Ranked by engagement

Top topics — all time page 31

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 31 of 40

Topic	Participants	Replies	Views	Activity
Personal or family history of medullary thyroid carcinoma Safety › Contraindications thyroid C-cell question pancreatitis pregnancy & planning Personal or family history of medullary thyroid carcinoma Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+31	37	709	26d
What published stability data actually covers, and what it does not — what changed since Practice › Storage & stability freeze-thaw storage temperature excursion cloudy or discoloured solution Solved What published stability data actually covers, and what it does not — what changed since — that is the question, and I have not found it answered plainly anywhere I have looked. Practical question with the…		3	43k	6mo
[2026 update] Conference abstracts as evidence: the weakest common citation Evidence › Preprints needs a source effect size preprint risk of bias Closed Conference abstracts as evidence: the weakest common citation — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURMOUNT-4 ( JAMA , 2024) and finding…		2	48k	7mo
[2026 update] Hello from a laboratory that does not do peptides Lounge › Introductions onboarding beginner friendly Hello from a laboratory that does not do peptides Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still applies if anyone makes a…		2	49k	4mo
A newcomer's list of things that confused me, and the fixes Start Here › Welcome beginner friendly trust levels onboarding A newcomer's list of things that confused me, and the fixes — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to include the things…	+9	13	34k	12mo
Coming back to: Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses meta-analysis publication bias heterogeneity risk of bias Reading a meta-analysis you disagree with, fairly Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…	+30	34	9.3k	17mo
AOD-9604 and the fragment hypothesis, revisited — does this still hold? Compounds › Other compounds research use only needs a source mislabelling Solved The question in the title: AOD-9604 and the fragment hypothesis, revisited — does this still hold? I will give what I have already checked below so nobody repeats it. Comparing FLOW ( N Engl J Med , 2024)…	+7	11	31k	19h
Insurance and replacement policies, compared — the long version Sourcing › Logistics shipping cold chain packaging temperature excursion Insurance and replacement policies, compared — the long version — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal, separately…	+29	33	4.9k	9mo
Coming back to: Injection-site reactions: describing them precisely enough to be useful Practice › Side effects hair shedding fatigue constipation nausea On the subject in the title: Injection-site reactions: describing them precisely enough to be useful Working notes rather than a conclusion. Reporting something rather than asking about it, in case the…	+21	25	22k	8mo
Peer-to-peer review: what actually happens on the call — one year on Access › Insurance & coverage appeals formulary insurance Peer-to-peer review: what actually happens on the call — one year on — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this…	+2	6	41k	5mo
About the Contraindications category Safety › Contraindications thyroid C-cell question pancreatitis pregnancy & planning Pinned Wiki Absolute and relative contraindications, and the conditions that change the calculus. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+6	10	35k	14mo
Random versus fixed effects: choosing rather than defaulting Evidence › Meta-analyses effect size publication bias risk of bias heterogeneity Closed Random versus fixed effects: choosing rather than defaulting — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before posting;…	+16	20	22k	13mo
Why side effects reset at each escalation and that is not a failure — the long version Practice › Side effects nausea vomiting fatigue delayed gastric emptying The question in the title: Why side effects reset at each escalation and that is not a failure — the long version I will give what I have already checked below so nobody repeats it. Reporting something rather…		2	46k	17mo
An ABAB design with a data table and honest limitations Research Methods › N-of-1 designs effect size confounding worked example An ABAB design with a data table and honest limitations Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please read it before…		2	45k	5mo
Bleeding at the injection site: normal, and what to do about it — does this still hold? Practice › Administration injection site rotation aseptic technique subcutaneous injection needle gauge & length Bleeding at the injection site: normal, and what to do about it — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Reporting something rather than…	+20	24	16k	15mo
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one year on Compounds › Oral incretins PIONEER programme SOUL trial orforglipron Solved Asking directly, because I could not find a straight answer: Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one — one year on I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited…	+16	20	18k	2mo
About the Receptor biology category Pharmacology › Receptor biology amylin analogues semaglutide tirzepatide Pinned Wiki GLP-1, GIP, glucagon and amylin receptor signalling, bias, desensitisation and central versus peripheral action. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+6	10	34k	20d
How this community labels and discusses unrefereed work — the long version Evidence › Preprints needs a source effect size risk of bias Asking directly, because I could not find a straight answer: How this community labels and discusses unrefereed work — the long version I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a…	+18	23	21k	2mo
Reading an MS report that only gives you a single number — the long version Analytics › Mass spectrometry mass error (ppm) counter-ion content LC-MS high-resolution MS Reading an MS report that only gives you a single number — the long version — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I…		2	47k	18mo
Confounding by indication, explained with a concrete example Evidence › Study critique confounding observational data disputed On the subject in the title: Confounding by indication, explained with a concrete example Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-2 ( N Engl J Med ,…	+21	25	21k	11mo
I have no scientific background — can I still follow the analytics categories? Start Here › Welcome onboarding beginner friendly trust levels The question in the title: I have no scientific background — can I still follow the analytics categories? I will give what I have already checked below so nobody repeats it. I want to check my reasoning…	+29	40	1.4k	12d
Introducing myself: pharmacist, sceptic, reluctant participant Lounge › Introductions onboarding beginner friendly Introducing myself: pharmacist, sceptic, reluctant participant Writing it up because I had to work it out twice and would rather nobody else did. Lower-stakes topic, but the sourcing rule still applies if…	+13	17	23k	2mo
Insomnia at a dose step: reported experiences Wellbeing › Sleep fatigue obstructive sleep apnoea heart rate Solved On the subject in the title: Insomnia at a dose step: reported experiences Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference and I…	+20	24	18k	8mo
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — does this still hold? Sourcing › Independent verification PeptideMeter VendorInvestigate third-party testing Janoshik Analytical Asking directly, because I could not find a straight answer: How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — does this still hold? Structured report rather than an opinion, following the…	+24	28	8k	1mo
Travelling with an injectable: documentation and practicalities Access › International NHS personal import EMA MHRA Posting this under the heading it deserves: Travelling with an injectable: documentation and practicalities Everything below is what sits behind that. Documenting an access outcome, dated, because everything…	+37	42	2.1k	1d
Excipient function in a licensed injectable Pharmacology › Formulation chemistry bacteriostatic water cloudy or discoloured solution sterile water Solved Wiki Closed Excipient function in a licensed injectable Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+3	7	36k	14mo
Validating a calculator against hand arithmetic Data & Tools › Calculators syringe units concentration maths worked example Solved Validating a calculator against hand arithmetic Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+17	21	12k	3mo
Needle changes between doses on a reusable pen — does this still hold? Devices › Pens & autoinjectors dead volume missed dose storage Solved Wiki Needle changes between doses on a reusable pen — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I have read the maintained page on this and I…	+1	5	38k	13mo
Follow-up: UK access routes, dated and sourced Regional › UK & Ireland personal import cost per milligram MHRA Solved On the subject in the title: UK access routes, dated and sourced Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As of May 2026, in…	+10	14	27k	2d
Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club estimand number needed to treat journal club randomised trial Solved Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+7	11	33k	7mo