Here › How to Ask guidelines beginner friendly onboarding site feedback Solved How much context is too much context in a first post? I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I have tried to…	+70	74	935	18d
Second pass at: LOD and LOQ: definitions people get wrong Analytics › Method validation recovery precision & repeatability linearity LOD & LOQ Posting this under the heading it deserves: Second pass at: LOD and LOQ: definitions people get wrong Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+47	51	40k	10mo
Follow-up: A supplier that answers analytical questions with restated claims Sourcing › Red flags documentation quality disputed mislabelling moderation A supplier that answers analytical questions with restated claims — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+74	82	2.8k	6mo
Second pass at: Regression to the mean in progress reports Research Methods › Statistics effect size worked example heterogeneity Second pass at: Regression to the mean in progress reports Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with STEP 4 ( JAMA ,…	+71	75	4k	17mo
Electrolyte supplements: which ones do anything Nutrition & Training › Hydration & electrolytes blood pressure heart rate fatigue Solved On the subject in the title: Electrolyte supplements: which ones do anything Working notes rather than a conclusion. Maintenance rather than loss, which is the part of this that almost nobody writes about. I…	+47	51	31k	18d
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset Sourcing › Independent verification Janoshik Analytical blind sampling PeptideMeter VendorInvestigate Solved How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. A logistics question, since the…	+42	46	46k	2mo
Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide Compounds › Semaglutide effect size type 2 diabetes randomised trial Solved Posting this under the heading it deserves: Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA ,…	+72	77	7.2k	19mo
Holding a dose indefinitely: is there a documented downside? Practice › Dosing & titration dose reduction missed dose semaglutide Holding a dose indefinitely: is there a documented downside? — that is the question, and I have not found it answered plainly anywhere I have looked. A question about technique rather than about dose. I have…	+28	32	57k	12mo
Publishing an inconvenient result: a case study — the long version Sourcing › Independent verification Janoshik Analytical PeptideMeter Medutest blind sampling Publishing an inconvenient result: a case study — the long version Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+68	74	12k	7mo
Second pass at: Journal club: LEADER as the historical anchor Evidence › Journal club randomised trial journal club effect size estimand Posting this under the heading it deserves: Second pass at: Journal club: LEADER as the historical anchor Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with SURPASS-2 ( N…	+75	81	2k	2y
Programming during a large energy deficit Nutrition & Training › Resistance training lean mass loss fatigue DXA Programming during a large energy deficit — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes about. I have…	+39	49	36k	2d
Injection volume, overload, and peak distortion Analytics › HPLC & UHPLC peak integration system suitability HPLC data table Solved Posting this under the heading it deserves: Injection volume, overload, and peak distortion Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+43	47	36k	2mo
What "marked as solution" means and who gets to mark it — does this still hold? Start Here › Welcome onboarding beginner friendly guidelines Solved What "marked as solution" means and who gets to mark it — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather…	+69	74	2.4k	3mo
Coming back to: Research-use-only labelling: what it means and what it does not Sourcing › Regulatory MHRA personal import research use only Solved Research-use-only labelling: what it means and what it does not — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…	+45	50	39k	20mo
Journal club: STEP 4 and what a withdrawal design can prove Evidence › Journal club randomised trial risk of bias effect size Solved On the subject in the title: Journal club: STEP 4 and what a withdrawal design can prove Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+61	65	2k	13mo
Waist circumference technique and its repeatability Outcomes › Progress reports data table long read effect size DXA Waist circumference technique and its repeatability — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that almost nobody writes…	+55	60	11k	5mo
Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration missed dose semaglutide tirzepatide titration Solved On the subject in the title: Where the four-week escalation interval comes from, and what it is not Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I…	+56	60	21k	2y
Transporting a vial for a weekend away Practice › Storage & stability temperature excursion freeze-thaw beyond-use date cloudy or discoloured solution Closed On the subject in the title: Transporting a vial for a weekend away Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go wrong without…	+39	45	35k	21mo
Second pass at: Circumference measurements as a poor man's composition estimate Outcomes › Body composition DXA lean mass loss data table Second pass at: Circumference measurements as a poor man's composition estimate — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a…	+64	68	13k	4mo
Why fasting instructions for oral semaglutide are not optional advice Compounds › Oral incretins PIONEER programme orforglipron randomised trial SOUL trial Solved Why fasting instructions for oral semaglutide are not optional advice I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SUSTAIN 6 ( N Engl J Med , 2016)…	+70	74	1.1k	23d
Follow-up: The lowest dose that does anything: is that a real question? Practice › Dosing & titration worked example missed dose tirzepatide dose reduction Closed The question in the title: The lowest dose that does anything: is that a real question? I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still…	+70	75	12k	8mo
Why "any advice?" is the least effective ending for a post — the long version Start Here › How to Ask guidelines site feedback worked example onboarding Solved Asking directly, because I could not find a straight answer: Why "any advice?" is the least effective ending for a post — the long version Question in the title. Context below, and I have tried to include the…	+79	83	1.6k	9mo
Guidelines revision: what changed and why — one year on Meta › Announcements trust levels moderation site feedback guidelines Pinned On the subject in the title: Guidelines revision: what changed and why — one year on Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the…	+75	81	3.9k	4mo
Second pass at: The mass-error checker and its intended scope Data & Tools › Calculators site feedback worked example concentration maths Solved Pinned Posting this under the heading it deserves: Second pass at: The mass-error checker and its intended scope Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+70	74	1.7k	8mo
Hepatic steatosis: what the MASH trial evidence supports Clinical › Comorbidities MASH / hepatic steatosis PCOS type 2 diabetes chronic kidney disease Hepatic steatosis: what the MASH trial evidence supports — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in…	+77	83	950	13mo
[2026 update] What we do not know about retatrutide, listed explicitly Compounds › Retatrutide TRIUMPH programme preprint effect size randomised trial Wiki What we do not know about retatrutide, listed explicitly — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SCALE ( N Engl J Med , 2015) with STEP 2 ( Lancet ,…	+79	83	952	11mo
A checklist for reading a certificate in under two minutes Analytics › COA interpretation certificate of analysis batch & lot numbers amino acid analysis Solved A checklist for reading a certificate in under two minutes — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere.…	+39	46	38k	1mo
Amylin receptor signalling and satiety — what changed since Pharmacology › Receptor biology tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…	+73	78	3.5k	2mo
Coming back to: Getting a referral rather than a refusal Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes beginner friendly Solved Posting this under the heading it deserves: Getting a referral rather than a refusal Everything below is what sits behind that. General question, not a request for advice about my own care — I know the…	+69	74	1.7k	13mo