Ranked by engagement

Top topics — all time page 29

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 29 of 40

Topic	Participants	Replies	Views	Activity
Follow-up: The most useful thing you learned here that was not the answer you came for Lounge › Off topic beginner friendly long read On the subject in the title: The most useful thing you learned here that was not the answer you came for Working notes rather than a conclusion. Lower-stakes topic, but the sourcing rule still applies if…	+30	34	9.7k	11h
Revisiting: How this community labels and discusses unrefereed work Evidence › Preprints needs a source risk of bias preprint effect size Solved Revisiting: How this community labels and discusses unrefereed work Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited in…	+31	35	7k	1d
Amylin and gastric emptying: overlapping mechanisms with incretins Compounds › Cagrilintide & amylin analogues cagrisema amylin analogues randomised trial On the subject in the title: Amylin and gastric emptying: overlapping mechanisms with incretins Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting;…		2	50k	17mo
Why a preprint's supplementary material is often the best part Evidence › Preprints needs a source risk of bias preprint effect size Why a preprint's supplementary material is often the best part I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: SUSTAIN 6 ( N Engl J Med , 2016). Please…	+38	42	863	22mo
Follow-up: What a seizure notice actually says Sourcing › Logistics customs shipping cold chain packaging Solved What a seizure notice actually says — that is the question, and I have not found it answered plainly anywhere I have looked. Structured report rather than an opinion, following the format the maintainers…	+35	41	490	9mo
Second pass at: Fasting versus non-fasting and which tests care Clinical › Bloodwork lipase & amylase liver enzymes lipid panel HbA1c On the subject in the title: Second pass at: Fasting versus non-fasting and which tests care Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…	+20	25	21k	3mo
[2026 update] Whether protein timing matters at a large deficit Nutrition & Training › Protein & intake lean mass loss fatigue constipation micronutrients Whether protein timing matters at a large deficit — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number without a method is not a…	+4	8	46k	7mo
Lipid changes during rapid weight loss: the expected trajectory Clinical › Bloodwork liver enzymes thyroid function lipid panel lipase & amylase Solved Posting this under the heading it deserves: Lipid changes during rapid weight loss: the expected trajectory Everything below is what sits behind that. General question, not a request for advice about my own…	+11	15	34k	11h
Bariatric surgery history: altered anatomy, altered expectations Clinical › Special populations pregnancy & planning disordered eating older adults adolescents Solved Posting this under the heading it deserves: Bariatric surgery history: altered anatomy, altered expectations Everything below is what sits behind that. General question, not a request for advice about my own…	+35	39	486	2mo
Coming back to: Feature request: should a dose-equivalence tool exist at all? Data & Tools › Calculators syringe units concentration maths worked example site feedback Solved Feature request: should a dose-equivalence tool exist at all? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first…	+37	41	725	7mo
Second pass at: Reading a combination trial: attributing effect to components Compounds › Cagrilintide & amylin analogues cagrilintide randomised trial amylin analogues effect size Second pass at: Reading a combination trial: attributing effect to components — setting out what I have, and where I think it stops being reliable. I have seen SURMOUNT-2 ( Lancet , 2023) cited in support of…	+39	43	7.3k	12mo
Second pass at: Choosing a concentration on purpose rather than by accident Practice › Reconstitution worked example dead volume reconstitution Second pass at: Choosing a concentration on purpose rather than by accident Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because…	+44	48	1k	19mo
The report format the maintainers ask for, and why each field is there — what changed since Sourcing › Vendor reports third-party testing disputed Janoshik Analytical The report format the maintainers ask for, and why each field is there — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an…	+29	35	6.6k	13mo
Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry cloudy or discoloured solution storage counter-ion content Solubility limits and what a cloudy solution is telling you — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate…	+11	15	34k	20h
Needle changes between doses on a reusable pen Devices › Pens & autoinjectors subcutaneous injection dead volume missed dose storage Posting this under the heading it deserves: Needle changes between doses on a reusable pen Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so I am…	+34	38	1.5k	10mo
Revisiting: Holding a dose indefinitely: is there a documented downside? Practice › Dosing & titration titration tirzepatide worked example missed dose Solved The question in the title: Revisiting: Holding a dose indefinitely: is there a documented downside? I will give what I have already checked below so nobody repeats it. A question about technique rather than…	+26	30	4.5k	18mo
A pen that felt like it delivered nothing: diagnosing it afterwards Devices › Pens & autoinjectors storage subcutaneous injection missed dose dead volume Solved On the subject in the title: A pen that felt like it delivered nothing: diagnosing it afterwards Working notes rather than a conclusion. A question about technique rather than about dose. I have been doing…	+35	39	584	6mo
Revisiting: Aggregate verification data across the directory, with caveats Sourcing › Independent verification PeptideMeter third-party testing blind sampling Medutest Closed Revisiting: Aggregate verification data across the directory, with caveats — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal,…	+22	26	23k	17mo
Coming back to: Official shortage notices and what they authorise Access › Shortages shortage FDA formulary Solved Closed Official shortage notices and what they authorise — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines…	+39	43	510	17mo
Measurement error in home scales, with a worked standard deviation Research Methods › Statistics effect size heterogeneity number needed to treat confounding Solved Wiki Measurement error in home scales, with a worked standard deviation Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 1 ( N Engl…	+26	31	4.3k	4mo
Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Compounds › Oral incretins randomised trial oral semaglutide SOUL trial PIONEER programme Posting this under the heading it deserves: Oral versus injectable exposure: comparing apples to a different fruit — a second dataset Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022)…	+27	31	17k	25d
Journal club: semaglutide in MASH, and surrogate endpoints Evidence › Journal club randomised trial journal club effect size risk of bias Posting this under the heading it deserves: Journal club: semaglutide in MASH, and surrogate endpoints Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with SURMOUNT-2 (…	+24	28	17k	15h
Injecting into an area that has become firm: why not to — does this still hold? Practice › Administration injection site rotation aseptic technique missed dose subcutaneous injection Asking directly, because I could not find a straight answer: Injecting into an area that has become firm: why not to — does this still hold? I have read the maintained page on this and I still have a gap, so…		2	49k	9mo
A friction point in the promotion workflow — the long version Meta › Site feedback moderation site feedback guidelines On the subject in the title: A friction point in the promotion workflow — the long version Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic…	+1	5	46k	13mo
Reaching a dose and staying there for a year: a longitudinal note — does this still hold? Practice › Dosing & titration missed dose tirzepatide dose reduction titration Solved Asking directly, because I could not find a straight answer: Reaching a dose and staying there for a year: a longitudinal note — does this still hold? I have read the maintained page on this and I still have…	+35	39	547	11mo
Risk-of-bias tools and the judgement they conceal — does this still hold? Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Risk-of-bias tools and the judgement they conceal — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021)…	+26	30	5.8k	23h
The most common factual error about semaglutide on the internet Compounds › Semaglutide STEP programme randomised trial type 2 diabetes effect size On the subject in the title: The most common factual error about semaglutide on the internet Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the…		2	49k	2y
Semaglutide formulation: what is in the licensed product besides the peptide Compounds › Semaglutide SELECT trial type 2 diabetes semaglutide Semaglutide formulation: what is in the licensed product besides the peptide — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-1 ( N…	+29	35	4.4k	1h
Reading U-100 graduations, with a conversion table Devices › Syringes & needles dead volume worked example subcutaneous injection needle gauge & length Posting this under the heading it deserves: Reading U-100 graduations, with a conversion table Everything below is what sits behind that. Practical question with the units stated, because I have seen how…	+35	41	2k	1d
Choosing which test to pay for, given a fixed budget — does this still hold? Sourcing › Independent verification PeptideMeter blind sampling Janoshik Analytical VendorInvestigate Choosing which test to pay for, given a fixed budget — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to talk about documentation…	+35	39	755	20mo